[日本語] English
万見
- PDB-7s7i: Crystal structure of Fab in complex with MICA alpha3 domain -

+
データを開く


IDまたはキーワード:

読み込み中...

-
基本情報

登録情報
データベース: PDB / ID: 7s7i
タイトルCrystal structure of Fab in complex with MICA alpha3 domain
要素
  • Fab heavy chain
  • Fab light chain
  • MHC class I chain-related protein A
キーワードIMMUNE SYSTEM / Immunoglobulin / checkpoint / antibody / complex
機能・相同性
機能・相同性情報


Class I Histocompatibility antigen, domains alpha 1 and 2 / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
類似検索 - ドメイン・相同性
MHC class I chain-related protein A
類似検索 - 構成要素
生物種Homo sapiens (ヒト)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å
データ登録者Lee, P.S. / Strop, P.
資金援助1件
組織認可番号国
Not funded
引用ジャーナル: Anal.Chem. / 年: 2023
タイトル: Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting.
著者: Hogan, J.M. / Lee, P.S. / Wong, S.C. / West, S.M. / Morishige, W.H. / Bee, C. / Tapia, G.C. / Rajpal, A. / Strop, P. / Dollinger, G.
履歴
登録2021年9月16日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02022年10月5日Provider: repository / タイプ: Initial release
改定 1.12023年3月1日Group: Database references / カテゴリ: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name
改定 1.22023年3月15日Group: Database references / カテゴリ: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
改定 1.32023年10月25日Group: Data collection / Refinement description
カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

-
構造の表示

構造ビューア分子:
MolmilJmol/JSmol

ダウンロードとリンク

-
集合体

登録構造単位
A: MHC class I chain-related protein A
H: Fab heavy chain
L: Fab light chain
B: MHC class I chain-related protein A
I: Fab heavy chain
M: Fab light chain
C: MHC class I chain-related protein A
J: Fab heavy chain
N: Fab light chain
D: MHC class I chain-related protein A
U: Fab heavy chain
V: Fab light chain
E: MHC class I chain-related protein A
W: Fab heavy chain
X: Fab light chain
F: MHC class I chain-related protein A
Y: Fab heavy chain
Z: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)359,11027
ポリマ－357,75618
非ポリマー1,3549
水7,602422
1
A: MHC class I chain-related protein A
H: Fab heavy chain
L: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)59,9095
ポリマ－59,6263
非ポリマー2832
水543
タイプ名称対称操作数
identity operation1_555x,y,z1
2
B: MHC class I chain-related protein A
I: Fab heavy chain
M: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)59,9095
ポリマ－59,6263
非ポリマー2832
水543
タイプ名称対称操作数
identity operation1_555x,y,z1
3
C: MHC class I chain-related protein A
J: Fab heavy chain
N: Fab light chain


分子量 (理論値)分子数
合計 (水以外)59,6263
ポリマ－59,6263
非ポリマー00
水543
タイプ名称対称操作数
identity operation1_555x,y,z1
4
D: MHC class I chain-related protein A
U: Fab heavy chain
V: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)59,6884
ポリマ－59,6263
非ポリマー621
水543
タイプ名称対称操作数
identity operation1_555x,y,z1
5
E: MHC class I chain-related protein A
W: Fab heavy chain
X: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)59,9095
ポリマ－59,6263
非ポリマー2832
水543
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area5150 Å2
ΔGint-17 kcal/mol
Surface area24300 Å2
手法PISA
6
F: MHC class I chain-related protein A
Y: Fab heavy chain
Z: Fab light chain
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)60,0685
ポリマ－59,6263
非ポリマー4422
水362
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area5620 Å2
ΔGint-13 kcal/mol
Surface area24380 Å2
手法PISA
単位格子
Length a, b, c (Å)92.778, 170.432, 148.894
Angle α, β, γ (deg.)90.000, 105.810, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z
非結晶学的対称性 (NCS)NCSドメイン:
IDEns-ID詳細
d_1ens_1(chain "A" and resid 204 through 296)
d_2ens_1(chain "B" and resid 204 through 296)
d_3ens_1chain "C"
d_4ens_1chain "D"
d_5ens_1(chain "E" and resid 204 through 296)
d_6ens_1(chain "F" and resid 204 through 296)
d_1ens_2(chain "H" and (resid 2 through 133 or resid 142 through 220))
d_2ens_2chain "I"
d_3ens_2(chain "J" and (resid 2 through 133 or resid 142 through 220))
d_4ens_2(chain "U" and (resid 2 through 133 or resid 142 through 220))
d_5ens_2(chain "W" and (resid 2 through 133 or resid 142 through 220))
d_6ens_2(chain "Y" and (resid 2 through 133 or resid 142 through 220))
d_1ens_3chain "L"
d_2ens_3chain "M"
d_3ens_3chain "N"
d_4ens_3chain "V"
d_5ens_3chain "X"
d_6ens_3chain "Z"

