登録情報 データベース : PDB / ID : 8u4k 構造の表示 ダウンロードとリンクタイトル Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain 要素Betacellulin Isoform JM-A CYT-1 of Receptor tyrosine-protein kinase erbB-4 Receptor tyrosine-protein kinase erbB-2 詳細キーワード MEMBRANE PROTEIN / TRANSFERASE / Receptor Tyrosine Kinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / negative regulation of immature T cell proliferation in thymus / ERBB3:ERBB2 complex / ERBB2-ERBB4 signaling pathway ... establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / negative regulation of immature T cell proliferation in thymus / ERBB3:ERBB2 complex / ERBB2-ERBB4 signaling pathway / GRB7 events in ERBB2 signaling / immature T cell proliferation in thymus / RNA polymerase I core binding / mitochondrial fragmentation involved in apoptotic process / GABA receptor binding / positive regulation of urine volume / PI3K events in ERBB4 signaling / negative regulation of epithelial cell apoptotic process / mammary gland epithelial cell differentiation / embryonic pattern specification / regulation of microtubule-based process / positive regulation of protein localization to cell surface / ErbB-3 class receptor binding / semaphorin receptor complex / Sema4D induced cell migration and growth-cone collapse / motor neuron axon guidance / neurotransmitter receptor localization to postsynaptic specialization membrane / neural crest cell migration / Inhibition of Signaling by Overexpressed EGFR / epidermal growth factor receptor activity / EGFR interacts with phospholipase C-gamma / epithelial cell apoptotic process / PLCG1 events in ERBB2 signaling / neuromuscular junction development / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / ERBB2 Activates PTK6 Signaling / positive regulation of Rho protein signal transduction / Drug-mediated inhibition of ERBB2 signaling / Resistance of ERBB2 KD mutants to trastuzumab / Resistance of ERBB2 KD mutants to sapitinib / Resistance of ERBB2 KD mutants to tesevatinib / Resistance of ERBB2 KD mutants to neratinib / Resistance of ERBB2 KD mutants to osimertinib / Resistance of ERBB2 KD mutants to afatinib / Resistance of ERBB2 KD mutants to AEE788 / Resistance of ERBB2 KD mutants to lapatinib / Drug resistance in ERBB2 TMD/JMD mutants / enzyme-linked receptor protein signaling pathway / positive regulation of transcription by RNA polymerase I / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / ERBB2-ERBB3 signaling pathway / Signaling by ERBB4 / oligodendrocyte differentiation / ERBB2 Regulates Cell Motility / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / semaphorin-plexin signaling pathway / positive regulation of cell division / PI3K events in ERBB2 signaling / positive regulation of cell adhesion / SHC1 events in ERBB4 signaling / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / GABA-ergic synapse / positive regulation of protein targeting to membrane / mammary gland alveolus development / cell fate commitment / GAB1 signalosome / regulation of angiogenesis / coreceptor activity / Schwann cell development / Nuclear signaling by ERBB4 / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / Signaling by ERBB2 / regulation of cell migration / cellular response to epidermal growth factor stimulus / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Downregulation of ERBB4 signaling / lactation / GRB2 events in ERBB2 signaling / myelination / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / Downregulation of ERBB2:ERBB3 signaling / transmembrane receptor protein tyrosine kinase activity / SHC1 events in ERBB2 signaling / Constitutive Signaling by Overexpressed ERBB2 / positive regulation of mitotic nuclear division / phosphatidylinositol 3-kinase/protein kinase B signal transduction / neurogenesis / regulation of ERK1 and ERK2 cascade / basal plasma membrane / positive regulation of epithelial cell proliferation / positive regulation of translation / positive regulation of cell differentiation / EGFR downregulation 類似検索 - 分子機能 : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain ... : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Receptor tyrosine-protein kinase erbB-2 / Probetacellulin / Receptor tyrosine-protein kinase erbB-4 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 4.27 Å 詳細データ登録者 Trenker, R. / Diwanji, D. / Bingham, T. / Verba, K.A. / Jura, N. 資金援助 ドイツ, 米国, 3件 詳細 詳細を隠す組織 認可番号 国 German Research Foundation (DFG) TR 1668/1-1 ドイツ National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM139636 米国 National Institutes of Health/National Cancer Institute (NIH/NCI) CA274502 米国
引用ジャーナル : To Be Published タイトル : Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain著者 : Trenker, R. / Diwanji, D. / Bingham, T. / Verba, K.A. / Jura, N. 履歴 登録 2023年9月10日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年3月13日 Provider : repository / タイプ : Initial release