+
Open data
-
Basic information
Entry | Database: SASBDB / ID: SASDES6 |
---|---|
![]() | The 11S subunit of the Plasmodium falciparum proteasome, PA28
|
Function / homology | ![]() Cross-presentation of soluble exogenous antigens (endosomes) / Orc1 removal from chromatin / CDK-mediated phosphorylation and removal of Cdc6 / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / KEAP1-NFE2L2 pathway / UCH proteinases / Ub-specific processing proteases / Neddylation / MAPK6/MAPK4 signaling / Antigen processing: Ubiquitination & Proteasome degradation ...Cross-presentation of soluble exogenous antigens (endosomes) / Orc1 removal from chromatin / CDK-mediated phosphorylation and removal of Cdc6 / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / KEAP1-NFE2L2 pathway / UCH proteinases / Ub-specific processing proteases / Neddylation / MAPK6/MAPK4 signaling / Antigen processing: Ubiquitination & Proteasome degradation / ABC-family proteins mediated transport / AUF1 (hnRNP D0) binds and destabilizes mRNA / proteasome activator complex / regulation of G1/S transition of mitotic cell cycle / endopeptidase activator activity / regulation of proteasomal protein catabolic process / nucleoplasm / cytoplasm Similarity search - Function |
Biological species | ![]() ![]() |
![]() | ![]() Title: The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis Authors: Xie S / Metcalfe R / Hanssen E / Yang T / Gillett D / Leis A / Morton C / Kuiper M / Parker M / Spillman N / Wong W / Tsu C / Dick L / Griffin M |
![]() |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-Data source
SASBDB page | ![]() |
---|
-Related structure data
Similar structure data |
---|
-
External links
Related items in Molecule of the Month |
---|
-Models
Model #2502 | ![]() Type: mix / Software: (CORAL05) / Radius of dummy atoms: 1.90 A / Symmetry: P7 Comment: Model of the flexible regions of PfPA28. P7 symmetry in core and flexible regions. Chi-square value: 5.56 ![]() |
---|---|
Model #2501 | ![]() Type: mix / Software: (CORAL05) / Radius of dummy atoms: 1.90 A / Symmetry: P1 Comment: Model of the flexible regions of PfPA28. P1 symmetry in flexible regions, P7 in core. Chi-square value: 4.69 ![]() |
Model #2498 | ![]() Type: dummy / Radius of dummy atoms: 1.90 A / Symmetry: P7 / Chi-square value: 1.87 / P-value: 0.000023 ![]() |
-
Sample
![]() | Name: The 11S subunit of the Plasmodium falciparum proteasome, PA28 Specimen concentration: 10 mg/ml |
---|---|
Buffer | Name: 20 mM Tris-HCl, 150 mM NaCl, 0.5 mM TCEP, 0.1% sodium azide pH: 7.4 |
Entity #1333 | Name: PA28 / Type: protein / Description: Proteasome activator PA28 / Formula weight: 33.182 / Num. of mol.: 7 / Source: Plasmodium falciparum (isolate 3D7) / References: UniProt: Q8I374 Sequence: GMEAYLNKID KIEPSDQKIK EEYNKFKYDI TKQAIESLRE RIPKRIIFFN NLVNVNSEPG SILNVNDLDG VSYKYKINKI EENVRKKHKG NNSSDFDERE KKKDSLDGHV KHFSNNEDSK LIIDDKVLYT HYVPSHKQIY LELEKIKTYA SELIEIIGNI KLWIQLNVPR ...Sequence: GMEAYLNKID KIEPSDQKIK EEYNKFKYDI TKQAIESLRE RIPKRIIFFN NLVNVNSEPG SILNVNDLDG VSYKYKINKI EENVRKKHKG NNSSDFDERE KKKDSLDGHV KHFSNNEDSK LIIDDKVLYT HYVPSHKQIY LELEKIKTYA SELIEIIGNI KLWIQLNVPR IEDGNNFGVG IQEEAIQELA RVEESAFNLY DAIVKYYMER AKISTKVLKY PNVSDYQEAV RELDEKEWIH IKITIVDMRN NYIMLYDLLY KNWEKVVKPK NEDAHHRMTF |
-Experimental information
Beam | Instrument name: Australian Synchrotron SAXS/WAXS / City: Melbourne / 国: Australia ![]() | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Detector | Name: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
Scan | Measurement date: Dec 2, 2017 / Cell temperature: 22 °C / Exposure time: 1 sec. / Number of frames: 10 / Unit: 1/A /
| ||||||||||||||||||||||||||||||
Distance distribution function P(R) |
| ||||||||||||||||||||||||||||||
Result |
|