+Open data
-Basic information
Entry | Database: PDB / ID: 7k5j | ||||||||||||
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Title | Structure of an E1-E2-ubiquitin thioester mimetic | ||||||||||||
Components |
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Keywords | SIGNALING PROTEIN / CONFORMATIONAL CHANGE / ADENYLATION / THIOESTER TRANSFER / TRANSTHIOESTERIFICATION / ATP-BINDING / UBIQUITIN E2-BINDING / UBIQUITINATION | ||||||||||||
Function / homology | Function and homology information E1 ubiquitin-activating enzyme / regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Neddylation / ubiquitin activating enzyme activity / regulation of metabolic process / positive regulation of glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / silent mating-type cassette heterochromatin formation ...E1 ubiquitin-activating enzyme / regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Neddylation / ubiquitin activating enzyme activity / regulation of metabolic process / positive regulation of glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / silent mating-type cassette heterochromatin formation / mitochondrial fusion / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / E2 ubiquitin-conjugating enzyme / SCF ubiquitin ligase complex / ubiquitin conjugating enzyme activity / regulation of mitotic cell cycle / subtelomeric heterochromatin formation / protein autoubiquitination / G1/S transition of mitotic cell cycle / protein polyubiquitination / ubiquitin-protein transferase activity / G2/M transition of mitotic cell cycle / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA replication / chromosome, telomeric region / protein ubiquitination / cell division / mRNA binding / DNA damage response / ATP binding / nucleus / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Triticum aestivum (bread wheat) Saccharomyces cerevisiae (brewer's yeast) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.42 Å | ||||||||||||
Authors | Yuan, L. / Lv, Z. / Olsen, S.K. | ||||||||||||
Funding support | United States, 3items
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Citation | Journal: Nat Commun / Year: 2021 Title: Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification. Authors: Yuan, L. / Lv, Z. / Adams, M.J. / Olsen, S.K. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7k5j.cif.gz | 3.8 MB | Display | PDBx/mmCIF format |
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PDB format | pdb7k5j.ent.gz | 3.2 MB | Display | PDB format |
PDBx/mmJSON format | 7k5j.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/k5/7k5j ftp://data.pdbj.org/pub/pdb/validation_reports/k5/7k5j | HTTPS FTP |
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-Related structure data
Related structure data | 6nyaS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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