+Open data
-Basic information
Entry | Database: PDB / ID: 7lsw | ||||||
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Title | Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP | ||||||
Components | Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein | ||||||
Keywords | SIGNALING PROTEIN / AUTOPHAGY / ATG8 / LIR | ||||||
Function / homology | Function and homology information FNIP-folliculin RagC/D GAP / positive regulation of protein K48-linked ubiquitination / regulation of Rac protein signal transduction / GABA receptor binding / ATPase inhibitor activity / Amino acids regulate mTORC1 / cellular response to nitrogen starvation / phosphatidylethanolamine binding / TBC/RABGAPs / microtubule associated complex ...FNIP-folliculin RagC/D GAP / positive regulation of protein K48-linked ubiquitination / regulation of Rac protein signal transduction / GABA receptor binding / ATPase inhibitor activity / Amino acids regulate mTORC1 / cellular response to nitrogen starvation / phosphatidylethanolamine binding / TBC/RABGAPs / microtubule associated complex / Macroautophagy / beta-tubulin binding / axoneme / autophagosome membrane / autophagosome maturation / autophagosome assembly / centriolar satellite / extrinsic apoptotic signaling pathway via death domain receptors / smooth endoplasmic reticulum / autophagosome / protein targeting / sperm midpiece / positive regulation of TORC1 signaling / regulation of protein phosphorylation / positive regulation of protein-containing complex assembly / microtubule cytoskeleton organization / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein transport / actin cytoskeleton / positive regulation of peptidyl-serine phosphorylation / protein-folding chaperone binding / cytoplasmic vesicle / microtubule binding / chemical synaptic transmission / microtubule / lysosome / lysosomal membrane / Golgi membrane / protein phosphorylation / ubiquitin protein ligase binding / synapse / negative regulation of transcription by RNA polymerase II / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.05 Å | ||||||
Authors | Appleton, B.A. | ||||||
Citation | Journal: Sci Adv / Year: 2021 Title: GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Authors: Goodwin, J.M. / Walkup 4th, W.G. / Hooper, K. / Li, T. / Kishi-Itakura, C. / Ng, A. / Lehmberg, T. / Jha, A. / Kommineni, S. / Fletcher, K. / Garcia-Fortanet, J. / Fan, Y. / Tang, Q. / Wei, ...Authors: Goodwin, J.M. / Walkup 4th, W.G. / Hooper, K. / Li, T. / Kishi-Itakura, C. / Ng, A. / Lehmberg, T. / Jha, A. / Kommineni, S. / Fletcher, K. / Garcia-Fortanet, J. / Fan, Y. / Tang, Q. / Wei, M. / Agrawal, A. / Budhe, S.R. / Rouduri, S.R. / Baird, D. / Saunders, J. / Kiselar, J. / Chance, M.R. / Ballabio, A. / Appleton, B.A. / Brumell, J.H. / Florey, O. / Murphy, L.O. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7lsw.cif.gz | 184.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7lsw.ent.gz | 147.9 KB | Display | PDB format |
PDBx/mmJSON format | 7lsw.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7lsw_validation.pdf.gz | 473.8 KB | Display | wwPDB validaton report |
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Full document | 7lsw_full_validation.pdf.gz | 481.6 KB | Display | |
Data in XML | 7lsw_validation.xml.gz | 30.1 KB | Display | |
Data in CIF | 7lsw_validation.cif.gz | 40.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ls/7lsw ftp://data.pdbj.org/pub/pdb/validation_reports/ls/7lsw | HTTPS FTP |
-Related structure data
Related structure data | 7lt6C 6hyoS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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