- PDB-7p2v: Crystal structure of Schistosoma mansoni HDAC8 in complex with a ... -
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基本情報
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データベース: PDB / ID: 7p2v
タイトル
Crystal structure of Schistosoma mansoni HDAC8 in complex with a 4-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site
histone deacetylase / histone deacetylase activity / negative regulation of transcription by RNA polymerase II / nucleus / metal ion binding 類似検索 - 分子機能
解像度: 2.25→39.14 Å / SU ML: 0.35 / 交差検証法: THROUGHOUT / σ(F): 0.53 / 位相誤差: 28.4 / 立体化学のターゲット値: ML 詳細: Refinement has been run by including XYZ refinement both in reciprocal and real-space, group and individual B-factors, TLS, occupancies, and by optimizing X-ray to stereochemistry and ADP weights.
Rfactor
反射数
%反射
Rfree
0.2515
2070
4.76 %
Rwork
0.2117
41408
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obs
0.2136
23664
99.99 %
溶媒の処理
減衰半径: 1.1 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL