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- PDB-7k5j: Structure of an E1-E2-ubiquitin thioester mimetic -

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Basic information

Entry
Database: PDB / ID: 7k5j
TitleStructure of an E1-E2-ubiquitin thioester mimetic
Components
  • Ubiquitin
  • Ubiquitin-activating enzyme E1 1
  • Ubiquitin-conjugating enzyme E2-34 kDa
KeywordsSIGNALING PROTEIN / CONFORMATIONAL CHANGE / ADENYLATION / THIOESTER TRANSFER / TRANSTHIOESTERIFICATION / ATP-BINDING / UBIQUITIN E2-BINDING / UBIQUITINATION
Function / homology
Function and homology information


regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / E1 ubiquitin-activating enzyme / ubiquitin activating enzyme activity / positive regulation of D-glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / mitochondrial fusion / regulation of metabolic process ...regulation of transcription by galactose / regulation of sulfur amino acid metabolic process / cellular response to methylmercury / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / E1 ubiquitin-activating enzyme / ubiquitin activating enzyme activity / positive regulation of D-glucose transmembrane transport / mitotic intra-S DNA damage checkpoint signaling / mitochondrial fusion / regulation of metabolic process / silent mating-type cassette heterochromatin formation / SCF ubiquitin ligase complex / E2 ubiquitin-conjugating enzyme / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / ubiquitin conjugating enzyme activity / Antigen processing: Ubiquitination & Proteasome degradation / subtelomeric heterochromatin formation / protein autoubiquitination / regulation of mitotic cell cycle / G1/S transition of mitotic cell cycle / protein polyubiquitination / ubiquitin-protein transferase activity / G2/M transition of mitotic cell cycle / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / chromosome, telomeric region / DNA replication / protein ubiquitination / cell division / mRNA binding / DNA damage response / ATP binding / nucleus / cytoplasm
Similarity search - Function
Ubiquitin-activating enzyme E1, UFD domain / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, conserved site / Ubiquitin-activating enzyme signature 1. / Ubiquitin-activating enzyme E1 / Ubiquitin-activating enzyme E1, C-terminal / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, four-helix bundle / Ubiquitin-activating enzyme E1, C-terminal domain superfamily / Ubiquitin-activating enzyme E1, SCCH domain ...Ubiquitin-activating enzyme E1, UFD domain / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, conserved site / Ubiquitin-activating enzyme signature 1. / Ubiquitin-activating enzyme E1 / Ubiquitin-activating enzyme E1, C-terminal / Ubiquitin-activating enzyme E1, FCCH domain / Ubiquitin-activating enzyme E1, four-helix bundle / Ubiquitin-activating enzyme E1, C-terminal domain superfamily / Ubiquitin-activating enzyme E1, SCCH domain / Ubiquitin-activating enzyme E1, FCCH domain superfamily / Ubiquitin fold domain / Ubiquitin-activating enzyme E1 FCCH domain / Ubiquitin-activating enzyme E1 four-helix bundle / Ubiquitin-activating enzyme e1 C-terminal domain / Ubiquitin-activating enzyme, SCCH domain / Ubiquitin-activating enzyme, SCCH domain / Ubiquitin/SUMO-activating enzyme E1-like / Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 / Ubiquitin-activating enzyme E1, Cys active site / Ubiquitin-activating enzyme active site. / ThiF/MoeB/HesA family / THIF-type NAD/FAD binding fold / ThiF family / Ubiquitin-activating enzyme / Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A / : / Ubiquitin-conjugating enzyme, active site / Ubiquitin-conjugating (UBC) active site signature. / Ubiquitin-conjugating enzyme E2 / Ubiquitin-conjugating enzyme / Ubiquitin-conjugating (UBC) core domain profile. / Ubiquitin-conjugating enzyme E2, catalytic domain homologues / Ubiquitin-conjugating enzyme/RWD-like / Elongation Factor Tu (Ef-tu); domain 3 / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / : / Ubiquitin domain signature. / Ubiquitin conserved site / Ubiquitin domain / Ubiquitin-like (UB roll) / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Roll / Beta Barrel / Mainly Beta / Alpha Beta
Similarity search - Domain/homology
ADENOSINE MONOPHOSPHATE / Ubiquitin-conjugating enzyme E2-34 kDa / Ubiquitin-activating enzyme E1 1 / Ubiquitin
Similarity search - Component
Biological speciesTriticum aestivum (bread wheat)
Saccharomyces cerevisiae (brewer's yeast)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.42 Å
AuthorsYuan, L. / Lv, Z. / Olsen, S.K.
Funding support United States, 3items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM115568-05 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM128731-02 United States
Cancer Prevention and Research Institute of Texas (CPRIT)RR200030 United States
CitationJournal: Nat Commun / Year: 2021
Title: Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
Authors: Yuan, L. / Lv, Z. / Adams, M.J. / Olsen, S.K.
History
DepositionSep 16, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Apr 28, 2021Provider: repository / Type: Initial release
Revision 1.1May 5, 2021Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID
Revision 1.2Oct 18, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.3Dec 25, 2024Group: Advisory / Derived calculations / Structure summary
Category: pdbx_entry_details / pdbx_modification_feature ...pdbx_entry_details / pdbx_modification_feature / pdbx_validate_close_contact / struct_conn
Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
N: Ubiquitin
D: Ubiquitin-activating enzyme E1 1
F: Ubiquitin-conjugating enzyme E2-34 kDa
A: Ubiquitin-activating enzyme E1 1
B: Ubiquitin-conjugating enzyme E2-34 kDa
C: Ubiquitin-activating enzyme E1 1
E: Ubiquitin-conjugating enzyme E2-34 kDa
G: Ubiquitin-activating enzyme E1 1
H: Ubiquitin-conjugating enzyme E2-34 kDa
I: Ubiquitin-activating enzyme E1 1
J: Ubiquitin-conjugating enzyme E2-34 kDa
K: Ubiquitin-activating enzyme E1 1
L: Ubiquitin-conjugating enzyme E2-34 kDa
M: Ubiquitin
O: Ubiquitin
P: Ubiquitin
Q: Ubiquitin
R: Ubiquitin
S: Ubiquitin-activating enzyme E1 1
T: Ubiquitin-conjugating enzyme E2-34 kDa
U: Ubiquitin-activating enzyme E1 1
V: Ubiquitin-conjugating enzyme E2-34 kDa
W: Ubiquitin
X: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)1,169,49031
Polymers1,167,05924
Non-polymers2,4317
Water00
1
N: Ubiquitin
I: Ubiquitin-activating enzyme E1 1
J: Ubiquitin-conjugating enzyme E2-34 kDa
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
C: Ubiquitin-activating enzyme E1 1
E: Ubiquitin-conjugating enzyme E2-34 kDa
O: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
G: Ubiquitin-activating enzyme E1 1
H: Ubiquitin-conjugating enzyme E2-34 kDa
R: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
K: Ubiquitin-activating enzyme E1 1
L: Ubiquitin-conjugating enzyme E2-34 kDa
P: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
S: Ubiquitin-activating enzyme E1 1
T: Ubiquitin-conjugating enzyme E2-34 kDa
W: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
6
U: Ubiquitin-activating enzyme E1 1
V: Ubiquitin-conjugating enzyme E2-34 kDa
X: Ubiquitin


Theoretical massNumber of molelcules
Total (without water)145,8823
Polymers145,8823
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
7
D: Ubiquitin-activating enzyme E1 1
F: Ubiquitin-conjugating enzyme E2-34 kDa
M: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5260 Å2
ΔGint-20 kcal/mol
Surface area53220 Å2
MethodPISA
8
A: Ubiquitin-activating enzyme E1 1
B: Ubiquitin-conjugating enzyme E2-34 kDa
Q: Ubiquitin
hetero molecules


Theoretical massNumber of molelcules
Total (without water)146,2304
Polymers145,8823
Non-polymers3471
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5620 Å2
ΔGint-26 kcal/mol
Surface area52750 Å2
MethodPISA
Unit cell
Length a, b, c (Å)95.181, 272.917, 258.342
Angle α, β, γ (deg.)90.000, 94.590, 90.000
Int Tables number4
Space group name H-MP1211
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain A and (resid 600 or (resid 601 through 602...
21(chain C and (resid 600 or (resid 601 through 602...
31(chain D and (resid 600 or (resid 601 through 602...
41(chain G and (resid 600 or (resid 601 through 602...
51(chain I and (resid 600 or (resid 601 through 602...
61(chain K and (resid 600 or (resid 601 through 602...
71(chain S and (resid 600 or (resid 601 through 602...
81(chain U and (resid 600 or (resid 601 through 602...
12(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
22(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
32(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
42(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
52(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
62(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
72(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
82(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))
13(chain A and (resid 173 through 181 or (resid 182...
23(chain C and (resid 173 through 181 or (resid 182...
33(chain D and (resid 173 through 181 or (resid 182...
43(chain G and (resid 173 through 181 or (resid 182...
53(chain I and (resid 173 through 181 or (resid 182...
63(chain K and (resid 173 through 181 or (resid 182...
73(chain S and (resid 173 through 181 or (resid 182...
83(chain U and (resid 173 through 181 or (resid 182...
14(chain A and resid 912 through 1024)
24(chain C and resid 912 through 1024)
34(chain D and resid 912 through 1024)
44(chain G and resid 912 through 1024)
54(chain I and resid 912 through 1024)
64(chain K and resid 912 through 1024)
74(chain S and resid 912 through 1024)
84(chain U and resid 912 through 1024)
15(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
25(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
35(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
45(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
55(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
65(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
75(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))
85(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))
16(chain M and (resid 1 through 18 or resid 29...
26(chain N and (resid 1 through 18 or resid 29...
36(chain O and (resid 1 through 18 or resid 29...
46(chain P and (resid 1 through 18 or resid 29...
56(chain Q and (resid 1 through 18 or resid 29...
66(chain R and (resid 1 through 18 or resid 29...
76(chain W and (resid 1 through 18 or resid 29...
86(chain X and (resid 1 through 18 or resid 29...

