[日本語] English
万見
- PDB-7k5j: Structure of an E1-E2-ubiquitin thioester mimetic -

+
データを開く


IDまたはキーワード:

読み込み中...

-
基本情報

登録情報
データベース: PDB / ID: 7k5j
タイトルStructure of an E1-E2-ubiquitin thioester mimetic
要素
  • Ubiquitin
  • Ubiquitin-activating enzyme E1 1
  • Ubiquitin-conjugating enzyme E2-34 kDa
キーワードSIGNALING PROTEIN / CONFORMATIONAL CHANGE / ADENYLATION / THIOESTER TRANSFER / TRANSTHIOESTERIFICATION / ATP-BINDING / UBIQUITIN E2-BINDING / UBIQUITINATION
機能・相同性
機能・相同性情報


regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / E1 ubiquitin-activating enzyme / ubiquitin activating enzyme activity / regulation of metabolic process / positive regulation of glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / silent mating-type cassette heterochromatin formation ...regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / E1 ubiquitin-activating enzyme / ubiquitin activating enzyme activity / regulation of metabolic process / positive regulation of glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / silent mating-type cassette heterochromatin formation / mitochondrial fusion / SCF ubiquitin ligase complex / E2 ubiquitin-conjugating enzyme / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / ubiquitin conjugating enzyme activity / Antigen processing: Ubiquitination & Proteasome degradation / subtelomeric heterochromatin formation / protein autoubiquitination / regulation of mitotic cell cycle / modification-dependent protein catabolic process / G1/S transition of mitotic cell cycle / protein polyubiquitination / ubiquitin-protein transferase activity / protein tag activity / G2/M transition of mitotic cell cycle / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA replication / chromosome, telomeric region / protein ubiquitination / cell division / mRNA binding / ubiquitin protein ligase binding / DNA damage response / ATP binding / nucleus / cytoplasm
類似検索 - 分子機能
Ubiquitin-activating enzyme E1, conserved site / Ubiquitin-activating enzyme signature 1. / Ubiquitin-activating enzyme E1 / Ubiquitin-activating enzyme E1, C-terminal / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, four-helix bundle / Ubiquitin-activating enzyme E1, C-terminal domain superfamily / Ubiquitin-activating enzyme E1, SCCH domain / Ubiquitin-activating enzyme E1, FCCH domain superfamily / Ubiquitin fold domain ...Ubiquitin-activating enzyme E1, conserved site / Ubiquitin-activating enzyme signature 1. / Ubiquitin-activating enzyme E1 / Ubiquitin-activating enzyme E1, C-terminal / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, four-helix bundle / Ubiquitin-activating enzyme E1, C-terminal domain superfamily / Ubiquitin-activating enzyme E1, SCCH domain / Ubiquitin-activating enzyme E1, FCCH domain superfamily / Ubiquitin fold domain / Ubiquitin-activating enzyme E1 FCCH domain / Ubiquitin-activating enzyme E1 four-helix bundle / Ubiquitin-activating enzyme e1 C-terminal domain / Ubiquitin-activating enzyme, SCCH domain / Ubiquitin-activating enzyme, SCCH domain / Ubiquitin/SUMO-activating enzyme E1-like / Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 / Ubiquitin-activating enzyme E1, Cys active site / Ubiquitin-activating enzyme active site. / ThiF/MoeB/HesA family / Ubiquitin-activating enzyme / THIF-type NAD/FAD binding fold / ThiF family / Ubiquitin-conjugating enzyme, active site / Ubiquitin-conjugating (UBC) active site signature. / Ubiquitin-conjugating enzyme E2, catalytic domain homologues / Ubiquitin-conjugating enzyme E2 / Ubiquitin-conjugating enzyme / Ubiquitin-conjugating (UBC) core domain profile. / Ubiquitin-conjugating enzyme/RWD-like / Ubiquitin domain signature. / Ubiquitin conserved site / Ubiquitin domain / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily
類似検索 - ドメイン・相同性
ADENOSINE MONOPHOSPHATE / Ubiquitin-conjugating enzyme E2-34 kDa / Ubiquitin-activating enzyme E1 1 / Ubiquitin
類似検索 - 構成要素
生物種Triticum aestivum (コムギ)
Saccharomyces cerevisiae (パン酵母)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 3.42 Å
データ登録者Yuan, L. / Lv, Z. / Olsen, S.K.
資金援助 米国, 3件
組織認可番号国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM115568-05 米国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM128731-02 米国
Cancer Prevention and Research Institute of Texas (CPRIT)RR200030 米国
引用ジャーナル: Nat Commun / 年: 2021
タイトル: Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
著者: Yuan, L. / Lv, Z. / Adams, M.J. / Olsen, S.K.
履歴
登録2020年9月16日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02021年4月28日Provider: repository / タイプ: Initial release
改定 1.12021年5月5日Group: Database references / カテゴリ: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID
改定 1.22023年10月18日Group: Data collection / Database references / Refinement description
カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

-
構造の表示

構造ビューア分子:
MolmilJmol/JSmol

ダウンロードとリンク

-
集合体

登録構造単位
N: Ubiquitin
D: Ubiquitin-activating enzyme E1 1
F: Ubiquitin-conjugating enzyme E2-34 kDa
A: Ubiquitin-activating enzyme E1 1
B: Ubiquitin-conjugating enzyme E2-34 kDa
C: Ubiquitin-activating enzyme E1 1
E: Ubiquitin-conjugating enzyme E2-34 kDa
G: Ubiquitin-activating enzyme E1 1
H: Ubiquitin-conjugating enzyme E2-34 kDa
I: Ubiquitin-activating enzyme E1 1
J: Ubiquitin-conjugating enzyme E2-34 kDa
K: Ubiquitin-activating enzyme E1 1
L: Ubiquitin-conjugating enzyme E2-34 kDa
M: Ubiquitin
O: Ubiquitin
P: Ubiquitin
Q: Ubiquitin
R: Ubiquitin
S: Ubiquitin-activating enzyme E1 1
T: Ubiquitin-conjugating enzyme E2-34 kDa
U: Ubiquitin-activating enzyme E1 1
V: Ubiquitin-conjugating enzyme E2-34 kDa
W: Ubiquitin
X: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)1,169,49031
ポリマ－1,167,05924
非ポリマー2,4317
水00
1
N: Ubiquitin
I: Ubiquitin-activating enzyme E1 1
J: Ubiquitin-conjugating enzyme E2-34 kDa
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
2
C: Ubiquitin-activating enzyme E1 1
E: Ubiquitin-conjugating enzyme E2-34 kDa
O: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
3
G: Ubiquitin-activating enzyme E1 1
H: Ubiquitin-conjugating enzyme E2-34 kDa
R: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
4
K: Ubiquitin-activating enzyme E1 1
L: Ubiquitin-conjugating enzyme E2-34 kDa
P: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
5
S: Ubiquitin-activating enzyme E1 1
T: Ubiquitin-conjugating enzyme E2-34 kDa
W: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
6
U: Ubiquitin-activating enzyme E1 1
V: Ubiquitin-conjugating enzyme E2-34 kDa
X: Ubiquitin


分子量 (理論値)分子数
合計 (水以外)145,8823
ポリマ－145,8823
非ポリマー00
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
7
D: Ubiquitin-activating enzyme E1 1
F: Ubiquitin-conjugating enzyme E2-34 kDa
M: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area5260 Å2
ΔGint-20 kcal/mol
Surface area53220 Å2
手法PISA
8
A: Ubiquitin-activating enzyme E1 1
B: Ubiquitin-conjugating enzyme E2-34 kDa
Q: Ubiquitin
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)146,2304
ポリマ－145,8823
非ポリマー3471
水0
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area5620 Å2
ΔGint-26 kcal/mol
Surface area52750 Å2
手法PISA
単位格子
Length a, b, c (Å)95.181, 272.917, 258.342
Angle α, β, γ (deg.)90.000, 94.590, 90.000
Int Tables number4
Space group name H-MP1211
非結晶学的対称性 (NCS)NCSドメイン:
IDEns-ID詳細
11(chain A and (resid 600 or (resid 601 through 602...
21(chain C and (resid 600 or (resid 601 through 602...
31(chain D and (resid 600 or (resid 601 through 602...
41(chain G and (resid 600 or (resid 601 through 602...
51(chain I and (resid 600 or (resid 601 through 602...
61(chain K and (resid 600 or (resid 601 through 602...
71(chain S and (resid 600 or (resid 601 through 602...
81(chain U and (resid 600 or (resid 601 through 602...
12(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
22(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
32(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
42(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
52(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
62(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
72(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
82(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
13(chain A and (resid 173 through 181 or (resid 182...
23(chain C and (resid 173 through 181 or (resid 182...
33(chain D and (resid 173 through 181 or (resid 182...
43(chain G and (resid 173 through 181 or (resid 182...
53(chain I and (resid 173 through 181 or (resid 182...
63(chain K and (resid 173 through 181 or (resid 182...
73(chain S and (resid 173 through 181 or (resid 182...
83(chain U and (resid 173 through 181 or (resid 182...
14(chain A and resid 912 through 1024)
24(chain C and resid 912 through 1024)
34(chain D and resid 912 through 1024)
44(chain G and resid 912 through 1024)
54(chain I and resid 912 through 1024)
64(chain K and resid 912 through 1024)
74(chain S and resid 912 through 1024)
84(chain U and resid 912 through 1024)
15(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
25(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
35(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
45(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
55(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
65(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
75(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))
85(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
16(chain M and (resid 1 through 18 or resid 29...
26(chain N and (resid 1 through 18 or resid 29...
36(chain O and (resid 1 through 18 or resid 29...
46(chain P and (resid 1 through 18 or resid 29...
56(chain Q and (resid 1 through 18 or resid 29...
66(chain R and (resid 1 through 18 or resid 29...
76(chain W and (resid 1 through 18 or resid 29...
86(chain X and (resid 1 through 18 or resid 29...

NCSドメイン領域:
Dom-IDComponent-IDEns-IDSelection detailsAuth asym-IDAuth seq-ID
111(chain A and (resid 600 or (resid 601 through 602...A600
121(chain A and (resid 600 or (resid 601 through 602...A601 - 602
131(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
141(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
151(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
161(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
211(chain C and (resid 600 or (resid 601 through 602...C600
221(chain C and (resid 600 or (resid 601 through 602...C601 - 602
231(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
241(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
251(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
261(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
311(chain D and (resid 600 or (resid 601 through 602...D600
321(chain D and (resid 600 or (resid 601 through 602...D601 - 602
331(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
341(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
351(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
361(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
411(chain G and (resid 600 or (resid 601 through 602...G600
421(chain G and (resid 600 or (resid 601 through 602...G601 - 602
431(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
441(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
451(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
461(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
511(chain I and (resid 600 or (resid 601 through 602...I600
521(chain I and (resid 600 or (resid 601 through 602...I601 - 602
531(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
541(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
551(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
561(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
611(chain K and (resid 600 or (resid 601 through 602...K600
621(chain K and (resid 600 or (resid 601 through 602...K601 - 602
631(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
641(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
651(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
661(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
711(chain S and (resid 600 or (resid 601 through 602...S600
721(chain S and (resid 600 or (resid 601 through 602...S601 - 602
731(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
741(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
751(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
761(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
811(chain U and (resid 600 or (resid 601 through 602...U600
821(chain U and (resid 600 or (resid 601 through 602...U601 - 602
831(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
841(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
851(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
861(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
112(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A12 - 172
122(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A263 - 589
132(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A865 - 911
212(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C12 - 172
222(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C263 - 589
232(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C865 - 911
312(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D12 - 172
322(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D263 - 589
332(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D865 - 911
412(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G12 - 172
422(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G263 - 589
432(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G865 - 911
512(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I12 - 172
522(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I263 - 589
532(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I865 - 911
612(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K12 - 172
622(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K263 - 589
632(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K865 - 911
712(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S12 - 172
722(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S263 - 589
732(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S865 - 911
812(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U12 - 172
822(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U263 - 589
832(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U865 - 911
113(chain A and (resid 173 through 181 or (resid 182...A173 - 181
123(chain A and (resid 173 through 181 or (resid 182...A182
133(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
143(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
153(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
163(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
213(chain C and (resid 173 through 181 or (resid 182...C173 - 181
223(chain C and (resid 173 through 181 or (resid 182...C182
313(chain D and (resid 173 through 181 or (resid 182...D173 - 181
323(chain D and (resid 173 through 181 or (resid 182...D182
333(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
343(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
353(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
363(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
413(chain G and (resid 173 through 181 or (resid 182...G173 - 181
423(chain G and (resid 173 through 181 or (resid 182...G182
513(chain I and (resid 173 through 181 or (resid 182...I173 - 181
523(chain I and (resid 173 through 181 or (resid 182...I182
533(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
543(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
553(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
563(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
613(chain K and (resid 173 through 181 or (resid 182...K173 - 181
623(chain K and (resid 173 through 181 or (resid 182...K182
713(chain S and (resid 173 through 181 or (resid 182...S173 - 181
723(chain S and (resid 173 through 181 or (resid 182...S182
733(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
743(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
753(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
763(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
813(chain U and (resid 173 through 181 or (resid 182...U173 - 181
823(chain U and (resid 173 through 181 or (resid 182...U182
114(chain A and resid 912 through 1024)A912 - 1024
214(chain C and resid 912 through 1024)C912 - 1024
314(chain D and resid 912 through 1024)D912 - 1024
414(chain G and resid 912 through 1024)G912 - 1024
514(chain I and resid 912 through 1024)I912 - 1024
614(chain K and resid 912 through 1024)K912 - 1024
714(chain S and resid 912 through 1024)S912 - 1024
814(chain U and resid 912 through 1024)U912 - 1024
115(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B7 - 87
125(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B118 - 140
135(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B142 - 178
215(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E7 - 87
225(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E118 - 140
235(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E142 - 178
315(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F7 - 87
325(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F118 - 140
335(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F142 - 178
415(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H7 - 87
425(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H118 - 140
435(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H142 - 178
515(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J7 - 87
525(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J118 - 140
535(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J142 - 178
615(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L7 - 87
625(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L118 - 140
635(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L142 - 178
715(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T7 - 88
725(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T119 - 140
735(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T142 - 178
815(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V7 - 87
825(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V118 - 140
835(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V142 - 178
116(chain M and (resid 1 through 18 or resid 29...M1 - 18
126(chain M and (resid 1 through 18 or resid 29...M29 - 31
136(chain M and (resid 1 through 18 or resid 29...M32 - 3
146(chain M and (resid 1 through 18 or resid 29...M0 - 76
156(chain M and (resid 1 through 18 or resid 29...M0 - 76
166(chain M and (resid 1 through 18 or resid 29...M0 - 76
176(chain M and (resid 1 through 18 or resid 29...M0 - 76
216(chain N and (resid 1 through 18 or resid 29...N1 - 18
226(chain N and (resid 1 through 18 or resid 29...N29 - 31
236(chain N and (resid 1 through 18 or resid 29...N32 - 34
246(chain N and (resid 1 through 18 or resid 29...N-3 - 76
256(chain N and (resid 1 through 18 or resid 29...N-3 - 76
266(chain N and (resid 1 through 18 or resid 29...N-3 - 76
276(chain N and (resid 1 through 18 or resid 29...N-3 - 76
316(chain O and (resid 1 through 18 or resid 29...O1 - 18
326(chain O and (resid 1 through 18 or resid 29...O29 - 31
336(chain O and (resid 1 through 18 or resid 29...O32 - 34
346(chain O and (resid 1 through 18 or resid 29...O1 - 73
356(chain O and (resid 1 through 18 or resid 29...O1 - 73
366(chain O and (resid 1 through 18 or resid 29...O1 - 73
376(chain O and (resid 1 through 18 or resid 29...O1 - 73
416(chain P and (resid 1 through 18 or resid 29...P1 - 18
426(chain P and (resid 1 through 18 or resid 29...P29 - 31
436(chain P and (resid 1 through 18 or resid 29...P-3 - 76
446(chain P and (resid 1 through 18 or resid 29...P-3 - 76
456(chain P and (resid 1 through 18 or resid 29...P-3 - 76
466(chain P and (resid 1 through 18 or resid 29...P-3 - 76
476(chain P and (resid 1 through 18 or resid 29...P-3 - 76
486(chain P and (resid 1 through 18 or resid 29...P-3 - 76
516(chain Q and (resid 1 through 18 or resid 29...Q1 - 18
526(chain Q and (resid 1 through 18 or resid 29...Q29 - 31
536(chain Q and (resid 1 through 18 or resid 29...Q32 - 34
546(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
556(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
566(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
576(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
616(chain R and (resid 1 through 18 or resid 29...R1 - 18
626(chain R and (resid 1 through 18 or resid 29...R29 - 31
636(chain R and (resid 1 through 18 or resid 29...R-2 - 73
646(chain R and (resid 1 through 18 or resid 29...R-2 - 73
656(chain R and (resid 1 through 18 or resid 29...R-2 - 73
666(chain R and (resid 1 through 18 or resid 29...R-2 - 73
676(chain R and (resid 1 through 18 or resid 29...R-2 - 73
686(chain R and (resid 1 through 18 or resid 29...R-2 - 73
716(chain W and (resid 1 through 18 or resid 29...W1 - 18
726(chain W and (resid 1 through 18 or resid 29...W29 - 31
736(chain W and (resid 1 through 18 or resid 29...W32 - 3
746(chain W and (resid 1 through 18 or resid 29...W1 - 70
756(chain W and (resid 1 through 18 or resid 29...W1 - 70
766(chain W and (resid 1 through 18 or resid 29...W1 - 70
776(chain W and (resid 1 through 18 or resid 29...W1 - 70
816(chain X and (resid 1 through 18 or resid 29...X1 - 18
826(chain X and (resid 1 through 18 or resid 29...X29 - 31
836(chain X and (resid 1 through 18 or resid 29...X32 - 34
846(chain X and (resid 1 through 18 or resid 29...X-2 - 70
856(chain X and (resid 1 through 18 or resid 29...X-2 - 70
866(chain X and (resid 1 through 18 or resid 29...X-2 - 70
876(chain X and (resid 1 through 18 or resid 29...X-2 - 70

