登録情報 | データベース: PDB / ID: 1shy |
---|
タイトル | The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor. |
---|
要素 | - Hepatocyte growth factor receptorC-Met
- Hepatocyte growth factor肝細胞増殖因子
|
---|
キーワード | GROWTH FACTOR/GROWTH FACTOR RECEPTOR / protease (プロテアーゼ) / sema domain / PSI domain / receptor ectodomain growth factor / GROWTH FACTOR-GROWTH FACTOR RECEPTOR COMPLEX |
---|
機能・相同性 | 機能・相同性情報
regulation of p38MAPK cascade / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / Drug-mediated inhibition of MET activation / skeletal muscle cell proliferation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins ...regulation of p38MAPK cascade / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / Drug-mediated inhibition of MET activation / skeletal muscle cell proliferation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins / MET Receptor Activation / hepatocyte growth factor receptor signaling pathway / semaphorin receptor activity / positive regulation of endothelial cell chemotaxis / MET receptor recycling / 膵臓 / MET activates PTPN11 / MET activates RAP1 and RAC1 / Sema4D mediated inhibition of cell attachment and migration / myoblast proliferation / MET activates PI3K/AKT signaling / negative regulation of stress fiber assembly / negative regulation of Rho protein signal transduction / MET activates PTK2 signaling / positive regulation of DNA biosynthetic process / cellular response to hepatocyte growth factor stimulus / branching morphogenesis of an epithelial tube / positive chemotaxis / negative regulation of thrombin-activated receptor signaling pathway / negative regulation of release of cytochrome c from mitochondria / chemoattractant activity / negative regulation of interleukin-6 production / semaphorin-plexin signaling pathway / positive regulation of interleukin-10 production / 上皮間葉転換 / establishment of skin barrier / positive regulation of osteoblast differentiation / MET activates RAS signaling / negative regulation of peptidyl-serine phosphorylation / 食作用 / MECP2 regulates neuronal receptors and channels / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of microtubule polymerization / Interleukin-7 signaling / cell chemotaxis / basal plasma membrane / negative regulation of autophagy / InlB-mediated entry of Listeria monocytogenes into host cell / platelet alpha granule lumen / liver development / epithelial cell proliferation / molecular function activator activity / growth factor activity / cell morphogenesis / Negative regulation of MET activity / 受容体型チロシンキナーゼ / neuron differentiation / negative regulation of inflammatory response / cell surface receptor protein tyrosine kinase signaling pathway / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of peptidyl-tyrosine phosphorylation / 遊走 / Platelet degranulation / PIP3 activates AKT signaling / mitotic cell cycle / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / protein phosphatase binding / protein tyrosine kinase activity / Interleukin-4 and Interleukin-13 signaling / positive regulation of MAPK cascade / cell surface receptor signaling pathway / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / positive regulation of cell migration / positive regulation of protein phosphorylation / リン酸化 / signaling receptor binding / negative regulation of apoptotic process / 細胞膜 / シグナル伝達 / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / ATP binding / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 肝細胞増殖因子 / Hepatocyte growth factor/Macrophage stimulatory protein / ligand-binding face of the semaphorins, domain 2 / ligand-binding face of the semaphorins, domain 2 / divergent subfamily of APPLE domains / Tyrosine-protein kinase, HGF/MSP receptor / Plexin family / Plexin repeat / Plexin repeat / Sema domain ...肝細胞増殖因子 / Hepatocyte growth factor/Macrophage stimulatory protein / ligand-binding face of the semaphorins, domain 2 / ligand-binding face of the semaphorins, domain 2 / divergent subfamily of APPLE domains / Tyrosine-protein kinase, HGF/MSP receptor / Plexin family / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / IPT/TIG domain / ig-like, plexins, transcription factors / PSI domain / domain found in Plexins, Semaphorins and Integrins / IPT domain / YVTN repeat-like/Quinoprotein amine dehydrogenase / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / 7 Propeller / Methylamine Dehydrogenase; Chain H / Kringle-like fold / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Immunoglobulin E-set / トリプシン / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Trypsin-like serine proteases / Tyrosine-protein kinase, active site / Thrombin, subunit H / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / WD40/YVTN repeat-like-containing domain superfamily / Peptidase S1, PA clan, chymotrypsin-like fold / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Peptidase S1, PA clan / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Βバレル / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.22 Å |
---|
データ登録者 | Stamos, J. / Wiesmann, C. |
---|
引用 | #1: ジャーナル: To be Publishedタイトル: Structural and functional basis of the serine protease-like HGF b-chain in Met binding and signaling 著者: Kirchhofer, D. / Xiaoyi, Y. / Peek, M. / Eigenbrot, C. / Lipari, M.T. / Billeci, K.L. / Maun, H.R. / Moran, P. / Santell, L. / Lazarus, R.A. |
---|
履歴 | 登録 | 2004年2月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2004年6月15日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月29日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Advisory / Version format compliance |
---|
改定 1.3 | 2021年10月27日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
改定 1.4 | 2024年4月3日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|
Remark 650 | HELIX DETERMINATION METHOD: AUTHOR PROVIDED |
---|
Remark 700 | SHEET DETERMINATION METHOD: AUTHOR PROVIDED |
---|
Remark 999 | SEQUENCE IN CHAIN B, THE FURIN CLEAVAGE SITE WAS REPLACED WITH A THROMBIN CLEAVAGE SITE. |
---|