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Structure paper

TitleStructural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Journal, issue, pagesMol. Cell, Vol. 11, Page 1093-1100, Year 2003
Publish dateMar 20, 2003 (structure data deposition date)
AuthorsMi, L.Z. / Devarakonda, S. / Harp, J.M. / Han, Q. / Pellicciari, R. / Willson, T.M. / Khorasanizadeh, S. / Rastinejad, F.
External linksMol. Cell / PubMed:12718893
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-1osv:
STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1ot7:
Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CHC:
6-ETHYL-CHENODEOXYCHOLIC ACID / medication*YM

ChemComp-HOH:
WATER

ChemComp-IU5:
ISO-URSODEOXYCHOLIC ACID

Source
  • rattus norvegicus (Norway rat)
KeywordsDNA BINDING PROTEIN / LBD / bile acid / coactivator / nuclear receptor / HORMONE/GROWTH FACTOR RECEPTOR / LIGAND BINDING DOMAIN / FXR / HORMONE-GROWTH FACTOR RECEPTOR COMPLEX

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