NCSアンサンブル:
ID
1
2
3
4
5
6

-
要素

#1: タンパク質
Ubiquitin


分子量: 9692.942 Da / 分子数: 8 / 由来タイプ: 組換発現 / 由来: (組換発現) Triticum aestivum (コムギ) / プラスミド: pET28B / 発現宿主: Escherichia coli BL21(DE3) (大腸菌) / 株 (発現宿主): BL21(DE3) / Variant (発現宿主): CODON PLUS / 参照: UniProt: P69326
#2: タンパク質
Ubiquitin-activating enzyme E1 1


分子量: 113704.211 Da / 分子数: 8 / 由来タイプ: 組換発現
由来: (組換発現) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (パン酵母)
株: ATCC 204508 / S288c / 遺伝子: UBA1, YKL210W / プラスミド: pET29NTEV / 発現宿主: Escherichia coli BL21(DE3) (大腸菌) / 株 (発現宿主): BL21(DE3) / Variant (発現宿主): codon plus / 参照: UniProt: P22515, E1 ubiquitin-activating enzyme
#3: タンパク質
Ubiquitin-conjugating enzyme E2-34 kDa / Cell division control protein 34 / E2 ubiquitin-conjugating enzyme 3 / E3 ubiquitin ligase complex ...Cell division control protein 34 / E2 ubiquitin-conjugating enzyme 3 / E3 ubiquitin ligase complex SCF subunit CDC34 / Ubiquitin carrier protein / Ubiquitin-protein ligase


分子量: 22485.254 Da / 分子数: 8 / Mutation: A141K / 由来タイプ: 組換発現
由来: (組換発現) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (パン酵母)
株: ATCC 204508 / S288c / 遺伝子: CDC34, DNA6, UBC3, YDR054C, D4211, YD9609.08C / プラスミド: pET29NTEV / 発現宿主: Escherichia coli BL21(DE3) (大腸菌) / 株 (発現宿主): BL21(DE3) / Variant (発現宿主): codon plus / 参照: UniProt: P14682, E2 ubiquitin-conjugating enzyme
#4: 化合物
ChemComp-AMP / ADENOSINE MONOPHOSPHATE / AMP


分子量: 347.221 Da / 分子数: 7 / 由来タイプ: 合成 / 式: C10H14N5O7P / コメント: AMP*YM
研究の焦点であるリガンドがあるかN

-
実験情報

-
実験

実験手法: X線回折 / 使用した結晶の数: 1

-
試料調製

結晶マシュー密度: 2.87 Å3/Da / 溶媒含有率: 57.08 %
結晶化温度: 291 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 6.91
詳細: 0.2 M NH4Ac, pH 6.91, 20% PEG3350, 0.02% (+/-)-2-Methyl-2,4-pentanediol, 0.02% 1,2,3,-Heptanetriol, 0.02% Diethylenetriaminepentakis (methylphosphonic acid), 0.02% D-Sorbitol, 0.02% Glycerol, ...詳細: 0.2 M NH4Ac, pH 6.91, 20% PEG3350, 0.02% (+/-)-2-Methyl-2,4-pentanediol, 0.02% 1,2,3,-Heptanetriol, 0.02% Diethylenetriaminepentakis (methylphosphonic acid), 0.02% D-Sorbitol, 0.02% Glycerol, 0.002 M HEPES sodium pH 6.8

-
データ収集

回折平均測定温度: 108 K / Serial crystal experiment: N
放射光源由来: シンクロトロン / サイト: APS / ビームライン: 24-ID-C / 波長: 1 Å
検出器タイプ: DECTRIS PILATUS 6M-F / 検出器: PIXEL / 日付: 2018年2月16日
放射プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 1 Å / 相対比: 1
反射解像度: 3.42→187.298 Å / Num. obs: 175210 / % possible obs: 99.8 % / 冗長度: 13.5 % / Rpim(I) all: 0.084 / Rrim(I) all: 0.308 / Rsym value: 0.287 / Net I/av σ(I): 1.4 / Net I/σ(I): 9
反射 シェル

Diffraction-ID: 1

解像度 (Å)冗長度 (%)Rmerge(I) obsMean I/σ(I) obsNum. measured allNum. unique obsRpim(I) allRrim(I) allRsym valueNet I/σ(I) obs% possible all
3.43-3.6213.82.1250.4353739255820.6122.292.1251.6100
3.62-3.8413.51.3940.5325836241840.4071.5031.3942.599.9
3.84-4.112.70.8040.9288718226610.2430.8710.8044.199.8
4.1-4.4314.20.4821.5299937211640.1370.5170.4826.799.9
4.43-4.8613.80.3272.2268831194830.0940.3510.3279.3100
4.86-5.4312.90.2812.6227138175850.0840.3040.2811099.7
5.43-6.2714.20.2462.9220875156070.070.2630.24611.999.9
6.27-7.6813.20.164172833131410.0480.1730.1616.799.8
7.68-10.86130.1293.5132509101750.0370.1370.12927.699.6
10.86-187.29812.30.152.76922156280.0440.160.1534.499.3

-
解析

ソフトウェア
名称バージョン分類
PHENIX1.17.1_3660精密化
XDSデータ削減
SCALA3.3.22データスケーリング
PDB_EXTRACT3.25データ抽出
PHASER位相決定
精密化構造決定の手法: 分子置換
開始モデル: 6NYA

6nya


解像度: 3.42→136.46 Å / SU ML: 0.51 / 交差検証法: THROUGHOUT / σ(F): 1.34 / 位相誤差: 29.86 / 立体化学のターゲット値: ML
Rfactor反射数%反射
Rfree0.2463 2014 1.15 %
Rwork0.2027 172677 -
obs0.2032 174691 99.25 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
原子変位パラメータBiso max: 362.66 Å2 / Biso mean: 144.149 Å2 / Biso min: 42.68 Å2
精密化ステップサイクル: final / 解像度: 3.42→136.46 Å
タンパク質核酸リガンド溶媒全体
原子数76482 0 161 0 76643
Biso mean--128.54 --
残基数----9613
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-ID数Refine-IDRmsタイプ
11A5456X-RAY DIFFRACTION5.07TORSIONAL
12C5456X-RAY DIFFRACTION5.07TORSIONAL
13D5456X-RAY DIFFRACTION5.07TORSIONAL
14G5456X-RAY DIFFRACTION5.07TORSIONAL
15I5456X-RAY DIFFRACTION5.07TORSIONAL
16K5456X-RAY DIFFRACTION5.07TORSIONAL
17S5456X-RAY DIFFRACTION5.07TORSIONAL
18U5456X-RAY DIFFRACTION5.07TORSIONAL
21A12912X-RAY DIFFRACTION5.07TORSIONAL
22C12912X-RAY DIFFRACTION5.07TORSIONAL
23D12912X-RAY DIFFRACTION5.07TORSIONAL
24G12912X-RAY DIFFRACTION5.07TORSIONAL
25I12912X-RAY DIFFRACTION5.07TORSIONAL
26K12912X-RAY DIFFRACTION5.07TORSIONAL
27S12912X-RAY DIFFRACTION5.07TORSIONAL
28U12912X-RAY DIFFRACTION5.07TORSIONAL
31A2160X-RAY DIFFRACTION5.07TORSIONAL
32C2160X-RAY DIFFRACTION5.07TORSIONAL
33D2160X-RAY DIFFRACTION5.07TORSIONAL
34G2160X-RAY DIFFRACTION5.07TORSIONAL
35I2160X-RAY DIFFRACTION5.07TORSIONAL
36K2160X-RAY DIFFRACTION5.07TORSIONAL
37S2160X-RAY DIFFRACTION5.07TORSIONAL
38U2160X-RAY DIFFRACTION5.07TORSIONAL
41A2712X-RAY DIFFRACTION5.07TORSIONAL
42C2712X-RAY DIFFRACTION5.07TORSIONAL
43D2712X-RAY DIFFRACTION5.07TORSIONAL
44G2712X-RAY DIFFRACTION5.07TORSIONAL
45I2712X-RAY DIFFRACTION5.07TORSIONAL
46K2712X-RAY DIFFRACTION5.07TORSIONAL
47S2712X-RAY DIFFRACTION5.07TORSIONAL
48U2712X-RAY DIFFRACTION5.07TORSIONAL
51B3365X-RAY DIFFRACTION5.07TORSIONAL
52E3365X-RAY DIFFRACTION5.07TORSIONAL
53F3365X-RAY DIFFRACTION5.07TORSIONAL
54H3365X-RAY DIFFRACTION5.07TORSIONAL
55J3365X-RAY DIFFRACTION5.07TORSIONAL
56L3365X-RAY DIFFRACTION5.07TORSIONAL
57T3365X-RAY DIFFRACTION5.07TORSIONAL
58V3365X-RAY DIFFRACTION5.07TORSIONAL
61M1448X-RAY DIFFRACTION5.07TORSIONAL
62N1448X-RAY DIFFRACTION5.07TORSIONAL
63O1448X-RAY DIFFRACTION5.07TORSIONAL
64P1448X-RAY DIFFRACTION5.07TORSIONAL
65Q1448X-RAY DIFFRACTION5.07TORSIONAL
66R1448X-RAY DIFFRACTION5.07TORSIONAL
67W1448X-RAY DIFFRACTION5.07TORSIONAL
68X1448X-RAY DIFFRACTION5.07TORSIONAL
LS精密化 シェル

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 14

解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.42-3.510.40391440.3394118391198395
3.51-3.610.30921330.29311229312426100
3.61-3.710.30581400.2813123461248699
3.71-3.830.29641410.25421239412535100
3.83-3.970.32121520.25661237212524100
3.97-4.130.30411390.22481235112490100
4.13-4.320.25541460.20431237612522100
4.32-4.540.22741460.1851241912565100
4.54-4.830.23691470.17341232012467100
4.83-5.20.22031450.18231235512500100
5.2-5.720.26351390.20141241612555100
5.72-6.550.25371490.20341242812577100
6.55-8.250.20761430.1882124091255299
8.25-136.460.19241500.1588123591250998
精密化 TLS

