登録情報 | データベース: PDB / ID: 8g25 |
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タイトル | Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5 |
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要素 | - Cathepsin-G
- MAP domain-containing protein
- Neutrophil elastase
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キーワード | HYDROLASE/INHIBITOR / Protease Inhibitor / Immune Evasion / Neutrophil / S. aureus / HYDROLASE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
cathepsin G / biofilm matrix disassembly / neutrophil-mediated killing of gram-positive bacterium / leukocyte elastase / biosynthetic process of antibacterial peptides active against Gram-negative bacteria / neutrophil-mediated killing of fungus / acute inflammatory response to antigenic stimulus / purinergic nucleotide receptor signaling pathway / negative regulation of chemotaxis / positive regulation of leukocyte tethering or rolling ...cathepsin G / biofilm matrix disassembly / neutrophil-mediated killing of gram-positive bacterium / leukocyte elastase / biosynthetic process of antibacterial peptides active against Gram-negative bacteria / neutrophil-mediated killing of fungus / acute inflammatory response to antigenic stimulus / purinergic nucleotide receptor signaling pathway / negative regulation of chemotaxis / positive regulation of leukocyte tethering or rolling / response to yeast / caspase binding / leukocyte migration involved in inflammatory response / negative regulation of interleukin-8 production / negative regulation of T cell activation / neutrophil activation / negative regulation of chemokine production / Suppression of apoptosis / protein metabolic process / positive regulation of platelet aggregation / Interleukin-1 processing / Antimicrobial peptides / pyroptotic inflammatory response / Activation of Matrix Metalloproteinases / monocyte chemotaxis / neutrophil-mediated killing of gram-negative bacterium / cytokine binding / Collagen degradation / extracellular matrix disassembly / angiotensin maturation / Pyroptosis / defense response to fungus / Metabolism of Angiotensinogen to Angiotensins / Purinergic signaling in leishmaniasis infection / phagocytosis / response to UV / phagocytic vesicle / transcription repressor complex / Degradation of the extracellular matrix / serine-type peptidase activity / positive regulation of smooth muscle cell proliferation / positive regulation of MAP kinase activity / secretory granule / Regulation of Complement cascade / positive regulation of interleukin-8 production / negative regulation of inflammatory response / protein catabolic process / protein processing / platelet activation / cytokine-mediated signaling pathway / intracellular calcium ion homeostasis / cytoplasmic stress granule / specific granule lumen / transcription corepressor activity / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of immune response / azurophil granule lumen / heparin binding / peptidase activity / antibacterial humoral response / endopeptidase activity / protease binding / cellular response to lipopolysaccharide / collagen-containing extracellular matrix / defense response to Gram-negative bacterium / response to lipopolysaccharide / lysosome / receptor ligand activity / defense response to Gram-positive bacterium / defense response to bacterium / immune response / protein phosphorylation / serine-type endopeptidase activity / intracellular membrane-bounded organelle / Neutrophil degranulation / negative regulation of transcription by RNA polymerase II / cell surface / proteolysis / extracellular space / extracellular exosome / extracellular region / membrane / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 MAP domain / MAP domain / MAP repeat profile. / : / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. ...MAP domain / MAP domain / MAP repeat profile. / : / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan類似検索 - ドメイン・相同性 MAP domain-containing protein / Neutrophil elastase / Cathepsin G類似検索 - 構成要素 |
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生物種 | Staphylococcus aureus subsp. aureus Mu50 (黄色ブドウ球菌) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Mishra, N.B. / Geisbrecht, B.V. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM140852 | 米国 |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2023 タイトル: Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. 著者: Mishra, N. / Herdendorf, T.J. / Prakash, O. / Geisbrecht, B.V. |
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履歴 | 登録 | 2023年2月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年4月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月14日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年7月19日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume |
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改定 1.3 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model Item: _pdbx_initial_refinement_model.details |
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