Entry | Database: PDB / ID: 7exe |
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Title | Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide |
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Components | - 14-3-3 protein zeta/delta
- Disintegrin and metalloproteinase domain-containing protein 22
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Keywords | SIGNALING PROTEIN / Complex |
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Function / homology | Function and homology information
NOTCH4 Activation and Transmission of Signal to the Nucleus / : / GP1b-IX-V activation signalling / KSRP (KHSRP) binds and destabilizes mRNA / Regulation of localization of FOXO transcription factors / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / RHO GTPases activate PKNs / Activation of BAD and translocation to mitochondria / : / LGI-ADAM interactions ...NOTCH4 Activation and Transmission of Signal to the Nucleus / : / GP1b-IX-V activation signalling / KSRP (KHSRP) binds and destabilizes mRNA / Regulation of localization of FOXO transcription factors / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / RHO GTPases activate PKNs / Activation of BAD and translocation to mitochondria / : / LGI-ADAM interactions / Schwann cell differentiation / TP53 Regulates Metabolic Genes / Deactivation of the beta-catenin transactivating complex / Golgi reassembly / synaptic target recognition / Rap1 signalling / response to xenobiotic stimulus => GO:0009410 / respiratory system process / regulation of synapse maturation / Interleukin-3, Interleukin-5 and GM-CSF signaling / establishment of Golgi localization / myelination in peripheral nervous system / histamine secretion by mast cell / tube formation / protein targeting to mitochondrion / gliogenesis / neurotransmitter receptor localization to postsynaptic specialization membrane / cell leading edge / protein targeting / ERK1 and ERK2 cascade / hippocampal mossy fiber to CA3 synapse / adult locomotory behavior / regulation of ERK1 and ERK2 cascade / lung development / metalloendopeptidase activity / melanosome / angiogenesis / DNA-binding transcription factor binding / transmembrane transporter binding / membrane => GO:0016020 / postsynaptic density / protein domain specific binding / axon / protein phosphorylation / glutamatergic synapse / ubiquitin protein ligase binding / protein-containing complex binding / protein kinase binding / perinuclear region of cytoplasm / signal transduction / protein-containing complex / mitochondrion / identical protein binding / nucleus / plasma membrane / cytosolSimilarity search - Function ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. / Peptidase M12B, propeptide / Reprolysin family propeptide / Reprolysin domain, adamalysin-type / Reprolysin (M12B) family zinc metalloprotease / Disintegrin ...ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. / Peptidase M12B, propeptide / Reprolysin family propeptide / Reprolysin domain, adamalysin-type / Reprolysin (M12B) family zinc metalloprotease / Disintegrin / Disintegrin domain profile. / Homologues of snake disintegrins / Disintegrin domain / Disintegrin domain superfamily / Peptidase M12B, ADAM/reprolysin / ADAM type metalloprotease domain profile. / EGF-like domain, extracellular / EGF-like domain / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Metallopeptidase, catalytic domain superfamily / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domainSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.75 Å |
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Authors | Yan, L. / Okatsu, K. / Fukai, S. |
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Funding support | Japan, 1items Organization | Grant number | Country |
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Japan Society for the Promotion of Science (JSPS) | 18H03983 | Japan |
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Citation | Journal: Cell Rep / Year: 2021 Title: LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice Authors: Yokoi, N. / Fukata, Y. / Okatsu, K. / Yamagata, A. / Yan, L. / Sanbo, M. / Miyazaki, Y. / Goto, T. / Abe, M. / Natsume, R. / Aiba, A. / Sakimura, K. / Meijer, D. / Hirabayashi, M. / Fukai, S. / Fukata, M. |
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History | Deposition | May 27, 2021 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Nov 24, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 29, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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