手法: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.022-4.4777-0.32699.33910.47396.79770.40460.2721-0.7678-2.1742-0.07132.385-1.2256-0.2795-0.17951.82430.5563-0.04232.0437-0.38931.959662.8950.478227.981
27.21657.55954.89999.06164.69713.48840.8844-0.69820.5302-0.3406-1.73711.8792-0.9079-1.12751.0071.65430.232-0.01922.1063-0.50372.501461.61143.093232.197
31.92972.4994-0.83273.2541-1.45448.65470.62480.5971.87522.1272-0.36071.274-0.313-1.3372-0.22280.99110.14020.18561.2906-0.49711.876362.56643.824240.152
42.5767-0.8491-4.09347.41760.68896.5623-2.90610.3342.61021.29961.5170.00940.3216-0.27611.45761.22060.1284-0.21211.70720.37041.752667.33536.473240.799
53.69750.54520.90657.87520.14560.21880.729-0.5990.2781-1.2055-0.6603-0.5086-0.5014-1.8763-0.24671.59620.5253-0.16862.25760.10840.974772.26344.021232.754
62.9698-0.547-1.71034.4829-0.62835.9191-0.54890.19680.1428-0.10790.24480.00670.99360.47470.32720.80990.0628-0.17481.008-0.31880.823790.546-9.896279.475
73.8341-1.8477-0.48911.2668-0.58311.61450.1458-0.17890.16670.10840.08670.3024-0.2486-0.4676-0.0790.701-0.0987-0.18421.3556-0.41031.20662.70813.236281.432
81.3412-0.0761-0.77930.86510.25111.79360.0748-0.34280.71370.05930.2332-0.2847-0.33850.93680.14610.7711-0.2067-0.11591.355-0.4961.376396.5810.786285.975
94.36450.5363-0.58453.2737-0.26761.612-0.4927-0.74410.01320.48490.33850.20370.72250.75490.13790.93710.1766-0.16791.9046-0.23140.913588.301-8.845307.335
103.4949-0.14970.28650.6815-0.1258.512-0.6418-0.15810.2798-0.4020.0337-0.11232.5717-1.22360.43171.3718-0.3750.12741.3636-0.41490.963849.122-13.315307.387
110.199-0.10740.17760.058-0.09590.1569-0.45990.2845-0.1879-0.58430.60670.14230.8977-0.757-0.54163.06880.03341.49921.76650.71022.529139.65-18.871311.752
129.82410.1432-0.71112.36570.0114.4905-0.98490.1149-0.89780.3393-0.61090.13420.6704-0.6678-4.0241.1972-1.0420.20242.1725-0.65081.003737.289-19.171295.18
132.58540.2265-0.17351.3552-1.49631.6542-0.2953-0.41521.0650.4774-0.2467-0.0636-0.70930.56130.97140.9542-0.3562-0.41212.1005-0.56981.495531.2319.566295.023
141.89810.72860.85330.9701-0.23860.8430.1347-0.90491.04350.4743-0.5193-0.1897-0.4205-0.03051.02560.4196-0.3381-0.36012.1959-0.64341.540137.7652.879290.988
155.3834-0.6077-0.16673.1366-3.56724.2282-0.35851.5275-0.19720.47610.2581.3299-0.457-0.218-0.30630.9753-0.33080.17550.7376-0.27720.802746.585-23.019290.006
165.58011.49973.52574.4385-3.48559.60610.94161.20770.1678-0.47170.4257-0.06661.0593-0.44240.00491.8769-0.55230.61131.3534-0.37430.964841.747-28.147281.983
174.95573.07223.15824.03255.05248.0297-1.0631-0.46811.7571-1.44631.36410.6039-0.11810.9643-0.46261.419-0.65910.09922.7578-0.31251.692927.734-16.355293.204
186.04633.45141.91941.97521.21333.3936-3.27611.9316-1.37510.33150.74641.40871.90530.82452.56493.3694-0.63340.91151.70980.07231.929635.8-26.807316.79
192.8854-2.11581.44739.6651-7.09926.2949-0.09950.56960.22330.3051-0.9107-0.23290.05411.7748-0.00530.8305-0.31460.05211.0736-0.39160.591453.595-18.415295.454
203.76421.74213.60080.96751.48823.65770.02931.08-0.2554-0.1557-0.3697-0.07290.14-0.3940.34360.8357-0.1082-0.01481.2361-0.26331.105858.663-7.013290.263
210.9345-0.23120.24681.2926-0.53530.22260.0256-1.4090.53580.52280.4957-0.0906-0.41571.52390.00290.99120.0399-0.22121.9922-0.59781.207784.6186.995312.276
222.4492-0.80681.97871.5349-0.33482.47480.0061-1.1988-0.13190.60060.2845-0.0423-0.05430.8311-0.20361.25910.3349-0.08422.6698-0.48770.846469.3040.974337.459
239.49980.00680.55741.9932-1.31391.0750.6178-1.1739-0.25880.1507-0.19121.28440.4761-1.17761.99630.9801-0.6063-0.59222.3634-0.34091.859560.798.367327.051
240.1570.4505-0.49121.4865-1.10521.9717-0.6063-0.01410.09750.6414-0.08570.1517-0.7269-0.7110.68481.4806-0.3888-0.09481.5082-0.88531.244650.30114.054332.681
257.3575-1.88134.0763.34521.95695.3962-1.2821-1.8377-0.8053-1.0461-1.7166-1.07362.6524-0.31511.91751.17990.28130.37411.5810.37991.492550.9670.629330.324
268.5239-3.10035.13966.2624-1.61744.1735-0.29-0.11641.59280.2657-0.2843-0.4783-0.1917-0.10380.68060.80370.0686-0.28823.1068-0.61691.559542.6736.159325.075
277.79693.6518-2.23736.1352-5.45585.0330.41690.3777-0.4192-0.50680.13890.04113.6931-0.0043-0.54821.9578-0.2346-0.56122.3345-0.4051.008146.575-1.158322.361
280.9158-2.08771.15194.8137-2.78681.87580.73460.15622.3584-1.5985-1.4726-2.40440.89023.9320.21491.27160.2731-0.11273.4509-0.18672.466856.011.426316.228
299.36876.0846-2.65327.0151-4.80213.8485-0.4887-0.6682-0.2860.1866-0.0366-0.93390.1351-0.66580.02581.3344-0.4309-0.17231.9787-0.69081.244439.427-1.807313.415
305.21694.2945-0.2893.55220.21327.5759-0.75680.46882.5530.371-0.40270.5981-0.991-1.77490.87640.54970.0872-0.4190.7488-0.25561.227348.21511.718317.228
312.35561.5174-0.28612.7040.69810.4857-0.9310.6073-0.0213-0.94660.29030.3864-0.8023-0.0505-0.76371.1335-0.1849-0.34041.5865-0.85191.558537.9756.632306.131
323.2569-4.37980.6868.88572.86955.7672-0.17850.42950.377-0.02331.1326-1.82280.8142-1.2449-0.83430.9339-0.26920.02133.195-0.64841.364128.684.257306.093
332.00212.9972-4.58555.22880.26142.70580.2407-3.63040.40380.4057-1.25991.91370.4234-2.4071.06571.308-0.3994-0.18083.3161-0.41831.657727.2512.06318.719
346.2398-2.4167-1.63662.0007-5.42555.31450.44730.19390.10380.0688-2.3876-0.87250.20380.40111.60720.92870.2107-0.10373.1508-0.18621.136937.4443.569334.33
353.4003-0.5492-0.29251.0620.03092.43860.0819-0.9938-0.03060.1477-0.1219-0.0160.24230.10850.03310.7028-0.211-0.15831.53-0.17130.9265123.0696.678418.489
360.751-0.03681.4283.4053-2.32294.4197-0.3334-0.807-0.2257-0.39760.8153-0.54061.084-0.6841-0.63410.836-0.0253-0.0462.3171-0.01851.019786.087-5.344434.723
371.97271.1512-0.89751.7399-1.67671.651-0.1531-0.0598-0.6392-0.0974-0.5291-0.57620.86490.1457-0.18222.7757-0.30061.06972.71630.82041.828175.509-12.957438.639
385.4032-4.0554-2.24378.24524.09325.7639-0.8269-0.7259-0.35961.5689-0.03680.51660.971-0.8282-0.43760.988-0.4672-0.15941.89010.39590.664175.844-17.77423.157
390.2699-0.5525-1.42815.84115.88519.41970.1087-0.37540.26391.5602-0.5097-0.47181.2202-0.1523-1.06230.8579-0.4072-0.23332.264-0.20090.828967.9854.429422.063
406.595-2.9103-4.38261.28431.9342.9123-0.37510.17010.6230.5405-0.8062.0231-4.47041.7771.0881.8547-0.2225-0.2361.0034-0.51091.710567.85721.835425.685
411.1790.08560.38671.43660.47320.2713-0.1526-0.14570.94-0.02470.0544-0.0204-0.15040.30261.16380.6185-0.4952-0.23152.4505-0.47881.250574.4649.79418.772
421.7203-3.07551.42757.963-5.17625.21790.2203-0.1295-0.52930.5325-0.00770.6283-0.437-0.5310.06970.6778-0.4728-0.22871.53910.22290.648282.859-16.221417.983
433.4376-2.28333.72412.765-3.14384.39280.8305-0.2607-1.4765-0.74710.34460.65921.8235-1.1052-1.20271.1486-0.14060.14061.13630.03640.972178.255-21.43410.233
446.329-6.7517-5.21538.71483.91296.1020.7499-1.88071.7491-1.60581.55370.3998-0.56260.6915-2.02771.2882-0.7680.02481.8714-0.2021.637764.196-9.284421.02
451.4277-0.84430.07925.669-0.08373.60440.47170.9308-0.25480.6834-0.63370.45190.6620.3129-0.44311.1832-0.0082-0.06841.48260.3590.677783.912-18.743435.181
462.9862-0.31211.8610.4393-0.02821.4444-0.09590.37070.78140.06870.3108-0.32570.02280.1193-0.17910.8797-0.2407-0.13712.1051-0.23310.99291.453-2.493418.375
477.13651.53346.59684.07812.15446.25240.1906-1.5841.4460.5003-0.50330.321-0.006-0.19690.33480.7026-0.178-0.10072.0485-0.21210.9895124.53612.043428.63
480.1107-0.1004-0.41080.04990.26522.50190.7383-1.24840.20950.1614-0.41830.1134-0.2874-0.25520.7341.2705-0.56090.06684.192-0.54791.2292110.6414.246461.147
490.7383-0.0053-0.59860.6967-0.52960.895-0.34720.7583-0.25680.2989-0.08810.68790.8523-1.8110.16691.9459-0.39520.34454.2774-0.09021.121698.5354.415472.87
509.9794-3.80760.90277.7034-4.85986.31571.5809-0.3394-1.796-0.21480.1940.8862-0.24442.635-1.60861.1849-0.1811-0.26123.01480.29191.3965106.281-4.829463.123
517.5191-0.24810.70724.3936-5.47116.85340.3765-2.46860.62781.62990.01260.2694-0.5057-2.19450.21841.4624-0.4553-0.12534.3736-0.17861.2487109.49313.994460.442
523.0961-1.25743.85130.5255-1.41525.55530.6382-2.044-0.21641.34-0.3489-0.38630.3317-1.36550.68070.958-0.4922-0.48582.6358-0.29411.343793.9916.799456.233
538.2867-1.5389-2.94612.87821.29933.5236-0.7879-2.63460.20520.52120.05760.3520.03990.30720.25311.1019-0.3469-0.1943.5465-0.38241.538181.88511.413453.926
547.41580.6731-1.49275.3369-1.75340.80990.17550.2069-0.065-0.0018-0.5069-1.64270.336-0.0010.21650.8554-0.54620.15393.3806-0.52341.661488.7947.524445.885
551.60560.4262-1.01410.5689-0.35630.66270.3705-0.0216-0.61020.3564-0.0785-0.41740.50310.1-2.41230.9684-0.518-0.2912.7439-0.86521.194875.8325.192440.917
566.8793-2.6487-2.73492.19862.71646.12170.73010.12512.31920.9135-0.0666-0.5446-1.782-0.28110.12240.7874-0.2248-0.31941.3273-0.16191.251484.59818.556444.75
572.84340.98250.13886.29761.96723.6947-0.96350.2304-0.1483-1.48110.68480.253-0.6629-0.3247-0.04581.0448-0.2966-0.38021.4941-0.66881.463274.35413.703433.831
585.5658-2.5838-3.95046.77492.73412.94840.3285-1.97930.03320.9406-1.0113-0.5787-0.279-2.41750.44170.7913-0.2006-0.09562.6493-0.50631.256865.111.391433.582
596.2192-6.16344.0917.2599-2.2765.51550.6736-1.3811-1.7876-0.0381-0.03891.53951.471-0.05880.01371.0854-0.52450.00013.4647-0.05171.401268.1419.546452.723
601.6089-0.1545-0.59332.6138-0.23781.08670.0059-0.1250.0456-0.046-0.0836-0.22230.21950.03880.05060.7062-0.0941-0.18610.7262-0.16620.8001101.765-42.27243.887
614.7442-1.9754-2.02841.05060.36261.69120.41-0.87290.35410.6458-0.15110.0284-0.65490.5439-0.0291.5821-0.0714-0.13920.9964-0.1131.136114.743-54.335282.858
622.6359-0.56020.26780.18580.67877.9257-0.7527-0.0683-0.18770.66750.4119-0.04191.2257-1.14940.2814.3572-0.0973-0.26131.26120.00971.0622120.327-55.581294.072
636.7096-1.4219-4.15084.229-1.73685.0689-0.2397-0.67240.6821.9480.0549-1.0430.14452.3744-0.19411.92710.0234-0.85431.3561-0.00961.4227134.76-55.01284.453
644.6659-3.1067-3.82597.30483.86523.4979-0.7676-0.4442-0.810.3823-0.71871.9956-0.73850.90841.00781.85440.0281-0.56471.34780.53721.9482124.592-75.41280.522
655.556.30044.49338.41036.22374.6398-3.0370.00723.7276-1.0523-2.04271.0404-0.92760.27934.87861.42480.6279-0.00682.30290.31662.1124111.41-87.835276.47
664.52295.5549-6.45689.3882-9.12189.77063.05262.0485-5.21263.87592.1328-1.7284.9562-1.5577-4.55031.852-0.1229-0.96351.845-0.14812.3316115.396-81.47273.082
677.88081.27481.86152.60670.03221.8642-0.99870.0211.0215-0.29880.3543-0.5-0.35790.50532.48331.69940.2507-0.82930.95670.40971.6258129.786-68.904271.474
686.22780.19062.20.2871-0.8984.13540.3641.28820.77031.92240.0919-2.01331.40110.3182-0.36471.5727-0.018-0.53720.89840.32971.1089132.075-50.22277.569
698.1148-5.5483-3.15774.40841.27372.48031.11081.4841-0.05830.53140.1826-0.861.10752.25160.51191.4418-0.4405-0.71282.18410.1951.3784143.323-53.639273.947
701.22590.29360.68360.36570.23333.2461-0.13880.3703-0.0917-0.1240.41420.2347-0.00360.35480.55542.56490.1548-1.06071.50890.18441.3827136.457-68.244286.588
713.54670.69680.20821.6870.49350.1385-1.3933-1.27880.7159-1.69730.56970.1828-1.27120.39970.61862.25370.4258-0.25271.4976-0.11870.6071122.759-52.746303.109
