登録情報 データベース : PDB / ID : 7nuf 構造の表示 ダウンロードとリンクタイトル Vaccinia virus protein 018 in complex with STAT1 要素Signal transducer and activator of transcription 1-alpha/beta Uncharacterized protein 18 詳細キーワード TRANSCRIPTION / Transcription factor / Inhibitor / Complex / Viral機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
metanephric mesenchymal cell differentiation / negative regulation of metanephric nephron tubule epithelial cell differentiation / negative regulation by virus of viral protein levels in host cell / renal tubule development / ISGF3 complex / response to interferon-beta / metanephric mesenchymal cell proliferation involved in metanephros development / interleukin-27-mediated signaling pathway / negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / CCR5 chemokine receptor binding ... metanephric mesenchymal cell differentiation / negative regulation of metanephric nephron tubule epithelial cell differentiation / negative regulation by virus of viral protein levels in host cell / renal tubule development / ISGF3 complex / response to interferon-beta / metanephric mesenchymal cell proliferation involved in metanephros development / interleukin-27-mediated signaling pathway / negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / CCR5 chemokine receptor binding / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / tumor necrosis factor receptor binding / Signaling by cytosolic FGFR1 fusion mutants / blood circulation / Interleukin-35 Signalling / Interleukin-27 signaling / NOTCH3 Intracellular Domain Regulates Transcription / positive regulation of mesenchymal cell proliferation / macrophage derived foam cell differentiation / histone acetyltransferase binding / Interleukin-20 family signaling / type I interferon-mediated signaling pathway / Interleukin-6 signaling / response to type II interferon / ubiquitin-like protein ligase binding / positive regulation of nitric-oxide synthase biosynthetic process / negative regulation of endothelial cell proliferation / cell surface receptor signaling pathway via JAK-STAT / cellular response to organic cyclic compound / Regulation of IFNA/IFNB signaling / positive regulation of interferon-alpha production / cellular response to interferon-beta / RNA polymerase II core promoter sequence-specific DNA binding / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / Regulation of IFNG signaling / type II interferon-mediated signaling pathway / response to mechanical stimulus / Growth hormone receptor signaling / negative regulation of canonical NF-kappaB signal transduction / Signaling by CSF3 (G-CSF) / positive regulation of defense response to virus by host / response to cAMP / tumor necrosis factor-mediated signaling pathway / Downstream signal transduction / negative regulation of angiogenesis / response to nutrient / transcription corepressor binding / positive regulation of erythrocyte differentiation / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / protein phosphatase 2A binding / response to cytokine / promoter-specific chromatin binding / nuclear receptor binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / RNA polymerase II transcription regulatory region sequence-specific DNA binding / positive regulation of smooth muscle cell proliferation / PKR-mediated signaling / response to hydrogen peroxide / Inactivation of CSF3 (G-CSF) signaling / Signaling by SCF-KIT / ISG15 antiviral mechanism / response to peptide hormone / transcription coactivator binding / defense response / cellular response to type II interferon / RNA polymerase II transcription regulator complex / cellular response to insulin stimulus / Regulation of RUNX2 expression and activity / Signaling by CSF1 (M-CSF) in myeloid cells / Interferon gamma signaling / Interferon alpha/beta signaling / Signaling by ALK fusions and activated point mutants / regulation of cell population proliferation / histone binding / double-stranded DNA binding / regulation of apoptotic process / Interleukin-4 and Interleukin-13 signaling / defense response to virus / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / cadherin binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / axon / dendrite / chromatin / nucleolus / regulation of transcription by RNA polymerase II / SARS-CoV-2 activates/modulates innate and adaptive immune responses / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / enzyme binding / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm 類似検索 - 分子機能 Orthopoxvirus C10L / Orthopoxvirus C10L protein / Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal / STAT1, SH2 domain / STAT1, C-terminal domain superfamily / STAT1 TAZ2 binding domain / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction ... Orthopoxvirus C10L / Orthopoxvirus C10L protein / Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal / STAT1, SH2 domain / STAT1, C-terminal domain superfamily / STAT1 TAZ2 binding domain / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / p53-like transcription factor, DNA-binding / SH2 domain / Src homology 2 (SH2) domain profile. / SH2 domain / SH2 domain superfamily 類似検索 - ドメイン・相同性 ACETYL GROUP / Uncharacterized protein 18 / Signal transducer and activator of transcription 1-alpha/beta 類似検索 - 構成要素生物種 Homo sapiens (ヒト) Vaccinia virus (ワクチニアウイルス)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.00040159011 Å 詳細データ登録者 Pantelejevs, T. / Talbot-Cooper, C. / Smith, G.L. / Hyvonen, M. 資金援助 英国, 3件 詳細 詳細を隠す組織 認可番号 国 Medical Research Council (MRC, United Kingdom) 英国 Biotechnology and Biological Sciences Research Council (BBSRC) 英国 Wellcome Trust 英国
引用 残り1件を表示 表示を減らす履歴 登録 2021年3月12日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年7月28日 Provider : repository / タイプ : Initial release改定 2.0 2021年8月25日 Group : Advisory / Atomic model ... Advisory / Atomic model / Database references / Derived calculations / Polymer sequence / Source and taxonomy / Structure summary カテゴリ : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / database_2 / entity / entity_poly / entity_poly_seq / entity_src_gen / pdbx_entity_src_syn / pdbx_poly_seq_scheme / pdbx_struct_sheet_hbond / pdbx_unobs_or_zero_occ_residues / struct_conf / struct_mon_prot_cis / struct_ref / struct_ref_seq / struct_ref_seq_dif / struct_sheet_range Item : _atom_site.label_seq_id / _atom_site_anisotrop.pdbx_label_seq_id ... _atom_site.label_seq_id / _atom_site_anisotrop.pdbx_label_seq_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.formula_weight / _entity.pdbx_description / _entity_poly.pdbx_seq_one_letter_code / _entity_poly.pdbx_seq_one_letter_code_can / _entity_src_gen.pdbx_end_seq_num / _pdbx_entity_src_syn.ncbi_taxonomy_id / _pdbx_entity_src_syn.organism_common_name / _pdbx_entity_src_syn.organism_scientific / _pdbx_entity_src_syn.pdbx_end_seq_num / _pdbx_struct_sheet_hbond.range_1_label_seq_id / _pdbx_struct_sheet_hbond.range_2_label_seq_id / _struct_conf.beg_label_seq_id / _struct_conf.end_label_seq_id / _struct_mon_prot_cis.label_seq_id / _struct_mon_prot_cis.pdbx_label_seq_id_2 / _struct_ref.db_code / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq.seq_align_beg / _struct_ref_seq.seq_align_end / _struct_sheet_range.beg_label_seq_id / _struct_sheet_range.end_label_seq_id 改定 2.1 2023年3月29日 Group : Database references / カテゴリ : citation / citation_author改定 2.2 2024年2月7日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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