Entry | Database: PDB / ID: 7qhg |
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Title | LIM domain kinase 2 (LIMK2) in complex with TH-470 |
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Components | LIM domain kinase 2 |
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Keywords | TRANSFERASE / Kinase / Type-2 inhibitor / Actin dynamics / CFL-1 |
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Function / homology | Function and homology information
cornea development in camera-type eye / establishment of vesicle localization / head development / astral microtubule organization / negative regulation of cilium assembly / cis-Golgi network / RHO GTPases Activate ROCKs / Sema4D induced cell migration and growth-cone collapse / EPHB-mediated forward signaling / phosphorylation ...cornea development in camera-type eye / establishment of vesicle localization / head development / astral microtubule organization / negative regulation of cilium assembly / cis-Golgi network / RHO GTPases Activate ROCKs / Sema4D induced cell migration and growth-cone collapse / EPHB-mediated forward signaling / phosphorylation / mitotic spindle / positive regulation of protein localization to nucleus / actin cytoskeleton organization / spermatogenesis / non-specific serine/threonine protein kinase / positive regulation of protein phosphorylation / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / perinuclear region of cytoplasm / ATP binding / nucleus / metal ion binding / cytoplasmSimilarity search - Function : / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain ...: / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.45 Å |
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Authors | Mathea, S. / Salah, E. / Hanke, T. / Knapp, S. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | Journal: J.Med.Chem. / Year: 2022 Title: Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Authors: Hanke, T. / Mathea, S. / Woortman, J. / Salah, E. / Berger, B.T. / Tumber, A. / Kashima, R. / Hata, A. / Kuster, B. / Muller, S. / Knapp, S. |
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History | Deposition | Dec 12, 2021 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Dec 22, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 11, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Jan 31, 2024 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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