722.90250.4663-0.11250.4407-1.12013.26280.61830.63670.30420.312-0.4135-0.2513-0.4891-0.07131.00951.58370.3526-0.65290.62940.10620.9679124.213-49.8274.455
73-0.0034-0.0219-0.14880.0780.56214.1476-0.643-0.4695-0.02651.2849-0.193-0.54160.7886-0.56980.55191.49620.0099-0.65191.17110.06241.3825117.999-55.733263.215
747.8698-7.6225-3.24818.54491.71683.1311-0.3869-0.4096-0.90690.31050.16551.15070.1983-0.24150.21560.7855-0.0776-0.13830.6758-0.04720.8991.215-42.693248.324
751.91860.74991.46244.5362-1.91693.3978-0.36110.63910.5661.02750.4838-0.49291.3507-2.98410.13051.1895-0.38060.29431.4342-0.29351.663172.007-49.709264.753
764.89671.9499-3.44260.7653-1.32872.72110.2956-0.10140.43041.1995-0.16521.41460.4256-0.275-0.11932.2467-0.39780.53931.0683-0.18511.262673.425-44.062286.025
775.6328-1.0651-2.09218.3067-1.56591.298-0.2698-0.17060.30192.04270.4152-0.1485-0.0127-0.2831-0.16191.9152-0.22120.351.1203-0.18991.001578.249-41.86283.219
787.94341.66262.14354.8221.22942.413-0.0271-1.64260.33151.7194-0.51381.2054-0.2214-0.06390.69931.9075-0.16210.00170.9337-0.14610.798485.615-59.12288.223
795.0963-0.9899-0.40395.90923.07581.60750.1206-0.1453-1.71622.3892-0.38680.12151.2705-0.2696-0.042.5798-0.0475-0.21150.6846-0.40161.227396.067-70.875294.033
807.25190.2461-1.22640.069-0.61985.6408-0.11140.14641.4161-0.4984-0.1795-1.76063.1289-2.2490.22562.0662-0.2762-0.05421.1013-0.37051.405395.511-57.439279.332
812.13490.9364-1.03914.76412.12742.1813-2.5101-0.7937-1.39860.21011.0305-0.1354-0.28510.78881.03471.8885-0.01940.27211.48420.13691.96107.236-66.202288.691
827.0284-4.7511.90633.5998-1.55892.31250.37871.5626-0.0473-0.3967-0.11080.05320.18891.0016-0.38352.0064-0.38570.05151.0451-0.35741.201597.921-71.623282.223
832.16071.8205-2.57791.674-2.57924.25830.3112-0.9798-1.108-0.6532-1.65291.5705-0.54932.78071.30310.9753-0.0119-0.59752.1567-0.12742.6338113.596-79.246288.768
842.24572.495-0.29067.57293.57743.19650.3680.4547-0.0613-0.7242-1.7833-1.4983-2.1664-0.08361.38482.41750.0618-0.56042.05980.65271.7076107.699-76.911299.028
859.80473.4502-2.1942.887-1.93746.28311.0146-0.24852.03510.9488-0.568-0.1823-0.21030.9481-0.58742.2387-0.04590.21731.60540.09381.740292.93-66.608303.102
862.52321.2254-0.47224.49661.38872.8198-0.0049-0.45530.0877-0.0345-0.0145-1.00710.14320.68190.06490.60230.0675-0.06910.64220.1411.0473148.914-29.448364.109
876.1516-3.59442.81795.5698-4.58465.1660.2462-0.9362-0.11670.0923-0.02450.05810.2082-0.336-0.27740.97450.0157-0.08880.90050.19721.2078146.981-62.686375.999
880.52720.05061.22822.9551-2.21224.3551-0.0427-0.2349-0.5898-0.2734-0.2728-0.71660.77380.21350.12061.37590.32340.1610.83410.30691.4705147.873-68.924377.29
893.5222-1.2780.65622.73520.49873.32490.25050.4794-0.2986-0.4898-0.32830.37110.3826-0.48650.11530.8119-0.0869-0.17170.5683-0.04140.7513128.742-35.79357.493
903.76630.5128-1.62162.82120.03024.95850.3644-0.43470.16150.5472-0.2236-0.11430.1478-0.0158-0.15140.6589-0.086-0.1860.5119-0.03980.7745133.536-21.275383.934
914.2648-0.5734-4.85262.13231.12457.01820.01570.0674-0.59170.9986-0.5710.61470.681-0.43610.50741.027-0.2594-0.07740.65270.16930.7501126.83-36.845390.72
923.76693.29914.26733.37064.08985.18190.143-1.2037-0.7347-0.7908-1.07431.5915-0.6394-0.21661.08473.28190.1356-0.38151.89340.23212.5302147.775-59.723403.185
933.1217-0.2512-1.33172.98540.04427.06230.2573-0.9509-0.77421.3043-0.11780.29990.59280.2973-0.53162.10470.3116-0.41241.74490.74431.2311152.475-62.657398.869
944.4614-1.6893-0.01743.8411-3.22555.4901-0.4119-1.3562-0.4181.28950.0975-0.5742-0.24960.89450.59111.6630.4504-0.47861.40180.61821.2089156.507-50.652402.919
956.29950.7191.53952.66681.65042.45190.5141-0.13450.69280.8399-0.4961-0.75042.0838-0.7730.12432.7462-0.158-0.64821.21870.13211.2573156.967-39.723419.351
964.6943.64153.17074.86565.12869.9344-2.80270.5051-2.9198-3.40163.4477-1.3584-2.70370.6275-0.68062.1735-0.41980.53121.48530.00872.1144149.626-42.501428.271
971.3048-1.5977-1.27924.69124.66764.7661-0.30510.0004-0.21790.3196-0.23940.50071.1302-0.4249-0.52944.07190.3574-0.73591.0977-0.12411.2498159.023-49.352421.658
987.8563-3.0395-1.16662.4581-1.30094.58150.0091.8008-0.92161.32240.26180.63532.2342.6798-0.27082.0472-0.2914-0.92561.8648-0.38832.226174.354-42.09416.972
991.272-0.50210.46981.2445-1.02123.07620.3156-0.2749-0.622-0.12720.21830.39291.4065-0.3272-1.57121.5536-0.1623-0.68961.52050.54951.0936171.627-51.686409.007
1001.3448-0.282-0.86412.6926-1.88222.38520.3899-0.2246-0.52930.311-0.6978-0.3594-0.53460.57030.33541.72840.03-0.66180.99740.66081.6963161.927-70.307408.208
1012.8654-0.46361.33480.1052-0.29530.8279-0.64571.9283.0654-2.1502-0.6470.0662-0.12550.27351.24322.23840.3403-0.23551.18710.33062.1121148.811-81.762404.831
1024.6388-4.54463.81436.7836-2.86883.45481.6061.2642-1.94331.8402-0.87580.70481.2670.5936-0.75731.8132-0.1753-0.76891.29330.11761.5556153.243-72.87399.476
1032.3107-4.02561.36739.0053-1.79432.98010.05570.35391.0202-0.3552-0.5985-1.7389-0.46130.6661.52661.35690.4682-0.22121.13550.51591.7816172.436-60.296399.18
1044.0202-0.0827-2.0885.6676.83239.2341-0.06590.1104-0.37350.845-1.4438-1.85220.595-0.38810.56151.6463-0.0873-0.47211.36990.64881.6358169.581-44.092404.654
1050.12390.64320.94386.3424.32537.18511.68630.90070.42222.0917-0.8814-1.83540.34230.8161-0.47781.1353-0.7045-0.37591.99370.49672.1539180.858-47.792400.741
1068.70382.08174.97164.89374.86076.7107-1.090.3191-1.0608-1.09932.42070.79010.5372-1.8396-1.44212.270.1582-0.6072.05240.6211.6617174.361-62.166413.421
1074.3662-1.8432-0.57021.2187-0.15070.3890.0281-0.43471.25090.12290.159-1.2293-0.74380.42940.04062.84630.3831-0.01710.7943-0.17431.0702161.091-41.209416.466
1081.8044-0.8231-0.50410.9331.33912.3929-0.2476-0.6079-0.85890.87820.40180.28060.351-0.4032-1.71311.11630.0585-0.68590.94720.5551.1508158.135-50.573393.804
1094.5787-3.7038-4.40056.77473.08197.93310.14470.2583-0.44530.1027-0.13080.34160.5061-0.76540.02650.684-0.115-0.13290.71040.10860.8676128.021-36.469376.414
1106.9591-0.6647-3.95130.29340.76373.5440.0984-0.0272-0.33181.0705-0.03560.3560.5699-2.7792-0.06061.6815-0.36210.40381.53090.06561.5165109.344-38.693404.752
1112.4166-1.7673-0.9261.8841-1.16046.3537-0.1596-0.47370.14211.7002-0.05470.45330.6803-0.88330.11542.143-0.38980.25021.1479-0.13590.924115.221-37.246415.539
1124.661-0.4827-0.3163.32751.3090.5186-0.1440.7415-0.24990.98820.1189-0.16383.1943-0.5481-0.04242.8498-0.1564-0.33131.2754-0.15231.0779119.73-51.188411.236
1133.1655-0.8198-1.84621.78962.76624.84740.333-0.8020.02171.2367-0.1694-0.5957-2.0039-0.3282-0.34042.727-0.45420.03721.74890.23940.8991125.283-53.726419.356
1140.5879-0.8603-1.38561.23911.99083.1837-0.3782-0.398-0.2511.247-0.30410.09961.253-0.3907-0.03412.8117-0.3305-0.24731.7806-0.09270.6331133.897-64.596422.278
1150.8977-0.85092.10563.9228-1.77534.93690.74440.75230.4965-0.36120.73770.66340.2326-0.1085-0.64542.131-0.20340.13073.29050.54140.8961132.966-51.259407.414
1163.79083.19862.50454.35430.71232.9847-0.73280.5993-0.53550.47550.7909-1.5596-1.0377-0.2793-0.01891.6791-0.2020.11282.45830.30481.1743144.919-59.798416.8
1175.3308-1.18853.93595.1193-3.61384.4445-0.15273.2508-0.60890.4857-0.56470.7872-0.97382.92520.88521.516-0.47270.12571.7922-0.28221.3232135.951-65.677410.818
1182.0414-1.8452.31562.4934-1.06293.9020.1736-0.6337-0.81180.71330.3087-0.69630.13270.1869-0.10110.89750.0435-0.59722.72720.1991.5608151.345-73.049416.557
1191.67382.1637-1.14468.59695.02598.06330.032-1.4298-0.6817-0.28361.0296-0.57640.9267-0.2854-0.63692.09910.6337-0.21613.06880.33251.0548145.445-69.163427.085
1201.10260.70261.17295.7676-1.05428.88460.03051.24832.0812-1.08540.54390.3738-1.90030.508-0.212.1018-0.0080.35321.82090.91551.9798129.451-59.987431.613
1211.01620.7542-1.35.84281.5525.75780.1006-0.32980.0142-0.0339-0.1704-0.24360.38640.07710.07540.6473-0.0329-0.23090.9211-0.13641.109358.284-19.395254.545
1228.527-1.2548-5.8664.51450.48945.10350.2114-1.7124-1.00720.4192-0.26471.08930.27041.21620.01410.7948-0.1902-0.20450.9121-0.0030.986553.763-22.3264.804
1230.17040.275-0.6493.9731-1.39032.33750.4002-0.28040.13730.9603-0.1191-0.0155-0.4132-0.1688-0.19430.6443-0.1335-0.16831.3671-0.45641.183551.211-5.826264.892
1244.37370.1693-3.01244.6483-3.14194.04940.8764-0.22660.4340.5877-0.0328-0.606-1.25550.0894-0.8891.0727-0.1169-0.08721.1651-0.27041.182767.9825.736265.149
1257.02943.6725-2.76394.0234-1.42631.75290.3730.03090.77210.6208-0.64381.0922-0.5879-0.12350.04760.7871-0.0665-0.02711.3341-0.56961.324851.2136.33264.253
1262.29610.67110.78181.5902-0.8881.15690.0828-0.01650.0498-0.25770.35610.90320.3099-0.7438-0.24840.6015-0.2018-0.19931.9013-0.48511.707727.834-11.236256.89
1271.4512-0.2360.43681.1106-0.6731.39620.00470.34310.81880.0001-0.04870.521-0.4657-0.69950.33670.6197-0.1673-0.16631.4164-0.28941.446439.233-6.043250.971
1284.0863-0.3643-1.79962.2231-1.14273.5527-0.18810.3827-0.0216-0.6814-0.1018-0.03740.315-0.30360.22650.7221-0.0777-0.28850.9428-0.21421.09856.629-14.833232.356
1291.77050.6169-2.95064.717-1.29857.46550.02940.68430.8407-0.7223-0.38910.3957-0.57280.28770.51530.7322-0.1255-0.34711.1944-0.19921.529256.8023.393231.256
1307.8096-1.6341-0.91856.90987.0577.29320.4689-0.18371.2783-2.17870.6999-0.5153-2.1878-0.4484-0.86781.2506-0.3006-0.22441.23460.22491.485781.90419.235246.588
1317.8336-8.0969-5.87829.99157.29255.32980.74342.1188-0.0712-0.9241-0.85690.1716-0.6623-1.00350.29490.6939-0.0329-0.27010.79330.06751.222187.5369.173243.845
1324.95940.599-5.03812.2163-1.49526.62320.44010.48891.6195-0.81240.93020.4151.9077-2.0131-1.191.08470.1854-0.05851.4536-0.10440.975796.3224.733228.075
1334.3643-3.159-0.05093.5312.15883.77990.93290.17810.9018-3.7975-0.1863-0.5755-1.093-0.3799-0.82951.90730.30170.1561.5262-0.21181.219999.1455.889218.799
1341.12790.35670.24391.0199-0.02881.5555-0.2863-0.10250.1623-0.92670.41631.3974-0.6288-0.485-0.35272.00260.2475-0.03331.14470.85211.998896.1815.085218.336
1355.5555-4.881-0.49217.83562.9186.98480.27680.19840.8559-1.5451-0.1394-1.4805-0.36390.9879-0.15080.8674-0.1810.13691.1717-0.06231.326103.1097.855240.4
1363.6196-1.386-0.55844.2269-5.39868.623-0.00410.0558-0.7252-0.7341-1.1724-0.2052-0.00940.15510.65751.1296-0.1426-0.4450.6491-0.17581.695996.82226.113252.02
1371.9192-0.3282-0.75888.2076-3.41366.72840.1498-0.93960.91611.59810.23821.7881-1.22630.7543-0.07430.847-0.2819-0.16350.8874-0.18251.595790.64323.075255.891
1386.9125-2.3993-5.68597.66213.30818.87920.2460.472-0.4703-0.422-0.9935-0.32540.2496-1.95940.83740.6165-0.0476-0.22121.0517-0.11160.834797.994-0.521246.172
1395.2833.832-1.04674.5291.69713.6505-0.45651.4781-0.74190.7980.9678-1.33560.4030.7449-0.12260.58710.2179-0.05951.5194-0.21621.6108104.554-2.796256.554
1407.9773-1.0668-3.47170.9558-0.9984.36720.1408-0.89170.36821.5166-0.0442-0.145-0.9541.6310.06360.7314-0.2894-0.34220.933-0.01711.2695109.00216.265250.632
1416.72451.29241.08855.978-0.53668.68920.00510.45080.1451-0.5196-0.3104-0.18541.26380.18140.2160.59060.0659-0.21110.9585-0.07210.89395.5544.435237.924
