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- PDB-7s7i: Crystal structure of Fab in complex with MICA alpha3 domain -

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Basic information

Entry
Database: PDB / ID: 7s7i
TitleCrystal structure of Fab in complex with MICA alpha3 domain
Components
  • Fab heavy chain
  • Fab light chain
  • MHC class I chain-related protein A
KeywordsIMMUNE SYSTEM / Immunoglobulin / checkpoint / antibody / complex
Function / homology
Function and homology information


negative regulation of defense response / natural killer cell lectin-like receptor binding / gamma-delta T cell activation / regulation of immune response / response to heat / killing of cells of another organism / plasma membrane
Similarity search - Function
Class I Histocompatibility antigen, domains alpha 1 and 2 / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain ...Class I Histocompatibility antigen, domains alpha 1 and 2 / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
MHC class I chain-related protein A
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å
AuthorsLee, P.S. / Strop, P.
Funding support1items
OrganizationGrant numberCountry
Not funded
CitationJournal: Anal.Chem. / Year: 2023
Title: Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting.
Authors: Hogan, J.M. / Lee, P.S. / Wong, S.C. / West, S.M. / Morishige, W.H. / Bee, C. / Tapia, G.C. / Rajpal, A. / Strop, P. / Dollinger, G.
History
DepositionSep 16, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0Oct 5, 2022Provider: repository / Type: Initial release
Revision 1.1Mar 1, 2023Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Mar 15, 2023Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
Revision 1.3Oct 25, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Revision 1.4Nov 13, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: MHC class I chain-related protein A
H: Fab heavy chain
L: Fab light chain
B: MHC class I chain-related protein A
I: Fab heavy chain
M: Fab light chain
C: MHC class I chain-related protein A
J: Fab heavy chain
N: Fab light chain
D: MHC class I chain-related protein A
U: Fab heavy chain
V: Fab light chain
E: MHC class I chain-related protein A
W: Fab heavy chain
X: Fab light chain
F: MHC class I chain-related protein A
Y: Fab heavy chain
Z: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)359,11027
Polymers357,75618
Non-polymers1,3549
Water7,602422
1
A: MHC class I chain-related protein A
H: Fab heavy chain
L: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)59,9095
Polymers59,6263
Non-polymers2832
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: MHC class I chain-related protein A
I: Fab heavy chain
M: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)59,9095
Polymers59,6263
Non-polymers2832
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
C: MHC class I chain-related protein A
J: Fab heavy chain
N: Fab light chain


Theoretical massNumber of molelcules
Total (without water)59,6263
Polymers59,6263
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
D: MHC class I chain-related protein A
U: Fab heavy chain
V: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)59,6884
Polymers59,6263
Non-polymers621
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
E: MHC class I chain-related protein A
W: Fab heavy chain
X: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)59,9095
Polymers59,6263
Non-polymers2832
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5150 Å2
ΔGint-17 kcal/mol
Surface area24300 Å2
MethodPISA
6
F: MHC class I chain-related protein A
Y: Fab heavy chain
Z: Fab light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)60,0685
Polymers59,6263
Non-polymers4422
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5620 Å2
ΔGint-13 kcal/mol
Surface area24380 Å2
MethodPISA
Unit cell
Length a, b, c (Å)92.778, 170.432, 148.894
Angle α, β, γ (deg.)90.000, 105.810, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
d_1ens_1(chain "A" and resid 204 through 296)
d_2ens_1(chain "B" and resid 204 through 296)
d_3ens_1chain "C"
d_4ens_1chain "D"
d_5ens_1(chain "E" and resid 204 through 296)
d_6ens_1(chain "F" and resid 204 through 296)
d_1ens_2(chain "H" and (resid 2 through 133 or resid 142 through 220))
d_2ens_2chain "I"
d_3ens_2(chain "J" and (resid 2 through 133 or resid 142 through 220))
d_4ens_2(chain "U" and (resid 2 through 133 or resid 142 through 220))
d_5ens_2(chain "W" and (resid 2 through 133 or resid 142 through 220))
d_6ens_2(chain "Y" and (resid 2 through 133 or resid 142 through 220))
d_1ens_3chain "L"
d_2ens_3chain "M"
d_3ens_3chain "N"
d_4ens_3chain "V"
d_5ens_3chain "X"
d_6ens_3chain "Z"

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg label comp-IDEnd label comp-IDLabel asym-IDLabel seq-ID
d_11ens_1THRPROA1 - 93
d_21ens_1THRPROE2 - 94
d_31ens_1THRPROI1 - 93
d_41ens_1THRPROL1 - 93
d_51ens_1THRPROO1 - 93
d_61ens_1THRPROS1 - 93
d_11ens_2GLUPROC1 - 132
d_12ens_2THRPROC135 - 213
d_21ens_2GLUPROG1 - 211
d_31ens_2GLUPROJ1 - 132
d_32ens_2THRPROJ136 - 214
d_41ens_2GLUPROM1 - 132
d_42ens_2THRPROM134 - 212
d_51ens_2GLUPROQ1 - 132
d_52ens_2THRPROQ135 - 213
d_61ens_2GLUPROV1 - 132
d_62ens_2THRPROV137 - 215
d_11ens_3GLUGLUD1 - 213
d_21ens_3GLUGLUH1 - 213
d_31ens_3GLUGLUK1 - 213
d_41ens_3GLUGLUN1 - 213
d_51ens_3GLUGLUR1 - 213
d_61ens_3GLUGLUW1 - 213

NCS ensembles :
ID
ens_1
ens_2
ens_3

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Components

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Antibody , 2 types, 12 molecules HIJUWYLMNVXZ

#2: Antibody
Fab heavy chain


Mass: 24751.551 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#3: Antibody
Fab light chain


Mass: 23265.760 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)

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Protein / Sugars , 2 types, 11 molecules ABCDEF

#1: Protein
MHC class I chain-related protein A


Mass: 11608.696 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MICA / Production host: Homo sapiens (human) / References: UniProt: H9CTV0
#4: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 2 types, 426 molecules

#5: Chemical
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C2H6O2
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 422 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.31 Å3/Da / Density % sol: 62.8 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop
Details: 10% PEG 20000, 0.1 M Na citrate pH 5.4, 0.2 M MgCl2

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 17-ID / Wavelength: 1 Å
DetectorType: DECTRIS EIGER2 X 9M / Detector: PIXEL / Date: Jun 27, 2018
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.4→170.43 Å / Num. obs: 172438 / % possible obs: 99.4 % / Redundancy: 3.5 % / Biso Wilson estimate: 45.87 Å2 / CC1/2: 0.996 / Rmerge(I) obs: 0.087 / Rpim(I) all: 0.055 / Net I/σ(I): 8.9
Reflection shellResolution: 2.4→2.44 Å / Rmerge(I) obs: 0.734 / Mean I/σ(I) obs: 1.5 / Num. unique obs: 7781 / CC1/2: 0.653 / Rpim(I) all: 0.478

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Processing

Software
NameVersionClassification
PHENIX1.19.2_4158refinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 5XJ4, 4NM4, 1HYR

5xj4

4nm4

1hyr


Resolution: 2.4→44.63 Å / SU ML: 0.3836 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 27.8573
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2595 8728 5.06 %
Rwork0.2202 163592 -
obs0.2222 172320 99.36 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 62.2 Å2
Refinement stepCycle: LAST / Resolution: 2.4→44.63 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms23950 0 86 422 24458
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.010324614
X-RAY DIFFRACTIONf_angle_d1.602433493
X-RAY DIFFRACTIONf_chiral_restr0.09993714
X-RAY DIFFRACTIONf_plane_restr0.01834316
X-RAY DIFFRACTIONf_dihedral_angle_d10.24943445
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDRefine-IDTypeRms dev position (Å)
ens_1d_2AX-RAY DIFFRACTIONTorsion NCS0.72506332879
ens_1d_3AX-RAY DIFFRACTIONTorsion NCS1.10952702834
ens_1d_4AX-RAY DIFFRACTIONTorsion NCS1.21676407555
ens_1d_5AX-RAY DIFFRACTIONTorsion NCS0.781070172838
ens_1d_6AX-RAY DIFFRACTIONTorsion NCS0.78082857337
ens_2d_2CX-RAY DIFFRACTIONTorsion NCS0.892257720402
ens_2d_3CX-RAY DIFFRACTIONTorsion NCS0.626031690052
ens_2d_4CX-RAY DIFFRACTIONTorsion NCS0.716905117549
ens_2d_5CX-RAY DIFFRACTIONTorsion NCS4.44832250737
ens_2d_6CX-RAY DIFFRACTIONTorsion NCS3.78769622334
ens_3d_2DX-RAY DIFFRACTIONTorsion NCS1.31310963131
ens_3d_3DX-RAY DIFFRACTIONTorsion NCS0.823296159179
ens_3d_4DX-RAY DIFFRACTIONTorsion NCS1.04864951297
ens_3d_5DX-RAY DIFFRACTIONTorsion NCS4.12469789827
ens_3d_6DX-RAY DIFFRACTIONTorsion NCS3.47704557653
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.4-2.430.46922800.42344674X-RAY DIFFRACTION86.22
2.43-2.460.37043060.36255485X-RAY DIFFRACTION99.88
2.46-2.490.3282800.33975447X-RAY DIFFRACTION99.91
2.49-2.520.35832550.31965521X-RAY DIFFRACTION99.81
2.52-2.550.34932890.30975419X-RAY DIFFRACTION99.84
2.55-2.580.35512680.29175540X-RAY DIFFRACTION99.91
2.58-2.620.32112860.27495441X-RAY DIFFRACTION99.91
2.62-2.660.33572910.27355492X-RAY DIFFRACTION99.98
2.66-2.70.29682710.25825470X-RAY DIFFRACTION99.98
2.7-2.750.2982760.25265490X-RAY DIFFRACTION99.93
2.75-2.790.30122880.26375516X-RAY DIFFRACTION99.91
2.79-2.850.33223080.27585370X-RAY DIFFRACTION99.96
2.85-2.90.3323150.28675522X-RAY DIFFRACTION99.95
2.9-2.960.33132680.29295465X-RAY DIFFRACTION99.91
2.96-3.020.34892910.28445478X-RAY DIFFRACTION99.84
3.02-3.090.34343150.27915479X-RAY DIFFRACTION99.83
3.09-3.170.28293070.25575447X-RAY DIFFRACTION99.76
3.17-3.260.2883250.24145400X-RAY DIFFRACTION99.86
3.26-3.350.26653050.22925461X-RAY DIFFRACTION99.86
3.35-3.460.28142840.22945548X-RAY DIFFRACTION99.73
3.46-3.580.23752950.22675439X-RAY DIFFRACTION99.84
3.58-3.730.26642940.22345483X-RAY DIFFRACTION99.9
3.73-3.90.25982830.21095490X-RAY DIFFRACTION99.93
3.9-4.10.23012770.18745485X-RAY DIFFRACTION99.88
4.1-4.360.20712870.16665524X-RAY DIFFRACTION99.73
4.36-4.70.18662800.15245455X-RAY DIFFRACTION99.32
4.7-5.170.19362980.16195501X-RAY DIFFRACTION99.71
5.17-5.910.20113140.16885481X-RAY DIFFRACTION99.83
5.91-7.440.23562690.18845556X-RAY DIFFRACTION99.78
7.45-44.630.21613230.18615513X-RAY DIFFRACTION98.78
Refinement TLS params.Method: refined / Origin x: 38.384 Å / Origin y: -37.205 Å / Origin z: -47.039 Å
111213212223313233
T0.194016034914 Å20.000230410376552 Å2-0.0753541127055 Å2-0.245058842601 Å2-0.00891260638394 Å2--0.308253444308 Å2
L0.422303290662 °2-0.0764789140275 °2-0.289609440066 °2-0.32707899994 °2-0.0379668723327 °2--0.842252921438 °2
S0.0230611806538 Å °0.0350355880033 Å °-0.0554883035416 Å °-0.0257018031795 Å °-0.00171472414424 Å °0.011598684593 Å °0.1015163523 Å °0.0113838726203 Å °-0.0383986015159 Å °
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A204 - 297
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )A501 - 528
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )H2 - 220
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )H301 - 358
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L1 - 213
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L401 - 422
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )L301
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B203 - 297
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B401
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B501 - 528
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )B402
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )I2 - 220
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )I301 - 354
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )M1 - 213
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )M301 - 313
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )C204 - 296
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )C401 - 409
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )J2 - 220
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )J301 - 352
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )N1 - 213
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )N301 - 316
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )D204 - 296
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )D401 - 406
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U2 - 220
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U401 - 431
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )U301
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )V1 - 213
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )V301 - 311
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E204 - 297
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E401
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E501 - 522
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )E402
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )W2 - 222
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )W301 - 330
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )X1 - 213
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )X301 - 312
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F204 - 297
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F401 - 402
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )F501 - 514
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Y2 - 222
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Y301 - 316
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:528 ) ) OR ( CHAIN H AND ( RESID 2:220 OR RESID 301:358 ) ) OR ( CHAIN L AND ( RESID 1:213 OR RESID 401:422 OR RESID 301:301 ) ) OR ( CHAIN B AND ( RESID 203:297 OR RESID 401:401 OR RESID 501:528 OR RESID 402:402 ) ) OR ( CHAIN I AND ( RESID 2:220 OR RESID 301:354 ) ) OR ( CHAIN M AND ( RESID 1:213 OR RESID 301:313 ) ) OR ( CHAIN C AND ( RESID 204:296 OR RESID 401:409 ) ) OR ( CHAIN J AND ( RESID 2:220 OR RESID 301:352 ) ) OR ( CHAIN N AND ( RESID 1:213 OR RESID 301:316 ) ) OR ( CHAIN D AND ( RESID 204:296 OR RESID 401:406 ) ) OR ( CHAIN U AND ( RESID 2:220 OR RESID 401:431 OR RESID 301:301 ) ) OR ( CHAIN V AND ( RESID 1:213 OR RESID 301:311 ) ) OR ( CHAIN E AND ( RESID 204:297 OR RESID 401:401 OR RESID 501:522 OR RESID 402:402 ) ) OR ( CHAIN W AND ( RESID 2:222 OR RESID 301:330 ) ) OR ( CHAIN X AND ( RESID 1:213 OR RESID 301:312 ) ) OR ( CHAIN F AND ( RESID 204:297 OR RESID 401:402 OR RESID 501:514 ) ) OR ( CHAIN Y AND ( RESID 2:222 OR RESID 301:316 ) ) OR ( CHAIN Z AND RESID 1:213 )Z1 - 213

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