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- PDB-7khh: Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin... -

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Basic information

Entry
Database: PDB / ID: 7khh
TitleTernary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)
Components
  • Bromodomain-containing protein 4
  • Elongin-B
  • Elongin-C
  • von Hippel-Lindau disease tumor suppressor
KeywordsPEPTIDE BINDING PROTEIN / PROTAC
Function / homology
Function and homology information


regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex ...regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / RNA polymerase II C-terminal domain binding / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / negative regulation of DNA damage checkpoint / P-TEFb complex binding / ubiquitin-like ligase-substrate adaptor activity / negative regulation by host of viral transcription / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / negative regulation of signal transduction / positive regulation of T-helper 17 cell lineage commitment / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / negative regulation of autophagy / RNA polymerase II CTD heptapeptide repeat kinase activity / transcription corepressor binding / condensed nuclear chromosome / transcription elongation by RNA polymerase II / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / transcription initiation at RNA polymerase II promoter / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / Vif-mediated degradation of APOBEC3G / lysine-acetylated histone binding / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / ubiquitin-protein transferase activity / transcription corepressor activity / Antigen processing: Ubiquitination & Proteasome degradation / p53 binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / chromosome / Neddylation / Replication of the SARS-CoV-2 genome / regulation of inflammatory response / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / regulation of gene expression / protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / positive regulation of canonical NF-kappaB signal transduction / amyloid fibril formation / Potential therapeutics for SARS / molecular adaptor activity / transcription coactivator activity / protein stabilization / transcription cis-regulatory region binding / protein ubiquitination / chromatin remodeling / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / DNA damage response / chromatin binding / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / mitochondrion / proteolysis / nucleoplasm / nucleus / plasma membrane / cytosol
Similarity search - Function
von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Elongin B / Elongin-C ...von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Elongin B / Elongin-C / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / SKP1/BTB/POZ domain superfamily / Bromodomain, conserved site / Bromodomain signature. / Ubiquitin family / Bromodomain / Ubiquitin homologues / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily
Similarity search - Domain/homology
Chem-WEP / Bromodomain-containing protein 4 / von Hippel-Lindau disease tumor suppressor / Elongin-C / Elongin-B
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.281 Å
AuthorsMurray, J.M.
CitationJournal: J.Med.Chem. / Year: 2021
Title: Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
Authors: Dragovich, P.S. / Pillow, T.H. / Blake, R.A. / Sadowsky, J.D. / Adaligil, E. / Adhikari, P. / Chen, J. / Corr, N. / Dela Cruz-Chuh, J. / Del Rosario, G. / Fullerton, A. / Hartman, S.J. / ...Authors: Dragovich, P.S. / Pillow, T.H. / Blake, R.A. / Sadowsky, J.D. / Adaligil, E. / Adhikari, P. / Chen, J. / Corr, N. / Dela Cruz-Chuh, J. / Del Rosario, G. / Fullerton, A. / Hartman, S.J. / Jiang, F. / Kaufman, S. / Kleinheinz, T. / Kozak, K.R. / Liu, L. / Lu, Y. / Mulvihill, M.M. / Murray, J.M. / O'Donohue, A. / Rowntree, R.K. / Sawyer, W.S. / Staben, L.R. / Wai, J. / Wang, J. / Wei, B. / Wei, W. / Xu, Z. / Yao, H. / Yu, S.F. / Zhang, D. / Zhang, H. / Zhang, S. / Zhao, Y. / Zhou, H. / Zhu, X.
History
DepositionOct 21, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 24, 2021Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2021Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
Revision 1.2Oct 18, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Elongin-B
B: Elongin-C
C: von Hippel-Lindau disease tumor suppressor
D: Bromodomain-containing protein 4
hetero molecules


Theoretical massNumber of molelcules
Total (without water)63,1125
Polymers62,0154
Non-polymers1,0961
Water6,053336
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: gel filtration
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)78.979, 78.979, 195.399
Angle α, β, γ (deg.)90.000, 90.000, 120.000
Int Tables number152
Space group name H-MP3121

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Components

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Protein , 4 types, 4 molecules ABCD

#1: Protein Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / ...EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2


Mass: 13163.781 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ELOB, TCEB2 / Plasmid: pDUET / Production host: Escherichia coli (E. coli) / References: UniProt: Q15370
#2: Protein Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / ...EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / Transcription elongation factor B polypeptide 1


