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Yorodumi- PDB-7stz: Crystal Structure of Human E-cadherin EC1-5 bound by mouse monocl... -
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-Basic information
Entry | Database: PDB / ID: 7stz | ||||||
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Title | Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11 | ||||||
Components |
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Keywords | cell adhesion/immune system / SSGCID / Cadherin-1 / cell adhesion / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / cell adhesion-immune system complex | ||||||
Function / homology | Function and homology information response to Gram-positive bacterium / regulation of protein catabolic process at postsynapse, modulating synaptic transmission / pituitary gland development / gamma-catenin binding / negative regulation of axon extension / cell-cell adhesion mediated by cadherin / cellular response to indole-3-methanol / flotillin complex / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / Formation of definitive endoderm ...response to Gram-positive bacterium / regulation of protein catabolic process at postsynapse, modulating synaptic transmission / pituitary gland development / gamma-catenin binding / negative regulation of axon extension / cell-cell adhesion mediated by cadherin / cellular response to indole-3-methanol / flotillin complex / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / Formation of definitive endoderm / catenin complex / Apoptotic cleavage of cell adhesion proteins / Adherens junctions interactions / GTPase activating protein binding / cell-cell junction assembly / adherens junction organization / apical junction complex / ankyrin binding / negative regulation of cell-cell adhesion / cellular response to lithium ion / homophilic cell adhesion via plasma membrane adhesion molecules / lateral plasma membrane / RHO GTPases activate IQGAPs / Integrin cell surface interactions / cell adhesion molecule binding / synapse assembly / InlA-mediated entry of Listeria monocytogenes into host cells / Degradation of the extracellular matrix / protein tyrosine kinase binding / negative regulation of cell migration / protein localization to plasma membrane / adherens junction / cell-cell adhesion / trans-Golgi network / cell morphogenesis / cytoplasmic side of plasma membrane / response to toxic substance / beta-catenin binding / positive regulation of protein import into nucleus / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / cell junction / neuron projection development / actin cytoskeleton / cell migration / lamellipodium / regulation of gene expression / postsynapse / endosome / cadherin binding / response to xenobiotic stimulus / glutamatergic synapse / calcium ion binding / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Mus musculus (house mouse) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.95 Å | ||||||
Authors | Seattle Structural Genomics Center for Infectious Disease / Seattle Structural Genomics Center for Infectious Disease (SSGCID) | ||||||
Funding support | United States, 1items
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Citation | Journal: Pnas Nexus / Year: 2022 Title: Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography. Authors: Maker, A. / Bolejack, M. / Schecterson, L. / Hammerson, B. / Abendroth, J. / Edwards, T.E. / Staker, B. / Myler, P.J. / Gumbiner, B.M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7stz.cif.gz | 758.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7stz.ent.gz | 616 KB | Display | PDB format |
PDBx/mmJSON format | 7stz.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7stz_validation.pdf.gz | 566.8 KB | Display | wwPDB validaton report |
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Full document | 7stz_full_validation.pdf.gz | 593.7 KB | Display | |
Data in XML | 7stz_validation.xml.gz | 70.7 KB | Display | |
Data in CIF | 7stz_validation.cif.gz | 98.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/st/7stz ftp://data.pdbj.org/pub/pdb/validation_reports/st/7stz | HTTPS FTP |
-Related structure data
Related structure data | 6velC 6cxyS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
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-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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