- PDB-1osv: STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCL... -
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基本情報
登録情報
データベース: PDB / ID: 1osv
タイトル
STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
要素
Bile acid receptor
Nuclear receptor coactivator 2核内受容体コアクチベーター2
キーワード
DNA BINDING PROTEIN (DNA結合タンパク質) / LBD / bile acid (胆汁酸) / coactivator (コアクチベーター) / nuclear receptor (核内受容体)
機能・相同性
機能・相同性情報
response to norepinephrine / Endogenous sterols / Synthesis of bile acids and bile salts / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / negative regulation of triglyceride biosynthetic process / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol ...response to norepinephrine / Endogenous sterols / Synthesis of bile acids and bile salts / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / negative regulation of triglyceride biosynthetic process / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / regulation of carbohydrate metabolic process / Synthesis of bile acids and bile salts / positive regulation of glucocorticoid receptor signaling pathway / regulation of lipid storage / Endogenous sterols / HATs acetylate histones / hepatocyte proliferation / regulation of bile acid secretion / regulation of urea metabolic process / intracellular bile acid receptor signaling pathway / chenodeoxycholic acid binding / positive regulation of phosphatidic acid biosynthetic process / positive regulation of glutamate metabolic process / positive regulation of ammonia assimilation cycle / negative regulation of collagen biosynthetic process / bile acid receptor activity / regulation of low-density lipoprotein particle clearance / intracellular triglyceride homeostasis / cellular response to bile acid / SUMOylation of intracellular receptors / Nuclear Receptor transcription pathway / negative regulation of very-low-density lipoprotein particle remodeling / Regulation of lipid metabolism by PPARalpha / negative regulation of interleukin-1 production / Cytoprotection by HMOX1 / leukocyte migration involved in inflammatory response / nuclear glucocorticoid receptor binding / Estrogen-dependent gene expression / regulation of insulin secretion involved in cellular response to glucose stimulus / cellular response to organonitrogen compound / toll-like receptor 9 signaling pathway / negative regulation of monocyte chemotactic protein-1 production / nuclear retinoic acid receptor binding / intracellular receptor signaling pathway / bile acid metabolic process / digestive tract development / bile acid and bile salt transport / response to cholesterol / triglyceride homeostasis / positive regulation of female receptivity / cell-cell junction assembly / bile acid binding / bile acid signaling pathway / nuclear thyroid hormone receptor binding / negative regulation of interleukin-2 production / cellular response to fatty acid / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / positive regulation of interleukin-17 production / intracellular glucose homeostasis / locomotor rhythm / positive regulation of insulin secretion involved in cellular response to glucose stimulus / negative regulation of interleukin-6 production / aryl hydrocarbon receptor binding / negative regulation of type II interferon production / regulation of lipid metabolic process / negative regulation of tumor necrosis factor production / cellular response to Thyroglobulin triiodothyronine / regulation of glucose metabolic process / negative regulation of tumor necrosis factor-mediated signaling pathway / response to glucose / fatty acid homeostasis / DNA polymerase binding / nuclear retinoid X receptor binding / negative regulation of canonical NF-kappaB signal transduction / positive regulation of insulin receptor signaling pathway / regulation of cellular response to insulin stimulus / Notchシグナリング / cellular response to hormone stimulus / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / response to nutrient levels / nuclear receptor coactivator activity / response to progesterone / cholesterol homeostasis / liver regeneration / transcription coregulator binding / nuclear estrogen receptor binding / nuclear receptor binding / peptide binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / circadian regulation of gene expression / ユークロマチン / mRNA transcription by RNA polymerase II / response to organic cyclic compound / negative regulation of inflammatory response / 概日リズム / response to estrogen / RNA polymerase II transcription regulator complex / nuclear receptor activity 類似検索 - 分子機能
分子量: 1464.664 Da / 分子数: 3 / 断片: Residues (741-752) / 由来タイプ: 合成 詳細: The coactivator peptide was synthesized. The sequence of the GRIP is naturally found in Rattus Norvegicus (Norway Rat). 参照: UniProt: Q61026