NCS domain segments:
Dom-IDComponent-IDEns-IDSelection detailsAuth asym-IDAuth seq-ID
111(chain A and (resid 600 or (resid 601 through 602...A600
121(chain A and (resid 600 or (resid 601 through 602...A601 - 602
131(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
141(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
151(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
161(chain A and (resid 600 or (resid 601 through 602...A12 - 1103
211(chain C and (resid 600 or (resid 601 through 602...C600
221(chain C and (resid 600 or (resid 601 through 602...C601 - 602
231(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
241(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
251(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
261(chain C and (resid 600 or (resid 601 through 602...C12 - 1103
311(chain D and (resid 600 or (resid 601 through 602...D600
321(chain D and (resid 600 or (resid 601 through 602...D601 - 602
331(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
341(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
351(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
361(chain D and (resid 600 or (resid 601 through 602...D12 - 1103
411(chain G and (resid 600 or (resid 601 through 602...G600
421(chain G and (resid 600 or (resid 601 through 602...G601 - 602
431(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
441(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
451(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
461(chain G and (resid 600 or (resid 601 through 602...G12 - 1103
511(chain I and (resid 600 or (resid 601 through 602...I600
521(chain I and (resid 600 or (resid 601 through 602...I601 - 602
531(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
541(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
551(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
561(chain I and (resid 600 or (resid 601 through 602...I12 - 1103
611(chain K and (resid 600 or (resid 601 through 602...K600
621(chain K and (resid 600 or (resid 601 through 602...K601 - 602
631(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
641(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
651(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
661(chain K and (resid 600 or (resid 601 through 602...K12 - 1103
711(chain S and (resid 600 or (resid 601 through 602...S600
721(chain S and (resid 600 or (resid 601 through 602...S601 - 602
731(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
741(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
751(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
761(chain S and (resid 600 or (resid 601 through 602...S12 - 1103
811(chain U and (resid 600 or (resid 601 through 602...U600
821(chain U and (resid 600 or (resid 601 through 602...U601 - 602
831(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
841(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
851(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
861(chain U and (resid 600 or (resid 601 through 602...U12 - 1024
112(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A12 - 172
122(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A263 - 589
132(chain A and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))A865 - 911
212(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C12 - 172
222(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C263 - 589
232(chain C and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))C865 - 911
312(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D12 - 172
322(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D263 - 589
332(chain D and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))D865 - 911
412(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G12 - 172
422(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G263 - 589
432(chain G and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))G865 - 911
512(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I12 - 172
522(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I263 - 589
532(chain I and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))I865 - 911
612(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K12 - 172
622(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K263 - 589
632(chain K and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))K865 - 911
712(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S12 - 172
722(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S263 - 589
732(chain S and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))S865 - 911
812(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U12 - 172
822(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U263 - 589
832(chain U and (resid 12 through 172 or resid 263 through 589 or resid 865 through 911))U865 - 911
113(chain A and (resid 173 through 181 or (resid 182...A173 - 181
123(chain A and (resid 173 through 181 or (resid 182...A182
133(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
143(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
153(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
163(chain A and (resid 173 through 181 or (resid 182...A12 - 1103
213(chain C and (resid 173 through 181 or (resid 182...C173 - 181
223(chain C and (resid 173 through 181 or (resid 182...C182
313(chain D and (resid 173 through 181 or (resid 182...D173 - 181
323(chain D and (resid 173 through 181 or (resid 182...D182
333(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
343(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
353(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
363(chain D and (resid 173 through 181 or (resid 182...D12 - 1103
413(chain G and (resid 173 through 181 or (resid 182...G173 - 181
423(chain G and (resid 173 through 181 or (resid 182...G182
513(chain I and (resid 173 through 181 or (resid 182...I173 - 181
523(chain I and (resid 173 through 181 or (resid 182...I182
533(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
543(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
553(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
563(chain I and (resid 173 through 181 or (resid 182...I12 - 1103
613(chain K and (resid 173 through 181 or (resid 182...K173 - 181
623(chain K and (resid 173 through 181 or (resid 182...K182
713(chain S and (resid 173 through 181 or (resid 182...S173 - 181
723(chain S and (resid 173 through 181 or (resid 182...S182
733(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
743(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
753(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
763(chain S and (resid 173 through 181 or (resid 182...S12 - 1103
813(chain U and (resid 173 through 181 or (resid 182...U173 - 181
823(chain U and (resid 173 through 181 or (resid 182...U182
114(chain A and resid 912 through 1024)A912 - 1024
214(chain C and resid 912 through 1024)C912 - 1024
314(chain D and resid 912 through 1024)D912 - 1024
414(chain G and resid 912 through 1024)G912 - 1024
514(chain I and resid 912 through 1024)I912 - 1024
614(chain K and resid 912 through 1024)K912 - 1024
714(chain S and resid 912 through 1024)S912 - 1024
814(chain U and resid 912 through 1024)U912 - 1024
115(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B7 - 87
125(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B118 - 140
135(chain B and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))B142 - 178
215(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E7 - 87
225(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E118 - 140
235(chain E and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))E142 - 178
315(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F7 - 87
325(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F118 - 140
335(chain F and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))F142 - 178
415(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H7 - 87
425(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H118 - 140
435(chain H and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))H142 - 178
515(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J7 - 87
525(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J118 - 140
535(chain J and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))J142 - 178
615(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L7 - 87
625(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L118 - 140
635(chain L and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))L142 - 178
715(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T7 - 88
725(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T119 - 140
735(chain T and (resid 7 through 88 or resid 119 through 140 or resid 142 through 178))T142 - 178
815(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V7 - 87
825(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V118 - 140
835(chain V and (resid 7 through 87 or resid 118 through 140 or resid 142 through 178))V142 - 178
116(chain M and (resid 1 through 18 or resid 29...M1 - 18
126(chain M and (resid 1 through 18 or resid 29...M29 - 31
136(chain M and (resid 1 through 18 or resid 29...M32 - 3
146(chain M and (resid 1 through 18 or resid 29...M0 - 76
156(chain M and (resid 1 through 18 or resid 29...M0 - 76
166(chain M and (resid 1 through 18 or resid 29...M0 - 76
176(chain M and (resid 1 through 18 or resid 29...M0 - 76
216(chain N and (resid 1 through 18 or resid 29...N1 - 18
226(chain N and (resid 1 through 18 or resid 29...N29 - 31
236(chain N and (resid 1 through 18 or resid 29...N32 - 34
246(chain N and (resid 1 through 18 or resid 29...N-3 - 76
256(chain N and (resid 1 through 18 or resid 29...N-3 - 76
266(chain N and (resid 1 through 18 or resid 29...N-3 - 76
276(chain N and (resid 1 through 18 or resid 29...N-3 - 76
316(chain O and (resid 1 through 18 or resid 29...O1 - 18
326(chain O and (resid 1 through 18 or resid 29...O29 - 31
336(chain O and (resid 1 through 18 or resid 29...O32 - 34
346(chain O and (resid 1 through 18 or resid 29...O1 - 73
356(chain O and (resid 1 through 18 or resid 29...O1 - 73
366(chain O and (resid 1 through 18 or resid 29...O1 - 73
376(chain O and (resid 1 through 18 or resid 29...O1 - 73
416(chain P and (resid 1 through 18 or resid 29...P1 - 18
426(chain P and (resid 1 through 18 or resid 29...P29 - 31
436(chain P and (resid 1 through 18 or resid 29...P-3 - 76
446(chain P and (resid 1 through 18 or resid 29...P-3 - 76
456(chain P and (resid 1 through 18 or resid 29...P-3 - 76
466(chain P and (resid 1 through 18 or resid 29...P-3 - 76
476(chain P and (resid 1 through 18 or resid 29...P-3 - 76
486(chain P and (resid 1 through 18 or resid 29...P-3 - 76
516(chain Q and (resid 1 through 18 or resid 29...Q1 - 18
526(chain Q and (resid 1 through 18 or resid 29...Q29 - 31
536(chain Q and (resid 1 through 18 or resid 29...Q32 - 34
546(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
556(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
566(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
576(chain Q and (resid 1 through 18 or resid 29...Q1 - 76
616(chain R and (resid 1 through 18 or resid 29...R1 - 18
626(chain R and (resid 1 through 18 or resid 29...R29 - 31
636(chain R and (resid 1 through 18 or resid 29...R-2 - 73
646(chain R and (resid 1 through 18 or resid 29...R-2 - 73
656(chain R and (resid 1 through 18 or resid 29...R-2 - 73
666(chain R and (resid 1 through 18 or resid 29...R-2 - 73
676(chain R and (resid 1 through 18 or resid 29...R-2 - 73
686(chain R and (resid 1 through 18 or resid 29...R-2 - 73
716(chain W and (resid 1 through 18 or resid 29...W1 - 18
726(chain W and (resid 1 through 18 or resid 29...W29 - 31
736(chain W and (resid 1 through 18 or resid 29...W32 - 3
746(chain W and (resid 1 through 18 or resid 29...W1 - 70
756(chain W and (resid 1 through 18 or resid 29...W1 - 70
766(chain W and (resid 1 through 18 or resid 29...W1 - 70
776(chain W and (resid 1 through 18 or resid 29...W1 - 70
816(chain X and (resid 1 through 18 or resid 29...X1 - 18
826(chain X and (resid 1 through 18 or resid 29...X29 - 31
836(chain X and (resid 1 through 18 or resid 29...X32 - 34
846(chain X and (resid 1 through 18 or resid 29...X-2 - 70
856(chain X and (resid 1 through 18 or resid 29...X-2 - 70
866(chain X and (resid 1 through 18 or resid 29...X-2 - 70
876(chain X and (resid 1 through 18 or resid 29...X-2 - 70

NCS ensembles :
ID
1
2
3
4
5
6

-
Components

#1: Protein
Ubiquitin


Mass: 9692.942 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Triticum aestivum (bread wheat) / Plasmid: pET28B / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / Variant (production host): CODON PLUS / References: UniProt: P69326
#2: Protein
Ubiquitin-activating enzyme E1 1


Mass: 113704.211 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Strain: ATCC 204508 / S288c / Gene: UBA1, YKL210W / Plasmid: pET29NTEV / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / Variant (production host): codon plus / References: UniProt: P22515, E1 ubiquitin-activating enzyme
#3: Protein
Ubiquitin-conjugating enzyme E2-34 kDa / Cell division control protein 34 / E2 ubiquitin-conjugating enzyme 3 / E3 ubiquitin ligase complex ...Cell division control protein 34 / E2 ubiquitin-conjugating enzyme 3 / E3 ubiquitin ligase complex SCF subunit CDC34 / Ubiquitin carrier protein / Ubiquitin-protein ligase


Mass: 22485.254 Da / Num. of mol.: 8 / Mutation: A141K
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Strain: ATCC 204508 / S288c / Gene: CDC34, DNA6, UBC3, YDR054C, D4211, YD9609.08C / Plasmid: pET29NTEV / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / Variant (production host): codon plus
References: UniProt: P14682, E2 ubiquitin-conjugating enzyme
#4: Chemical
ChemComp-AMP / ADENOSINE MONOPHOSPHATE


Mass: 347.221 Da / Num. of mol.: 7 / Source method: obtained synthetically / Formula: C10H14N5O7P / Comment: AMP*YM
Has ligand of interestN
Has protein modificationY

-
Experimental details

-
Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

-
Sample preparation

CrystalDensity Matthews: 2.87 Å3/Da / Density % sol: 57.08 %
Crystal growTemperature: 291 K / Method: vapor diffusion, sitting drop / pH: 6.91
Details: 0.2 M NH4Ac, pH 6.91, 20% PEG3350, 0.02% (+/-)-2-Methyl-2,4-pentanediol, 0.02% 1,2,3,-Heptanetriol, 0.02% Diethylenetriaminepentakis (methylphosphonic acid), 0.02% D-Sorbitol, 0.02% ...Details: 0.2 M NH4Ac, pH 6.91, 20% PEG3350, 0.02% (+/-)-2-Methyl-2,4-pentanediol, 0.02% 1,2,3,-Heptanetriol, 0.02% Diethylenetriaminepentakis (methylphosphonic acid), 0.02% D-Sorbitol, 0.02% Glycerol, 0.002 M HEPES sodium pH 6.8

-
Data collection

DiffractionMean temperature: 108 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-C / Wavelength: 1 Å
DetectorType: DECTRIS PILATUS 6M-F / Detector: PIXEL / Date: Feb 16, 2018
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 3.42→187.298 Å / Num. obs: 175210 / % possible obs: 99.8 % / Redundancy: 13.5 % / Rpim(I) all: 0.084 / Rrim(I) all: 0.308 / Rsym value: 0.287 / Net I/av σ(I): 1.4 / Net I/σ(I): 9
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsMean I/σ(I) obsNum. measured allNum. unique obsRpim(I) allRrim(I) allRsym valueNet I/σ(I) obs% possible all
3.43-3.6213.82.1250.4353739255820.6122.292.1251.6100
3.62-3.8413.51.3940.5325836241840.4071.5031.3942.599.9
3.84-4.112.70.8040.9288718226610.2430.8710.8044.199.8
4.1-4.4314.20.4821.5299937211640.1370.5170.4826.799.9
4.43-4.8613.80.3272.2268831194830.0940.3510.3279.3100
4.86-5.4312.90.2812.6227138175850.0840.3040.2811099.7
5.43-6.2714.20.2462.9220875156070.070.2630.24611.999.9
6.27-7.6813.20.164172833131410.0480.1730.1616.799.8
7.68-10.86130.1293.5132509101750.0370.1370.12927.699.6
10.86-187.29812.30.152.76922156280.0440.160.1534.499.3

-
Processing

Software
NameVersionClassification
PHENIX1.17.1_3660refinement
XDSdata reduction
SCALA3.3.22data scaling
PDB_EXTRACT3.25data extraction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 6NYA

6nya


Resolution: 3.42→136.46 Å / SU ML: 0.51 / Cross valid method: THROUGHOUT / σ(F): 1.34 / Phase error: 29.86 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2463 2014 1.15 %
Rwork0.2027 172677 -
obs0.2032 174691 99.25 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso max: 362.66 Å2 / Biso mean: 144.149 Å2 / Biso min: 42.68 Å2
Refinement stepCycle: final / Resolution: 3.42→136.46 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms76482 0 161 0 76643
Biso mean--128.54 --
Num. residues----9613
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11A5456X-RAY DIFFRACTION5.07TORSIONAL
12C5456X-RAY DIFFRACTION5.07TORSIONAL
13D5456X-RAY DIFFRACTION5.07TORSIONAL
14G5456X-RAY DIFFRACTION5.07TORSIONAL
15I5456X-RAY DIFFRACTION5.07TORSIONAL
16K5456X-RAY DIFFRACTION5.07TORSIONAL
17S5456X-RAY DIFFRACTION5.07TORSIONAL
18U5456X-RAY DIFFRACTION5.07TORSIONAL
21A12912X-RAY DIFFRACTION5.07TORSIONAL
22C12912X-RAY DIFFRACTION5.07TORSIONAL
23D12912X-RAY DIFFRACTION5.07TORSIONAL
24G12912X-RAY DIFFRACTION5.07TORSIONAL
25I12912X-RAY DIFFRACTION5.07TORSIONAL
26K12912X-RAY DIFFRACTION5.07TORSIONAL
27S12912X-RAY DIFFRACTION5.07TORSIONAL
28U12912X-RAY DIFFRACTION5.07TORSIONAL
31A2160X-RAY DIFFRACTION5.07TORSIONAL
32C2160X-RAY DIFFRACTION5.07TORSIONAL
33D2160X-RAY DIFFRACTION5.07TORSIONAL
34G2160X-RAY DIFFRACTION5.07TORSIONAL
35I2160X-RAY DIFFRACTION5.07TORSIONAL
36K2160X-RAY DIFFRACTION5.07TORSIONAL
37S2160X-RAY DIFFRACTION5.07TORSIONAL
38U2160X-RAY DIFFRACTION5.07TORSIONAL
41A2712X-RAY DIFFRACTION5.07TORSIONAL
42C2712X-RAY DIFFRACTION5.07TORSIONAL
43D2712X-RAY DIFFRACTION5.07TORSIONAL
44G2712X-RAY DIFFRACTION5.07TORSIONAL
45I2712X-RAY DIFFRACTION5.07TORSIONAL
46K2712X-RAY DIFFRACTION5.07TORSIONAL
47S2712X-RAY DIFFRACTION5.07TORSIONAL
48U2712X-RAY DIFFRACTION5.07TORSIONAL
51B3365X-RAY DIFFRACTION5.07TORSIONAL
52E3365X-RAY DIFFRACTION5.07TORSIONAL
53F3365X-RAY DIFFRACTION5.07TORSIONAL
54H3365X-RAY DIFFRACTION5.07TORSIONAL
55J3365X-RAY DIFFRACTION5.07TORSIONAL
56L3365X-RAY DIFFRACTION5.07TORSIONAL
57T3365X-RAY DIFFRACTION5.07TORSIONAL
58V3365X-RAY DIFFRACTION5.07TORSIONAL
61M1448X-RAY DIFFRACTION5.07TORSIONAL
62N1448X-RAY DIFFRACTION5.07TORSIONAL
63O1448X-RAY DIFFRACTION5.07TORSIONAL
64P1448X-RAY DIFFRACTION5.07TORSIONAL
65Q1448X-RAY DIFFRACTION5.07TORSIONAL
66R1448X-RAY DIFFRACTION5.07TORSIONAL
67W1448X-RAY DIFFRACTION5.07TORSIONAL
68X1448X-RAY DIFFRACTION5.07TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 14

