登録情報 | データベース: PDB / ID: 1npa |
---|
タイトル | crystal structure of HIV-1 protease-hup |
---|
要素 | POL polyprotein |
---|
キーワード | HYDROLASE (加水分解酵素) / protease (プロテアーゼ) / HIV (ヒト免疫不全ウイルス) / Aspartyl protease (アスパラギン酸プロテアーゼ) |
---|
機能・相同性 | 機能・相同性情報
HIV-1 retropepsin / : / retroviral ribonuclease H / exoribonuclease H / : / exoribonuclease H activity / host multivesicular body / DNA integration / 逆転写酵素 / viral genome integration into host DNA ...HIV-1 retropepsin / : / retroviral ribonuclease H / exoribonuclease H / : / exoribonuclease H activity / host multivesicular body / DNA integration / 逆転写酵素 / viral genome integration into host DNA / viral penetration into host nucleus / establishment of integrated proviral latency / RNA-directed DNA polymerase activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / RNA-DNA hybrid ribonuclease activity / viral nucleocapsid / DNA recombination / 加水分解酵素; エステル加水分解酵素 / DNAポリメラーゼ / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / symbiont-mediated suppression of host gene expression / lipid binding / host cell nucleus / host cell plasma membrane / virion membrane / structural molecule activity / タンパク質分解 / DNA binding / RNA binding / zinc ion binding / 生体膜類似検索 - 分子機能 Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain ...Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / リボヌクレアーゼH / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / ジンクフィンガー / Zinc knuckle / Zinc finger, CCHC-type superfamily / Cathepsin D, subunit A; domain 1 / Acid Proteases / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 Chem-3NH / Gag-Pol polyprotein / Gag-Pol polyprotein類似検索 - 構成要素 |
---|
生物種 | Human immunodeficiency virus 1 (ヒト免疫不全ウイルス) |
---|
手法 | X線回折 / フーリエ合成 / 解像度: 2 Å |
---|
データ登録者 | Smith III, A.B. / Hirschmann, R. / Pasternak, A. / Yao, W. / Sprengeler, P.A. / Holloway, M.K. / Kuo, L.C. / Chen, Z. / Darke, P.L. / Schleif, W.A. |
---|
引用 | ジャーナル: J.MED.CHEM. / 年: 1997 タイトル: An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. 著者: Smith III, A.B. / Hirschmann, R. / Pasternak, A. / Yao, W. / Sprengeler, P.A. / Holloway, M.K. / Kuo, L.C. / Chen, Z. / Darke, P.L. / Schleif, W.A. |
---|
履歴 | 登録 | 2003年1月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2004年1月27日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月29日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.3 | 2017年10月11日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.4 | 2024年2月14日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|