1425.49157.04962.00628.9992.82963.7419-0.42320.3757-0.0512-0.4388-0.14550.9011-0.0289-0.52520.62340.56750.0217-0.11710.9137-0.11491.519778.8354.579251.649
1431.00560.5453-0.17431.4919-0.8963.6972-0.05520.60920.6323-0.47060.0460.603-0.4794-0.5163-0.02990.9010.0542-0.37261.4844-0.1081.504350.1657.237227.653
1443.6758-1.0155-0.6594.3905-1.95131.20510.04390.17070.4124-0.833-0.03520.1994-0.07360.1293-0.0071.3421-0.1408-0.40871.3317-0.00621.244264.90914.956208.248
1459.94511.0708-7.50589.22010.80425.95891.87350.6209-1.3887-0.3106-0.65921.21970.2101-2.2307-0.59270.9551-0.1518-0.45431.35390.19410.864566.33520.846220.138
1461.6538-1.8821-2.23332.21172.55553.02220.17871.48191.4945-1.1312-0.19990.1857-1.2342-0.5929-0.06972.49110.01790.01911.37810.86511.622470.89833.345216.017
1472.5211-2.4686-1.00012.62172.35579.68710.71170.50151.0902-1.7161-1.2075-0.8259-1.1114-0.57640.4641.29720.1053-0.20961.46820.11591.694881.22129.386220.606
1485.87680.2218-0.89156.0029-3.34269.9547-0.2451-0.70180.1547-0.1277-0.6010.12540.25510.66040.69981.285-0.0253-0.29781.54950.07711.785877.14319.479226.908
1495.8068-3.0061-3.93482.8692-0.89629.8342-0.11370.1294-1.23360.1960.4409-0.58280.99970.8234-0.46831.17150.1198-0.34711.2650.03221.755986.67724.886232.775
1508.0676-0.94713.55020.39760.60965.2358-0.77150.84631.83370.1465-0.22691.7959-1.58990.22010.94441.29560.1627-0.40390.66590.08971.944475.54931.345230.367
1512.03452.0249-0.56862.2134-0.07052.301-0.3161-1.48440.46680.02531.0964-1.2176-2.72150.8904-0.91451.939-0.162-0.50611.257-0.1482.038490.74334.226241.843
1529.6352-0.7485-3.22633.1752-1.44712.02020.2257-1.01980.3927-0.46440.1486-1.8604-0.90822.1065-0.20411.5554-0.60660.14871.78950.19321.743196.82637.688229.405
1536.0384.14170.28732.98771.26858.02180.80420.94320.2946-0.77451.1621-0.22170.5408-0.44180.38691.8206-0.730.02641.06780.20380.994986.435.722213.529
1541.2258-1.0655-1.60313.24820.23733.97760.3512-0.2648-0.35680.3039-0.264-0.66850.32360.2912-0.10620.61740.0131-0.2940.75710.07720.942494.943-13.053382.635
1552.775-2.6177-0.22272.8023-0.4541.2788-0.2623-1.4851-0.17740.8425-0.00340.52660.04190.3192-0.40240.5506-0.1459-0.2311.11850.09450.891686.241-9.018393.776
1568.8249-3.2861-2.41147.2019-3.61487.90970.3922-0.3789-0.5052-0.1328-0.0714-0.6145-0.83640.3309-0.26350.6899-0.1036-0.18110.775-0.12970.8197105.229.565392.228
1575.08871.982-0.54897.3307-0.16353.9610.3154-0.57780.90870.6697-0.50930.4632-1.1997-0.74970.11850.6883-0.05690.02561.0837-0.29740.960480.8677.897392.332
1581.8705-2.39181.76844.5236-1.36993.2419-0.002-0.3004-0.3492-0.02890.25550.7590.4157-0.6713-0.15220.604-0.1757-0.23931.4377-0.09361.227564.482-4.853384.844
1593.45621.01140.7562.90910.88095.75880.073-0.58150.1168-0.1362-0.19880.5221-0.4446-0.65460.12060.47820.0012-0.21470.7598-0.04980.85575.8970.296378.939
1605.3047-0.8169-0.6583.9847-1.41763.9147-0.13340.576-0.0453-0.5121-0.024-0.35520.222-0.05930.13480.61450.0185-0.2470.7953-0.07170.749393.737-6.799359.698
1613.57582.58022.69992.09470.94625.6541-0.50540.17390.1962-0.11220.05670.2582-0.9374-0.31820.40620.65480.0227-0.10520.98970.01740.848290.879.801362.008
1628.60983.26674.81994.90783.90254.17180.60290.6413-1.4865-1.06110.2774-1.81140.0844-0.4405-0.86720.68750.0361-0.04350.48350.11781.0993118.76625.249374.492
1638.6908-5.39165.43024.3768-2.6394.28410.95112.2919-0.3588-1.4584-1.12840.1749-0.61730.9748-0.00210.75430.1066-0.28750.6791-0.0950.8617124.30915.346371.743
1642.3085-1.7073-0.10272.037-2.37598.57621.82050.6488-0.2889-1.534-0.39150.7619-1.0026-2.429-1.33751.08340.28310.03881.02370.16220.9225133.15111.18355.924
1654.48074.4509-1.16326.5539-5.22428.0678-0.84851.69310.9597-3.6277-0.2612-0.09360.49470.79630.73881.48210.1826-0.25791.60810.13460.9076134.39716.965346.415
1668.3522-7.69221.34718.7764-1.4920.2544-0.3469-0.0431.5745-0.20640.2075-1.5407-1.8096-1.7950.25241.57920.61940.40231.1575-0.14611.2554137.96419.173358.745
1676.3849-3.91844.65075.0898-0.26675.9036-0.29573.43161.7254-1.2705-1.6652-4.35890.4843.34121.7281.01150.17950.02651.55390.14721.4922145.8756.394366.376
1682.4425-2.62630.02394.8552-4.06398.0509-0.43320.7875-0.0035-1.5823-0.3236-0.9398-0.14251.16860.13210.5638-0.0398-0.10440.8591-0.21881.0053139.66312.797375.48
1692.51593.6859-0.46485.7506-1.04430.4734-0.20080.1409-0.69810.3599-0.031-1.5632-0.31870.3364-1.68880.8754-0.0524-0.21080.8661-0.64751.7669133.69132.237380.158
1706.2119-6.1415-0.80758.5549-3.64198.0422-0.53410.5306-0.57561.0487-0.2585-0.9952-1.0458-1.09190.83651.5845-0.0663-0.44020.9768-0.51742.081122.86745.896380.322
1719.4974-5.8193-8.5437.29173.01479.0070.13220.91590.91710.5542-1.06022.0093-1.5107-1.6776-0.14751.64690.4895-0.15770.911-0.2512.0774122.35138.383382.162
1725.9264-4.115-3.89485.7585-0.51746.3273-0.2957-0.45933.36391.42790.4858-0.4904-0.8818-0.62640.04661.2546-0.1434-0.18930.9306-0.15921.4759127.32227.142384.121
1736.6461-0.01881.18137.15920.72016.0970.3074-1.5221-0.75280.0262-0.2043-0.34180.4351-0.33730.05850.5166-0.017-0.25050.58490.07340.7169135.1536.795377.076
1742.22653.01132.74229.42610.58316.91250.3251-1.2614-2.37310.11250.1258-1.24140.2111.4857-0.51640.62710.0455-0.26131.28770.00511.2369141.2593.363384.348
1754.4146-5.0252.30557.3421-3.46574.3886-0.5285-0.36731.47551.9894-0.8761-1.1622-0.97110.89271.33150.7229-0.1684-0.29371.1158-0.18541.5391145.81822.463378.743
1765.09490.07971.79943.28010.23996.4080.24350.7654-0.04760.0215-0.0243-0.01471.0743-0.2464-0.17120.5453-0.0321-0.24060.7471-0.00930.6755132.34110.674365.824
1773.19042.43863.97958.93323.66845.9521-0.1565-1.2375-0.1209-0.2185-0.17980.4634-0.2717-0.64010.50920.496-0.0188-0.08811.13180.02561.1122115.61410.687379.538
1783.73790.633-0.98911.085-1.79327.67990.16790.21590.8126-0.1570.24260.3795-0.587-0.8499-0.33540.67650.0884-0.22460.71240.01530.977385.9411.682359.723
1794.408-0.0776-1.37582.1875-1.3622.0811-0.18820.81570.2022-0.77950.3266-0.42970.1849-0.4956-0.1541.27040.0468-0.19191.17470.23471.0076100.6821.535335.668
1803.1832-2.3048-4.05274.72182.32496.90590.2588-0.28930.426-0.14670.7861.0742-0.7113-2.6154-0.93770.682-0.0073-0.19221.37030.33240.8469103.20927.494348.271
1810.1992-0.0481-0.02760.01180.00370.0048-0.11630.00320.0267-0.5515-0.0690.0404-0.48610.0263-0.53891.89570.1344-0.10281.35071.00721.0223108.06439.539344.64
1829.7474-1.1941-3.4320.82530.0221.4443-0.26790.61231.2253-1.0491.4065-0.8904-0.4511-0.2129-0.18531.0971-0.0625-0.15190.8398-0.20950.683115.82428.822344.004
1831.2859-1.5770.19521.9673-0.68686.89930.0347-0.02490.88270.28330.1326-0.0471-0.69960.2282-0.1910.90990.0302-0.00960.36420.03971.2945119.19238.782351.342
1845.75274.3075-4.88573.4129-3.22467.59260.5593-1.29780.5927-0.5074-0.5607-0.00330.87950.95230.06741.1002-0.0798-0.16131.1210.51411.5238113.94725.884355.402
1858.94531.5529-0.78383.6442.13356.21560.08650.35830.45270.83550.343-0.3510.56451.4027-0.42281.02270.0727-0.20920.66040.16711.127123.58631.236361.065
1860.6242-0.41520.39741.8683-0.49750.5635-0.2669-0.12920.21860.3437-0.08-0.574-0.6741-0.0196-1.21591.0690.3679-0.23760.281-0.28031.3253116.29937.97362.833
1877.2340.3629-2.60633.55041.10168.65630.33870.68741.53960.00441.0754-2.2427-0.73660.2002-1.350.9819-0.1947-0.04361.08090.13841.6566132.94843.166362.804
1880.32470.16390.37721.21020.10170.44490.0514-0.2013-0.64760.36080.0054-0.06870.68240.1098-0.4351.6143-0.06910.0110.67270.50861.2906124.2941.494341.899
1893.1418-4.0096-4.69285.12015.98547.0437-0.35561.0526-3.0706-2.15811.06191.1609-0.98381.1444-0.64160.9982-0.3198-0.14132.5344-0.25571.834540.31335.097291.167
1903.03150.289-2.68643.15923.55648.3541-0.24361.5642-1.77881.70862.1132-1.7884-1.78742.0773-1.74182.1711-0.7237-0.5452.4799-0.08481.37536.32520.517290.744
1915.6591-3.3263-0.31453.1261-1.98344.20660.2834-0.54820.81060.2941.08081.2151-0.2332-0.5755-0.61310.57440.3817-0.0492.5512-0.18252.458237.46134.14293.578
1920.3706-0.2256-0.76350.13730.46451.57130.58060.01780.2806-0.32610.3332-0.5074-0.80631.2231-0.37281.9391-0.69150.98963.2235-2.11134.00845.81540.836300.499
1933.88964.22061.37388.8461-1.07978.20233.22921.6832-0.28090.286-1.72941.499-1.4418-0.9789-1.2151.74690.31590.4071.7382-0.44831.662938.72629.382301.987
1943.1532-0.47313.03215.86572.61774.66031.42381.5001-1.2633-1.1762-0.4129-0.57761.11480.9643-0.9572.5481-0.1608-0.14213.1432-1.21761.727241.49521.875305.414
1952.922-0.203-2.29877.96831.55279.4757-0.56470.4558-2.25560.1937-0.99661.51980.1794-1.72362.01861.08230.24330.13652.4416-0.50011.388851.94926.692296.667
1966.6294-1.9643.76272.06521.07038.5019-0.04030.39180.9609-0.6722-0.92040.7492-1.46462.02890.9241.281-0.12440.06141.8017-0.23751.438348.66632.838294.896
1974.02716.21850.31119.74441.29264.64480.89530.7612-1.07820.1247-0.53220.48350.61570.186-0.16582.55050.3902-0.26051.8071-0.05122.179997.255-93.048260.717
1983.49531.17314.37462.7385-0.79868.103-0.97640.02213.2044-0.5173-0.9791-1.21051.09892.85791.45451.3660.66970.61611.84350.59313.1353102.146-92.402266.407
1993.783-3.8614-3.79917.8595-0.1057.8647-2.008-0.083-0.1194-2.2839-0.3413-0.32992.58931.18392.04722.2542-0.2258-0.34921.82531.36174.399784.937-91.939262.04
2003.59853.9101-1.25645.43470.47793.80521.5704-1.3795-0.0520.1737-1.1294-1.71351.4644-3.5257-0.50562.4876-0.3382-0.21211.88590.08331.400491.74-88.305270.553
2013.74183.6854-1.61367.18513.64149.1713-0.1813-0.1722-0.08941.12290.01831.19111.0891-1.40830.20611.81110.16460.18681.65820.40542.189292.865-81.692263.836
2020.92641.2446-0.00587.02881.01850.19520.1366-0.2116-0.64710.3553-0.1018-0.29390.76820.00981.07421.8585-0.48230.13790.74460.52351.894892.105-92.474253.504
2035.00714.25522.3125.1586-0.09624.0339-1.3949-0.72550.5467-1.9155-0.9137-0.7969-0.0817-0.40362.06581.78340.1675-0.21160.910.09031.4657100.404-82.171265.239
2044.62690.43410.34994.66833.52195.4340.318-0.51440.3544-2.3102-1.3612.2295-0.0996-0.14811.2191.07880.6089-0.10651.30130.2971.191999.91656.776356.724
2059.60562.87658.09386.85931.13787.10390.6666-1.4666-0.33350.22980.5864-0.0289-0.5142-1.0147-0.33261.04760.2830.45910.852-0.06091.303598.64449.407360.922
2064.79431.6218-0.17977.98850.72838.94220.41390.6053-0.48491.96960.15521.07580.78252.2164-0.22431.43780.705-0.14511.33430.09281.384499.60349.916368.816
2072.81780.81261.0434.4863-5.60748.5928-0.92470.28622.24660.39341.42141.79390.5027-1.8147-0.52111.57140.25310.08271.52010.05711.3246104.31442.661369.402
2085.8471-3.6292-3.72715.40095.10794.95921.3288-1.18150.4631-1.320.0061-1.0084-0.9261-1.091-1.06281.09230.2756-0.11411.33490.18061.0283111.12553.101363.341
2091.87732.7287-0.16037.2195-1.56636.60091.00981.6030.76290.0329-1.06610.8617-2.4609-2.3182-0.04072.06480.51050.12711.9752-0.04941.6514105.78856.99355.362
2101.9548-1.3954-0.49142.48642.40862.9460.31650.24960.2029-1.2558-0.9261-0.55781.1845-1.84340.6850.98830.1671-0.15410.92070.10681.0554109.98241.227364.547
2115.2722-0.66240.24580.2153-1.00577.1872-0.42380.89250.1697-0.9539-0.07391.61480.2488-2.11260.66750.8826-0.1574-0.05562.039-0.7541.299976.22835.561419.69