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
3.42-3.510.40391440.3394118391198395
3.51-3.610.30921330.29311229312426100
3.61-3.710.30581400.2813123461248699
3.71-3.830.29641410.25421239412535100
3.83-3.970.32121520.25661237212524100
3.97-4.130.30411390.22481235112490100
4.13-4.320.25541460.20431237612522100
4.32-4.540.22741460.1851241912565100
4.54-4.830.23691470.17341232012467100
4.83-5.20.22031450.18231235512500100
5.2-5.720.26351390.20141241612555100
5.72-6.550.25371490.20341242812577100
6.55-8.250.20761430.1882124091255299
8.25-136.460.19241500.1588123591250998
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.022-4.4777-0.32699.33910.47396.79770.40460.2721-0.7678-2.1742-0.07132.385-1.2256-0.2795-0.17951.82430.5563-0.04232.0437-0.38931.959662.8950.478227.981
27.21657.55954.89999.06164.69713.48840.8844-0.69820.5302-0.3406-1.73711.8792-0.9079-1.12751.0071.65430.232-0.01922.1063-0.50372.501461.61143.093232.197
31.92972.4994-0.83273.2541-1.45448.65470.62480.5971.87522.1272-0.36071.274-0.313-1.3372-0.22280.99110.14020.18561.2906-0.49711.876362.56643.824240.152
42.5767-0.8491-4.09347.41760.68896.5623-2.90610.3342.61021.29961.5170.00940.3216-0.27611.45761.22060.1284-0.21211.70720.37041.752667.33536.473240.799
53.69750.54520.90657.87520.14560.21880.729-0.5990.2781-1.2055-0.6603-0.5086-0.5014-1.8763-0.24671.59620.5253-0.16862.25760.10840.974772.26344.021232.754
62.9698-0.547-1.71034.4829-0.62835.9191-0.54890.19680.1428-0.10790.24480.00670.99360.47470.32720.80990.0628-0.17481.008-0.31880.823790.546-9.896279.475
73.8341-1.8477-0.48911.2668-0.58311.61450.1458-0.17890.16670.10840.08670.3024-0.2486-0.4676-0.0790.701-0.0987-0.18421.3556-0.41031.20662.70813.236281.432
81.3412-0.0761-0.77930.86510.25111.79360.0748-0.34280.71370.05930.2332-0.2847-0.33850.93680.14610.7711-0.2067-0.11591.355-0.4961.376396.5810.786285.975
94.36450.5363-0.58453.2737-0.26761.612-0.4927-0.74410.01320.48490.33850.20370.72250.75490.13790.93710.1766-0.16791.9046-0.23140.913588.301-8.845307.335
103.4949-0.14970.28650.6815-0.1258.512-0.6418-0.15810.2798-0.4020.0337-0.11232.5717-1.22360.43171.3718-0.3750.12741.3636-0.41490.963849.122-13.315307.387
110.199-0.10740.17760.058-0.09590.1569-0.45990.2845-0.1879-0.58430.60670.14230.8977-0.757-0.54163.06880.03341.49921.76650.71022.529139.65-18.871311.752
129.82410.1432-0.71112.36570.0114.4905-0.98490.1149-0.89780.3393-0.61090.13420.6704-0.6678-4.0241.1972-1.0420.20242.1725-0.65081.003737.289-19.171295.18
132.58540.2265-0.17351.3552-1.49631.6542-0.2953-0.41521.0650.4774-0.2467-0.0636-0.70930.56130.97140.9542-0.3562-0.41212.1005-0.56981.495531.2319.566295.023
141.89810.72860.85330.9701-0.23860.8430.1347-0.90491.04350.4743-0.5193-0.1897-0.4205-0.03051.02560.4196-0.3381-0.36012.1959-0.64341.540137.7652.879290.988
155.3834-0.6077-0.16673.1366-3.56724.2282-0.35851.5275-0.19720.47610.2581.3299-0.457-0.218-0.30630.9753-0.33080.17550.7376-0.27720.802746.585-23.019290.006
165.58011.49973.52574.4385-3.48559.60610.94161.20770.1678-0.47170.4257-0.06661.0593-0.44240.00491.8769-0.55230.61131.3534-0.37430.964841.747-28.147281.983
174.95573.07223.15824.03255.05248.0297-1.0631-0.46811.7571-1.44631.36410.6039-0.11810.9643-0.46261.419-0.65910.09922.7578-0.31251.692927.734-16.355293.204
186.04633.45141.91941.97521.21333.3936-3.27611.9316-1.37510.33150.74641.40871.90530.82452.56493.3694-0.63340.91151.70980.07231.929635.8-26.807316.79
192.8854-2.11581.44739.6651-7.09926.2949-0.09950.56960.22330.3051-0.9107-0.23290.05411.7748-0.00530.8305-0.31460.05211.0736-0.39160.591453.595-18.415295.454
203.76421.74213.60080.96751.48823.65770.02931.08-0.2554-0.1557-0.3697-0.07290.14-0.3940.34360.8357-0.1082-0.01481.2361-0.26331.105858.663-7.013290.263
210.9345-0.23120.24681.2926-0.53530.22260.0256-1.4090.53580.52280.4957-0.0906-0.41571.52390.00290.99120.0399-0.22121.9922-0.59781.207784.6186.995312.276
222.4492-0.80681.97871.5349-0.33482.47480.0061-1.1988-0.13190.60060.2845-0.0423-0.05430.8311-0.20361.25910.3349-0.08422.6698-0.48770.846469.3040.974337.459
239.49980.00680.55741.9932-1.31391.0750.6178-1.1739-0.25880.1507-0.19121.28440.4761-1.17761.99630.9801-0.6063-0.59222.3634-0.34091.859560.798.367327.051
240.1570.4505-0.49121.4865-1.10521.9717-0.6063-0.01410.09750.6414-0.08570.1517-0.7269-0.7110.68481.4806-0.3888-0.09481.5082-0.88531.244650.30114.054332.681
257.3575-1.88134.0763.34521.95695.3962-1.2821-1.8377-0.8053-1.0461-1.7166-1.07362.6524-0.31511.91751.17990.28130.37411.5810.37991.492550.9670.629330.324
268.5239-3.10035.13966.2624-1.61744.1735-0.29-0.11641.59280.2657-0.2843-0.4783-0.1917-0.10380.68060.80370.0686-0.28823.1068-0.61691.559542.6736.159325.075
277.79693.6518-2.23736.1352-5.45585.0330.41690.3777-0.4192-0.50680.13890.04113.6931-0.0043-0.54821.9578-0.2346-0.56122.3345-0.4051.008146.575-1.158322.361
280.9158-2.08771.15194.8137-2.78681.87580.73460.15622.3584-1.5985-1.4726-2.40440.89023.9320.21491.27160.2731-0.11273.4509-0.18672.466856.011.426316.228
299.36876.0846-2.65327.0151-4.80213.8485-0.4887-0.6682-0.2860.1866-0.0366-0.93390.1351-0.66580.02581.3344-0.4309-0.17231.9787-0.69081.244439.427-1.807313.415
305.21694.2945-0.2893.55220.21327.5759-0.75680.46882.5530.371-0.40270.5981-0.991-1.77490.87640.54970.0872-0.4190.7488-0.25561.227348.21511.718317.228
312.35561.5174-0.28612.7040.69810.4857-0.9310.6073-0.0213-0.94660.29030.3864-0.8023-0.0505-0.76371.1335-0.1849-0.34041.5865-0.85191.558537.9756.632306.131
323.2569-4.37980.6868.88572.86955.7672-0.17850.42950.377-0.02331.1326-1.82280.8142-1.2449-0.83430.9339-0.26920.02133.195-0.64841.364128.684.257306.093
332.00212.9972-4.58555.22880.26142.70580.2407-3.63040.40380.4057-1.25991.91370.4234-2.4071.06571.308-0.3994-0.18083.3161-0.41831.657727.2512.06318.719
346.2398-2.4167-1.63662.0007-5.42555.31450.44730.19390.10380.0688-2.3876-0.87250.20380.40111.60720.92870.2107-0.10373.1508-0.18621.136937.4443.569334.33
353.4003-0.5492-0.29251.0620.03092.43860.0819-0.9938-0.03060.1477-0.1219-0.0160.24230.10850.03310.7028-0.211-0.15831.53-0.17130.9265123.0696.678418.489
360.751-0.03681.4283.4053-2.32294.4197-0.3334-0.807-0.2257-0.39760.8153-0.54061.084-0.6841-0.63410.836-0.0253-0.0462.3171-0.01851.019786.087-5.344434.723
371.97271.1512-0.89751.7399-1.67671.651-0.1531-0.0598-0.6392-0.0974-0.5291-0.57620.86490.1457-0.18222.7757-0.30061.06972.71630.82041.828175.509-12.957438.639
385.4032-4.0554-2.24378.24524.09325.7639-0.8269-0.7259-0.35961.5689-0.03680.51660.971-0.8282-0.43760.988-0.4672-0.15941.89010.39590.664175.844-17.77423.157
390.2699-0.5525-1.42815.84115.88519.41970.1087-0.37540.26391.5602-0.5097-0.47181.2202-0.1523-1.06230.8579-0.4072-0.23332.264-0.20090.828967.9854.429422.063
406.595-2.9103-4.38261.28431.9342.9123-0.37510.17010.6230.5405-0.8062.0231-4.47041.7771.0881.8547-0.2225-0.2361.0034-0.51091.710567.85721.835425.685
411.1790.08560.38671.43660.47320.2713-0.1526-0.14570.94-0.02470.0544-0.0204-0.15040.30261.16380.6185-0.4952-0.23152.4505-0.47881.250574.4649.79418.772
421.7203-3.07551.42757.963-5.17625.21790.2203-0.1295-0.52930.5325-0.00770.6283-0.437-0.5310.06970.6778-0.4728-0.22871.53910.22290.648282.859-16.221417.983
433.4376-2.28333.72412.765-3.14384.39280.8305-0.2607-1.4765-0.74710.34460.65921.8235-1.1052-1.20271.1486-0.14060.14061.13630.03640.972178.255-21.43410.233
446.329-6.7517-5.21538.71483.91296.1020.7499-1.88071.7491-1.60581.55370.3998-0.56260.6915-2.02771.2882-0.7680.02481.8714-0.2021.637764.196-9.284421.02
451.4277-0.84430.07925.669-0.08373.60440.47170.9308-0.25480.6834-0.63370.45190.6620.3129-0.44311.1832-0.0082-0.06841.48260.3590.677783.912-18.743435.181
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1341.12790.35670.24391.0199-0.02881.5555-0.2863-0.10250.1623-0.92670.41631.3974-0.6288-0.485-0.35272.00260.2475-0.03331.14470.85211.998896.1815.085218.336
1355.5555-4.881-0.49217.83562.9186.98480.27680.19840.8559-1.5451-0.1394-1.4805-0.36390.9879-0.15080.8674-0.1810.13691.1717-0.06231.326103.1097.855240.4
1363.6196-1.386-0.55844.2269-5.39868.623-0.00410.0558-0.7252-0.7341-1.1724-0.2052-0.00940.15510.65751.1296-0.1426-0.4450.6491-0.17581.695996.82226.113252.02
1371.9192-0.3282-0.75888.2076-3.41366.72840.1498-0.93960.91611.59810.23821.7881-1.22630.7543-0.07430.847-0.2819-0.16350.8874-0.18251.595790.64323.075255.891
1386.9125-2.3993-5.68597.66213.30818.87920.2460.472-0.4703-0.422-0.9935-0.32540.2496-1.95940.83740.6165-0.0476-0.22121.0517-0.11160.834797.994-0.521246.172
1395.2833.832-1.04674.5291.69713.6505-0.45651.4781-0.74190.7980.9678-1.33560.4030.7449-0.12260.58710.2179-0.05951.5194-0.21621.6108104.554-2.796256.554
1407.9773-1.0668-3.47170.9558-0.9984.36720.1408-0.89170.36821.5166-0.0442-0.145-0.9541.6310.06360.7314-0.2894-0.34220.933-0.01711.2695109.00216.265250.632
