登録情報 データベース : PDB / ID : 1f5x 構造の表示 ダウンロードとリンクタイトル NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN 要素RHO-GEF VAV 詳細 キーワード SIGNALING PROTEIN / 11 alpha-HELICES機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Azathioprine ADME / CD28 dependent Vav1 pathway / Erythropoietin activates RAS / RAC2 GTPase cycle / GPVI-mediated activation cascade / FCERI mediated MAPK activation / NRAGE signals death through JNK / Signaling by SCF-KIT / RAC1 GTPase cycle / VEGFR2 mediated vascular permeability ... Azathioprine ADME / CD28 dependent Vav1 pathway / Erythropoietin activates RAS / RAC2 GTPase cycle / GPVI-mediated activation cascade / FCERI mediated MAPK activation / NRAGE signals death through JNK / Signaling by SCF-KIT / RAC1 GTPase cycle / VEGFR2 mediated vascular permeability / RHOA GTPase cycle / RHOG GTPase cycle / FCERI mediated Ca+2 mobilization / G alpha (12/13) signalling events / phosphorylation-dependent protein binding / PIP3 activates AKT signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / Regulation of actin dynamics for phagocytic cup formation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of natural killer cell mediated cytotoxicity / Interleukin-3, Interleukin-5 and GM-CSF signaling / VEGFA-VEGFR2 Pathway / regulation of cell size / positive regulation of cell adhesion / T cell differentiation / phagocytosis / T cell activation / neutrophil chemotaxis / phosphotyrosine residue binding / reactive oxygen species metabolic process / guanyl-nucleotide exchange factor activity / integrin-mediated signaling pathway / cell-cell junction / cell migration / intracellular signal transduction / immune response / G protein-coupled receptor signaling pathway / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Dbl Homology Domain; Chain A / Dbl homology (DH) domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site ... VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Dbl Homology Domain; Chain A / Dbl homology (DH) domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Calponin homology domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / PH-like domain superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Mus musculus (ハツカネズミ)手法 溶液NMR / torsion angle dynamics 詳細データ登録者 Aghazadeh, B. / Rosen, M.K. / Lowry, W.E. / Huang, X.Y. 引用ジャーナル : Cell(Cambridge,Mass.) / 年 : 2000タイトル : Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.著者 : Aghazadeh, B. / Lowry, W.E. / Huang, X.Y. / Rosen, M.K. 履歴 登録 2000年6月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2000年9月15日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月27日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2022年2月16日 Group : Data collection / Database references / Derived calculationsカテゴリ : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details 改定 1.4 2024年5月22日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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