NCSドメイン領域:
Dom-IDComponent-IDEns-IDBeg label comp-IDEnd label comp-IDLabel asym-IDLabel seq-ID
d_11ens_1THRPROA1 - 93
d_21ens_1THRPROE2 - 94
d_31ens_1THRPROI1 - 93
d_41ens_1THRPROL1 - 93
d_51ens_1THRPROO1 - 93
d_61ens_1THRPROS1 - 93
d_11ens_2GLUPROC1 - 132
d_12ens_2THRPROC135 - 213
d_21ens_2GLUPROG1 - 211
d_31ens_2GLUPROJ1 - 132
d_32ens_2THRPROJ136 - 214
d_41ens_2GLUPROM1 - 132
d_42ens_2THRPROM134 - 212
d_51ens_2GLUPROQ1 - 132
d_52ens_2THRPROQ135 - 213
d_61ens_2GLUPROV1 - 132
d_62ens_2THRPROV137 - 215
d_11ens_3GLUGLUD1 - 213
d_21ens_3GLUGLUH1 - 213
d_31ens_3GLUGLUK1 - 213
d_41ens_3GLUGLUN1 - 213
d_51ens_3GLUGLUR1 - 213
d_61ens_3GLUGLUW1 - 213

NCSアンサンブル:
ID
ens_1
ens_2
ens_3

-
要素

-
抗体 , 2種, 12分子 HIJUWYLMNVXZ

#2: 抗体
Fab heavy chain


分子量: 24751.551 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 発現宿主: Homo sapiens (ヒト)
#3: 抗体
Fab light chain


分子量: 23265.760 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 発現宿主: Homo sapiens (ヒト)

-
タンパク質 / 糖 , 2種, 11分子 ABCDEF

#1: タンパク質
MHC class I chain-related protein A


分子量: 11608.696 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: MICA / 発現宿主: Homo sapiens (ヒト) / 参照: UniProt: H9CTV0
#4: 糖
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-アセチル-β-D-グルコサミン


タイプ: D-saccharide, beta linking / 分子量: 221.208 Da / 分子数: 5 / 由来タイプ: 合成 / 式: C8H15NO6
識別子タイププログラム
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

-
非ポリマー , 2種, 426分子

#5: 化合物
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL / エチレングリコ-ル


分子量: 62.068 Da / 分子数: 4 / 由来タイプ: 合成 / 式: C2H6O2
#6: 水 ChemComp-HOH / water


分子量: 18.015 Da / 分子数: 422 / 由来タイプ: 天然 / 式: H2O

-
詳細

研究の焦点であるリガンドがあるかN

-
実験情報

-
実験

実験手法: X線回折 / 使用した結晶の数: 1

-
試料調製

結晶マシュー密度: 3.31 Å3/Da / 溶媒含有率: 62.8 %
結晶化温度: 293 K / 手法: 蒸気拡散法, シッティングドロップ法 / 詳細: 10% PEG 20000, 0.1 M Na citrate pH 5.4, 0.2 M MgCl2