1416.72451.29241.08855.978-0.53668.68920.00510.45080.1451-0.5196-0.3104-0.18541.26380.18140.2160.59060.0659-0.21110.9585-0.07210.89395.5544.435237.924
1425.49157.04962.00628.9992.82963.7419-0.42320.3757-0.0512-0.4388-0.14550.9011-0.0289-0.52520.62340.56750.0217-0.11710.9137-0.11491.519778.8354.579251.649
1431.00560.5453-0.17431.4919-0.8963.6972-0.05520.60920.6323-0.47060.0460.603-0.4794-0.5163-0.02990.9010.0542-0.37261.4844-0.1081.504350.1657.237227.653
1443.6758-1.0155-0.6594.3905-1.95131.20510.04390.17070.4124-0.833-0.03520.1994-0.07360.1293-0.0071.3421-0.1408-0.40871.3317-0.00621.244264.90914.956208.248
1459.94511.0708-7.50589.22010.80425.95891.87350.6209-1.3887-0.3106-0.65921.21970.2101-2.2307-0.59270.9551-0.1518-0.45431.35390.19410.864566.33520.846220.138
1461.6538-1.8821-2.23332.21172.55553.02220.17871.48191.4945-1.1312-0.19990.1857-1.2342-0.5929-0.06972.49110.01790.01911.37810.86511.622470.89833.345216.017
1472.5211-2.4686-1.00012.62172.35579.68710.71170.50151.0902-1.7161-1.2075-0.8259-1.1114-0.57640.4641.29720.1053-0.20961.46820.11591.694881.22129.386220.606
1485.87680.2218-0.89156.0029-3.34269.9547-0.2451-0.70180.1547-0.1277-0.6010.12540.25510.66040.69981.285-0.0253-0.29781.54950.07711.785877.14319.479226.908
1495.8068-3.0061-3.93482.8692-0.89629.8342-0.11370.1294-1.23360.1960.4409-0.58280.99970.8234-0.46831.17150.1198-0.34711.2650.03221.755986.67724.886232.775
1508.0676-0.94713.55020.39760.60965.2358-0.77150.84631.83370.1465-0.22691.7959-1.58990.22010.94441.29560.1627-0.40390.66590.08971.944475.54931.345230.367
1512.03452.0249-0.56862.2134-0.07052.301-0.3161-1.48440.46680.02531.0964-1.2176-2.72150.8904-0.91451.939-0.162-0.50611.257-0.1482.038490.74334.226241.843
1529.6352-0.7485-3.22633.1752-1.44712.02020.2257-1.01980.3927-0.46440.1486-1.8604-0.90822.1065-0.20411.5554-0.60660.14871.78950.19321.743196.82637.688229.405
1536.0384.14170.28732.98771.26858.02180.80420.94320.2946-0.77451.1621-0.22170.5408-0.44180.38691.8206-0.730.02641.06780.20380.994986.435.722213.529
1541.2258-1.0655-1.60313.24820.23733.97760.3512-0.2648-0.35680.3039-0.264-0.66850.32360.2912-0.10620.61740.0131-0.2940.75710.07720.942494.943-13.053382.635
1552.775-2.6177-0.22272.8023-0.4541.2788-0.2623-1.4851-0.17740.8425-0.00340.52660.04190.3192-0.40240.5506-0.1459-0.2311.11850.09450.891686.241-9.018393.776
1568.8249-3.2861-2.41147.2019-3.61487.90970.3922-0.3789-0.5052-0.1328-0.0714-0.6145-0.83640.3309-0.26350.6899-0.1036-0.18110.775-0.12970.8197105.229.565392.228
1575.08871.982-0.54897.3307-0.16353.9610.3154-0.57780.90870.6697-0.50930.4632-1.1997-0.74970.11850.6883-0.05690.02561.0837-0.29740.960480.8677.897392.332
1581.8705-2.39181.76844.5236-1.36993.2419-0.002-0.3004-0.3492-0.02890.25550.7590.4157-0.6713-0.15220.604-0.1757-0.23931.4377-0.09361.227564.482-4.853384.844
1593.45621.01140.7562.90910.88095.75880.073-0.58150.1168-0.1362-0.19880.5221-0.4446-0.65460.12060.47820.0012-0.21470.7598-0.04980.85575.8970.296378.939
1605.3047-0.8169-0.6583.9847-1.41763.9147-0.13340.576-0.0453-0.5121-0.024-0.35520.222-0.05930.13480.61450.0185-0.2470.7953-0.07170.749393.737-6.799359.698
1613.57582.58022.69992.09470.94625.6541-0.50540.17390.1962-0.11220.05670.2582-0.9374-0.31820.40620.65480.0227-0.10520.98970.01740.848290.879.801362.008
1628.60983.26674.81994.90783.90254.17180.60290.6413-1.4865-1.06110.2774-1.81140.0844-0.4405-0.86720.68750.0361-0.04350.48350.11781.0993118.76625.249374.492
1638.6908-5.39165.43024.3768-2.6394.28410.95112.2919-0.3588-1.4584-1.12840.1749-0.61730.9748-0.00210.75430.1066-0.28750.6791-0.0950.8617124.30915.346371.743
1642.3085-1.7073-0.10272.037-2.37598.57621.82050.6488-0.2889-1.534-0.39150.7619-1.0026-2.429-1.33751.08340.28310.03881.02370.16220.9225133.15111.18355.924
1654.48074.4509-1.16326.5539-5.22428.0678-0.84851.69310.9597-3.6277-0.2612-0.09360.49470.79630.73881.48210.1826-0.25791.60810.13460.9076134.39716.965346.415
1668.3522-7.69221.34718.7764-1.4920.2544-0.3469-0.0431.5745-0.20640.2075-1.5407-1.8096-1.7950.25241.57920.61940.40231.1575-0.14611.2554137.96419.173358.745
1676.3849-3.91844.65075.0898-0.26675.9036-0.29573.43161.7254-1.2705-1.6652-4.35890.4843.34121.7281.01150.17950.02651.55390.14721.4922145.8756.394366.376
1682.4425-2.62630.02394.8552-4.06398.0509-0.43320.7875-0.0035-1.5823-0.3236-0.9398-0.14251.16860.13210.5638-0.0398-0.10440.8591-0.21881.0053139.66312.797375.48
1692.51593.6859-0.46485.7506-1.04430.4734-0.20080.1409-0.69810.3599-0.031-1.5632-0.31870.3364-1.68880.8754-0.0524-0.21080.8661-0.64751.7669133.69132.237380.158
1706.2119-6.1415-0.80758.5549-3.64198.0422-0.53410.5306-0.57561.0487-0.2585-0.9952-1.0458-1.09190.83651.5845-0.0663-0.44020.9768-0.51742.081122.86745.896380.322
1719.4974-5.8193-8.5437.29173.01479.0070.13220.91590.91710.5542-1.06022.0093-1.5107-1.6776-0.14751.64690.4895-0.15770.911-0.2512.0774122.35138.383382.162
1725.9264-4.115-3.89485.7585-0.51746.3273-0.2957-0.45933.36391.42790.4858-0.4904-0.8818-0.62640.04661.2546-0.1434-0.18930.9306-0.15921.4759127.32227.142384.121
1736.6461-0.01881.18137.15920.72016.0970.3074-1.5221-0.75280.0262-0.2043-0.34180.4351-0.33730.05850.5166-0.017-0.25050.58490.07340.7169135.1536.795377.076
1742.22653.01132.74229.42610.58316.91250.3251-1.2614-2.37310.11250.1258-1.24140.2111.4857-0.51640.62710.0455-0.26131.28770.00511.2369141.2593.363384.348
1754.4146-5.0252.30557.3421-3.46574.3886-0.5285-0.36731.47551.9894-0.8761-1.1622-0.97110.89271.33150.7229-0.1684-0.29371.1158-0.18541.5391145.81822.463378.743
1765.09490.07971.79943.28010.23996.4080.24350.7654-0.04760.0215-0.0243-0.01471.0743-0.2464-0.17120.5453-0.0321-0.24060.7471-0.00930.6755132.34110.674365.824
1773.19042.43863.97958.93323.66845.9521-0.1565-1.2375-0.1209-0.2185-0.17980.4634-0.2717-0.64010.50920.496-0.0188-0.08811.13180.02561.1122115.61410.687379.538
1783.73790.633-0.98911.085-1.79327.67990.16790.21590.8126-0.1570.24260.3795-0.587-0.8499-0.33540.67650.0884-0.22460.71240.01530.977385.9411.682359.723
1794.408-0.0776-1.37582.1875-1.3622.0811-0.18820.81570.2022-0.77950.3266-0.42970.1849-0.4956-0.1541.27040.0468-0.19191.17470.23471.0076100.6821.535335.668
1803.1832-2.3048-4.05274.72182.32496.90590.2588-0.28930.426-0.14670.7861.0742-0.7113-2.6154-0.93770.682-0.0073-0.19221.37030.33240.8469103.20927.494348.271
1810.1992-0.0481-0.02760.01180.00370.0048-0.11630.00320.0267-0.5515-0.0690.0404-0.48610.0263-0.53891.89570.1344-0.10281.35071.00721.0223108.06439.539344.64
1829.7474-1.1941-3.4320.82530.0221.4443-0.26790.61231.2253-1.0491.4065-0.8904-0.4511-0.2129-0.18531.0971-0.0625-0.15190.8398-0.20950.683115.82428.822344.004
1831.2859-1.5770.19521.9673-0.68686.89930.0347-0.02490.88270.28330.1326-0.0471-0.69960.2282-0.1910.90990.0302-0.00960.36420.03971.2945119.19238.782351.342
1845.75274.3075-4.88573.4129-3.22467.59260.5593-1.29780.5927-0.5074-0.5607-0.00330.87950.95230.06741.1002-0.0798-0.16131.1210.51411.5238113.94725.884355.402
1858.94531.5529-0.78383.6442.13356.21560.08650.35830.45270.83550.343-0.3510.56451.4027-0.42281.02270.0727-0.20920.66040.16711.127123.58631.236361.065
1860.6242-0.41520.39741.8683-0.49750.5635-0.2669-0.12920.21860.3437-0.08-0.574-0.6741-0.0196-1.21591.0690.3679-0.23760.281-0.28031.3253116.29937.97362.833
1877.2340.3629-2.60633.55041.10168.65630.33870.68741.53960.00441.0754-2.2427-0.73660.2002-1.350.9819-0.1947-0.04361.08090.13841.6566132.94843.166362.804
1880.32470.16390.37721.21020.10170.44490.0514-0.2013-0.64760.36080.0054-0.06870.68240.1098-0.4351.6143-0.06910.0110.67270.50861.2906124.2941.494341.899
1893.1418-4.0096-4.69285.12015.98547.0437-0.35561.0526-3.0706-2.15811.06191.1609-0.98381.1444-0.64160.9982-0.3198-0.14132.5344-0.25571.834540.31335.097291.167
1903.03150.289-2.68643.15923.55648.3541-0.24361.5642-1.77881.70862.1132-1.7884-1.78742.0773-1.74182.1711-0.7237-0.5452.4799-0.08481.37536.32520.517290.744
1915.6591-3.3263-0.31453.1261-1.98344.20660.2834-0.54820.81060.2941.08081.2151-0.2332-0.5755-0.61310.57440.3817-0.0492.5512-0.18252.458237.46134.14293.578
1920.3706-0.2256-0.76350.13730.46451.57130.58060.01780.2806-0.32610.3332-0.5074-0.80631.2231-0.37281.9391-0.69150.98963.2235-2.11134.00845.81540.836300.499
1933.88964.22061.37388.8461-1.07978.20233.22921.6832-0.28090.286-1.72941.499-1.4418-0.9789-1.2151.74690.31590.4071.7382-0.44831.662938.72629.382301.987
1943.1532-0.47313.03215.86572.61774.66031.42381.5001-1.2633-1.1762-0.4129-0.57761.11480.9643-0.9572.5481-0.1608-0.14213.1432-1.21761.727241.49521.875305.414
1952.922-0.203-2.29877.96831.55279.4757-0.56470.4558-2.25560.1937-0.99661.51980.1794-1.72362.01861.08230.24330.13652.4416-0.50011.388851.94926.692296.667
1966.6294-1.9643.76272.06521.07038.5019-0.04030.39180.9609-0.6722-0.92040.7492-1.46462.02890.9241.281-0.12440.06141.8017-0.23751.438348.66632.838294.896
1974.02716.21850.31119.74441.29264.64480.89530.7612-1.07820.1247-0.53220.48350.61570.186-0.16582.55050.3902-0.26051.8071-0.05122.179997.255-93.048260.717
