登録情報 | データベース: PDB / ID: 7u0t |
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タイトル | Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520 |
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要素 | - Peptidylprolyl isomerase
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,Calcineurin subunit B type 1 fusion
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キーワード | HYDROLASE/ISOMERASE / SSGCID / CnA / CnB / FKBP12 / peptidyl prolyl cis-trans isomerase / phosphatase / FK-520 / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / HYDROLASE-ISOMERASE complex / Anti-fungal |
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機能・相同性 | 機能・相同性情報
positive regulation of voltage-gated calcium channel activity / calcium-dependent protein serine/threonine phosphatase regulator activity / negative regulation of calcium ion import across plasma membrane / calcium-dependent protein serine/threonine phosphatase activity / protein serine/threonine phosphatase complex / positive regulation of calcium ion import across plasma membrane / calmodulin-dependent protein phosphatase activity / calcineurin complex / calcineurin-mediated signaling / negative regulation of voltage-gated calcium channel activity ...positive regulation of voltage-gated calcium channel activity / calcium-dependent protein serine/threonine phosphatase regulator activity / negative regulation of calcium ion import across plasma membrane / calcium-dependent protein serine/threonine phosphatase activity / protein serine/threonine phosphatase complex / positive regulation of calcium ion import across plasma membrane / calmodulin-dependent protein phosphatase activity / calcineurin complex / calcineurin-mediated signaling / negative regulation of voltage-gated calcium channel activity / lung epithelial cell differentiation / calcineurin-NFAT signaling cascade / regulation of synaptic vesicle cycle / positive regulation of synaptic vesicle endocytosis / positive regulation of calcineurin-NFAT signaling cascade / myelination in peripheral nervous system / regulation of postsynaptic neurotransmitter receptor internalization / parallel fiber to Purkinje cell synapse / cyclosporin A binding / CLEC7A (Dectin-1) induces NFAT activation / branching involved in blood vessel morphogenesis / postsynaptic modulation of chemical synaptic transmission / protein-serine/threonine phosphatase / Calcineurin activates NFAT / DARPP-32 events / Activation of BAD and translocation to mitochondria / epithelial to mesenchymal transition / phosphatase binding / hippocampal mossy fiber to CA3 synapse / FCERI mediated Ca+2 mobilization / protein dephosphorylation / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / Schaffer collateral - CA1 synapse / brain development / sarcolemma / protein import into nucleus / presynapse / Ca2+ pathway / heart development / postsynapse / calmodulin binding / protein domain specific binding / glutamatergic synapse / calcium ion binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 Calcineurin B protein / PP2B, metallophosphatase domain / PP2B / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. ...Calcineurin B protein / PP2B, metallophosphatase domain / PP2B / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase / Peptidyl-prolyl cis-trans isomerase domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 Chem-KXX / Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform / Calcineurin subunit B type 1 / Peptidylprolyl isomerase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.45 Å |
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データ登録者 | Fox III, D. / Mayclin, S.J. / DeBouver, N.D. / Hoy, M.J. / Heitman, J. / Lorimer, D.D. / Horanyi, P.S. / Edwards, T.E. / Seattle Structural Genomics Center for Infectious Disease (SSGCID) |
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資金援助 | 1件 |
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引用 | ジャーナル: Mbio / 年: 2022 タイトル: Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. 著者: Hoy, M.J. / Park, E. / Lee, H. / Lim, W.Y. / Cole, D.C. / DeBouver, N.D. / Bobay, B.G. / Pierce, P.G. / Fox 3rd, D. / Ciofani, M. / Juvvadi, P.R. / Steinbach, W. / Hong, J. / Heitman, J. |
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履歴 | 登録 | 2022年2月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年8月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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