2122.9284-2.9245-2.72833.07912.14114.73180.7140.5151-0.23090.1602-0.1553-0.32470.2365-0.06010.9851.7211-0.15110.30972.6944-1.5872.576681.45946.619428.281
2133.9166-3.43963.19576.7051-1.09373.49521.07880.2302-1.06171.83680.20792.33841.3361.0663-0.54381.8490.08770.55881.2982-0.84952.415277.32334.503431.932
2142.78961.0852.50013.5563-3.3538.1962-0.3607-0.06520.47040.2969-1.0854-0.0351-1.50330.14760.23751.23770.02550.2121.7126-0.75752.001787.23436.81424.535
2154.0022-1.9864-4.82285.7176.56589.495-0.23620.9785-1.83291.7546-1.63092.16653.7072-1.71571.98042.7495-0.65480.08561.60490.09921.7832134.549-86.63389.161
2160.4756-2.2022-1.973828.56159.76761.4068-1.80956.42230.61950.7966-2.4183-1.02790.7752-1.75191.31060.2257-0.28871.5632-0.62494.3456144.891-83.093395.462
2173.5588-2.68061.00736.1967-1.39181.88540.8949-0.091-0.49651.5372-0.21281.94630.2825-0.5927-0.98451.6170.20910.5390.60230.2452.4761128.006-87.395392.18
2182.0138-0.16450.61498.1551-2.63141.22540.11760.10930.2105-0.51410.0330.77110.1306-0.08110.08812.3201-0.04480.03620.50280.06321.0669130.041-82.102399.402
2193.2529-3.07551.53286.8139-6.62839.67660.24350.1151.14513.36120.9960.3555-1.5217-0.5593-1.23911.6562-0.2786-0.09391.15730.47671.3098134.137-74.508399.185
2202.34932.6251-2.64474.0245-1.15876.4712-0.42740.04071.7692-1.11560.0705-0.85560.9991-0.24480.66711.51410.0005-0.16991.28040.50441.6924128.332-73.466387.889
2211.2965-1.04462.34332.4573-2.09974.25440.58690.44860.804-3.1312-0.2246-2.64263.5055-0.2642-0.25391.79510.0280.26291.20350.40731.6955126.962-82.684383.962
2225.3772-1.8148-1.86099.09121.46616.7025-0.4828-1.40990.6842-0.49130.1068-0.9632-1.02921.07540.32911.1526-0.07950.1080.84240.1950.9536137.581-75.778393.604
2236.2492-0.2643-1.68282.3420.85875.005-0.1264-2.07140.28940.55310.20740.8498-1.23710.807-0.09611.4625-0.0018-0.26191.2513-0.03131.6352106.38881.325278.29
2242.43-0.01950.3887-0.0011-0.31226.08360.1718-0.12280.0714-0.11740.6341.1741-0.5503-1.5984-0.47590.990.1535-0.44420.98170.25152.310792.86679.607265.368
2255.36360.55923.18881.2990.42935.45360.10450.405-0.0302-0.2158-0.41720.8471.19190.24610.09321.1139-0.1855-0.11160.58870.00541.3266113.38660.056271.945
2263.47690.2969-0.46970.52830.29873.4338-0.2864-0.27031.34120.47630.10011.73230.6203-1.10520.37231.212-0.4538-0.52430.9025-0.05572.295991.79357.862267.542
2270.5905-0.85950.74942.8339-0.99075.12940.3141-0.2156-0.12570.63540.31241.2914-0.3453-1.4155-0.50940.95330.0882-0.06332.12480.16322.240582.44470.299289.271
2284.99241.624-3.53483.3315-5.50429.2395-0.8666-0.06870.59590.45571.54511.12640.4051-0.5792-0.58571.4074-0.20090.44821.20670.07152.526391.85756.587295.22
2294.6062-0.0276-1.47030.157-0.93925.85030.7511-1.62280.3241.34070.08460.6023-0.6207-0.2057-0.50992.0369-0.28790.5991.26470.33241.3183113.66676.01315.659
2302.395-0.4026-1.89010.31730.75763.90240.50340.20190.6687-0.2655-0.1049-0.0666-1.3510.0607-1.18042.50180.2621.16591.7857-0.07060.9575116.51179.438326.279
2313.4828-0.7428-2.53540.40321.66397.12080.3715-0.56610.14410.309-0.26060.21190.3271-0.244-0.33892.1329-0.35450.53512.0218-0.35810.7005116.09696.042323.033
2324.9972-5.0515-1.2695.83492.71453.09880.0538-2.0548-0.10731.6837-0.16712.0371-0.03940.15920.0582.2669-0.34420.59811.4358-0.12371.446124.15390.945313.906
2332.58680.6955-0.2656.03265.81895.9628-0.8791-0.9472-0.14983.219-1.0067-0.2344-1.6740.20781.8862.13310.2467-0.14391.21210.21731.3507135.24577.102315.559
2344.9637-3.40485.12673.9837-4.64528.8994-0.1912-0.7986-1.79120.77270.0241-1.20973.39571.03480.16191.65380.4065-0.12351.17220.47141.2806141.2669.001311.387
2356.45662.4146-1.48733.0245-1.77731.1748-1.1298-1.7085-2.33270.12630.9201-1.708-0.2711-0.44290.31862.8970.9359-0.73531.6378-0.19812.3752142.30257.838311.377
2363.37473.029-0.43634.62811.92952.8938-0.1188-0.2907-1.51971.30860.7313-0.15141.24772.076-0.44221.51550.191-0.32591.1040.29411.4216136.02370.322306.102
2375.00512.6455-4.52927.0347-2.2964.7456-0.3741-1.359-1.05340.628-0.47961.1477-0.70161.12170.85261.3523-0.07260.18891.33020.1111.4819119.77892.358307.701
2388.5338-0.6452-4.14686.66691.98935.6781-0.33110.40262.8670.521.340.8359-3.63781.222-0.39421.895-0.34310.1840.70530.04791.3764124.743100.855305.348
2391.1986-0.6958-0.77610.58761.27144.17460.295-0.02340.1337-0.71170.336-0.2512-0.59520.89310.24051.9899-0.2374-0.36431.5531-0.47890.8142134.86489.163318.881
2401.32061.4332-1.1993.2829-0.50921.44850.4437-1.0132-0.52893.2935-0.51451.5255-1.2581.1439-0.14042.4416-0.14980.79991.6619-0.15881.4641112.74286.308333.856
2413.9855-0.95072.06638.5473-0.67592.4918-0.07810.60470.68960.24060.29110.91510.5045-0.3336-0.18351.24-0.18750.36111.03230.13571.3713113.72384.619305.094
2424.51345.2335.85286.76296.24388.69870.11720.7003-0.07421.0807-0.90690.86391.40820.79880.92561.0831-0.11570.19681.08370.17651.4055116.35976.48295.474
2433.15372.704-0.25722.36860.39236.71930.2078-0.12641.58860.06710.02440.53980.7298-1.4191-0.26910.9184-0.3223-0.15110.81240.18742.062793.16556.961281.14
2441.2567-0.50471.36792.1569-1.72922.2016-0.52820.00190.2094-0.48230.52850.5266-1.4456-0.12660.57852.2160.02970.39641.05960.87782.46791.63537.785298.903
2453.02460.3958-2.73880.1339-0.07893.4722-0.5705-0.4123-0.2681-0.85410.11860.2443-0.04471.1136-0.00182.7902-0.71311.49331.84060.07783.384682.26244.953309.347
2463.3459-2.5553-1.83213.40471.19811.02881.54840.68090.4488-1.7147-0.35140.6065-2.4441-0.6691-0.83533.0712-0.2781-0.37362.25581.37842.383581.67637.122319.391
2478.70520.6479-2.88896.08836.22619.24140.0987-2.274-2.1711-0.92653.06970.85790.9808-0.1885-2.74572.36850.2999-0.12692.21790.83352.17391.76844.066320.789
2487.17543.905-3.86153.63050.79597.81620.7915-0.01221.47220.58751.28040.28841.70930.9327-2.22632.33360.29590.05752.43080.09961.448386.59445.48331.446
2493.16280.2851.27718.57334.16692.4339-1.1870.5276-0.45191.01080.35443.10350.51310.86461.05371.5496-0.17490.18322.8297-0.05652.512682.70757.443322.338
2501.342-1.8654-0.61422.58610.98012.8917-0.4430.37911.26540.8553-0.00681.02780.2445-0.67860.33212.0106-0.3510.54522.22650.85623.244288.8842.022312.726
2514.1901-2.7585-4.00343.21590.74696.44640.9679-1.3149-0.09812.39940.94714.3828-0.08530.1198-1.7771.73050.39020.38342.09620.09692.2976101.63445.563315.969
2524.07962.04675.12238.88823.19666.5496-0.4035-0.6985-0.33551.5203-0.98390.9913-1.415-1.78410.72362.00890.01090.64132.20490.38811.0357106.36246.365325.645
2530.63952.44870.82279.37343.1481.05741.54520.06590.553-0.6005-1.97121.4852-1.6964-2.50120.09981.5190.61220.5352.70940.09751.2388106.25453.452322.425
2540.84610.34090.86390.28930.71571.76520.0981-0.0538-1.0895-0.61820.2597-1.33830.567-0.1764-0.04582.88290.0610.12320.83040.51222.3654125.99348.043330.213
2552.93911.1661-0.23484.6541-2.7991.75821.10941.05910.6717-1.2544-0.40770.5110.0703-0.387-0.62552.57621.27570.90272.57910.9321.7331107.93956.037315.995
2564.43665.17081.25268.2782.29730.6641-0.49120.2380.10320.3735-1.3307-0.9473-1.11971.8435-0.61082.80580.02510.82741.31220.65161.7982118.90861.519322.879
2570.7870.58770.89284.52591.72771.27980.41720.1213-0.83130.25540.2464-0.28850.22310.10520.82941.9620.90710.59280.82640.23031.8501118.32649.442317.555
2581.87731.0064-1.23090.9205-1.92865.1166-0.09750.1920.0889-0.21350.1952-0.0249-1.1065-0.1745-0.91173.76010.4461.60261.37550.45482.1139129.27460.189316.469
2597.27726.39414.24926.32763.5792.51311.3823-1.3165-2.46051.1388-0.8445-0.5076-0.0229-3.2652-0.32891.20110.12060.50031.75570.53522.157135.39964.121322.931
2604.0103-0.82521.38320.86680.50061.9306-0.2695-1.7064-0.72850.63020.17510.17620.4482-0.5736-0.07551.66710.1791-0.03751.18340.33170.5598122.38255.85334.92
2614.20682.0924-1.06431.53921.44787.2720.1828-0.53540.171-0.22780.6552-0.5141-0.63011.6216-0.80871.1692-0.0483-0.13671.14320.20492.129289.372-50.565372.903
2621.0106-0.2438-0.44040.89950.07231.0242-0.26910.7272-0.0598-0.0716-0.6258-1.09720.96990.0953-1.73880.97220.5291-0.15050.14830.86151.658178.513-71.129371.279
2630.22370.4992-0.21652.43762.11524.6106-0.3713-0.2837-0.416-0.20560.608-1.4792-0.1811.8528-0.48250.95950.34780.44641.51270.30882.4663100.092-63.929350.312
2642.4825-0.0046-0.22751.75770.82985.18440.1239-0.4469-0.3919-0.49410.4972-0.3726-0.11011.0062-0.661.65120.22810.55940.7446-0.07341.44171.471-55.136326.719
2650.74480.98840.42175.1011-3.0494.25510.03861.00951.0678-0.61070.61870.37281.4529-1.672-0.16572.9818-0.60871.43821.4974-0.21152.128968.052-50.877316.158
2666.09072.6479-1.9666.0458-2.65713.4389-0.51350.4873-0.6654-0.90970.3612-0.3830.8024-0.18860.73091.46770.26760.22790.4020.1561.00758.55-42.634326.403
2673.3025-3.2228-5.03548.57173.00588.55231.5618-0.00342.3422-1.17460.2303-0.77220.125-0.194-1.92791.726-0.1040.18881.09790.14912.269442.689-66.39331.506
2685.59741.47012.39821.9957-1.95635.08560.03050.3906-0.2481-0.47320.2075-0.45840.2705-0.412-0.41451.29360.13730.50770.6307-0.04311.238159.237-45.822335.389
2698.29092.6163-0.36597.99684.62487.57660.2623-0.25592.60420.5514-0.0999-0.242-1.4352-0.15880.20661.3485-0.10170.08860.3834-0.02011.150460.413-29.517337.167
2704.42444.1846-1.6086.4061-0.33021.14741.19560.49180.8165-0.0226-0.72910.6474-0.8524-1.2505-0.3371.72080.0882-0.32131.16190.14920.811949.862-41.097323.795
2714.691-0.3239-2.0263.20281.89397.26930.3368-0.42910.9317-0.81780.4033-0.3103-0.34351.3465-0.65371.22220.28520.32720.56950.27621.462971.033-45.686326.978
2720.452-0.13290.63220.0876-0.12931.485-0.2864-0.319-0.4955-0.21040.1801-1.00570.5093-0.0005-0.09061.40920.24090.46910.82570.5533.058885.614-72.123352.932
2737.24872.59671.12871.17110.96841.5613-1.55491.1072-1.8586-0.06081.78941.08570.5620.6714-0.2582.206-0.08820.7071.0384-0.35912.474897.579-88.405324.37
2740.2045-0.03120.74822.8181.20093.29990.26950.84111.5723-1.31630.8212-1.1861-0.63311.2696-0.33091.69960.01411.07931.37460.42632.335297.48-83.305321.534
2757.6079-1.8397-0.86934.14844.6946.8401-0.1839-0.1704-0.7623-3.02841.558-2.46520.4371-1.0853-1.23252.71610.1260.44681.36960.41441.755381.757-85.536324.834
2769.0695-0.52470.40590.6258-2.10017.27511.39351.49292.1844-0.1268-1.2695-0.2434-1.311.312-0.471.38680.04590.7471.63980.07481.178977.158-84.109315.785
2775.9186-0.48362.48531.3608-1.00252.8165-0.14390.3622-0.879-0.58841.0927-0.2623-1.0438-0.4457-0.53381.4248-0.30121.01071.11960.0031.492667.374-79.525315.464
2784.2889-2.8973-2.42954.8422-0.32352.7196-1.53810.64340.0356-0.2041-0.5653-0.13671.78150.58711.99862.2976-0.69540.61382.23170.03532.073472.314-73.269316.657
2797.0927-4.9176-3.63014.17674.20395.56891.3326-1.41335.1731-3.23671.79290.0255-1.07491.6724-3.15773.4616-1.29220.83132.4977-0.37292.38179.165-75.496332.532
2802.6214-2.76583.99155.1549-5.78451.9973-0.19910.43111.1921-0.6295-1.4456-0.64150.05221.21480.41092.535-0.11290.92740.84820.17021.93264.991-68.803319.157
2810.1470.1957-0.10620.2587-0.23980.58820.2066-0.10290.19590.29240.02680.1162-0.6573-0.01620.54562.5165-0.94180.73650.47980.01051.708261.837-76.872325.445