1983.49531.17314.37462.7385-0.79868.103-0.97640.02213.2044-0.5173-0.9791-1.21051.09892.85791.45451.3660.66970.61611.84350.59313.1353102.146-92.402266.407
1993.783-3.8614-3.79917.8595-0.1057.8647-2.008-0.083-0.1194-2.2839-0.3413-0.32992.58931.18392.04722.2542-0.2258-0.34921.82531.36174.399784.937-91.939262.04
2003.59853.9101-1.25645.43470.47793.80521.5704-1.3795-0.0520.1737-1.1294-1.71351.4644-3.5257-0.50562.4876-0.3382-0.21211.88590.08331.400491.74-88.305270.553
2013.74183.6854-1.61367.18513.64149.1713-0.1813-0.1722-0.08941.12290.01831.19111.0891-1.40830.20611.81110.16460.18681.65820.40542.189292.865-81.692263.836
2020.92641.2446-0.00587.02881.01850.19520.1366-0.2116-0.64710.3553-0.1018-0.29390.76820.00981.07421.8585-0.48230.13790.74460.52351.894892.105-92.474253.504
2035.00714.25522.3125.1586-0.09624.0339-1.3949-0.72550.5467-1.9155-0.9137-0.7969-0.0817-0.40362.06581.78340.1675-0.21160.910.09031.4657100.404-82.171265.239
2044.62690.43410.34994.66833.52195.4340.318-0.51440.3544-2.3102-1.3612.2295-0.0996-0.14811.2191.07880.6089-0.10651.30130.2971.191999.91656.776356.724
2059.60562.87658.09386.85931.13787.10390.6666-1.4666-0.33350.22980.5864-0.0289-0.5142-1.0147-0.33261.04760.2830.45910.852-0.06091.303598.64449.407360.922
2064.79431.6218-0.17977.98850.72838.94220.41390.6053-0.48491.96960.15521.07580.78252.2164-0.22431.43780.705-0.14511.33430.09281.384499.60349.916368.816
2072.81780.81261.0434.4863-5.60748.5928-0.92470.28622.24660.39341.42141.79390.5027-1.8147-0.52111.57140.25310.08271.52010.05711.3246104.31442.661369.402
2085.8471-3.6292-3.72715.40095.10794.95921.3288-1.18150.4631-1.320.0061-1.0084-0.9261-1.091-1.06281.09230.2756-0.11411.33490.18061.0283111.12553.101363.341
2091.87732.7287-0.16037.2195-1.56636.60091.00981.6030.76290.0329-1.06610.8617-2.4609-2.3182-0.04072.06480.51050.12711.9752-0.04941.6514105.78856.99355.362
2101.9548-1.3954-0.49142.48642.40862.9460.31650.24960.2029-1.2558-0.9261-0.55781.1845-1.84340.6850.98830.1671-0.15410.92070.10681.0554109.98241.227364.547
2115.2722-0.66240.24580.2153-1.00577.1872-0.42380.89250.1697-0.9539-0.07391.61480.2488-2.11260.66750.8826-0.1574-0.05562.039-0.7541.299976.22835.561419.69
2122.9284-2.9245-2.72833.07912.14114.73180.7140.5151-0.23090.1602-0.1553-0.32470.2365-0.06010.9851.7211-0.15110.30972.6944-1.5872.576681.45946.619428.281
2133.9166-3.43963.19576.7051-1.09373.49521.07880.2302-1.06171.83680.20792.33841.3361.0663-0.54381.8490.08770.55881.2982-0.84952.415277.32334.503431.932
2142.78961.0852.50013.5563-3.3538.1962-0.3607-0.06520.47040.2969-1.0854-0.0351-1.50330.14760.23751.23770.02550.2121.7126-0.75752.001787.23436.81424.535
2154.0022-1.9864-4.82285.7176.56589.495-0.23620.9785-1.83291.7546-1.63092.16653.7072-1.71571.98042.7495-0.65480.08561.60490.09921.7832134.549-86.63389.161
2160.4756-2.2022-1.973828.56159.76761.4068-1.80956.42230.61950.7966-2.4183-1.02790.7752-1.75191.31060.2257-0.28871.5632-0.62494.3456144.891-83.093395.462
2173.5588-2.68061.00736.1967-1.39181.88540.8949-0.091-0.49651.5372-0.21281.94630.2825-0.5927-0.98451.6170.20910.5390.60230.2452.4761128.006-87.395392.18
2182.0138-0.16450.61498.1551-2.63141.22540.11760.10930.2105-0.51410.0330.77110.1306-0.08110.08812.3201-0.04480.03620.50280.06321.0669130.041-82.102399.402
2193.2529-3.07551.53286.8139-6.62839.67660.24350.1151.14513.36120.9960.3555-1.5217-0.5593-1.23911.6562-0.2786-0.09391.15730.47671.3098134.137-74.508399.185
2202.34932.6251-2.64474.0245-1.15876.4712-0.42740.04071.7692-1.11560.0705-0.85560.9991-0.24480.66711.51410.0005-0.16991.28040.50441.6924128.332-73.466387.889
2211.2965-1.04462.34332.4573-2.09974.25440.58690.44860.804-3.1312-0.2246-2.64263.5055-0.2642-0.25391.79510.0280.26291.20350.40731.6955126.962-82.684383.962
2225.3772-1.8148-1.86099.09121.46616.7025-0.4828-1.40990.6842-0.49130.1068-0.9632-1.02921.07540.32911.1526-0.07950.1080.84240.1950.9536137.581-75.778393.604
2236.2492-0.2643-1.68282.3420.85875.005-0.1264-2.07140.28940.55310.20740.8498-1.23710.807-0.09611.4625-0.0018-0.26191.2513-0.03131.6352106.38881.325278.29
2242.43-0.01950.3887-0.0011-0.31226.08360.1718-0.12280.0714-0.11740.6341.1741-0.5503-1.5984-0.47590.990.1535-0.44420.98170.25152.310792.86679.607265.368
2255.36360.55923.18881.2990.42935.45360.10450.405-0.0302-0.2158-0.41720.8471.19190.24610.09321.1139-0.1855-0.11160.58870.00541.3266113.38660.056271.945
2263.47690.2969-0.46970.52830.29873.4338-0.2864-0.27031.34120.47630.10011.73230.6203-1.10520.37231.212-0.4538-0.52430.9025-0.05572.295991.79357.862267.542
2270.5905-0.85950.74942.8339-0.99075.12940.3141-0.2156-0.12570.63540.31241.2914-0.3453-1.4155-0.50940.95330.0882-0.06332.12480.16322.240582.44470.299289.271
2284.99241.624-3.53483.3315-5.50429.2395-0.8666-0.06870.59590.45571.54511.12640.4051-0.5792-0.58571.4074-0.20090.44821.20670.07152.526391.85756.587295.22
2294.6062-0.0276-1.47030.157-0.93925.85030.7511-1.62280.3241.34070.08460.6023-0.6207-0.2057-0.50992.0369-0.28790.5991.26470.33241.3183113.66676.01315.659
2302.395-0.4026-1.89010.31730.75763.90240.50340.20190.6687-0.2655-0.1049-0.0666-1.3510.0607-1.18042.50180.2621.16591.7857-0.07060.9575116.51179.438326.279
2313.4828-0.7428-2.53540.40321.66397.12080.3715-0.56610.14410.309-0.26060.21190.3271-0.244-0.33892.1329-0.35450.53512.0218-0.35810.7005116.09696.042323.033
2324.9972-5.0515-1.2695.83492.71453.09880.0538-2.0548-0.10731.6837-0.16712.0371-0.03940.15920.0582.2669-0.34420.59811.4358-0.12371.446124.15390.945313.906
2332.58680.6955-0.2656.03265.81895.9628-0.8791-0.9472-0.14983.219-1.0067-0.2344-1.6740.20781.8862.13310.2467-0.14391.21210.21731.3507135.24577.102315.559
2344.9637-3.40485.12673.9837-4.64528.8994-0.1912-0.7986-1.79120.77270.0241-1.20973.39571.03480.16191.65380.4065-0.12351.17220.47141.2806141.2669.001311.387
2356.45662.4146-1.48733.0245-1.77731.1748-1.1298-1.7085-2.33270.12630.9201-1.708-0.2711-0.44290.31862.8970.9359-0.73531.6378-0.19812.3752142.30257.838311.377
2363.37473.029-0.43634.62811.92952.8938-0.1188-0.2907-1.51971.30860.7313-0.15141.24772.076-0.44221.51550.191-0.32591.1040.29411.4216136.02370.322306.102
2375.00512.6455-4.52927.0347-2.2964.7456-0.3741-1.359-1.05340.628-0.47961.1477-0.70161.12170.85261.3523-0.07260.18891.33020.1111.4819119.77892.358307.701
2388.5338-0.6452-4.14686.66691.98935.6781-0.33110.40262.8670.521.340.8359-3.63781.222-0.39421.895-0.34310.1840.70530.04791.3764124.743100.855305.348
2391.1986-0.6958-0.77610.58761.27144.17460.295-0.02340.1337-0.71170.336-0.2512-0.59520.89310.24051.9899-0.2374-0.36431.5531-0.47890.8142134.86489.163318.881
2401.32061.4332-1.1993.2829-0.50921.44850.4437-1.0132-0.52893.2935-0.51451.5255-1.2581.1439-0.14042.4416-0.14980.79991.6619-0.15881.4641112.74286.308333.856
2413.9855-0.95072.06638.5473-0.67592.4918-0.07810.60470.68960.24060.29110.91510.5045-0.3336-0.18351.24-0.18750.36111.03230.13571.3713113.72384.619305.094
2424.51345.2335.85286.76296.24388.69870.11720.7003-0.07421.0807-0.90690.86391.40820.79880.92561.0831-0.11570.19681.08370.17651.4055116.35976.48295.474
2433.15372.704-0.25722.36860.39236.71930.2078-0.12641.58860.06710.02440.53980.7298-1.4191-0.26910.9184-0.3223-0.15110.81240.18742.062793.16556.961281.14
2441.2567-0.50471.36792.1569-1.72922.2016-0.52820.00190.2094-0.48230.52850.5266-1.4456-0.12660.57852.2160.02970.39641.05960.87782.46791.63537.785298.903
2453.02460.3958-2.73880.1339-0.07893.4722-0.5705-0.4123-0.2681-0.85410.11860.2443-0.04471.1136-0.00182.7902-0.71311.49331.84060.07783.384682.26244.953309.347
2463.3459-2.5553-1.83213.40471.19811.02881.54840.68090.4488-1.7147-0.35140.6065-2.4441-0.6691-0.83533.0712-0.2781-0.37362.25581.37842.383581.67637.122319.391
2478.70520.6479-2.88896.08836.22619.24140.0987-2.274-2.1711-0.92653.06970.85790.9808-0.1885-2.74572.36850.2999-0.12692.21790.83352.17391.76844.066320.789
2487.17543.905-3.86153.63050.79597.81620.7915-0.01221.47220.58751.28040.28841.70930.9327-2.22632.33360.29590.05752.43080.09961.448386.59445.48331.446
2493.16280.2851.27718.57334.16692.4339-1.1870.5276-0.45191.01080.35443.10350.51310.86461.05371.5496-0.17490.18322.8297-0.05652.512682.70757.443322.338
2501.342-1.8654-0.61422.58610.98012.8917-0.4430.37911.26540.8553-0.00681.02780.2445-0.67860.33212.0106-0.3510.54522.22650.85623.244288.8842.022312.726
2514.1901-2.7585-4.00343.21590.74696.44640.9679-1.3149-0.09812.39940.94714.3828-0.08530.1198-1.7771.73050.39020.38342.09620.09692.2976101.63445.563315.969
2524.07962.04675.12238.88823.19666.5496-0.4035-0.6985-0.33551.5203-0.98390.9913-1.415-1.78410.72362.00890.01090.64132.20490.38811.0357106.36246.365325.645
2530.63952.44870.82279.37343.1481.05741.54520.06590.553-0.6005-1.97121.4852-1.6964-2.50120.09981.5190.61220.5352.70940.09751.2388106.25453.452322.425
2540.84610.34090.86390.28930.71571.76520.0981-0.0538-1.0895-0.61820.2597-1.33830.567-0.1764-0.04582.88290.0610.12320.83040.51222.3654125.99348.043330.213
2552.93911.1661-0.23484.6541-2.7991.75821.10941.05910.6717-1.2544-0.40770.5110.0703-0.387-0.62552.57621.27570.90272.57910.9321.7331107.93956.037315.995
2564.43665.17081.25268.2782.29730.6641-0.49120.2380.10320.3735-1.3307-0.9473-1.11971.8435-0.61082.80580.02510.82741.31220.65161.7982118.90861.519322.879
2570.7870.58770.89284.52591.72771.27980.41720.1213-0.83130.25540.2464-0.28850.22310.10520.82941.9620.90710.59280.82640.23031.8501118.32649.442317.555
2581.87731.0064-1.23090.9205-1.92865.1166-0.09750.1920.0889-0.21350.1952-0.0249-1.1065-0.1745-0.91173.76010.4461.60261.37550.45482.1139129.27460.189316.469
2597.27726.39414.24926.32763.5792.51311.3823-1.3165-2.46051.1388-0.8445-0.5076-0.0229-3.2652-0.32891.20110.12060.50031.75570.53522.157135.39964.121322.931
2604.0103-0.82521.38320.86680.50061.9306-0.2695-1.7064-0.72850.63020.17510.17620.4482-0.5736-0.07551.66710.1791-0.03751.18340.33170.5598122.38255.85334.92
2614.20682.0924-1.06431.53921.44787.2720.1828-0.53540.171-0.22780.6552-0.5141-0.63011.6216-0.80871.1692-0.0483-0.13671.14320.20492.129289.372-50.565372.903
2621.0106-0.2438-0.44040.89950.07231.0242-0.26910.7272-0.0598-0.0716-0.6258-1.09720.96990.0953-1.73880.97220.5291-0.15050.14830.86151.658178.513-71.129371.279
2630.22370.4992-0.21652.43762.11524.6106-0.3713-0.2837-0.416-0.20560.608-1.4792-0.1811.8528-0.48250.95950.34780.44641.51270.30882.4663100.092-63.929350.312
2642.4825-0.0046-0.22751.75770.82985.18440.1239-0.4469-0.3919-0.49410.4972-0.3726-0.11011.0062-0.661.65120.22810.55940.7446-0.07341.44171.471-55.136326.719
2650.74480.98840.42175.1011-3.0494.25510.03861.00951.0678-0.61070.61870.37281.4529-1.672-0.16572.9818-0.60871.43821.4974-0.21152.128968.052-50.877316.158
2666.09072.6479-1.9666.0458-2.65713.4389-0.51350.4873-0.6654-0.90970.3612-0.3830.8024-0.18860.73091.46770.26760.22790.4020.1561.00758.55-42.634326.403
2673.3025-3.2228-5.03548.57173.00588.55231.5618-0.00342.3422-1.17460.2303-0.77220.125-0.194-1.92791.726-0.1040.18881.09790.14912.269442.689-66.39331.506
2685.59741.47012.39821.9957-1.95635.08560.03050.3906-0.2481-0.47320.2075-0.45840.2705-0.412-0.41451.29360.13730.50770.6307-0.04311.238159.237-45.822335.389
2698.29092.6163-0.36597.99684.62487.57660.2623-0.25592.60420.5514-0.0999-0.242-1.4352-0.15880.20661.3485-0.10170.08860.3834-0.02011.150460.413-29.517337.167
2704.42444.1846-1.6086.4061-0.33021.14741.19560.49180.8165-0.0226-0.72910.6474-0.8524-1.2505-0.3371.72080.0882-0.32131.16190.14920.811949.862-41.097323.795
2714.691-0.3239-2.0263.20281.89397.26930.3368-0.42910.9317-0.81780.4033-0.3103-0.34351.3465-0.65371.22220.28520.32720.56950.27621.462971.033-45.686326.978
2720.452-0.13290.63220.0876-0.12931.485-0.2864-0.319-0.4955-0.21040.1801-1.00570.5093-0.0005-0.09061.40920.24090.46910.82570.5533.058885.614-72.123352.932
2737.24872.59671.12871.17110.96841.5613-1.55491.1072-1.8586-0.06081.78941.08570.5620.6714-0.2582.206-0.08820.7071.0384-0.35912.474897.579-88.405324.37
2740.2045-0.03120.74822.8181.20093.29990.26950.84111.5723-1.31630.8212-1.1861-0.63311.2696-0.33091.69960.01411.07931.37460.42632.335297.48-83.305321.534
2757.6079-1.8397-0.86934.14844.6946.8401-0.1839-0.1704-0.7623-3.02841.558-2.46520.4371-1.0853-1.23252.71610.1260.44681.36960.41441.755381.757-85.536324.834
2769.0695-0.52470.40590.6258-2.10017.27511.39351.49292.1844-0.1268-1.2695-0.2434-1.311.312-0.471.38680.04590.7471.63980.07481.178977.158-84.109315.785
2775.9186-0.48362.48531.3608-1.00252.8165-0.14390.3622-0.879-0.58841.0927-0.2623-1.0438-0.4457-0.53381.4248-0.30121.01071.11960.0031.492667.374-79.525315.464
2784.2889-2.8973-2.42954.8422-0.32352.7196-1.53810.64340.0356-0.2041-0.5653-0.13671.78150.58711.99862.2976-0.69540.61382.23170.03532.073472.314-73.269316.657
2797.0927-4.9176-3.63014.17674.20395.56891.3326-1.41335.1731-3.23671.79290.0255-1.07491.6724-3.15773.4616-1.29220.83132.4977-0.37292.38179.165-75.496332.532
2802.6214-2.76583.99155.1549-5.78451.9973-0.19910.43111.1921-0.6295-1.4456-0.64150.05221.21480.41092.535-0.11290.92740.84820.17021.93264.991-68.803319.157
2810.1470.1957-0.10620.2587-0.23980.58820.2066-0.10290.19590.29240.02680.1162-0.6573-0.01620.54562.5165-0.94180.73650.47980.01051.708261.837-76.872325.445
2822.3604-2.15870.662.5643-2.92289.7747-0.6554-0.0777-0.1389-1.4059-0.46011.72551.42771.85090.92851.5291-0.03840.11511.5812-0.2891.499448.659-66.079319.702
2834.2073.10423.11734.51183.40924.6128-1.25081.29680.3479-4.5510.5438-0.6382-0.40421.10540.67882.8310.07490.40271.9288-0.07071.30354.715-69.955309.039
2845.3229-4.25065.02653.3993-4.00084.8248-0.70710.94980.8244-1.4788-0.1896-2.3831-0.84890.15950.24272.1172-0.4190.83710.9819-0.36581.615869.574-81.31305.248
2858.1195-1.90643.22734.8469-5.18535.7373-0.04080.5374-0.57-2.8649-0.9808-0.15771.85831.35280.27133.11590.4627-0.32121.42880.71321.7939121.15131.333314.69
2867.88021.36531.99951.1069-1.57384.7411.0307-1.8948-0.06320.07980.66821.2215-0.1422-0.2194-1.44531.3332-0.78540.44652.7664-1.03242.8835118.26835.653308.689
2873.75483.8737-0.18874.0047-0.12830.5054-1.2572-1.72070.1560.466-0.33060.99330.88490.44121.18451.82411.07690.17182.8612-0.77512.3715133.18728.268314.675
2880.33210.0725-0.22952.4697-3.7226.72520.25641.685-1.1344-1.0667-0.8775-1.75512.80171.26820.46511.88510.7187-0.17011.8614-0.57491.7253129.13838.627305.649
2896.71762.21333.79082.80014.52387.31771.6357-1.59440.4731-4.0317-0.6877-0.1035-0.1869-1.0951-1.15853.2492-0.49970.32541.58610.14921.7586126.18342.694315.343
2903.9577-2.9354-4.70042.28042.81659.75792.5710.10222.56513.8054-1.32910.8974-1.69660.0767-1.44922.83380.17410.68471.5007-0.35043.054132.55640.786319.863
2915.9773-2.69322.38842.6522-0.14092.8394-0.38960.0995-0.35270.2653-0.557-0.7704-0.39880.28090.72022.97521.26440.63321.89060.76082.5146132.04533.885322.746
2922.2335-0.01380.83525.4885-5.25355.33031.98652.03733.71762.6215-0.82060.2862-6.85071.9026-0.99673.7557-0.38680.51742.20690.08323.1898122.98928.63321.093
2932.6003-1.65281.28394.8481-0.94470.6386-0.4793-0.4622-1.76432.13820.48441.27420.624-0.02170.19662.52640.64140.47041.0735-0.19352.0752121.43740.709314.932
2943.3862-4.26132.17565.9013-4.59258.7613-1.8008-0.23650.75760.3015-0.06311.69872.9767-0.27221.40952.26970.14720.57641.7952-0.20162.254765.312-94.885330.123
2951.13722.82682.09667.44144.37488.103-0.012-0.1045-0.46620.75480.19850.51341.4091-0.47970.15191.5409-0.1909-0.2860.77850.24192.602663.569-99.84332.395
2967.5818-1.605-4.21152.82231.4753.72130.01170.34671.2261-0.43350.78910.670.54120.4273-0.40083.076-0.86921.18044.38870.65142.396650.883-101.93328.001
2977.1562-2.1971.38092.0099-1.05596.42331.74140.16321.8646-0.9772-1.1213-0.6105-1.08750.6067-0.32172.9510.30610.92891.99460.37992.532455.531-94.384336.085
2986.31631.44364.8990.32981.11256.10451.09580.17082.4371-0.3555-1.53-0.7918-0.19270.95290.21812.8102-0.46231.06961.48880.26062.338356.908-85.958334.694
2992.46912.2125-0.79573.8895-2.14911.3378-0.011-0.10490.39191.86380.28031.2338-1.609-0.4281-0.26473.2751.09261.37672.56651.42542.930452.058-89.037322.851
3005.3802-1.52895.48246.6431.60227.19160.97611.0391.3445-0.66330.0772-0.52192.1876-1.3329-0.1682.22020.11310.98531.42750.73112.074854.989-98.779320.647
3016.71892.34380.43042.61740.35359.4746-1.4514-0.1775-1.858-2.2446-1.0387-0.4133.1881.5972.332.6935-0.59050.78281.49940.38531.699462.355-90.782326.555
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN N AND RESID -3:6 )N-3 - 6
2X-RAY DIFFRACTION2( CHAIN N AND RESID 7:22 )N7 - 22
3X-RAY DIFFRACTION3( CHAIN N AND RESID 23:33 )N23 - 33
4X-RAY DIFFRACTION4( CHAIN N AND RESID 34:44 )N34 - 44
5X-RAY DIFFRACTION5( CHAIN N AND RESID 45:76 )N45 - 76
6X-RAY DIFFRACTION6( CHAIN D AND RESID 12:147 )D12 - 147
7X-RAY DIFFRACTION7( CHAIN D AND RESID 148:253 )D148 - 253
8X-RAY DIFFRACTION8( CHAIN D AND RESID 254:401 )D254 - 401
9X-RAY DIFFRACTION9( CHAIN D AND RESID 402:588 )D402 - 588
10X-RAY DIFFRACTION10( CHAIN D AND RESID 589:646 )D589 - 646
11X-RAY DIFFRACTION11( CHAIN D AND RESID 650:661 )D650 - 661
12X-RAY DIFFRACTION12( CHAIN D AND RESID 662:694 )D662 - 694
13X-RAY DIFFRACTION13( CHAIN D AND RESID 695:704 )D695 - 704
14X-RAY DIFFRACTION14( CHAIN D AND RESID 705:719 )D705 - 719
15X-RAY DIFFRACTION15( CHAIN D AND RESID 720:745 )D720 - 745
16X-RAY DIFFRACTION16( CHAIN D AND RESID 752:764 )D752 - 764
17X-RAY DIFFRACTION17( CHAIN D AND RESID 765:773 )D765 - 773
18X-RAY DIFFRACTION18( CHAIN D AND RESID 797:813 )D797 - 813
19X-RAY DIFFRACTION19( CHAIN D AND RESID 814:844 )D814 - 844
20X-RAY DIFFRACTION20( CHAIN D AND RESID 845:866 )D845 - 866
21X-RAY DIFFRACTION21( CHAIN D AND RESID 867:938 )D867 - 938
22X-RAY DIFFRACTION22( CHAIN D AND RESID 939:1024 )D939 - 1024
23X-RAY DIFFRACTION23( CHAIN F AND RESID 7:19 )F7 - 19
