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Open data
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Basic information
Entry | Database: PDB / ID: 8jeq | ||||||
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Title | Crystal structure of Tiragolumab | ||||||
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![]() | IMMUNE SYSTEM / immunotherapy / antibody / checkpoint inhibitor | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Sun, J. / Zhang, X.X. / Song, J. | ||||||
Funding support | 1items
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![]() | ![]() Title: Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Authors: Sun, J. / Zhang, X. / Xue, L. / Cheng, L. / Zhang, J. / Chen, X. / Shen, Z. / Li, K. / Wang, L. / Huang, C. / Song, J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 197.4 KB | Display | ![]() |
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PDB format | ![]() | 158.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 441.5 KB | Display | ![]() |
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Full document | ![]() | 446.9 KB | Display | |
Data in XML | ![]() | 20.7 KB | Display | |
Data in CIF | ![]() | 29.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Antibody | Mass: 25410.295 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
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#2: Antibody | Mass: 24246.883 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
#3: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.84 Å3/Da / Density % sol: 56.65 % |
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Crystal grow | Temperature: 293 K / Method: vapor diffusion, hanging drop Details: 1.6 M ammonium sulfate, 0.1 M MES pH 6.5, 0.01 M cobalt chloride |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 315r / Detector: CCD / Date: Nov 2, 2020 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.97918 Å / Relative weight: 1 |
Reflection | Resolution: 1.96→27.39 Å / Num. obs: 41248 / % possible obs: 99.8 % / Redundancy: 13 % / CC1/2: 0.999 / Rmerge(I) obs: 0.06 / Rpim(I) all: 0.017 / Rrim(I) all: 0.063 / Χ2: 0.95 / Net I/σ(I): 20.9 / Num. measured all: 536255 |
Reflection shell | Resolution: 1.96→2.01 Å / % possible obs: 100 % / Redundancy: 10.9 % / Rmerge(I) obs: 0.981 / Num. measured all: 32720 / Num. unique obs: 2993 / CC1/2: 0.763 / Rpim(I) all: 0.305 / Rrim(I) all: 1.029 / Χ2: 0.85 / Net I/σ(I) obs: 2.4 |
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Processing
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Refinement | Method to determine structure: ![]()
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.96→27.39 Å
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Refine LS restraints |
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LS refinement shell |
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Refinement TLS params. | Method: refined / Origin x: 35.7823 Å / Origin y: 71.8675 Å / Origin z: 41.9037 Å
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Refinement TLS group | Selection details: all |