- PDB-7vdp: The structure of cyclin-dependent kinase 5 (CDK5) in complex with... -
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基本情報
登録情報
データベース: PDB / ID: 7vdp
タイトル
The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 1
要素
Cyclin-dependent kinase 5 activator 1, p25
Cyclin-dependent-like kinase 5
キーワード
TRANSFERASE / CDK5 / p25
機能・相同性
機能・相同性情報
superior olivary nucleus maturation / protein kinase 5 complex / acetylcholine receptor activator activity / G1 to G0 transition involved in cell differentiation / ErbB-2 class receptor binding / negative regulation of synaptic plasticity / contractile muscle fiber / positive regulation of calcium ion-dependent exocytosis / neuron cell-cell adhesion / Activated NTRK2 signals through CDK5 ...superior olivary nucleus maturation / protein kinase 5 complex / acetylcholine receptor activator activity / G1 to G0 transition involved in cell differentiation / ErbB-2 class receptor binding / negative regulation of synaptic plasticity / contractile muscle fiber / positive regulation of calcium ion-dependent exocytosis / neuron cell-cell adhesion / Activated NTRK2 signals through CDK5 / layer formation in cerebral cortex / negative regulation of axon extension / protein localization to synapse / receptor catabolic process / regulation of synaptic vesicle cycle / corpus callosum development / regulation of dendritic spine morphogenesis / cerebellar cortex formation / CRMPs in Sema3A signaling / NGF-stimulated transcription / synaptic transmission, dopaminergic / ErbB-3 class receptor binding / axon extension / negative regulation of protein export from nucleus / cyclin-dependent protein serine/threonine kinase activator activity / calcium ion import / motor neuron axon guidance / regulation of synaptic vesicle recycling / axonal fasciculation / cyclin-dependent protein serine/threonine kinase activity / embryo development ending in birth or egg hatching / dendrite morphogenesis / regulation of neuron differentiation / synaptic vesicle transport / tau-protein kinase activity / regulation of cyclin-dependent protein serine/threonine kinase activity / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / protein kinase activator activity / receptor clustering / beta-tubulin binding / oligodendrocyte differentiation / central nervous system neuron development / cyclin-dependent protein kinase holoenzyme complex / synaptic vesicle exocytosis / behavioral response to cocaine / synaptic vesicle endocytosis / negative regulation of cell cycle / DARPP-32 events / alpha-tubulin binding / positive regulation of protein targeting to membrane / ephrin receptor signaling pathway / regulation of protein localization to plasma membrane / regulation of macroautophagy / Schwann cell development / skeletal muscle tissue development / negative regulation of protein ubiquitination / regulation of synaptic transmission, glutamatergic / positive regulation of microtubule polymerization / sensory perception of pain / synapse assembly / NPAS4 regulates expression of target genes / ionotropic glutamate receptor binding / regulation of cell migration / ephrin receptor binding / ionotropic glutamate receptor signaling pathway / phosphorylation / protein serine/threonine kinase activator activity / cerebellum development / cell-matrix adhesion / axonogenesis / excitatory postsynaptic potential / filopodium / synaptic transmission, glutamatergic / axon guidance / hippocampus development / negative regulation of proteolysis / regulation of actin cytoskeleton organization / peptidyl-threonine phosphorylation / intracellular protein transport / neuron migration / Hsp90 protein binding / visual learning / brain development / tau protein binding / neuromuscular junction / regulation of synaptic plasticity / G protein-coupled acetylcholine receptor signaling pathway / neuron differentiation / p53 binding / microtubule cytoskeleton organization / actin filament binding / cellular response to amyloid-beta / rhythmic process / cell junction / positive regulation of neuron apoptotic process / neuron projection development / Factors involved in megakaryocyte development and platelet production / lamellipodium / presynapse / kinase activity 類似検索 - 分子機能
Cyclin-dependent kinase 5 activator / Cyclin-dependent kinase 5 activator protein / : / Cyclin-like superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ...Cyclin-dependent kinase 5 activator / Cyclin-dependent kinase 5 activator protein / : / Cyclin-like superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
解像度: 2.09→51.79 Å / Cor.coef. Fo:Fc: 0.955 / Cor.coef. Fo:Fc free: 0.944 / SU B: 7.865 / SU ML: 0.109 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.178 / ESU R Free: 0.156 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED
Rfactor
反射数
%反射
Selection details
Rfree
0.2287
3645
4.9 %
RANDOM
Rwork
0.2009
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obs
0.2022
71280
99.95 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK