登録情報 データベース : PDB / ID : 7rl2 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in Complex with the Drug Losartan 要素Cytochrome P450 2C9 詳細 キーワード OXIDOREDUCTASE / Cytochrome P450 / CYP2C9機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
arachidonic acid 14,15-epoxygenase activity / arachidonic acid 11,12-epoxygenase activity / amide metabolic process / (S)-limonene 6-monooxygenase / (S)-limonene 7-monooxygenase / (R)-limonene 6-monooxygenase / (S)-limonene 6-monooxygenase activity / (S)-limonene 7-monooxygenase activity / (R)-limonene 6-monooxygenase activity / monocarboxylic acid metabolic process ... arachidonic acid 14,15-epoxygenase activity / arachidonic acid 11,12-epoxygenase activity / amide metabolic process / (S)-limonene 6-monooxygenase / (S)-limonene 7-monooxygenase / (R)-limonene 6-monooxygenase / (S)-limonene 6-monooxygenase activity / (S)-limonene 7-monooxygenase activity / (R)-limonene 6-monooxygenase activity / monocarboxylic acid metabolic process / urea metabolic process / Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) / omega-hydroxylase P450 pathway / CYP2E1 reactions / arachidonic acid epoxygenase activity / icosanoid biosynthetic process / epoxygenase P450 pathway / caffeine oxidase activity / Biosynthesis of maresin-like SPMs / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) / monoterpenoid metabolic process / oxidative demethylation / Xenobiotics / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / long-chain fatty acid biosynthetic process / estrogen metabolic process / unspecific monooxygenase / aromatase activity / Aspirin ADME / steroid metabolic process / steroid hydroxylase activity / xenobiotic catabolic process / monooxygenase activity / cholesterol metabolic process / xenobiotic metabolic process / oxidoreductase activity / iron ion binding / intracellular membrane-bounded organelle / heme binding / endoplasmic reticulum membrane / plasma membrane / cytoplasm 類似検索 - 分子機能 Cytochrome P450, E-class, group I / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / : / Chem-LSN / PHOSPHATE ION / Cytochrome P450 2C9 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.23 Å 詳細データ登録者 Shah, M.B. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Int J Mol Sci / 年 : 2021タイトル : Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.著者 : Parikh, S.J. / Kamat, S. / Phillips, M. / Boyson, S.P. / Yarbrough, T. / Davie, D. / Zhang, Q. / Glass, K.C. / Shah, M.B. 履歴 登録 2021年7月23日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年10月6日 Provider : repository / タイプ : Initial release改定 1.1 2021年10月27日 Group : Database references / カテゴリ : citation / Item : _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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