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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 9f1b | ||||||||||||||||||
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タイトル | Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E | ||||||||||||||||||
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![]() | TRANSLATION / ribosome / N-terminal acetyltransferase / NatA / NatE / NAC | ||||||||||||||||||
機能・相同性 | ![]() negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / negative regulation of protein localization to endoplasmic reticulum / nascent polypeptide-associated complex / regulation of skeletal muscle fiber development / : / negative regulation of striated muscle cell apoptotic process / mitotic sister chromatid cohesion, centromeric / peptide-glutamate-alpha-N-acetyltransferase activity / N-terminal methionine Nalpha-acetyltransferase NatE / N-terminal amino-acid Nalpha-acetyltransferase NatA ...negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / negative regulation of protein localization to endoplasmic reticulum / nascent polypeptide-associated complex / regulation of skeletal muscle fiber development / : / negative regulation of striated muscle cell apoptotic process / mitotic sister chromatid cohesion, centromeric / peptide-glutamate-alpha-N-acetyltransferase activity / N-terminal methionine Nalpha-acetyltransferase NatE / N-terminal amino-acid Nalpha-acetyltransferase NatA / positive regulation of cell proliferation involved in heart morphogenesis / peptide-serine-alpha-N-acetyltransferase activity / NatA complex / N-terminal protein amino acid acetylation / positive regulation of skeletal muscle tissue growth / cardiac ventricle development / peptide alpha-N-acetyltransferase activity / skeletal muscle tissue regeneration / histone H4 acetyltransferase activity / heart trabecula morphogenesis / establishment of mitotic sister chromatid cohesion / negative regulation of formation of translation preinitiation complex / N-acetyltransferase activity / GAIT complex / regulation of G1 to G0 transition / laminin receptor activity / exit from mitosis / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of translation involved in cellular response to UV / protein-DNA complex disassembly / positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / mitotic sister chromatid cohesion / optic nerve development / retinal ganglion cell axon guidance / mammalian oogenesis stage / G1 to G0 transition / homeostatic process / internal protein amino acid acetylation / protein acetylation / activation-induced cell death of T cells / macrophage chemotaxis / lung morphogenesis / positive regulation of signal transduction by p53 class mediator / glutathione transferase / phagocytic cup / ubiquitin ligase inhibitor activity / glutathione transferase activity / TOR signaling / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / chromosome organization / 90S preribosome / T cell proliferation involved in immune response / protein-RNA complex assembly / erythrocyte development / negative regulation of ubiquitin-dependent protein catabolic process / translation regulator activity / cellular response to actinomycin D / ribosomal small subunit export from nucleus / cytosolic ribosome / laminin binding / endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rough endoplasmic reticulum / gastrulation / MDM2/MDM4 family protein binding / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / glutathione metabolic process / class I DNA-(apurinic or apyrimidinic site) endonuclease activity / DNA-(apurinic or apyrimidinic site) lyase / rescue of stalled ribosome / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / positive regulation of apoptotic signaling pathway / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / ribosomal large subunit biogenesis / cellular response to leukemia inhibitory factor / maturation of SSU-rRNA / placenta development / small-subunit processome / positive regulation of translation / protein kinase C binding / wound healing / positive regulation of protein-containing complex assembly / G1/S transition of mitotic cell cycle / cellular response to gamma radiation / cellular response to type II interferon / transcription coactivator binding / mRNA 5'-UTR binding / modification-dependent protein catabolic process / spindle / cytoplasmic ribonucleoprotein granule / positive regulation of canonical Wnt signaling pathway / rhythmic process / rRNA processing / protein tag activity / antimicrobial humoral immune response mediated by antimicrobial peptide / glucose homeostasis / virus receptor activity / protein transport / ribosome biogenesis / ribosome binding 類似検索 - 分子機能 | ||||||||||||||||||
生物種 | ![]() ![]() ![]() ![]() ![]() | ||||||||||||||||||
手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.01 Å | ||||||||||||||||||
![]() | Yudin, D. / Scaiola, A. / Ban, N. | ||||||||||||||||||
資金援助 | ![]() ![]() ![]()
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![]() | ![]() タイトル: NAC guides a ribosomal multienzyme complex for nascent protein processing 著者: Lentzsch, A.M. / Yudin, D. / Gamerdinger, M. / Chandrasekar, S. / Rabl, L. / Scaiola, A. / Deuerling, E. / Ban, N. / Shan, S. | ||||||||||||||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 5.9 MB | 表示 | ![]() |
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PDB形式 | ![]() | 表示 | ![]() | |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
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-関連構造データ
関連構造データ | ![]() 50124MC ![]() 9f1cC ![]() 9f1dC M: このデータのモデリングに利用したマップデータ C: 同じ文献を引用 ( |
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類似構造データ | 類似検索 - 機能・相同性 ![]() |
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リンク
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集合体
登録構造単位 | ![]()
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要素
+Large ribosomal subunit protein ... , 11種, 11分子 BPBoBLBXBQBsBABSBBOBg
+40S ribosomal protein ... , 23種, 23分子 AqArAsAwAxAZAyAaAbAcAdAfAgAhAAAiABAkADAlAmAGAo
+RNA鎖 , 6種, 6分子 ATB5B7B8A2AH
+タンパク質 , 5種, 5分子 CuCtDAAjBm
+60S ribosomal protein ... , 23種, 23分子 BpBrBGBUBHBTBIBJAzBtBMBZBCBaBbBEBcBdBfBhBiBkBl
+Ribosomal protein ... , 12種, 12分子 BRAvBVBWBYBBBNAeBFBeACBj
+Small ribosomal subunit protein ... , 6種, 6分子 AtAuAEAFAnAp
+N-alpha-acetyltransferase ... , 2種, 2分子 DBDC
+タンパク質・ペプチド , 1種, 1分子 BK
+非ポリマー , 8種, 2885分子 ![](data/chem/img/MG.gif)
![](data/chem/img/ZN.gif)
![](data/chem/img/UNX.gif)
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![](data/chem/img/IHP.gif)
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![](data/chem/img/SPM.gif)
![](data/chem/img/GTP.gif)
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+詳細
-実験情報
-実験
実験 | 手法: 電子顕微鏡法 |
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EM実験 | 試料の集合状態: PARTICLE / 3次元再構成法: 単粒子再構成法 |
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試料調製
構成要素 |
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