2822.3604-2.15870.662.5643-2.92289.7747-0.6554-0.0777-0.1389-1.4059-0.46011.72551.42771.85090.92851.5291-0.03840.11511.5812-0.2891.499448.659-66.079319.702
2834.2073.10423.11734.51183.40924.6128-1.25081.29680.3479-4.5510.5438-0.6382-0.40421.10540.67882.8310.07490.40271.9288-0.07071.30354.715-69.955309.039
2845.3229-4.25065.02653.3993-4.00084.8248-0.70710.94980.8244-1.4788-0.1896-2.3831-0.84890.15950.24272.1172-0.4190.83710.9819-0.36581.615869.574-81.31305.248
2858.1195-1.90643.22734.8469-5.18535.7373-0.04080.5374-0.57-2.8649-0.9808-0.15771.85831.35280.27133.11590.4627-0.32121.42880.71321.7939121.15131.333314.69
2867.88021.36531.99951.1069-1.57384.7411.0307-1.8948-0.06320.07980.66821.2215-0.1422-0.2194-1.44531.3332-0.78540.44652.7664-1.03242.8835118.26835.653308.689
2873.75483.8737-0.18874.0047-0.12830.5054-1.2572-1.72070.1560.466-0.33060.99330.88490.44121.18451.82411.07690.17182.8612-0.77512.3715133.18728.268314.675
2880.33210.0725-0.22952.4697-3.7226.72520.25641.685-1.1344-1.0667-0.8775-1.75512.80171.26820.46511.88510.7187-0.17011.8614-0.57491.7253129.13838.627305.649
2896.71762.21333.79082.80014.52387.31771.6357-1.59440.4731-4.0317-0.6877-0.1035-0.1869-1.0951-1.15853.2492-0.49970.32541.58610.14921.7586126.18342.694315.343
2903.9577-2.9354-4.70042.28042.81659.75792.5710.10222.56513.8054-1.32910.8974-1.69660.0767-1.44922.83380.17410.68471.5007-0.35043.054132.55640.786319.863
2915.9773-2.69322.38842.6522-0.14092.8394-0.38960.0995-0.35270.2653-0.557-0.7704-0.39880.28090.72022.97521.26440.63321.89060.76082.5146132.04533.885322.746
2922.2335-0.01380.83525.4885-5.25355.33031.98652.03733.71762.6215-0.82060.2862-6.85071.9026-0.99673.7557-0.38680.51742.20690.08323.1898122.98928.63321.093
2932.6003-1.65281.28394.8481-0.94470.6386-0.4793-0.4622-1.76432.13820.48441.27420.624-0.02170.19662.52640.64140.47041.0735-0.19352.0752121.43740.709314.932
2943.3862-4.26132.17565.9013-4.59258.7613-1.8008-0.23650.75760.3015-0.06311.69872.9767-0.27221.40952.26970.14720.57641.7952-0.20162.254765.312-94.885330.123
2951.13722.82682.09667.44144.37488.103-0.012-0.1045-0.46620.75480.19850.51341.4091-0.47970.15191.5409-0.1909-0.2860.77850.24192.602663.569-99.84332.395
2967.5818-1.605-4.21152.82231.4753.72130.01170.34671.2261-0.43350.78910.670.54120.4273-0.40083.076-0.86921.18044.38870.65142.396650.883-101.93328.001
2977.1562-2.1971.38092.0099-1.05596.42331.74140.16321.8646-0.9772-1.1213-0.6105-1.08750.6067-0.32172.9510.30610.92891.99460.37992.532455.531-94.384336.085
2986.31631.44364.8990.32981.11256.10451.09580.17082.4371-0.3555-1.53-0.7918-0.19270.95290.21812.8102-0.46231.06961.48880.26062.338356.908-85.958334.694
2992.46912.2125-0.79573.8895-2.14911.3378-0.011-0.10490.39191.86380.28031.2338-1.609-0.4281-0.26473.2751.09261.37672.56651.42542.930452.058-89.037322.851
3005.3802-1.52895.48246.6431.60227.19160.97611.0391.3445-0.66330.0772-0.52192.1876-1.3329-0.1682.22020.11310.98531.42750.73112.074854.989-98.779320.647
3016.71892.34380.43042.61740.35359.4746-1.4514-0.1775-1.858-2.2446-1.0387-0.4133.1881.5972.332.6935-0.59050.78281.49940.38531.699462.355-90.782326.555
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN N AND RESID -3:6 )N-3 - 6
2X-RAY DIFFRACTION2( CHAIN N AND RESID 7:22 )N7 - 22
3X-RAY DIFFRACTION3( CHAIN N AND RESID 23:33 )N23 - 33
4X-RAY DIFFRACTION4( CHAIN N AND RESID 34:44 )N34 - 44
5X-RAY DIFFRACTION5( CHAIN N AND RESID 45:76 )N45 - 76
6X-RAY DIFFRACTION6( CHAIN D AND RESID 12:147 )D12 - 147
7X-RAY DIFFRACTION7( CHAIN D AND RESID 148:253 )D148 - 253
8X-RAY DIFFRACTION8( CHAIN D AND RESID 254:401 )D254 - 401
9X-RAY DIFFRACTION9( CHAIN D AND RESID 402:588 )D402 - 588
10X-RAY DIFFRACTION10( CHAIN D AND RESID 589:646 )D589 - 646
11X-RAY DIFFRACTION11( CHAIN D AND RESID 650:661 )D650 - 661
12X-RAY DIFFRACTION12( CHAIN D AND RESID 662:694 )D662 - 694
13X-RAY DIFFRACTION13( CHAIN D AND RESID 695:704 )D695 - 704
14X-RAY DIFFRACTION14( CHAIN D AND RESID 705:719 )D705 - 719
15X-RAY DIFFRACTION15( CHAIN D AND RESID 720:745 )D720 - 745
16X-RAY DIFFRACTION16( CHAIN D AND RESID 752:764 )D752 - 764
17X-RAY DIFFRACTION17( CHAIN D AND RESID 765:773 )D765 - 773
18X-RAY DIFFRACTION18( CHAIN D AND RESID 797:813 )D797 - 813
19X-RAY DIFFRACTION19( CHAIN D AND RESID 814:844 )D814 - 844
20X-RAY DIFFRACTION20( CHAIN D AND RESID 845:866 )D845 - 866
21X-RAY DIFFRACTION21( CHAIN D AND RESID 867:938 )D867 - 938
22X-RAY DIFFRACTION22( CHAIN D AND RESID 939:1024 )D939 - 1024
23X-RAY DIFFRACTION23( CHAIN F AND RESID 7:19 )F7 - 19
24X-RAY DIFFRACTION24( CHAIN F AND RESID 20:28 )F20 - 28
25X-RAY DIFFRACTION25( CHAIN F AND RESID 29:36 )F29 - 36
26X-RAY DIFFRACTION26( CHAIN F AND RESID 37:59 )F37 - 59
27X-RAY DIFFRACTION27( CHAIN F AND RESID 60:65 )F60 - 65
28X-RAY DIFFRACTION28( CHAIN F AND RESID 66:79 )F66 - 79
29X-RAY DIFFRACTION29( CHAIN F AND RESID 80:94 )F80 - 94
30X-RAY DIFFRACTION30( CHAIN F AND RESID 117:133 )F117 - 133
31X-RAY DIFFRACTION31( CHAIN F AND RESID 134:142 )F134 - 142
32X-RAY DIFFRACTION32( CHAIN F AND RESID 143:152 )F143 - 152
33X-RAY DIFFRACTION33( CHAIN F AND RESID 153:167 )F153 - 167
34X-RAY DIFFRACTION34( CHAIN F AND RESID 168:179 )F168 - 179
35X-RAY DIFFRACTION35( CHAIN A AND RESID 12:588 )A12 - 588
36X-RAY DIFFRACTION36( CHAIN A AND RESID 589:645 )A589 - 645
37X-RAY DIFFRACTION37( CHAIN A AND RESID 652:661 )A652 - 661
38X-RAY DIFFRACTION38( CHAIN A AND RESID 662:684 )A662 - 684
39X-RAY DIFFRACTION39( CHAIN A AND RESID 685:699 )A685 - 699
40X-RAY DIFFRACTION40( CHAIN A AND RESID 700:704 )A700 - 704
41X-RAY DIFFRACTION41( CHAIN A AND RESID 705:719 )A705 - 719
42X-RAY DIFFRACTION42( CHAIN A AND RESID 720:745 )A720 - 745
43X-RAY DIFFRACTION43( CHAIN A AND RESID 752:764 )A752 - 764
44X-RAY DIFFRACTION44( CHAIN A AND RESID 765:773 )A765 - 773
45X-RAY DIFFRACTION45( CHAIN A AND RESID 798:829 )A798 - 829
46X-RAY DIFFRACTION46( CHAIN A AND RESID 830:866 )A830 - 866
47X-RAY DIFFRACTION47( CHAIN A AND RESID 867:909 )A867 - 909
48X-RAY DIFFRACTION48( CHAIN A AND RESID 910:970 )A910 - 970
49X-RAY DIFFRACTION49( CHAIN A AND RESID 971:981 )A971 - 981
50X-RAY DIFFRACTION50( CHAIN A AND RESID 982:999 )A982 - 999
51X-RAY DIFFRACTION51( CHAIN A AND RESID 1000:1024 )A1000 - 1024
52X-RAY DIFFRACTION52( CHAIN B AND RESID 6:28 )B6 - 28
53X-RAY DIFFRACTION53( CHAIN B AND RESID 29:58 )B29 - 58
54X-RAY DIFFRACTION54( CHAIN B AND RESID 59:79 )B59 - 79
55X-RAY DIFFRACTION55( CHAIN B AND RESID 80:94 )B80 - 94
56X-RAY DIFFRACTION56( CHAIN B AND RESID 117:133 )B117 - 133
57X-RAY DIFFRACTION57( CHAIN B AND RESID 134:142 )B134 - 142
58X-RAY DIFFRACTION58( CHAIN B AND RESID 143:152 )B143 - 152
59X-RAY DIFFRACTION59( CHAIN B AND RESID 153:179 )B153 - 179
60X-RAY DIFFRACTION60( CHAIN C AND RESID 12:588 )C12 - 588
61X-RAY DIFFRACTION61( CHAIN C AND RESID 589:645 )C589 - 645
62X-RAY DIFFRACTION62( CHAIN C AND RESID 650:662 )C650 - 662
63X-RAY DIFFRACTION63( CHAIN C AND RESID 663:683 )C663 - 683
64X-RAY DIFFRACTION64( CHAIN C AND RESID 684:699 )C684 - 699
65X-RAY DIFFRACTION65( CHAIN C AND RESID 700:704 )C700 - 704
66X-RAY DIFFRACTION66( CHAIN C AND RESID 705:709 )C705 - 709
67X-RAY DIFFRACTION67( CHAIN C AND RESID 710:724 )C710 - 724
68X-RAY DIFFRACTION68( CHAIN C AND RESID 725:745 )C725 - 745
69X-RAY DIFFRACTION69( CHAIN C AND RESID 752:763 )C752 - 763
70X-RAY DIFFRACTION70( CHAIN C AND RESID 764:773 )C764 - 773
71X-RAY DIFFRACTION71( CHAIN C AND RESID 797:812 )C797 - 812
72X-RAY DIFFRACTION72( CHAIN C AND RESID 813:844 )C813 - 844
73X-RAY DIFFRACTION73( CHAIN C AND RESID 845:866 )C845 - 866
74X-RAY DIFFRACTION74( CHAIN C AND RESID 867:909 )C867 - 909
75X-RAY DIFFRACTION75( CHAIN C AND RESID 910:925 )C910 - 925
76X-RAY DIFFRACTION76( CHAIN C AND RESID 926:981 )C926 - 981
77X-RAY DIFFRACTION77( CHAIN C AND RESID 982:1024 )C982 - 1024
78X-RAY DIFFRACTION78( CHAIN E AND RESID 7:47 )E7 - 47
79X-RAY DIFFRACTION79( CHAIN E AND RESID 48:65 )E48 - 65
80X-RAY DIFFRACTION80( CHAIN E AND RESID 66:79 )E66 - 79
81X-RAY DIFFRACTION81( CHAIN E AND RESID 80:94 )E80 - 94
82X-RAY DIFFRACTION82( CHAIN E AND RESID 117:142 )E117 - 142
83X-RAY DIFFRACTION83( CHAIN E AND RESID 143:152 )E143 - 152
84X-RAY DIFFRACTION84( CHAIN E AND RESID 153:165 )E153 - 165
85X-RAY DIFFRACTION85( CHAIN E AND RESID 166:179 )E166 - 179
86X-RAY DIFFRACTION86( CHAIN G AND RESID 12:166 )G12 - 166
87X-RAY DIFFRACTION87( CHAIN G AND RESID 167:197 )G167 - 197
88X-RAY DIFFRACTION88( CHAIN G AND RESID 198:268 )G198 - 268
89X-RAY DIFFRACTION89( CHAIN G AND RESID 269:401 )G269 - 401
90X-RAY DIFFRACTION90( CHAIN G AND RESID 402:545 )G402 - 545
91X-RAY DIFFRACTION91( CHAIN G AND RESID 546:591 )G546 - 591
92X-RAY DIFFRACTION92( CHAIN G AND RESID 600:603 )G600 - 603
93X-RAY DIFFRACTION93( CHAIN G AND RESID 604:608 )G604 - 608
94X-RAY DIFFRACTION94( CHAIN G AND RESID 609:624 )G609 - 624
95X-RAY DIFFRACTION95( CHAIN G AND RESID 625:636 )G625 - 636
96X-RAY DIFFRACTION96( CHAIN G AND RESID 637:646 )G637 - 646
97X-RAY DIFFRACTION97( CHAIN G AND RESID 650:663 )G650 - 663
98X-RAY DIFFRACTION98( CHAIN G AND RESID 664:668 )G664 - 668
99X-RAY DIFFRACTION99( CHAIN G AND RESID 669:684 )G669 - 684
100X-RAY DIFFRACTION100( CHAIN G AND RESID 685:699 )G685 - 699
101X-RAY DIFFRACTION101( CHAIN G AND RESID 700:704 )G700 - 704
102X-RAY DIFFRACTION102( CHAIN G AND RESID 705:714 )G705 - 714
103X-RAY DIFFRACTION103( CHAIN G AND RESID 715:724 )G715 - 724
104X-RAY DIFFRACTION104( CHAIN G AND RESID 725:745 )G725 - 745
105X-RAY DIFFRACTION105( CHAIN G AND RESID 752:763 )G752 - 763
106X-RAY DIFFRACTION106( CHAIN G AND RESID 764:773 )G764 - 773
107X-RAY DIFFRACTION107( CHAIN G AND RESID 797:829 )G797 - 829
108X-RAY DIFFRACTION108( CHAIN G AND RESID 830:866 )G830 - 866
109X-RAY DIFFRACTION109( CHAIN G AND RESID 867:909 )G867 - 909
110X-RAY DIFFRACTION110( CHAIN G AND RESID 910:961 )G910 - 961
111X-RAY DIFFRACTION111( CHAIN G AND RESID 962:1024 )G962 - 1024
112X-RAY DIFFRACTION112( CHAIN H AND RESID 7:20 )H7 - 20
113X-RAY DIFFRACTION113( CHAIN H AND RESID 21:47 )H21 - 47
114X-RAY DIFFRACTION114( CHAIN H AND RESID 48:65 )H48 - 65
115X-RAY DIFFRACTION115( CHAIN H AND RESID 66:79 )H66 - 79
116X-RAY DIFFRACTION116( CHAIN H AND RESID 80:94 )H80 - 94
117X-RAY DIFFRACTION117( CHAIN H AND RESID 118:142 )H118 - 142
118X-RAY DIFFRACTION118( CHAIN H AND RESID 143:152 )H143 - 152
119X-RAY DIFFRACTION119( CHAIN H AND RESID 153:167 )H153 - 167
120X-RAY DIFFRACTION120( CHAIN H AND RESID 168:179 )H168 - 179
121X-RAY DIFFRACTION121( CHAIN I AND RESID 12:102 )I12 - 102
122X-RAY DIFFRACTION122( CHAIN I AND RESID 103:133 )I103 - 133
123X-RAY DIFFRACTION123( CHAIN I AND RESID 134:185 )I134 - 185
124X-RAY DIFFRACTION124( CHAIN I AND RESID 186:249 )I186 - 249
125X-RAY DIFFRACTION125( CHAIN I AND RESID 250:287 )I250 - 287
126X-RAY DIFFRACTION126( CHAIN I AND RESID 288:332 )I288 - 332
127X-RAY DIFFRACTION127( CHAIN I AND RESID 333:411 )I333 - 411
128X-RAY DIFFRACTION128( CHAIN I AND RESID 412:545 )I412 - 545
129X-RAY DIFFRACTION129( CHAIN I AND RESID 546:590 )I546 - 590
130X-RAY DIFFRACTION130( CHAIN I AND RESID 599:608 )I599 - 608