24X-RAY DIFFRACTION24( CHAIN F AND RESID 20:28 )F20 - 28
25X-RAY DIFFRACTION25( CHAIN F AND RESID 29:36 )F29 - 36
26X-RAY DIFFRACTION26( CHAIN F AND RESID 37:59 )F37 - 59
27X-RAY DIFFRACTION27( CHAIN F AND RESID 60:65 )F60 - 65
28X-RAY DIFFRACTION28( CHAIN F AND RESID 66:79 )F66 - 79
29X-RAY DIFFRACTION29( CHAIN F AND RESID 80:94 )F80 - 94
30X-RAY DIFFRACTION30( CHAIN F AND RESID 117:133 )F117 - 133
31X-RAY DIFFRACTION31( CHAIN F AND RESID 134:142 )F134 - 142
32X-RAY DIFFRACTION32( CHAIN F AND RESID 143:152 )F143 - 152
33X-RAY DIFFRACTION33( CHAIN F AND RESID 153:167 )F153 - 167
34X-RAY DIFFRACTION34( CHAIN F AND RESID 168:179 )F168 - 179
35X-RAY DIFFRACTION35( CHAIN A AND RESID 12:588 )A12 - 588
36X-RAY DIFFRACTION36( CHAIN A AND RESID 589:645 )A589 - 645
37X-RAY DIFFRACTION37( CHAIN A AND RESID 652:661 )A652 - 661
38X-RAY DIFFRACTION38( CHAIN A AND RESID 662:684 )A662 - 684
39X-RAY DIFFRACTION39( CHAIN A AND RESID 685:699 )A685 - 699
40X-RAY DIFFRACTION40( CHAIN A AND RESID 700:704 )A700 - 704
41X-RAY DIFFRACTION41( CHAIN A AND RESID 705:719 )A705 - 719
42X-RAY DIFFRACTION42( CHAIN A AND RESID 720:745 )A720 - 745
43X-RAY DIFFRACTION43( CHAIN A AND RESID 752:764 )A752 - 764
44X-RAY DIFFRACTION44( CHAIN A AND RESID 765:773 )A765 - 773
45X-RAY DIFFRACTION45( CHAIN A AND RESID 798:829 )A798 - 829
46X-RAY DIFFRACTION46( CHAIN A AND RESID 830:866 )A830 - 866
47X-RAY DIFFRACTION47( CHAIN A AND RESID 867:909 )A867 - 909
48X-RAY DIFFRACTION48( CHAIN A AND RESID 910:970 )A910 - 970
49X-RAY DIFFRACTION49( CHAIN A AND RESID 971:981 )A971 - 981
50X-RAY DIFFRACTION50( CHAIN A AND RESID 982:999 )A982 - 999
51X-RAY DIFFRACTION51( CHAIN A AND RESID 1000:1024 )A1000 - 1024
52X-RAY DIFFRACTION52( CHAIN B AND RESID 6:28 )B6 - 28
53X-RAY DIFFRACTION53( CHAIN B AND RESID 29:58 )B29 - 58
54X-RAY DIFFRACTION54( CHAIN B AND RESID 59:79 )B59 - 79
55X-RAY DIFFRACTION55( CHAIN B AND RESID 80:94 )B80 - 94
56X-RAY DIFFRACTION56( CHAIN B AND RESID 117:133 )B117 - 133
57X-RAY DIFFRACTION57( CHAIN B AND RESID 134:142 )B134 - 142
58X-RAY DIFFRACTION58( CHAIN B AND RESID 143:152 )B143 - 152
59X-RAY DIFFRACTION59( CHAIN B AND RESID 153:179 )B153 - 179
60X-RAY DIFFRACTION60( CHAIN C AND RESID 12:588 )C12 - 588
61X-RAY DIFFRACTION61( CHAIN C AND RESID 589:645 )C589 - 645
62X-RAY DIFFRACTION62( CHAIN C AND RESID 650:662 )C650 - 662
63X-RAY DIFFRACTION63( CHAIN C AND RESID 663:683 )C663 - 683
64X-RAY DIFFRACTION64( CHAIN C AND RESID 684:699 )C684 - 699
65X-RAY DIFFRACTION65( CHAIN C AND RESID 700:704 )C700 - 704
66X-RAY DIFFRACTION66( CHAIN C AND RESID 705:709 )C705 - 709
67X-RAY DIFFRACTION67( CHAIN C AND RESID 710:724 )C710 - 724
68X-RAY DIFFRACTION68( CHAIN C AND RESID 725:745 )C725 - 745
69X-RAY DIFFRACTION69( CHAIN C AND RESID 752:763 )C752 - 763
70X-RAY DIFFRACTION70( CHAIN C AND RESID 764:773 )C764 - 773
71X-RAY DIFFRACTION71( CHAIN C AND RESID 797:812 )C797 - 812
72X-RAY DIFFRACTION72( CHAIN C AND RESID 813:844 )C813 - 844
73X-RAY DIFFRACTION73( CHAIN C AND RESID 845:866 )C845 - 866
74X-RAY DIFFRACTION74( CHAIN C AND RESID 867:909 )C867 - 909
75X-RAY DIFFRACTION75( CHAIN C AND RESID 910:925 )C910 - 925
76X-RAY DIFFRACTION76( CHAIN C AND RESID 926:981 )C926 - 981
77X-RAY DIFFRACTION77( CHAIN C AND RESID 982:1024 )C982 - 1024
78X-RAY DIFFRACTION78( CHAIN E AND RESID 7:47 )E7 - 47
79X-RAY DIFFRACTION79( CHAIN E AND RESID 48:65 )E48 - 65
80X-RAY DIFFRACTION80( CHAIN E AND RESID 66:79 )E66 - 79
81X-RAY DIFFRACTION81( CHAIN E AND RESID 80:94 )E80 - 94
82X-RAY DIFFRACTION82( CHAIN E AND RESID 117:142 )E117 - 142
83X-RAY DIFFRACTION83( CHAIN E AND RESID 143:152 )E143 - 152
84X-RAY DIFFRACTION84( CHAIN E AND RESID 153:165 )E153 - 165
85X-RAY DIFFRACTION85( CHAIN E AND RESID 166:179 )E166 - 179
86X-RAY DIFFRACTION86( CHAIN G AND RESID 12:166 )G12 - 166
87X-RAY DIFFRACTION87( CHAIN G AND RESID 167:197 )G167 - 197
88X-RAY DIFFRACTION88( CHAIN G AND RESID 198:268 )G198 - 268
89X-RAY DIFFRACTION89( CHAIN G AND RESID 269:401 )G269 - 401
90X-RAY DIFFRACTION90( CHAIN G AND RESID 402:545 )G402 - 545
91X-RAY DIFFRACTION91( CHAIN G AND RESID 546:591 )G546 - 591
92X-RAY DIFFRACTION92( CHAIN G AND RESID 600:603 )G600 - 603
93X-RAY DIFFRACTION93( CHAIN G AND RESID 604:608 )G604 - 608
94X-RAY DIFFRACTION94( CHAIN G AND RESID 609:624 )G609 - 624
95X-RAY DIFFRACTION95( CHAIN G AND RESID 625:636 )G625 - 636
96X-RAY DIFFRACTION96( CHAIN G AND RESID 637:646 )G637 - 646
97X-RAY DIFFRACTION97( CHAIN G AND RESID 650:663 )G650 - 663
98X-RAY DIFFRACTION98( CHAIN G AND RESID 664:668 )G664 - 668
99X-RAY DIFFRACTION99( CHAIN G AND RESID 669:684 )G669 - 684
100X-RAY DIFFRACTION100( CHAIN G AND RESID 685:699 )G685 - 699
101X-RAY DIFFRACTION101( CHAIN G AND RESID 700:704 )G700 - 704
102X-RAY DIFFRACTION102( CHAIN G AND RESID 705:714 )G705 - 714
103X-RAY DIFFRACTION103( CHAIN G AND RESID 715:724 )G715 - 724
104X-RAY DIFFRACTION104( CHAIN G AND RESID 725:745 )G725 - 745
105X-RAY DIFFRACTION105( CHAIN G AND RESID 752:763 )G752 - 763
106X-RAY DIFFRACTION106( CHAIN G AND RESID 764:773 )G764 - 773
107X-RAY DIFFRACTION107( CHAIN G AND RESID 797:829 )G797 - 829
108X-RAY DIFFRACTION108( CHAIN G AND RESID 830:866 )G830 - 866
109X-RAY DIFFRACTION109( CHAIN G AND RESID 867:909 )G867 - 909
110X-RAY DIFFRACTION110( CHAIN G AND RESID 910:961 )G910 - 961
111X-RAY DIFFRACTION111( CHAIN G AND RESID 962:1024 )G962 - 1024
112X-RAY DIFFRACTION112( CHAIN H AND RESID 7:20 )H7 - 20
113X-RAY DIFFRACTION113( CHAIN H AND RESID 21:47 )H21 - 47
114X-RAY DIFFRACTION114( CHAIN H AND RESID 48:65 )H48 - 65
115X-RAY DIFFRACTION115( CHAIN H AND RESID 66:79 )H66 - 79
116X-RAY DIFFRACTION116( CHAIN H AND RESID 80:94 )H80 - 94
117X-RAY DIFFRACTION117( CHAIN H AND RESID 118:142 )H118 - 142
118X-RAY DIFFRACTION118( CHAIN H AND RESID 143:152 )H143 - 152
119X-RAY DIFFRACTION119( CHAIN H AND RESID 153:167 )H153 - 167
120X-RAY DIFFRACTION120( CHAIN H AND RESID 168:179 )H168 - 179
121X-RAY DIFFRACTION121( CHAIN I AND RESID 12:102 )I12 - 102
122X-RAY DIFFRACTION122( CHAIN I AND RESID 103:133 )I103 - 133
123X-RAY DIFFRACTION123( CHAIN I AND RESID 134:185 )I134 - 185
124X-RAY DIFFRACTION124( CHAIN I AND RESID 186:249 )I186 - 249
125X-RAY DIFFRACTION125( CHAIN I AND RESID 250:287 )I250 - 287
126X-RAY DIFFRACTION126( CHAIN I AND RESID 288:332 )I288 - 332
127X-RAY DIFFRACTION127( CHAIN I AND RESID 333:411 )I333 - 411
128X-RAY DIFFRACTION128( CHAIN I AND RESID 412:545 )I412 - 545
129X-RAY DIFFRACTION129( CHAIN I AND RESID 546:590 )I546 - 590
130X-RAY DIFFRACTION130( CHAIN I AND RESID 599:608 )I599 - 608
131X-RAY DIFFRACTION131( CHAIN I AND RESID 609:624 )I609 - 624
132X-RAY DIFFRACTION132( CHAIN I AND RESID 625:634 )I625 - 634
133X-RAY DIFFRACTION133( CHAIN I AND RESID 635:640 )I635 - 640
134X-RAY DIFFRACTION134( CHAIN I AND RESID 641:646 )I641 - 646
135X-RAY DIFFRACTION135( CHAIN I AND RESID 650:684 )I650 - 684
136X-RAY DIFFRACTION136( CHAIN I AND RESID 685:699 )I685 - 699
137X-RAY DIFFRACTION137( CHAIN I AND RESID 700:724 )I700 - 724
138X-RAY DIFFRACTION138( CHAIN I AND RESID 725:745 )I725 - 745
139X-RAY DIFFRACTION139( CHAIN I AND RESID 752:763 )I752 - 763
140X-RAY DIFFRACTION140( CHAIN I AND RESID 764:773 )I764 - 773
141X-RAY DIFFRACTION141( CHAIN I AND RESID 797:844 )I797 - 844
142X-RAY DIFFRACTION142( CHAIN I AND RESID 845:866 )I845 - 866
143X-RAY DIFFRACTION143( CHAIN I AND RESID 867:949 )I867 - 949
144X-RAY DIFFRACTION144( CHAIN I AND RESID 950:1024 )I950 - 1024
145X-RAY DIFFRACTION145( CHAIN J AND RESID 6:18 )J6 - 18
146X-RAY DIFFRACTION146( CHAIN J AND RESID 19:28 )J19 - 28
147X-RAY DIFFRACTION147( CHAIN J AND RESID 29:58 )J29 - 58
148X-RAY DIFFRACTION148( CHAIN J AND RESID 59:75 )J59 - 75
149X-RAY DIFFRACTION149( CHAIN J AND RESID 76:98 )J76 - 98
150X-RAY DIFFRACTION150( CHAIN J AND RESID 118:133 )J118 - 133
151X-RAY DIFFRACTION151( CHAIN J AND RESID 134:152 )J134 - 152
152X-RAY DIFFRACTION152( CHAIN J AND RESID 153:167 )J153 - 167
153X-RAY DIFFRACTION153( CHAIN J AND RESID 168:180 )J168 - 180
154X-RAY DIFFRACTION154( CHAIN K AND RESID 12:102 )K12 - 102
155X-RAY DIFFRACTION155( CHAIN K AND RESID 103:173 )K103 - 173
156X-RAY DIFFRACTION156( CHAIN K AND RESID 174:259 )K174 - 259
157X-RAY DIFFRACTION157( CHAIN K AND RESID 260:287 )K260 - 287
158X-RAY DIFFRACTION158( CHAIN K AND RESID 288:332 )K288 - 332
159X-RAY DIFFRACTION159( CHAIN K AND RESID 333:411 )K333 - 411
160X-RAY DIFFRACTION160( CHAIN K AND RESID 412:559 )K412 - 559
161X-RAY DIFFRACTION161( CHAIN K AND RESID 560:589 )K560 - 589
162X-RAY DIFFRACTION162( CHAIN K AND RESID 599:608 )K599 - 608
163X-RAY DIFFRACTION163( CHAIN K AND RESID 609:624 )K609 - 624
164X-RAY DIFFRACTION164( CHAIN K AND RESID 625:634 )K625 - 634
165X-RAY DIFFRACTION165( CHAIN K AND RESID 635:646 )K635 - 646
166X-RAY DIFFRACTION166( CHAIN K AND RESID 650:663 )K650 - 663
