登録情報 データベース : PDB / ID : 7lio 構造の表示 ダウンロードとリンクタイトル X-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide 要素Speckle-type POZ protein TP53-binding protein 1 peptide 詳細キーワード PROTEIN BINDING / SPOP / 53BP1 / DNA damage response / Homologous recombination / Ubiquitin ligase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ubiquitin-modified histone reader activity / positive regulation of isotype switching / cellular response to X-ray / double-strand break repair via classical nonhomologous end joining / protein localization to site of double-strand break / regulation of proteolysis / DNA repair complex / Cul3-RING ubiquitin ligase complex / molecular function inhibitor activity / telomeric DNA binding ... ubiquitin-modified histone reader activity / positive regulation of isotype switching / cellular response to X-ray / double-strand break repair via classical nonhomologous end joining / protein localization to site of double-strand break / regulation of proteolysis / DNA repair complex / Cul3-RING ubiquitin ligase complex / molecular function inhibitor activity / telomeric DNA binding / SUMOylation of transcription factors / localization / negative regulation of double-strand break repair via homologous recombination / methylated histone binding / histone reader activity / replication fork / DNA damage checkpoint signaling / Nonhomologous End-Joining (NHEJ) / transcription coregulator activity / Hedgehog 'on' state / protein homooligomerization / G2/M DNA damage checkpoint / kinetochore / positive regulation of DNA-binding transcription factor activity / double-strand break repair via nonhomologous end joining / protein polyubiquitination / p53 binding / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / site of double-strand break / Processing of DNA double-strand break ends / histone binding / proteasome-mediated ubiquitin-dependent protein catabolic process / RNA polymerase II-specific DNA-binding transcription factor binding / chromosome, telomeric region / damaged DNA binding / nuclear body / nuclear speck / ubiquitin protein ligase binding / DNA damage response / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm 類似検索 - 分子機能 SPOP, C-terminal BACK domain / : / BRCA1 C Terminus (BRCT) domain / Tumour suppressor p53-binding protein-1 Tudor domain / Tumour suppressor p53-binding protein-1 Tudor / : / : / MATH domain / MATH/TRAF domain / MATH/TRAF domain profile. ... SPOP, C-terminal BACK domain / : / BRCA1 C Terminus (BRCT) domain / Tumour suppressor p53-binding protein-1 Tudor domain / Tumour suppressor p53-binding protein-1 Tudor / : / : / MATH domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / breast cancer carboxy-terminal domain / BRCT domain profile. / BRCT domain / BRCT domain superfamily / SKP1/BTB/POZ domain superfamily / Ribosomal protein L2, domain 2 類似検索 - ドメイン・相同性 Speckle-type POZ protein / TP53-binding protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.01 Å 詳細データ登録者 Botuyan, M.V. / Cui, G. / Mer, G. 資金援助 米国, 3件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) R01 CA132878 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01 GM116829 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R35 GM136262 米国
引用ジャーナル : Sci Adv / 年 : 2021タイトル : ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.著者 : Wang, D. / Ma, J. / Botuyan, M.V. / Cui, G. / Yan, Y. / Ding, D. / Zhou, Y. / Krueger, E.W. / Pei, J. / Wu, X. / Wang, L. / Pei, H. / McNiven, M.A. / Ye, D. / Mer, G. / Huang, H. 履歴 登録 2021年1月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年4月14日 Provider : repository / タイプ : Initial release改定 1.1 2021年6月30日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2023年10月18日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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