- PDB-7mrz: Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with A... -
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基本情報
登録情報
データベース: PDB / ID: 7mrz
タイトル
Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment
要素
Activin receptor type-2B,Activin receptor type-1B
Fab Heavy Chain
Fab Light Chain
Growth/differentiation factor 11
キーワード
SIGNALING PROTEIN/IMMUNE SYSTEM / Growth factor / type I receptor / Transforming growth factor beta / type II receptor / ternary complex / GDF11 / SIGNALING PROTEIN / SIGNALING PROTEIN-IMMUNE SYSTEM complex
機能・相同性
機能・相同性情報
spinal cord anterior/posterior patterning / type B pancreatic cell maturation / negative regulation of amacrine cell differentiation / Regulation of signaling by NODAL / inhibin binding / activin receptor activity, type II / amacrine cell differentiation / lymphatic endothelial cell differentiation / positive regulation of activin receptor signaling pathway / nodal signaling pathway ...spinal cord anterior/posterior patterning / type B pancreatic cell maturation / negative regulation of amacrine cell differentiation / Regulation of signaling by NODAL / inhibin binding / activin receptor activity, type II / amacrine cell differentiation / lymphatic endothelial cell differentiation / positive regulation of activin receptor signaling pathway / nodal signaling pathway / activin receptor activity / venous blood vessel development / lymphangiogenesis / retina vasculature development in camera-type eye / positive regulation of trophoblast cell migration / activin receptor activity, type I / embryonic foregut morphogenesis / activin receptor complex / camera-type eye morphogenesis / artery development / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / activin binding / Signaling by BMP / activin receptor signaling pathway / SMAD protein signal transduction / Signaling by Activin / kinase activator activity / metanephros development / Signaling by NODAL / gastrulation with mouth forming second / pancreas development / determination of left/right symmetry / negative regulation of cold-induced thermogenesis / insulin secretion / skeletal system morphogenesis / anterior/posterior pattern specification / ureteric bud development / cell surface receptor protein serine/threonine kinase signaling pathway / organ growth / roof of mouth development / growth factor binding / SMAD binding / odontogenesis of dentin-containing tooth / mesoderm development / positive regulation of SMAD protein signal transduction / hair follicle development / blood vessel remodeling / BMP signaling pathway / positive regulation of osteoblast differentiation / positive regulation of bone mineralization / response to glucose / extrinsic apoptotic signaling pathway / protein serine/threonine/tyrosine kinase activity / positive regulation of erythrocyte differentiation / post-embryonic development / kidney development / skeletal system development / cytokine activity / peptidyl-threonine phosphorylation / lung development / growth factor activity / negative regulation of cell growth / cellular response to growth factor stimulus / G1/S transition of mitotic cell cycle / nervous system development / heart development / in utero embryonic development / cell population proliferation / protein autophosphorylation / receptor complex / negative regulation of cell population proliferation / protein phosphorylation / negative regulation of gene expression / intracellular membrane-bounded organelle / protein serine/threonine kinase activity / ubiquitin protein ligase binding / regulation of DNA-templated transcription / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / cell surface / signal transduction / protein-containing complex / extracellular space / nucleoplasm / ATP binding / metal ion binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能
TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family ...TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性