167X-RAY DIFFRACTION167( CHAIN K AND RESID 664:668 )K664 - 668
168X-RAY DIFFRACTION168( CHAIN K AND RESID 669:684 )K669 - 684
169X-RAY DIFFRACTION169( CHAIN K AND RESID 685:699 )K685 - 699
170X-RAY DIFFRACTION170( CHAIN K AND RESID 700:704 )K700 - 704
171X-RAY DIFFRACTION171( CHAIN K AND RESID 705:709 )K705 - 709
172X-RAY DIFFRACTION172( CHAIN K AND RESID 710:719 )K710 - 719
173X-RAY DIFFRACTION173( CHAIN K AND RESID 720:745 )K720 - 745
174X-RAY DIFFRACTION174( CHAIN K AND RESID 752:763 )K752 - 763
175X-RAY DIFFRACTION175( CHAIN K AND RESID 764:773 )K764 - 773
176X-RAY DIFFRACTION176( CHAIN K AND RESID 797:844 )K797 - 844
177X-RAY DIFFRACTION177( CHAIN K AND RESID 845:866 )K845 - 866
178X-RAY DIFFRACTION178( CHAIN K AND RESID 867:938 )K867 - 938
179X-RAY DIFFRACTION179( CHAIN K AND RESID 939:1024 )K939 - 1024
180X-RAY DIFFRACTION180( CHAIN L AND RESID 7:18 )L7 - 18
181X-RAY DIFFRACTION181( CHAIN L AND RESID 19:28 )L19 - 28
182X-RAY DIFFRACTION182( CHAIN L AND RESID 29:37 )L29 - 37
183X-RAY DIFFRACTION183( CHAIN L AND RESID 38:58 )L38 - 58
184X-RAY DIFFRACTION184( CHAIN L AND RESID 59:75 )L59 - 75
185X-RAY DIFFRACTION185( CHAIN L AND RESID 76:98 )L76 - 98
186X-RAY DIFFRACTION186( CHAIN L AND RESID 118:142 )L118 - 142
187X-RAY DIFFRACTION187( CHAIN L AND RESID 143:167 )L143 - 167
188X-RAY DIFFRACTION188( CHAIN L AND RESID 168:179 )L168 - 179
189X-RAY DIFFRACTION189( CHAIN M AND RESID 0:6 )M0 - 6
190X-RAY DIFFRACTION190( CHAIN M AND RESID 7:11 )M7 - 11
191X-RAY DIFFRACTION191( CHAIN M AND RESID 12:17 )M12 - 17
192X-RAY DIFFRACTION192( CHAIN M AND RESID 18:22 )M18 - 22
193X-RAY DIFFRACTION193( CHAIN M AND RESID 23:36 )M23 - 36
194X-RAY DIFFRACTION194( CHAIN M AND RESID 37:41 )M37 - 41
195X-RAY DIFFRACTION195( CHAIN M AND RESID 42:51 )M42 - 51
196X-RAY DIFFRACTION196( CHAIN M AND RESID 52:71 )M52 - 71
197X-RAY DIFFRACTION197( CHAIN O AND RESID 1:6 )O1 - 6
198X-RAY DIFFRACTION198( CHAIN O AND RESID 7:16 )O7 - 16
199X-RAY DIFFRACTION199( CHAIN O AND RESID 17:22 )O17 - 22
200X-RAY DIFFRACTION200( CHAIN O AND RESID 23:33 )O23 - 33
201X-RAY DIFFRACTION201( CHAIN O AND RESID 34:59 )O34 - 59
202X-RAY DIFFRACTION202( CHAIN O AND RESID 60:64 )O60 - 64
203X-RAY DIFFRACTION203( CHAIN O AND RESID 65:73 )O65 - 73
204X-RAY DIFFRACTION204( CHAIN P AND RESID -3:6 )P-3 - 6
205X-RAY DIFFRACTION205( CHAIN P AND RESID 7:22 )P7 - 22
206X-RAY DIFFRACTION206( CHAIN P AND RESID 23:33 )P23 - 33
207X-RAY DIFFRACTION207( CHAIN P AND RESID 34:44 )P34 - 44
208X-RAY DIFFRACTION208( CHAIN P AND RESID 45:56 )P45 - 56
209X-RAY DIFFRACTION209( CHAIN P AND RESID 57:65 )P57 - 65
210X-RAY DIFFRACTION210( CHAIN P AND RESID 66:76 )P66 - 76
211X-RAY DIFFRACTION211( CHAIN Q AND RESID 1:15 )Q1 - 15
212X-RAY DIFFRACTION212( CHAIN Q AND RESID 16:22 )Q16 - 22
213X-RAY DIFFRACTION213( CHAIN Q AND RESID 23:39 )Q23 - 39
214X-RAY DIFFRACTION214( CHAIN Q AND RESID 40:70 )Q40 - 70
215X-RAY DIFFRACTION215( CHAIN R AND RESID 1:6 )R1 - 6
216X-RAY DIFFRACTION216( CHAIN R AND RESID 7:11 )R7 - 11
217X-RAY DIFFRACTION217( CHAIN R AND RESID 12:22 )R12 - 22
218X-RAY DIFFRACTION218( CHAIN R AND RESID 23:34 )R23 - 34
219X-RAY DIFFRACTION219( CHAIN R AND RESID 35:44 )R35 - 44
220X-RAY DIFFRACTION220( CHAIN R AND RESID 45:54 )R45 - 54
221X-RAY DIFFRACTION221( CHAIN R AND RESID 55:64 )R55 - 64
222X-RAY DIFFRACTION222( CHAIN R AND RESID 65:73 )R65 - 73
223X-RAY DIFFRACTION223( CHAIN S AND RESID 12:45 )S12 - 45
224X-RAY DIFFRACTION224( CHAIN S AND RESID 46:147 )S46 - 147
225X-RAY DIFFRACTION225( CHAIN S AND RESID 148:332 )S148 - 332
226X-RAY DIFFRACTION226( CHAIN S AND RESID 333:411 )S333 - 411
227X-RAY DIFFRACTION227( CHAIN S AND RESID 412:545 )S412 - 545
228X-RAY DIFFRACTION228( CHAIN S AND RESID 546:588 )S546 - 588
229X-RAY DIFFRACTION229( CHAIN S AND RESID 589:645 )S589 - 645
230X-RAY DIFFRACTION230( CHAIN S AND RESID 650:661 )S650 - 661
231X-RAY DIFFRACTION231( CHAIN S AND RESID 662:668 )S662 - 668
232X-RAY DIFFRACTION232( CHAIN S AND RESID 669:684 )S669 - 684
233X-RAY DIFFRACTION233( CHAIN S AND RESID 685:694 )S685 - 694
234X-RAY DIFFRACTION234( CHAIN S AND RESID 695:699 )S695 - 699
235X-RAY DIFFRACTION235( CHAIN S AND RESID 700:704 )S700 - 704
236X-RAY DIFFRACTION236( CHAIN S AND RESID 705:719 )S705 - 719
237X-RAY DIFFRACTION237( CHAIN S AND RESID 720:745 )S720 - 745
238X-RAY DIFFRACTION238( CHAIN S AND RESID 752:763 )S752 - 763
239X-RAY DIFFRACTION239( CHAIN S AND RESID 764:773 )S764 - 773
240X-RAY DIFFRACTION240( CHAIN S AND RESID 798:814 )S798 - 814
241X-RAY DIFFRACTION241( CHAIN S AND RESID 815:844 )S815 - 844
242X-RAY DIFFRACTION242( CHAIN S AND RESID 845:866 )S845 - 866
243X-RAY DIFFRACTION243( CHAIN S AND RESID 867:909 )S867 - 909
244X-RAY DIFFRACTION244( CHAIN S AND RESID 910:925 )S910 - 925
245X-RAY DIFFRACTION245( CHAIN S AND RESID 926:938 )S926 - 938
246X-RAY DIFFRACTION246( CHAIN S AND RESID 939:949 )S939 - 949
247X-RAY DIFFRACTION247( CHAIN S AND RESID 950:970 )S950 - 970
248X-RAY DIFFRACTION248( CHAIN S AND RESID 971:981 )S971 - 981
249X-RAY DIFFRACTION249( CHAIN S AND RESID 982:999 )S982 - 999
250X-RAY DIFFRACTION250( CHAIN S AND RESID 1000:1024 )S1000 - 1024
251X-RAY DIFFRACTION251( CHAIN T AND RESID 6:20 )T6 - 20
252X-RAY DIFFRACTION252( CHAIN T AND RESID 21:37 )T21 - 37
253X-RAY DIFFRACTION253( CHAIN T AND RESID 38:47 )T38 - 47
254X-RAY DIFFRACTION254( CHAIN T AND RESID 48:58 )T48 - 58
255X-RAY DIFFRACTION255( CHAIN T AND RESID 59:75 )T59 - 75
256X-RAY DIFFRACTION256( CHAIN T AND RESID 76:88 )T76 - 88
257X-RAY DIFFRACTION257( CHAIN T AND RESID 119:133 )T119 - 133
258X-RAY DIFFRACTION258( CHAIN T AND RESID 134:142 )T134 - 142
259X-RAY DIFFRACTION259( CHAIN T AND RESID 143:152 )T143 - 152
260X-RAY DIFFRACTION260( CHAIN T AND RESID 153:178 )T153 - 178
261X-RAY DIFFRACTION261( CHAIN U AND RESID 12:147 )U12 - 147
262X-RAY DIFFRACTION262( CHAIN U AND RESID 148:411 )U148 - 411
263X-RAY DIFFRACTION263( CHAIN U AND RESID 412:588 )U412 - 588
264X-RAY DIFFRACTION264( CHAIN U AND RESID 589:646 )U589 - 646
265X-RAY DIFFRACTION265( CHAIN U AND RESID 650:661 )U650 - 661
266X-RAY DIFFRACTION266( CHAIN U AND RESID 662:694 )U662 - 694
267X-RAY DIFFRACTION267( CHAIN U AND RESID 695:704 )U695 - 704
268X-RAY DIFFRACTION268( CHAIN U AND RESID 705:745 )U705 - 745
269X-RAY DIFFRACTION269( CHAIN U AND RESID 752:763 )U752 - 763
270X-RAY DIFFRACTION270( CHAIN U AND RESID 764:773 )U764 - 773
271X-RAY DIFFRACTION271( CHAIN U AND RESID 797:844 )U797 - 844
272X-RAY DIFFRACTION272( CHAIN U AND RESID 845:925 )U845 - 925
273X-RAY DIFFRACTION273( CHAIN U AND RESID 926:970 )U926 - 970
274X-RAY DIFFRACTION274( CHAIN U AND RESID 971:1024 )U971 - 1024
275X-RAY DIFFRACTION275( CHAIN V AND RESID 7:20 )V7 - 20
276X-RAY DIFFRACTION276( CHAIN V AND RESID 21:37 )V21 - 37
277X-RAY DIFFRACTION277( CHAIN V AND RESID 38:58 )V38 - 58
278X-RAY DIFFRACTION278( CHAIN V AND RESID 59:65 )V59 - 65
279X-RAY DIFFRACTION279( CHAIN V AND RESID 66:75 )V66 - 75
280X-RAY DIFFRACTION280( CHAIN V AND RESID 76:88 )V76 - 88
281X-RAY DIFFRACTION281( CHAIN V AND RESID 118:142 )V118 - 142
282X-RAY DIFFRACTION282( CHAIN V AND RESID 143:152 )V143 - 152
283X-RAY DIFFRACTION283( CHAIN V AND RESID 153:167 )V153 - 167
284X-RAY DIFFRACTION284( CHAIN V AND RESID 168:179 )V168 - 179
285X-RAY DIFFRACTION285( CHAIN W AND RESID 1:6 )W1 - 6
286X-RAY DIFFRACTION286( CHAIN W AND RESID 7:16 )W7 - 16
287X-RAY DIFFRACTION287( CHAIN W AND RESID 17:22 )W17 - 22
288X-RAY DIFFRACTION288( CHAIN W AND RESID 23:40 )W23 - 40
289X-RAY DIFFRACTION289( CHAIN W AND RESID 41:45 )W41 - 45
290X-RAY DIFFRACTION290( CHAIN W AND RESID 46:55 )W46 - 55
291X-RAY DIFFRACTION291( CHAIN W AND RESID 56:60 )W56 - 60
292X-RAY DIFFRACTION292( CHAIN W AND RESID 61:65 )W61 - 65
293X-RAY DIFFRACTION293( CHAIN W AND RESID 66:70 )W66 - 70
294X-RAY DIFFRACTION294( CHAIN X AND RESID 1:11 )X1 - 11
295X-RAY DIFFRACTION295( CHAIN X AND RESID 12:16 )X12 - 16
296X-RAY DIFFRACTION296( CHAIN X AND RESID 17:22 )X17 - 22
297X-RAY DIFFRACTION297( CHAIN X AND RESID 23:34 )X23 - 34
298X-RAY DIFFRACTION298( CHAIN X AND RESID 35:44 )X35 - 44
299X-RAY DIFFRACTION299( CHAIN X AND RESID 45:54 )X45 - 54
300X-RAY DIFFRACTION300( CHAIN X AND RESID 55:64 )X55 - 64
301X-RAY DIFFRACTION301( CHAIN X AND RESID 65:70 )X65 - 70

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Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
  • This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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Yorodumi

Thousand views of thousand structures

  • Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
  • This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
  • The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.

Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi

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