Mass: 10843.420 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ELOC, TCEB1 / Plasmid: pDUET / Production host: Escherichia coli (E. coli) / References: UniProt: Q15369
#3: Protein von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL


Mass: 20383.080 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: VHL / Production host: Escherichia coli (E. coli) / References: UniProt: P40337
#4: Protein Bromodomain-containing protein 4 / Protein HUNK1


Mass: 17625.037 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: BRD4, HUNK1 / Production host: Escherichia coli (E. coli) / References: UniProt: O60885

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Non-polymers , 2 types, 337 molecules

#5: Chemical ChemComp-WEP / N-[11-({7-(3,5-difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide


Mass: 1096.313 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C56H67F2N9O8S2 / Feature type: SUBJECT OF INVESTIGATION
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 336 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.84 Å3/Da / Density % sol: 56.64 %
Crystal growTemperature: 291 K / Method: evaporation / pH: 8
Details: 18% w/v PEG 8K, 10% v/v PEG 200, 0.1 M BIS-TRIS propane pH 9.0

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 21-ID-D / Wavelength: 1.07822 Å
DetectorType: DECTRIS PILATUS 2M / Detector: PIXEL / Date: Nov 4, 2017
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.07822 Å / Relative weight: 1
ReflectionResolution: 2.278→68.398 Å / Num. obs: 478991 / % possible obs: 92.7 % / Redundancy: 19.7 % / CC1/2: 0.998 / Rmerge(I) obs: 0.174 / Rpim(I) all: 0.04 / Net I/σ(I): 15.3
Reflection shellResolution: 2.278→2.475 Å / Redundancy: 13.6 % / Rmerge(I) obs: 1.79 / Num. unique obs: 16514 / CC1/2: 0.537 / Rpim(I) all: 0.499 / % possible all: 71.1

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Processing

Software
NameVersionClassification
XDSdata reduction
Aimlessdata scaling
BUSTERrefinement
PDB_EXTRACT3.25data extraction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 5t35

5t35


Resolution: 2.281→68.38 Å / Cor.coef. Fo:Fc: 0.944 / Cor.coef. Fo:Fc free: 0.917 / SU R Cruickshank DPI: 0.35 / Cross valid method: THROUGHOUT / SU R Blow DPI: 0.41 / SU Rfree Blow DPI: 0.25 / SU Rfree Cruickshank DPI: 0.243
RfactorNum. reflection% reflectionSelection details
Rfree0.2288 1116 -RANDOM
Rwork0.1778 ---
obs0.1801 24048 72.8 %-
Displacement parametersBiso mean: 48.98 Å2
Baniso -1Baniso -2Baniso -3
1-0.7252 Å20 Å20 Å2
2--0.7252 Å20 Å2
3----1.4504 Å2
Refine analyzeLuzzati coordinate error obs: 0.28 Å
Refinement stepCycle: LAST / Resolution: 2.281→68.38 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms3822 0 77 336 4235
Refine LS restraints
Refine-IDTypeDev idealNumberRestraint functionWeight
X-RAY DIFFRACTIONt_bond_d0.0084024HARMONIC2
X-RAY DIFFRACTIONt_angle_deg0.975486HARMONIC2
X-RAY DIFFRACTIONt_dihedral_angle_d1396SINUSOIDAL2
X-RAY DIFFRACTIONt_gen_planes677HARMONIC5
X-RAY DIFFRACTIONt_it4020HARMONIC10
X-RAY DIFFRACTIONt_chiral_improper_torsion512SEMIHARMONIC5
X-RAY DIFFRACTIONt_sum_occupancies3HARMONIC1
X-RAY DIFFRACTIONt_ideal_dist_contact3561SEMIHARMONIC4
X-RAY DIFFRACTIONt_omega_torsion3.23
X-RAY DIFFRACTIONt_other_torsion18.01
LS refinement shellResolution: 2.281→2.4 Å
RfactorNum. reflection% reflection
Rfree0.2953 36 -
Rwork0.2337 --
obs--10.16 %
Refinement TLS params.

Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.36731.06433.418112.0847-3.15074.63990.4251-0.1688-0.5959-0.1688-0.13240.156-0.59590.156-0.29270.33130.1707-0.12240.1647-0.08340.1291-19.4832-28.258219.8446
21.57410.19370.31095.9424-0.10920.21870.2798-0.0318-0.0812-0.0318-0.06890.4285-0.08120.4285-0.2110.32980.1549-0.12640.2659-0.01420.1337-18.7469-28.864122.8191
33.7448-3.3636-0.77097.57071.43559.2097-0.02180.4535-0.19610.4535-0.04960.0705-0.19610.07050.07150.2260.1475-0.09710.1111-0.03210.1008-17.5575-35.812430.5814
424.0396.2405-1.793213.6001-4.59032.49530.0968-1.43430.9387-1.43430.1079-0.29870.9387-0.2987-0.20470.58220.2293-0.09840.3559-0.15630.2388-16.1355-40.373618.168
50.4759-1.43682.62673.5496-2.21373.09650.1351-0.60730.4953-0.60730.08980.62440.49530.6244-0.2250.37340.1775-0.07520.1914-0.08270.1451-19.7227-29.62416.04
67.62420.8449.82386.9155-10.017819.2969-0.17210.39670.46790.39670.9975-2.0560.4679-2.056-0.82540.50130.25190.09120.31430.08080.3505-28.4863-42.952430.7782
74.5006-4.2696-4.34644.8105-1.915100.637-1.06411.3369-1.06410.5737-0.97581.3369-0.9758-1.21070.49560.058-0.25860.34120.00720.3126-40.175-23.348314.9141
83.2509-5.72613.137836.483117.141119.2660.1763-0.50511.0793-0.5051-0.4243-1.59921.0793-1.59920.24790.5509-0.0851-0.25091.01540.15010.5512-43.5402-14.37331.7259
96.15140.30210.25454.05470.09123.3295-0.12860.0772-0.05610.07720.0873-0.077-0.0561-0.0770.04130.23540.1289-0.07840.084-0.03360.0338-25.4377-16.194628.558
105.7056-2.0934-3.93452.6601-0.45897.07060.01220.3771-0.15710.37710.02810.4763-0.15710.4763-0.04030.32120.1093-0.09630.1211-0.01530.1082-26.8798-15.353724.1227
114.3378-2.1757-1.43795.4281.118710.83250.0761-0.0458-0.2737-0.04580.23560.3089-0.27370.3089-0.31170.27690.0988-0.05110.20250.04450.1118-27.0379-12.143413.2525
1213.75375.0943-6.514211.399-10.299820.14110.33410.6387-1.18080.63870.13210.1034-1.18080.1034-0.46620.5052-0.1246-0.26510.31260.12930.4006-7.709514.4123-5.3239
138.32245.1612.07889.12093.56490-0.8723-0.50380.7047-0.50380.59890.47160.70470.47160.27330.2657-0.0105-0.10190.32710.13680.1435-6.1453-2.7023-7.4867
143.52081.3771-0.12461.7345-0.38782.7761-0.13330.1265-0.07660.12650.14770.1175-0.07660.1175-0.01440.25090.0715-0.10670.31180.13630.1508-14.28790.9829-6.4083
154.97641.3307-1.67780.0576-0.76070-0.84980.16640.13290.16640.38750.10640.13290.10640.46220.36240.1182-0.11480.44190.15140.2087-19.8436-2.98441.0259
1616.64221.6011-11.082916.4726-1.993522.9172-0.04510.6509-0.79990.6509-0.11011.4977-0.79991.49770.15520.2617-0.0012-0.25880.30820.01610.1744-5.94352.60.7582
171.6961-1.736413.54230.92696.60456.8049-0.6432-0.0996-0.6768-0.09960.61191.0837-0.67681.08370.03120.20790.0385-0.10350.43210.0150.2209-0.5648-3.6883-3.8505
182.0530.2559-3.39393.06131.71213.8615-0.2154-0.2418-0.149-0.24180.0727-0.3841-0.149-0.38410.14270.32120.1244-0.0820.3680.20140.3127-32.8826-6.60116.296
