登録情報 | データベース: PDB / ID: 1z4u |
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タイトル | hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585 |
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要素 | HCV NS5B POLYMERASE |
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キーワード | TRANSFERASE (転移酵素) / NS5B / polymerase (ポリメラーゼ) / HCV / fingers (指) / palm (パーム) / thumb (親指) |
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機能・相同性 | 機能・相同性情報
host cell lipid droplet / symbiont-mediated suppression of host TRAF-mediated signal transduction / transformation of host cell by virus / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / ribonucleoside triphosphate phosphatase activity / lipid droplet / : ...host cell lipid droplet / symbiont-mediated suppression of host TRAF-mediated signal transduction / transformation of host cell by virus / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / ribonucleoside triphosphate phosphatase activity / lipid droplet / : / protein complex oligomerization / monoatomic ion channel activity / viral nucleocapsid / RNA helicase activity / host cell endoplasmic reticulum membrane / host cell perinuclear region of cytoplasm / induction by virus of host autophagy / ribonucleoprotein complex / symbiont entry into host cell / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / virion attachment to host cell / host cell plasma membrane / virion membrane / structural molecule activity / タンパク質分解 / RNA binding / zinc ion binding / ATP binding / 細胞膜 / 細胞質類似検索 - 分子機能 Hepatitis C virus core protein, chain A superfamily / Hepatitus C virus, Non-structural 5a protein, C-terminal / Hepatitis C virus NS5A, 1B domain superfamily / Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / HCV NS5a protein C-terminal region / Hepatitis C virus, Non-structural protein NS4b / Hepatitis C virus, Core protein, N-terminal / Hepatitis C virus non-structural protein NS4b ...Hepatitis C virus core protein, chain A superfamily / Hepatitus C virus, Non-structural 5a protein, C-terminal / Hepatitis C virus NS5A, 1B domain superfamily / Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / HCV NS5a protein C-terminal region / Hepatitis C virus, Non-structural protein NS4b / Hepatitis C virus, Core protein, N-terminal / Hepatitis C virus non-structural protein NS4b / Hepatitis C virus capsid protein / Hepatitis C virus, Non-structural protein NS2 / Hepatitis C virus, Non-structural 5a protein / Hepatitis C virus, Non-structural 5a protein, domain 1a / Hepatitis C virus non-structural 5a, 1B domain / NS5A domain 1a superfamily / Hepatitis C virus non-structural 5a protein membrane anchor / Hepatitis C virus non-structural 5a zinc finger domain / Hepatitis C virus non-structural 5a domain 1b / Hepacivirus nonstructural protein 2 (NS2) protease domain profile. / Hepatitis C virus, Non-structural protein NS4a / Hepatitis C virus non-structural protein NS4a / Hepatitis C virus, Core protein, C-terminal / Hepatitis C virus core protein / Hepatitis C virus, Non-structural protein E2/NS1 / Hepatitis C virus non-structural protein E2/NS1 / Hepatitis C virus, Envelope glycoprotein E1 / Hepatitis C virus envelope glycoprotein E1 / RNA dependent RNA polymerase, hepatitis C virus / Viral RNA dependent RNA polymerase / Hepatitis C virus, NS3 protease, Peptidase S29 / Hepatitis C virus NS3 protease / Hepacivirus/Pegivirus NS3 protease domain profile. / Reverse transcriptase/Diguanylate cyclase domain / DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Reverse transcriptase/Diguanylate cyclase domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Alpha-Beta Plaits / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Hepatitis C virus (ウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Pfefferkorn, J.A. / Greene, M. / Nugent, R. / Gross, R.J. / Mitchell, M.A. / Finzel, B.C. / Harris, M.S. / Wells, P.A. / Shelly, J.A. / Anstadt, R. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2005タイトル: Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid 著者: Pfefferkorn, J.A. / Nugent, R. / Gross, R.J. / Greene, M. / Mitchell, M.A. / Reding, M.T. / Funk, L.A. / Anderson, R. / Wells, P.A. / Shelly, J.A. / Anstadt, R. / Finzel, B.C. / Harris, M.S. ...著者: Pfefferkorn, J.A. / Nugent, R. / Gross, R.J. / Greene, M. / Mitchell, M.A. / Reding, M.T. / Funk, L.A. / Anderson, R. / Wells, P.A. / Shelly, J.A. / Anstadt, R. / Finzel, B.C. / Harris, M.S. / Kilkuskie, R.E. / Kopta, L.A. / Schwende, F.J. #1: ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2005タイトル: Inhibitors of HCV NS5B polymerase: Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid 著者: Pfefferkorn, J.A. / Greene, M.L. / Nugent, R.A. / Gross, R.J. / Mitchell, M.A. / Finzel, B.C. / Harris, M.S. / Wells, P.A. / Shelly, J.A. / Anstadt, R.A. |
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履歴 | 登録 | 2005年3月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2005年6月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Derived calculations / Version format compliance |
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改定 1.3 | 2017年10月11日 | Group: Refinement description / カテゴリ: software / Item: _software.classification / _software.name |
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改定 1.4 | 2023年8月23日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 2.0 | 2024年4月3日 | Group: Advisory / Atomic model / カテゴリ: atom_site / database_PDB_caveat Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z |
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