登録情報 | データベース: PDB / ID: 7tuq |
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タイトル | Crystal structure of BRD4 bromodomain 1 in complex with monoacetylated SARS-CoV-2 E |
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要素 | - Bromodomain-containing protein 4
BRD4 - Envelope small membrane protein
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キーワード | TRANSCRIPTION (転写 (生物学)) / BRD4 (BRD4) / bromodomain (ブロモドメイン) / SARS-CoV-2 (SARSコロナウイルス2) / COVID (新型コロナウイルス感染症 (2019年)) / envelope protein (エンベロープ (ウイルス)) / E protein |
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機能・相同性 | 機能・相同性情報
disruption of cellular anatomical structure in another organism / viral budding from Golgi membrane / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / cytoplasmic capsid assembly / Regulation of gap junction activity / host cell Golgi membrane / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding ...disruption of cellular anatomical structure in another organism / viral budding from Golgi membrane / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / cytoplasmic capsid assembly / Regulation of gap junction activity / host cell Golgi membrane / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / endoplasmic reticulum-Golgi intermediate compartment / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / Maturation of protein E / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / 染色体 / monoatomic ion channel activity / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Translation of Structural Proteins / Virion Assembly and Release / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / structural constituent of virion / Attachment and Entry / transcription coactivator activity / transcription cis-regulatory region binding / クロマチンリモデリング / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / SARS-CoV-2 activates/modulates innate and adaptive immune responses / virion membrane / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / 核質 / 生体膜 / identical protein binding / 細胞核類似検索 - 分子機能 Envelope small membrane protein, SARS-CoV-2-like / Envelope small membrane protein, coronavirus / Envelope small membrane protein, betacoronavirus / Coronavirus small envelope protein E / Coronavirus envelope (CoV E) protein profile. / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II ...Envelope small membrane protein, SARS-CoV-2-like / Envelope small membrane protein, coronavirus / Envelope small membrane protein, betacoronavirus / Coronavirus small envelope protein E / Coronavirus envelope (CoV E) protein profile. / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト)
![](img/tx_virus.gif) ![](data/taxo/wicon/Novel_Coronavirus_SARS-CoV-2.jpg) Severe acute respiratory syndrome coronavirus 2 (SARSコロナウイルス2) |
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手法 | X線回折 / 分子置換 / 解像度: 2.68 Å |
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データ登録者 | Vann, K.R. / Kutateladze, T.G. |
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資金援助 | 1件 |
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引用 | ジャーナル: Structure / 年: 2022 タイトル: Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. 著者: Vann, K.R. / Acharya, A. / Jang, S.M. / Lachance, C. / Zandian, M. / Holt, T.A. / Smith, A.L. / Pandey, K. / Durden, D.L. / El-Gamal, D. / Cote, J. / Byrareddy, S.N. / Kutateladze, T.G. |
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履歴 | 登録 | 2022年2月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年7月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年9月14日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.page_first |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.3 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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