191.4433-2.3327.234711.90172.94747.34550.62310.3834-0.84470.38340.0225-1.5471-0.8447-1.5471-0.64550.37740.3302-0.0830.44620.06730.4113-38.1665-0.62669.9825
2026.00785.453213.083623.79693.593726.87050.47193.3873-0.43123.3873-0.3513-0.5442-0.4312-0.5442-0.12060.8440.21150.14070.54860.10380.3728-17.976710.66718.0849
21-4.37812.32598.45367.6067-1.12297.6962-0.7147-0.0234-0.4359-0.0234-0.02081.3707-0.43591.37070.73550.1848-0.0241-0.01080.35710.16820.1303-21.0620.6336-29.7316
225.4679-2.9535.019112.2425-1.43611.4573-0.15-0.06920.3502-0.06920.7761-1.14170.3502-1.1417-0.62610.1205-0.0515-0.01010.599-0.00480.2414-40.966913.7268-29.049
2310.58950.3873-0.388810.013-3.42180-0.20450.6384-0.27450.63840.1372-0.3985-0.2745-0.39850.06730.2867-0.0141-0.02290.3950.06280.0763-28.12936.4106-15.8122
2417.89574.0988.7175.12390.7920-0.0652-0.1676-0.7371-0.1676-0.31111.4635-0.73711.46350.37630.28880.0336-0.05640.44970.1770.2737-13.242314.3171-22.8578
256.38440.46710.19143.7881-1.0921.4057-0.139-0.44780.3903-0.44780.1166-0.23260.3903-0.23260.02240.1281-0.02360.00990.23230.0048-0.0238-27.231210.2185-29.5325
2610.4509-8.09666.6729-2.9204-0.432300.29112.07672.25072.07670.14262.65392.25072.6539-0.43371.04660.21770.16220.60870.13691.0148-11.4849-0.9204-24.3636
2735.34179.57086.13410.88851.7570-0.1931-0.23921.0356-0.2392-0.0178-0.33671.0356-0.33670.21090.1468-0.01690.01070.08460.03760.0781-27.684-1.5436-21.2644
280.01830.048916.991514.8922-5.47630-1.52560.658-1.19930.6581.7294-2.9139-1.1993-2.9139-0.20390.3781-0.2077-0.14681.25650.42020.8244-47.51433.3765-28.2911
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1{ A|1 - A|9 }A1 - 9
2X-RAY DIFFRACTION2{ A|10 - A|23 }A10 - 23
3X-RAY DIFFRACTION3{ A|24 - A|45 }A24 - 45
4X-RAY DIFFRACTION4{ A|46 - A|60 }A46 - 60
5X-RAY DIFFRACTION5{ A|61 - A|79 }A61 - 79
6X-RAY DIFFRACTION6{ A|80 - A|90 }A80 - 90
7X-RAY DIFFRACTION7{ A|91 - A|100 }A91 - 100
8X-RAY DIFFRACTION8{ A|101 - A|105 }A101 - 105
9X-RAY DIFFRACTION9{ B|17 - B|46 }B17 - 46
10X-RAY DIFFRACTION10{ B|47 - B|83 }B47 - 83
11X-RAY DIFFRACTION11{ B|84 - B|112 }B84 - 112
12X-RAY DIFFRACTION12{ C|61 - C|70 }C61 - 70
13X-RAY DIFFRACTION13{ C|71 - C|78 }C71 - 78
14X-RAY DIFFRACTION14{ C|79 - C|121 }C79 - 121
15X-RAY DIFFRACTION15{ C|122 - C|131 }C122 - 131
16X-RAY DIFFRACTION16{ C|132 - C|141 }C132 - 141
17X-RAY DIFFRACTION17{ C|142 - C|151 }C142 - 151
18X-RAY DIFFRACTION18{ C|152 - C|177 }C152 - 177
19X-RAY DIFFRACTION19{ C|178 - C|193 }C178 - 193
20X-RAY DIFFRACTION20{ C|194 - C|208 }C194 - 208
21X-RAY DIFFRACTION21{ D|42 - D|51 }D42 - 51
22X-RAY DIFFRACTION22{ D|52 - D|68 }D52 - 68
23X-RAY DIFFRACTION23{ D|69 - D|83 }D69 - 83
24X-RAY DIFFRACTION24{ D|84 - D|96 }D84 - 96
25X-RAY DIFFRACTION25{ D|97 - D|139 }D97 - 139
26X-RAY DIFFRACTION26{ D|140 - D|144 }D140 - 144
27X-RAY DIFFRACTION27{ D|145 - D|163 }D145 - 163
28X-RAY DIFFRACTION28{ D|164 - D|168 }D164 - 168

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