-
データ収集

回折平均測定温度: 100 K / Serial crystal experiment: N
放射光源由来: シンクロトロン / サイト: APS / ビームライン: 17-ID / 波長: 1 Å
検出器タイプ: DECTRIS EIGER2 X 9M / 検出器: PIXEL / 日付: 2018年6月27日
放射プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 1 Å / 相対比: 1
反射解像度: 2.4→170.43 Å / Num. obs: 172438 / % possible obs: 99.4 % / 冗長度: 3.5 % / Biso Wilson estimate: 45.87 Å2 / CC1/2: 0.996 / Rmerge(I) obs: 0.087 / Rpim(I) all: 0.055 / Net I/σ(I): 8.9
反射 シェル解像度: 2.4→2.44 Å / Rmerge(I) obs: 0.734 / Mean I/σ(I) obs: 1.5 / Num. unique obs: 7781 / CC1/2: 0.653 / Rpim(I) all: 0.478

-
解析

ソフトウェア
名称バージョン分類
PHENIX1.19.2_4158精密化
XDSデータ削減
XSCALEデータスケーリング
PHASER位相決定
精密化構造決定の手法: 分子置換
開始モデル: 5XJ4, 4NM4, 1HYR

5xj4

4nm4

1hyr


解像度: 2.4→44.63 Å / SU ML: 0.3836 / 交差検証法: FREE R-VALUE / σ(F): 1.36 / 位相誤差: 27.8573
立体化学のターゲット値: GeoStd + Monomer Library + CDL v1.2
Rfactor反射数%反射
Rfree0.2595 8728 5.06 %
Rwork0.2202 163592 -
obs0.2222 172320 99.36 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
原子変位パラメータBiso mean: 62.2 Å2
精密化ステップサイクル: LAST / 解像度: 2.4→44.63 Å
タンパク質核酸リガンド溶媒全体
原子数23950 0 86 422 24458
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.010324614
X-RAY DIFFRACTIONf_angle_d1.602433493
X-RAY DIFFRACTIONf_chiral_restr0.09993714
X-RAY DIFFRACTIONf_plane_restr0.01834316
X-RAY DIFFRACTIONf_dihedral_angle_d10.24943445
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDRefine-IDタイプRms dev position (Å)
ens_1d_2AX-RAY DIFFRACTIONTorsion NCS0.72506332879
ens_1d_3AX-RAY DIFFRACTIONTorsion NCS1.10952702834
ens_1d_4AX-RAY DIFFRACTIONTorsion NCS1.21676407555
ens_1d_5AX-RAY DIFFRACTIONTorsion NCS0.781070172838
ens_1d_6AX-RAY DIFFRACTIONTorsion NCS0.78082857337
ens_2d_2CX-RAY DIFFRACTIONTorsion NCS0.892257720402
ens_2d_3CX-RAY DIFFRACTIONTorsion NCS0.626031690052
ens_2d_4CX-RAY DIFFRACTIONTorsion NCS0.716905117549
ens_2d_5CX-RAY DIFFRACTIONTorsion NCS4.44832250737
ens_2d_6CX-RAY DIFFRACTIONTorsion NCS3.78769622334
ens_3d_2DX-RAY DIFFRACTIONTorsion NCS1.31310963131
ens_3d_3DX-RAY DIFFRACTIONTorsion NCS0.823296159179
ens_3d_4DX-RAY DIFFRACTIONTorsion NCS1.04864951297
ens_3d_5DX-RAY DIFFRACTIONTorsion NCS4.12469789827
ens_3d_6DX-RAY DIFFRACTIONTorsion NCS3.47704557653
LS精密化 シェル
解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.4-2.430.46922800.42344674X-RAY DIFFRACTION86.22
2.43-2.460.37043060.36255485X-RAY DIFFRACTION99.88
2.46-2.490.3282800.33975447X-RAY DIFFRACTION99.91
2.49-2.520.35832550.31965521X-RAY DIFFRACTION99.81
2.52-2.550.34932890.30975419X-RAY DIFFRACTION99.84
2.55-2.580.35512680.29175540X-RAY DIFFRACTION99.91
2.58-2.620.32112860.27495441X-RAY DIFFRACTION99.91
2.62-2.660.33572910.27355492X-RAY DIFFRACTION99.98
2.66-2.70.29682710.25825470X-RAY DIFFRACTION99.98
2.7-2.750.2982760.25265490X-RAY DIFFRACTION99.93
2.75-2.790.30122880.26375516X-RAY DIFFRACTION99.91
2.79-2.850.33223080.27585370X-RAY DIFFRACTION99.96
2.85-2.90.3323150.28675522X-RAY DIFFRACTION99.95
2.9-2.960.33132680.29295465X-RAY DIFFRACTION99.91
2.96-3.020.34892910.28445478X-RAY DIFFRACTION99.84
3.02-3.090.34343150.27915479X-RAY DIFFRACTION99.83
3.09-3.170.28293070.25575447X-RAY DIFFRACTION99.76
3.17-3.260.2883250.24145400X-RAY DIFFRACTION99.86
3.26-3.350.26653050.22925461X-RAY DIFFRACTION99.86
3.35-3.460.28142840.22945548X-RAY DIFFRACTION99.73
3.46-3.580.23752950.22675439X-RAY DIFFRACTION99.84
3.58-3.730.26642940.22345483X-RAY DIFFRACTION99.9
3.73-3.90.25982830.21095490X-RAY DIFFRACTION99.93
3.9-4.10.23012770.18745485X-RAY DIFFRACTION99.88
4.1-4.360.20712870.16665524X-RAY DIFFRACTION99.73
4.36-4.70.18662800.15245455X-RAY DIFFRACTION99.32
4.7-5.170.19362980.16195501X-RAY DIFFRACTION99.71
5.17-5.910.20113140.16885481X-RAY DIFFRACTION99.83