131X-RAY DIFFRACTION131( CHAIN I AND RESID 609:624 )I609 - 624
132X-RAY DIFFRACTION132( CHAIN I AND RESID 625:634 )I625 - 634
133X-RAY DIFFRACTION133( CHAIN I AND RESID 635:640 )I635 - 640
134X-RAY DIFFRACTION134( CHAIN I AND RESID 641:646 )I641 - 646
135X-RAY DIFFRACTION135( CHAIN I AND RESID 650:684 )I650 - 684
136X-RAY DIFFRACTION136( CHAIN I AND RESID 685:699 )I685 - 699
137X-RAY DIFFRACTION137( CHAIN I AND RESID 700:724 )I700 - 724
138X-RAY DIFFRACTION138( CHAIN I AND RESID 725:745 )I725 - 745
139X-RAY DIFFRACTION139( CHAIN I AND RESID 752:763 )I752 - 763
140X-RAY DIFFRACTION140( CHAIN I AND RESID 764:773 )I764 - 773
141X-RAY DIFFRACTION141( CHAIN I AND RESID 797:844 )I797 - 844
142X-RAY DIFFRACTION142( CHAIN I AND RESID 845:866 )I845 - 866
143X-RAY DIFFRACTION143( CHAIN I AND RESID 867:949 )I867 - 949
144X-RAY DIFFRACTION144( CHAIN I AND RESID 950:1024 )I950 - 1024
145X-RAY DIFFRACTION145( CHAIN J AND RESID 6:18 )J6 - 18
146X-RAY DIFFRACTION146( CHAIN J AND RESID 19:28 )J19 - 28
147X-RAY DIFFRACTION147( CHAIN J AND RESID 29:58 )J29 - 58
148X-RAY DIFFRACTION148( CHAIN J AND RESID 59:75 )J59 - 75
149X-RAY DIFFRACTION149( CHAIN J AND RESID 76:98 )J76 - 98
150X-RAY DIFFRACTION150( CHAIN J AND RESID 118:133 )J118 - 133
151X-RAY DIFFRACTION151( CHAIN J AND RESID 134:152 )J134 - 152
152X-RAY DIFFRACTION152( CHAIN J AND RESID 153:167 )J153 - 167
153X-RAY DIFFRACTION153( CHAIN J AND RESID 168:180 )J168 - 180
154X-RAY DIFFRACTION154( CHAIN K AND RESID 12:102 )K12 - 102
155X-RAY DIFFRACTION155( CHAIN K AND RESID 103:173 )K103 - 173
156X-RAY DIFFRACTION156( CHAIN K AND RESID 174:259 )K174 - 259
157X-RAY DIFFRACTION157( CHAIN K AND RESID 260:287 )K260 - 287
158X-RAY DIFFRACTION158( CHAIN K AND RESID 288:332 )K288 - 332
159X-RAY DIFFRACTION159( CHAIN K AND RESID 333:411 )K333 - 411
160X-RAY DIFFRACTION160( CHAIN K AND RESID 412:559 )K412 - 559
161X-RAY DIFFRACTION161( CHAIN K AND RESID 560:589 )K560 - 589
162X-RAY DIFFRACTION162( CHAIN K AND RESID 599:608 )K599 - 608
163X-RAY DIFFRACTION163( CHAIN K AND RESID 609:624 )K609 - 624
164X-RAY DIFFRACTION164( CHAIN K AND RESID 625:634 )K625 - 634
165X-RAY DIFFRACTION165( CHAIN K AND RESID 635:646 )K635 - 646
166X-RAY DIFFRACTION166( CHAIN K AND RESID 650:663 )K650 - 663
167X-RAY DIFFRACTION167( CHAIN K AND RESID 664:668 )K664 - 668
168X-RAY DIFFRACTION168( CHAIN K AND RESID 669:684 )K669 - 684
169X-RAY DIFFRACTION169( CHAIN K AND RESID 685:699 )K685 - 699
170X-RAY DIFFRACTION170( CHAIN K AND RESID 700:704 )K700 - 704
171X-RAY DIFFRACTION171( CHAIN K AND RESID 705:709 )K705 - 709
172X-RAY DIFFRACTION172( CHAIN K AND RESID 710:719 )K710 - 719
173X-RAY DIFFRACTION173( CHAIN K AND RESID 720:745 )K720 - 745
174X-RAY DIFFRACTION174( CHAIN K AND RESID 752:763 )K752 - 763
175X-RAY DIFFRACTION175( CHAIN K AND RESID 764:773 )K764 - 773
176X-RAY DIFFRACTION176( CHAIN K AND RESID 797:844 )K797 - 844
177X-RAY DIFFRACTION177( CHAIN K AND RESID 845:866 )K845 - 866
178X-RAY DIFFRACTION178( CHAIN K AND RESID 867:938 )K867 - 938
179X-RAY DIFFRACTION179( CHAIN K AND RESID 939:1024 )K939 - 1024
180X-RAY DIFFRACTION180( CHAIN L AND RESID 7:18 )L7 - 18
181X-RAY DIFFRACTION181( CHAIN L AND RESID 19:28 )L19 - 28
182X-RAY DIFFRACTION182( CHAIN L AND RESID 29:37 )L29 - 37
183X-RAY DIFFRACTION183( CHAIN L AND RESID 38:58 )L38 - 58
184X-RAY DIFFRACTION184( CHAIN L AND RESID 59:75 )L59 - 75
185X-RAY DIFFRACTION185( CHAIN L AND RESID 76:98 )L76 - 98
186X-RAY DIFFRACTION186( CHAIN L AND RESID 118:142 )L118 - 142
187X-RAY DIFFRACTION187( CHAIN L AND RESID 143:167 )L143 - 167
188X-RAY DIFFRACTION188( CHAIN L AND RESID 168:179 )L168 - 179
189X-RAY DIFFRACTION189( CHAIN M AND RESID 0:6 )M0 - 6
190X-RAY DIFFRACTION190( CHAIN M AND RESID 7:11 )M7 - 11
191X-RAY DIFFRACTION191( CHAIN M AND RESID 12:17 )M12 - 17
192X-RAY DIFFRACTION192( CHAIN M AND RESID 18:22 )M18 - 22
193X-RAY DIFFRACTION193( CHAIN M AND RESID 23:36 )M23 - 36
194X-RAY DIFFRACTION194( CHAIN M AND RESID 37:41 )M37 - 41
195X-RAY DIFFRACTION195( CHAIN M AND RESID 42:51 )M42 - 51
196X-RAY DIFFRACTION196( CHAIN M AND RESID 52:71 )M52 - 71
197X-RAY DIFFRACTION197( CHAIN O AND RESID 1:6 )O1 - 6
198X-RAY DIFFRACTION198( CHAIN O AND RESID 7:16 )O7 - 16
199X-RAY DIFFRACTION199( CHAIN O AND RESID 17:22 )O17 - 22
200X-RAY DIFFRACTION200( CHAIN O AND RESID 23:33 )O23 - 33
201X-RAY DIFFRACTION201( CHAIN O AND RESID 34:59 )O34 - 59
202X-RAY DIFFRACTION202( CHAIN O AND RESID 60:64 )O60 - 64
203X-RAY DIFFRACTION203( CHAIN O AND RESID 65:73 )O65 - 73
204X-RAY DIFFRACTION204( CHAIN P AND RESID -3:6 )P-3 - 6
205X-RAY DIFFRACTION205( CHAIN P AND RESID 7:22 )P7 - 22
206X-RAY DIFFRACTION206( CHAIN P AND RESID 23:33 )P23 - 33
207X-RAY DIFFRACTION207( CHAIN P AND RESID 34:44 )P34 - 44
208X-RAY DIFFRACTION208( CHAIN P AND RESID 45:56 )P45 - 56
209X-RAY DIFFRACTION209( CHAIN P AND RESID 57:65 )P57 - 65
210X-RAY DIFFRACTION210( CHAIN P AND RESID 66:76 )P66 - 76
211X-RAY DIFFRACTION211( CHAIN Q AND RESID 1:15 )Q1 - 15
212X-RAY DIFFRACTION212( CHAIN Q AND RESID 16:22 )Q16 - 22
213X-RAY DIFFRACTION213( CHAIN Q AND RESID 23:39 )Q23 - 39
214X-RAY DIFFRACTION214( CHAIN Q AND RESID 40:70 )Q40 - 70
215X-RAY DIFFRACTION215( CHAIN R AND RESID 1:6 )R1 - 6
216X-RAY DIFFRACTION216( CHAIN R AND RESID 7:11 )R7 - 11
217X-RAY DIFFRACTION217( CHAIN R AND RESID 12:22 )R12 - 22
218X-RAY DIFFRACTION218( CHAIN R AND RESID 23:34 )R23 - 34
219X-RAY DIFFRACTION219( CHAIN R AND RESID 35:44 )R35 - 44
220X-RAY DIFFRACTION220( CHAIN R AND RESID 45:54 )R45 - 54
221X-RAY DIFFRACTION221( CHAIN R AND RESID 55:64 )R55 - 64
222X-RAY DIFFRACTION222( CHAIN R AND RESID 65:73 )R65 - 73
223X-RAY DIFFRACTION223( CHAIN S AND RESID 12:45 )S12 - 45
224X-RAY DIFFRACTION224( CHAIN S AND RESID 46:147 )S46 - 147
225X-RAY DIFFRACTION225( CHAIN S AND RESID 148:332 )S148 - 332
226X-RAY DIFFRACTION226( CHAIN S AND RESID 333:411 )S333 - 411
227X-RAY DIFFRACTION227( CHAIN S AND RESID 412:545 )S412 - 545
228X-RAY DIFFRACTION228( CHAIN S AND RESID 546:588 )S546 - 588
229X-RAY DIFFRACTION229( CHAIN S AND RESID 589:645 )S589 - 645
230X-RAY DIFFRACTION230( CHAIN S AND RESID 650:661 )S650 - 661
231X-RAY DIFFRACTION231( CHAIN S AND RESID 662:668 )S662 - 668
232X-RAY DIFFRACTION232( CHAIN S AND RESID 669:684 )S669 - 684
233X-RAY DIFFRACTION233( CHAIN S AND RESID 685:694 )S685 - 694
234X-RAY DIFFRACTION234( CHAIN S AND RESID 695:699 )S695 - 699
235X-RAY DIFFRACTION235( CHAIN S AND RESID 700:704 )S700 - 704
236X-RAY DIFFRACTION236( CHAIN S AND RESID 705:719 )S705 - 719
237X-RAY DIFFRACTION237( CHAIN S AND RESID 720:745 )S720 - 745
238X-RAY DIFFRACTION238( CHAIN S AND RESID 752:763 )S752 - 763
239X-RAY DIFFRACTION239( CHAIN S AND RESID 764:773 )S764 - 773
240X-RAY DIFFRACTION240( CHAIN S AND RESID 798:814 )S798 - 814
241X-RAY DIFFRACTION241( CHAIN S AND RESID 815:844 )S815 - 844
242X-RAY DIFFRACTION242( CHAIN S AND RESID 845:866 )S845 - 866
243X-RAY DIFFRACTION243( CHAIN S AND RESID 867:909 )S867 - 909
244X-RAY DIFFRACTION244( CHAIN S AND RESID 910:925 )S910 - 925
245X-RAY DIFFRACTION245( CHAIN S AND RESID 926:938 )S926 - 938
246X-RAY DIFFRACTION246( CHAIN S AND RESID 939:949 )S939 - 949
247X-RAY DIFFRACTION247( CHAIN S AND RESID 950:970 )S950 - 970
248X-RAY DIFFRACTION248( CHAIN S AND RESID 971:981 )S971 - 981
249X-RAY DIFFRACTION249( CHAIN S AND RESID 982:999 )S982 - 999
250X-RAY DIFFRACTION250( CHAIN S AND RESID 1000:1024 )S1000 - 1024
251X-RAY DIFFRACTION251( CHAIN T AND RESID 6:20 )T6 - 20
252X-RAY DIFFRACTION252( CHAIN T AND RESID 21:37 )T21 - 37
253X-RAY DIFFRACTION253( CHAIN T AND RESID 38:47 )T38 - 47
254X-RAY DIFFRACTION254( CHAIN T AND RESID 48:58 )T48 - 58
255X-RAY DIFFRACTION255( CHAIN T AND RESID 59:75 )T59 - 75
256X-RAY DIFFRACTION256( CHAIN T AND RESID 76:88 )T76 - 88
257X-RAY DIFFRACTION257( CHAIN T AND RESID 119:133 )T119 - 133
258X-RAY DIFFRACTION258( CHAIN T AND RESID 134:142 )T134 - 142
259X-RAY DIFFRACTION259( CHAIN T AND RESID 143:152 )T143 - 152
260X-RAY DIFFRACTION260( CHAIN T AND RESID 153:178 )T153 - 178
261X-RAY DIFFRACTION261( CHAIN U AND RESID 12:147 )U12 - 147
262X-RAY DIFFRACTION262( CHAIN U AND RESID 148:411 )U148 - 411
263X-RAY DIFFRACTION263( CHAIN U AND RESID 412:588 )U412 - 588
264X-RAY DIFFRACTION264( CHAIN U AND RESID 589:646 )U589 - 646
265X-RAY DIFFRACTION265( CHAIN U AND RESID 650:661 )U650 - 661
266X-RAY DIFFRACTION266( CHAIN U AND RESID 662:694 )U662 - 694
267X-RAY DIFFRACTION267( CHAIN U AND RESID 695:704 )U695 - 704
268X-RAY DIFFRACTION268( CHAIN U AND RESID 705:745 )U705 - 745
269X-RAY DIFFRACTION269( CHAIN U AND RESID 752:763 )U752 - 763
270X-RAY DIFFRACTION270( CHAIN U AND RESID 764:773 )U764 - 773
271X-RAY DIFFRACTION271( CHAIN U AND RESID 797:844 )U797 - 844
272X-RAY DIFFRACTION272( CHAIN U AND RESID 845:925 )U845 - 925
273X-RAY DIFFRACTION273( CHAIN U AND RESID 926:970 )U926 - 970
274X-RAY DIFFRACTION274( CHAIN U AND RESID 971:1024 )U971 - 1024
275X-RAY DIFFRACTION275( CHAIN V AND RESID 7:20 )V7 - 20
276X-RAY DIFFRACTION276( CHAIN V AND RESID 21:37 )V21 - 37
277X-RAY DIFFRACTION277( CHAIN V AND RESID 38:58 )V38 - 58
278X-RAY DIFFRACTION278( CHAIN V AND RESID 59:65 )V59 - 65
279X-RAY DIFFRACTION279( CHAIN V AND RESID 66:75 )V66 - 75
280X-RAY DIFFRACTION280( CHAIN V AND RESID 76:88 )V76 - 88
281X-RAY DIFFRACTION281( CHAIN V AND RESID 118:142 )V118 - 142
282X-RAY DIFFRACTION282( CHAIN V AND RESID 143:152 )V143 - 152
283X-RAY DIFFRACTION283( CHAIN V AND RESID 153:167 )V153 - 167
284X-RAY DIFFRACTION284( CHAIN V AND RESID 168:179 )V168 - 179
285X-RAY DIFFRACTION285( CHAIN W AND RESID 1:6 )W1 - 6
286X-RAY DIFFRACTION286( CHAIN W AND RESID 7:16 )W7 - 16
287X-RAY DIFFRACTION287( CHAIN W AND RESID 17:22 )W17 - 22
288X-RAY DIFFRACTION288( CHAIN W AND RESID 23:40 )W23 - 40
289X-RAY DIFFRACTION289( CHAIN W AND RESID 41:45 )W41 - 45
290X-RAY DIFFRACTION290( CHAIN W AND RESID 46:55 )W46 - 55
291X-RAY DIFFRACTION291( CHAIN W AND RESID 56:60 )W56 - 60
292X-RAY DIFFRACTION292( CHAIN W AND RESID 61:65 )W61 - 65
293X-RAY DIFFRACTION293( CHAIN W AND RESID 66:70 )W66 - 70
294X-RAY DIFFRACTION294( CHAIN X AND RESID 1:11 )X1 - 11
295X-RAY DIFFRACTION295( CHAIN X AND RESID 12:16 )X12 - 16
296X-RAY DIFFRACTION296( CHAIN X AND RESID 17:22 )X17 - 22
297X-RAY DIFFRACTION297( CHAIN X AND RESID 23:34 )X23 - 34
298X-RAY DIFFRACTION298( CHAIN X AND RESID 35:44 )X35 - 44
299X-RAY DIFFRACTION299( CHAIN X AND RESID 45:54 )X45 - 54
300X-RAY DIFFRACTION300( CHAIN X AND RESID 55:64 )X55 - 64
301X-RAY DIFFRACTION301( CHAIN X AND RESID 65:70 )X65 - 70

+
万見について

-
お知らせ

-
2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

-
2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbjlvh1.pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

+
2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

+
2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

+
2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

-
万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る