登録情報 | データベース: PDB / ID: 7kll |
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タイトル | Human Arginase1 Complexed with Inhibitor Compound 18 |
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要素 | Arginase-1 |
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キーワード | HYDROLASE/INHIBITOR / Arginase / hydrolase / urea cycle / metabolism / HYDROLASE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
positive regulation of neutrophil mediated killing of fungus / Urea cycle / negative regulation of T-helper 2 cell cytokine production / arginase / arginase activity / arginine catabolic process to ornithine / urea cycle / negative regulation of type II interferon-mediated signaling pathway / defense response to protozoan / negative regulation of activated T cell proliferation ...positive regulation of neutrophil mediated killing of fungus / Urea cycle / negative regulation of T-helper 2 cell cytokine production / arginase / arginase activity / arginine catabolic process to ornithine / urea cycle / negative regulation of type II interferon-mediated signaling pathway / defense response to protozoan / negative regulation of activated T cell proliferation / arginine catabolic process / negative regulation of T cell proliferation / specific granule lumen / azurophil granule lumen / manganese ion binding / adaptive immune response / innate immune response / Neutrophil degranulation / extracellular space / extracellular region / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Arginase / Ureohydrolase, manganese-binding site / Arginase family signature. / Ureohydrolase / Arginase family / Arginase family profile. / Ureohydrolase domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.22 Å |
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データ登録者 | Palte, R.L. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2021 タイトル: Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. 著者: Lu, M. / Zhang, H. / Li, D. / Childers, M. / Pu, Q. / Palte, R.L. / Gathiaka, S. / Lyons, T.W. / Palani, A. / Fan, P.W. / Spacciapoli, P. / Miller, J.R. / Cho, H. / Cheng, M. / Chakravarthy, ...著者: Lu, M. / Zhang, H. / Li, D. / Childers, M. / Pu, Q. / Palte, R.L. / Gathiaka, S. / Lyons, T.W. / Palani, A. / Fan, P.W. / Spacciapoli, P. / Miller, J.R. / Cho, H. / Cheng, M. / Chakravarthy, K. / O'Neil, J. / Eangoor, P. / Beard, A. / Kim, H.Y. / Sauri, J. / Gunaydin, H. / Sloman, D.L. / Siliphaivanh, P. / Cumming, J. / Fischer, C. |
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履歴 | 登録 | 2020年10月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年9月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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