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- SASDD86: Full-length human NHLRC2 ( NHL repeat-containing protein 2 ) -

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Basic information

Entry
Database: SASBDB / ID: SASDD86
SampleFull-length human NHLRC2 ( NHL repeat-containing protein 2 )
  • NHL repeat-containing protein 2 (protein), NHLRC2, Homo sapiens
Function / homology
Function and homology information


platelet alpha granule lumen / Platelet degranulation / extracellular region / cytosol
Similarity search - Function
NHL2, NHL repeat domain / Thioredoxin-like / NHL repeat profile. / NHL repeat / NHL repeat / Thioredoxin-like fold / Six-bladed beta-propeller, TolB-like / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamily
Similarity search - Domain/homology
NHL repeat-containing protein 2
Similarity search - Component
Biological speciesHomo sapiens (human)
CitationDate: 2018 Aug 23
Title: Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease
Authors: Biterova E / Ignatyev A / Uusimaa J / Hinttala R
Contact author
  • Alexander Ignatyev (University of Oulu)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #1960
Type: dummy / Software: (DAMFILT5.0) / Radius of dummy atoms: 3.75 A / Symmetry: P1 / Comment: 12 models were averaged and filtered / Chi-square value: 0.159 / P-value: 0.108890
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Full-length human NHLRC2 ( NHL repeat-containing protein 2 )
Specimen concentration: 5 mg/ml
BufferName: 20 mM BisTris, 100 mM NaCl, 2 mM DTT / pH: 6.5
Entity #1051Name: NHLRC2 / Type: protein / Description: NHL repeat-containing protein 2 / Formula weight: 80.4 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q8NBF2
Sequence: MHHHHHHMAA PGGRGRSLSG LLPAQTSLEY ALLDAVTQQE KDSLVYQYLQ KVDGWEQDLS VPEFPEGLEW LNTEEPISVY KDLCGKIVVL DFFTYCCINC IHLLPDLHAL EHTYSDKDGL LIIGVHSAKF PNEKVLDNIK SAVLRYNITH PMVNDADASL WQELEVSCWP ...Sequence:
MHHHHHHMAA PGGRGRSLSG LLPAQTSLEY ALLDAVTQQE KDSLVYQYLQ KVDGWEQDLS VPEFPEGLEW LNTEEPISVY KDLCGKIVVL DFFTYCCINC IHLLPDLHAL EHTYSDKDGL LIIGVHSAKF PNEKVLDNIK SAVLRYNITH PMVNDADASL WQELEVSCWP TLVILGPRGN MLFSLIGEGH KDKLFLYTSI ALKYYKDRGQ IRDNKIGIKL YKDSLPPSPL LFPGKVTVDQ VTDRLVIADT GHHRILVVWK NGQIQYSIGG PNPGRKDGIF SESTFNSPQG VAIMNNIIYV ADTENHLIRK IDLEAEKVST VAGIGIQGTD KEGGAKGEQQ PISSPWDVVF GTSGSEVQRG DILWIAMAGT HQIWALLLDS GKLPKKNELT KGTCLRFAGS GNEENRNNAY PHKAGFAQPS GLSLASEDPW SCLFVADSES STVRTVSLKD GAVKHLVGGE RDPMNLFAFG DVDGVGINAK LQHPLGVTWD KKRNLLYVAD SYNHKIKVVD PKTKNCTTLA GTGDTNNVTS SSFTESTFNE PGGLCIGENG ELLYVADTNN HQIKVMDLET KMVSVLPIFR SENAVVDGPF LVEKQKTLPK LPKSAPSIRL SPVTACAGQT LQFKLRLDLP SGSKLTEGVS SCWFLTAEGN EWLLQGQIAA GDIENISSQP TISLQIPDDC LSLEAIVSVS VFLYYCSADS SACMMKAILF SQPLQITDTQ QGCIAPVELR YVF

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Experimental information

BeamInstrument name: Diamond Light Source B21 / City: Oxfordshire / 国: UK / Shape: 1 x 5 mm / Type of source: X-ray synchrotron / Wavelength: 0.1 Å / Dist. spec. to detc.: 4 mm
DetectorName: Pilatus 2M
Scan
Title: Full-length human NHLRC2 ( NHL repeat-containing protein 2 )
Measurement date: Jul 8, 2017 / Storage temperature: 4 °C / Cell temperature: 10 °C / Exposure time: 3 sec. / Number of frames: 60 / Unit: 1/A /
MinMax
Q0.0039 0.39
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 954 /
MinMax
Q0.00684733 0.222909
P(R) point1 954
R0 146.9
Result
Type of curve: single_conc /
ExperimentalPorod
MW71.2 kDa71.2 kDa
Volume-121 nm3

P(R)P(R) errorGuinierGuinier error
Forward scattering, I00.3031 0.0011 0.3008 0.0004
Radius of gyration, Rg3.76 nm0.027 3.59 nm0.1

MinMax
D-14.69
Guinier point14 143

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