登録情報 | データベース: PDB / ID: 7l8m |
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タイトル | Crystal structure of human GPX4-U46C mutant K48L |
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要素 | Phospholipid hydroperoxide glutathione peroxidase |
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キーワード | OXIDOREDUCTASE / alpha-beta protein |
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機能・相同性 | 機能・相同性情報
phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / negative regulation of ferroptosis / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins ...phospholipid-hydroperoxide glutathione peroxidase / phospholipid-hydroperoxide glutathione peroxidase activity / Synthesis of 15-eicosatetraenoic acid derivatives / Synthesis of 12-eicosatetraenoic acid derivatives / negative regulation of ferroptosis / selenium binding / Synthesis of 5-eicosatetraenoic acids / glutathione peroxidase / lipoxygenase pathway / Biosynthesis of aspirin-triggered D-series resolvins / Biosynthesis of E-series 18(R)-resolvins / arachidonic acid metabolic process / Biosynthesis of D-series resolvins / Biosynthesis of E-series 18(S)-resolvins / glutathione peroxidase activity / long-chain fatty acid biosynthetic process / protein polymerization / phospholipid metabolic process / response to estradiol / chromatin organization / nuclear envelope / cellular response to oxidative stress / spermatogenesis / response to oxidative stress / protein-containing complex / mitochondrion / extracellular exosome / identical protein binding / nucleus / cytosol類似検索 - 分子機能 Glutathione peroxidase active site / Glutathione peroxidases active site. / Glutathione peroxidase / Glutathione peroxidase conserved site / Glutathione peroxidase / Glutathione peroxidases signature 2. / Glutathione peroxidase profile. / Thioredoxin-like superfamily類似検索 - ドメイン・相同性 Phospholipid hydroperoxide glutathione peroxidase GPX4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.07 Å |
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データ登録者 | Forouhar, F. / Liu, H. / Seibt, T. / Saneto, R. / Friedman, J. / Xia, X. / Shchepinov, M.S. / Ramesh, S. / Conrad, M. / Stockwell, B.R. |
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資金援助 | 米国, ドイツ, ロシア, European Union, 8件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R61NS109407 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | P01CA87497 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | R35CA209896 | 米国 | Marie Sklodowska-Curie Actions, FragNET ITN | 03VP04260 | ドイツ | Ministry of Science and Higher Education of the Russian Federation | 075-15-2019-1933 | ロシア | European Research Council (ERC) | GA 884754 | European Union | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R24GM141256 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P30GM124165 | 米国 |
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引用 | ジャーナル: Nat.Chem.Biol. / 年: 2021 タイトル: Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism 著者: Liu, H. / Forouhar, F. / Seibt, T. / Saneto, R. / Wigby, K. / Friedman, J. / Xia, X. / Shchepinov, M.S. / Ramesh, S. / Conrad, M. / Stockwell, B.R. |
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履歴 | 登録 | 2020年12月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年12月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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