+Open data
-Basic information
Entry | Database: PDB / ID: 7tze | ||||||||||||
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Title | Structure of murine LAG3 domains 1-2 | ||||||||||||
Components | Lymphocyte activation gene 3 protein | ||||||||||||
Keywords | IMMUNOSUPPRESSANT / Immune checkpoint / T cell / Ig-like fold | ||||||||||||
Function / homology | Function and homology information plasmacytoid dendritic cell activation / negative regulation of regulatory T cell differentiation / negative regulation of T cell activation / MHC class II protein binding / positive regulation of natural killer cell mediated cytotoxicity / MHC class II antigen presentation / natural killer cell mediated cytotoxicity / negative regulation of interleukin-2 production / regulation of immune response / T cell activation ...plasmacytoid dendritic cell activation / negative regulation of regulatory T cell differentiation / negative regulation of T cell activation / MHC class II protein binding / positive regulation of natural killer cell mediated cytotoxicity / MHC class II antigen presentation / natural killer cell mediated cytotoxicity / negative regulation of interleukin-2 production / regulation of immune response / T cell activation / transmembrane signaling receptor activity / adaptive immune response / membrane => GO:0016020 / cell surface receptor signaling pathway / external side of plasma membrane / extracellular region Similarity search - Function | ||||||||||||
Biological species | Mus musculus (house mouse) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.12 Å | ||||||||||||
Authors | Ming, Q. / Tran, T.H. / Luca, V.C. | ||||||||||||
Funding support | United States, 3items
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Citation | Journal: Nat.Immunol. / Year: 2022 Title: LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Authors: Ming, Q. / Celias, D.P. / Wu, C. / Cole, A.R. / Singh, S. / Mason, C. / Dong, S. / Tran, T.H. / Amarasinghe, G.K. / Ruffell, B. / Luca, V.C. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7tze.cif.gz | 186 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7tze.ent.gz | 144.8 KB | Display | PDB format |
PDBx/mmJSON format | 7tze.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tz/7tze ftp://data.pdbj.org/pub/pdb/validation_reports/tz/7tze | HTTPS FTP |
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-Related structure data
Related structure data | 7tz2C 7tzgC 7tzhC 3b43S 4l1dS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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