5.91-7.440.23562690.18845556X-RAY DIFFRACTION99.78
7.45-44.630.21613230.18615513X-RAY DIFFRACTION98.78
精密化 TLS手法: refined / Origin x: 38.384 Å / Origin y: -37.205 Å / Origin z: -47.039 Å
111213212223313233
T0.194016034914 Å20.000230410376552 Å2-0.0753541127055 Å2-0.245058842601 Å2-0.00891260638394 Å2--0.308253444308 Å2
L0.422303290662 °2-0.0764789140275 °2-0.289609440066 °2-0.32707899994 °2-0.0379668723327 °2--0.842252921438 °2
S0.0230611806538 Å °0.0350355880033 Å °-0.0554883035416 Å °-0.0257018031795 Å °-0.00171472414424 Å °0.011598684593 Å °0.1015163523 Å °0.0113838726203 Å °-0.0383986015159 Å °
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A204 - 297
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A501 - 528
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )H2 - 220
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )H301 - 358
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L1 - 213
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L401 - 422
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L301
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B203 - 297
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B401
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B501 - 528
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B402
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )I2 - 220
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )I301 - 354
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )M1 - 213
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )M301 - 313
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )C204 - 296
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )C401 - 409
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )J2 - 220
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )J301 - 352
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )N1 - 213
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )N301 - 316
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )D204 - 296
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )D401 - 406
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U2 - 220
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U401 - 431
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U301
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )V1 - 213
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )V301 - 311
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E204 - 297
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E401
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E501 - 522
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E402
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )W2 - 222
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )W301 - 330
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )X1 - 213
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )X301 - 312
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F204 - 297
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F401 - 402
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F501 - 514
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Y2 - 222
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Y301 - 316
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Z1 - 213

+
万見について

-
お知らせ

-
2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

-
2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbjlvh1.pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

+
2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

+
2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

+
2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

-
万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る