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- PDB-8i1b: A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURIN... -
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Basic information
Entry | Database: PDB / ID: 8i1b | ||||||
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Title | A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B | ||||||
![]() | INTERLEUKIN-1 BETA | ||||||
![]() | CYTOKINE | ||||||
Function / homology | ![]() CLEC7A/inflammasome pathway / negative regulation of branching morphogenesis of a nerve / Pyroptosis / positive regulation of glial cell differentiation / Interleukin-1 processing / negative regulation of glutamate secretion / negative regulation of neural precursor cell proliferation / negative regulation of adiponectin secretion / monocyte aggregation / negative regulation of lipid metabolic process ...CLEC7A/inflammasome pathway / negative regulation of branching morphogenesis of a nerve / Pyroptosis / positive regulation of glial cell differentiation / Interleukin-1 processing / negative regulation of glutamate secretion / negative regulation of neural precursor cell proliferation / negative regulation of adiponectin secretion / monocyte aggregation / negative regulation of lipid metabolic process / positive regulation of lipid catabolic process / negative regulation of glucose transmembrane transport / regulation of nitric-oxide synthase activity / hyaluronan biosynthetic process / positive regulation of T-helper 1 cell cytokine production / positive regulation of complement activation / Interleukin-1 signaling / cellular response to interleukin-17 / sequestering of triglyceride / negative regulation of gap junction assembly / positive regulation of prostaglandin secretion / positive regulation of stress-activated MAPK cascade / positive regulation of prostaglandin biosynthetic process / positive regulation of immature T cell proliferation in thymus / vascular endothelial growth factor production / positive regulation of astrocyte differentiation / regulation of defense response to virus by host / fever generation / positive regulation of fever generation / regulation of establishment of endothelial barrier / neutrophil activation / response to carbohydrate / interleukin-1 receptor binding / positive regulation of monocyte chemotactic protein-1 production / positive regulation of neutrophil chemotaxis / positive regulation of heterotypic cell-cell adhesion / negative regulation of synaptic transmission / positive regulation of membrane protein ectodomain proteolysis / positive regulation of granulocyte macrophage colony-stimulating factor production / interleukin-1-mediated signaling pathway / positive regulation of p38MAPK cascade / response to ATP / : / leukocyte migration / macrophage chemotaxis / regulation of insulin secretion / social behavior / positive regulation of cell division / negative regulation of neuron differentiation / regulation of neurogenesis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of vascular endothelial growth factor production / ectopic germ cell programmed cell death / negative regulation of lipid catabolic process / positive regulation of epithelial to mesenchymal transition / positive regulation of chemokine production / positive regulation of glial cell proliferation / JNK cascade / extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of interleukin-2 production / negative regulation of insulin receptor signaling pathway / positive regulation of mitotic nuclear division / neutrophil chemotaxis / negative regulation of MAP kinase activity / secretory granule / cytokine activity / positive regulation of interleukin-8 production / astrocyte activation / positive regulation of JNK cascade / memory / cytokine-mediated signaling pathway / negative regulation of neurogenesis / positive regulation of non-canonical NF-kappaB signal transduction / cellular response to mechanical stimulus / positive regulation of angiogenesis / positive regulation of interleukin-6 production / positive regulation of nitric oxide biosynthetic process / positive regulation of type II interferon production / positive regulation of neuron apoptotic process / cellular response to xenobiotic stimulus / integrin binding / positive regulation of cytosolic calcium ion concentration / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / vesicle / response to lipopolysaccharide / receptor ligand activity / positive regulation of ERK1 and ERK2 cascade / lysosome / defense response to Gram-positive bacterium / inflammatory response / positive regulation of protein phosphorylation / immune response / positive regulation of apoptotic process / protein domain specific binding / negative regulation of gene expression / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Ohlendorf, D.H. / Weber, P.C. / Salemme, F.R. | ||||||
![]() | ![]() Title: A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B Authors: Ohlendorf, D.H. / Treharne, A.C. / Weber, P.C. / Wendoloski, J.J. / Salemme, F.R. | ||||||
History |
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Remark 700 | SHEET THE ARRANGEMENT OF THE STRANDS IN IL-1 MAKES A SHEET DESIGNATION MEANINGLESS. THE 12 STRANDS ...SHEET THE ARRANGEMENT OF THE STRANDS IN IL-1 MAKES A SHEET DESIGNATION MEANINGLESS. THE 12 STRANDS HAVE BEEN PRESENTED AS 12 SHEETS OF ONE STRAND EACH ON THE SHEET RECORDS BELOW. THE FIRST GROUP OF FOUR STRANDS ARE PART OF MOTIF A. THE SECOND GROUP OF FOUR STRANDS ARE PART OF MOTIF B. THE THIRD GROUP OF FOUR STRANDS ARE PART OF MOTIF C. |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 43.2 KB | Display | ![]() |
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PDB format | ![]() | 30.4 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 363.6 KB | Display | ![]() |
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Full document | ![]() | 370.8 KB | Display | |
Data in XML | ![]() | 5.5 KB | Display | |
Data in CIF | ![]() | 7.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Atom site foot note | 1: PRO 91 IS A CIS PROLINE. 2: SOLVENT MOLECULES 201, 202 AND 204 COORDINATE THE INTERSECTIONS OF THREE BETA STRANDS. 3: GLN 14, ILE 36, LYS 93 AND VAL 110 SIDECHAINS HAVE BEEN MODELED IN TWO ALTERNATE CONFORMATIONS OF EQUAL OCCUPANCY. | ||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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Components
#1: Protein | Mass: 17415.877 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() | ||
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#2: Water | ChemComp-HOH / | ||
Compound details | THE MOLECULE CAN BE DIVIDED INTO THREE SIMILAR MOTIFS, (RESIDUES 1 - 55, RESIDUES 56 - 107, AND ...THE MOLECULE CAN BE DIVIDED INTO THREE SIMILAR MOTIFS, (RESIDUES 1 - 55, RESIDUES 56 - 107, AND RESIDUES 108 - 153). THESE MOTIFS ARE RELATED BY A LOCAL THREE-FOLD AXIS. THE TRANSFORMA | ||
Nonpolymer details | SOLVENT MOLECULES 201, 202 AND 204 COORDINATESequence details | RESIDUES HAVE BEEN NUMBERED TO AGREE WITH HUMAN IL-1BETA. THIS MEANS THERE IS NO RESIDUE 140. | |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.52 Å3/Da / Density % sol: 65.03 % |
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Processing
Software | Name: PROLSQ / Classification: refinement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Refinement | Resolution: 2.4→5 Å /
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Refinement step | Cycle: LAST / Resolution: 2.4→5 Å
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