Entry Database : EMDB / ID : EMD-41884 Downloads & linksTitle Structure of the HER4/BTC Homodimer Extracellular Domain Map data Details SampleComplex : HER4/BTC homodimerProtein or peptide : Receptor tyrosine-protein kinase erbB-4Protein or peptide : BetacellulinLigand : 2-acetamido-2-deoxy-beta-D-glucopyranose Details Keywords Receptor Tyrosine Kinase / MEMBRANE PROTEIN / TRANSFERASEFunction / homology Function and homology informationFunction Domain/homology Component
establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / Inhibition of Signaling by Overexpressed EGFR / neuregulin receptor activity / EGFR interacts with phospholipase C-gamma / cardiac muscle tissue regeneration ... establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / Inhibition of Signaling by Overexpressed EGFR / neuregulin receptor activity / EGFR interacts with phospholipase C-gamma / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process / ERBB2-EGFR signaling pathway / ERBB2 Activates PTK6 Signaling / GABA receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of urine volume / PI3K events in ERBB4 signaling / negative regulation of epithelial cell apoptotic process / mammary gland epithelial cell differentiation / embryonic pattern specification / Signaling by ERBB4 / positive regulation of protein localization to cell surface / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / neural crest cell migration / epithelial cell apoptotic process / neurotransmitter receptor localization to postsynaptic specialization membrane / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / epidermal growth factor receptor binding / cell fate commitment / GAB1 signalosome / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / positive regulation of cell division / cellular response to epidermal growth factor stimulus / Signaling by ERBB2 / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / GABA-ergic synapse / mammary gland alveolus development / GRB2 events in ERBB2 signaling / transmembrane receptor protein tyrosine kinase activity / neurogenesis / SHC1 events in ERBB2 signaling / basal plasma membrane / Nuclear signaling by ERBB4 / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly / Downregulation of ERBB4 signaling / lactation / regulation of cell migration / positive regulation of mitotic nuclear division / EGFR downregulation / Signaling by ERBB2 TMD/JMD mutants / clathrin-coated endocytic vesicle membrane / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor protein-tyrosine kinase / positive regulation of cell differentiation / Downregulation of ERBB2 signaling / positive regulation of receptor signaling pathway via JAK-STAT / postsynaptic density membrane / growth factor activity / neuromuscular junction / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of fibroblast proliferation / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / cell migration / nervous system development / presynaptic membrane / heart development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / basolateral plasma membrane / protein tyrosine kinase activity / postsynaptic membrane / Estrogen-dependent gene expression / protein autophosphorylation / Extra-nuclear estrogen signaling / transcription cis-regulatory region binding / receptor complex / cell population proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / mitochondrial matrix / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / positive regulation of cell population proliferation / glutamatergic synapse / positive regulation of DNA-templated transcription / negative regulation of apoptotic process Similarity search - Function : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain ... : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / : / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 3.7 Å Details AuthorsTrenker R / Diwanji D / Bingham T / Verba KA / Jura N Funding support Germany, United States, 3 items Details Hide detailsOrganization Grant number Country German Research Foundation (DFG) TR 16681/1 Germany National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM139636 United States National Institutes of Health/National Cancer Institute (NIH/NCI) CA274502 United States
CitationJournal : To Be Published Title : Structure of the HER4/BTC Homodimer Extracellular DomainAuthors : Trenker R / Diwanji D / Bingham T / Verba KA / Jura N History Deposition Sep 10, 2023 - Header (metadata) release Mar 13, 2024 - Map release Mar 13, 2024 - Update Mar 13, 2024 - Current status Mar 13, 2024 Processing site : RCSB / Status : Released
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