PDB-7ere: Crystal structure of human Biliverdin IX-beta reductase B with Py...

ID or keywords:

Entry

Database: PDB / ID: 7ere

Title

Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA)

Components

Flavin reductase (NADPH)

Keywords

OXIDOREDUCTASE /

platelets /

Biliverdin reductase B /

BLVRB / inhibitors /

NADP / Pyrantel Pamoate

Function / homology

Function and homology information

biliberdin reductase NAD+ activity / biliverdin reductase (NADPH) activity /

biliverdin reductase / biliverdin reductase (NAD(P)H) activity / flavin reductase (NADPH) / riboflavin reductase (NADPH) activity / heme catabolic process / Heme degradation /

terminal bouton / Cytoprotection by HMOX1 ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 1.6 Å

Authors

Griesinger, C. / Lee, D. / Ryu, K.S. / Kim, M. / Ha, J.H.

Citation

Journal: J.Med.Chem. / Year: 2022
Title: Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
Authors: Kim, M. / Ha, J.H. / Choi, J. / Kim, B.R. / Gapsys, V. / Lee, K.O. / Jee, J.G. / Chakrabarti, K.S. / de Groot, B.L. / Griesinger, C. / Ryu, K.S. / Lee, D.

History

Deposition	May 6, 2021	Deposition site: PDBJ / Processing site: PDBJ
Revision 1.0	Jan 19, 2022	Provider: repository / Type: Initial release
Revision 1.1	Feb 23, 2022	Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID
Revision 1.2	Nov 29, 2023	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	7ere.cif.gz	421.8 KB	Display	PDBx/mmCIF format
PDB format	pdb7ere.ent.gz	286.4 KB	Display	PDB format
PDBx/mmJSON format	7ere.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/er/7ere ftp://data.pdbj.org/pub/pdb/validation_reports/er/7ere	HTTPS FTP

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Related structure data

Related structure data	7er6C 7er7C 7er8C 7er9C 7eraC 7erbC 7ercC 7erdC 1he5S S: Starting model for refinement C: citing same article (ref.)
Similar structure data	7erb-1 7erb-2 7er6-d 7era-d 7erc-d 7er9-d 1vpa-d 1kaq-1 7er7-d 7er8-d 1n4m-2 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#37 - Jan 2003 Serum Albumin similarity (1) #258 - Jun 2021 Glucocorticoid Receptor and Dexamethasone similarity (1)

Deposited unit

A: Flavin reductase (NADPH)

B: Flavin reductase (NADPH)

C: Flavin reductase (NADPH)

D: Flavin reductase (NADPH)

hetero molecules

94.3 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Flavin reductase (NADPH)

B: Flavin reductase (NADPH)

hetero molecules

defined by author&software
Evidence: gel filtration
47.1 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Flavin reductase (NADPH)

D: Flavin reductase (NADPH)

hetero molecules

defined by author&software
47.2 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	83.982, 117.381, 81.970
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	19
Space group name H-M	P2₁2₁2₁
Space group name Hall	P2ac2ab
Symmetry operation	#1: x,y,z #2: x+1/2,-y+1/2,-z #3: -x,y+1/2,-z+1/2 #4: -x+1/2,-y,z+1/2

#1: Protein	Flavin reductase (NADPH) / FR / Biliverdin reductase B / BVR-B / Biliverdin-IX beta-reductase / Green heme-binding protein / ...FR / Biliverdin reductase B / BVR-B / Biliverdin-IX beta-reductase / Green heme-binding protein / GHBP / NADPH-dependent diaphorase / NADPH-flavin reductase / FLR Mass: 22286.494 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: BLVRB, FLR / Production host: Escherichia coli (E. coli) References: UniProt: P30043, flavin reductase (NADPH), biliverdin reductase
#2: Chemical	ChemComp-NAP / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE / Nicotinamide adenine dinucleotide phosphate Mass: 743.405 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂₁H₂₈N₇O₁₇P₃ / Feature type: SUBJECT OF INVESTIGATION
#3: Chemical	ChemComp-JBR / 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid / Pamoic acid Mass: 388.370 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂₃H₁₆O₆ / Feature type: SUBJECT OF INVESTIGATION
#4: Chemical	ChemComp-SO4 / SULFATE ION / Sulfate Mass: 96.063 Da / Num. of mol.: 7 / Source method: obtained synthetically / Formula: SO₄ / Feature type: SUBJECT OF INVESTIGATION
#5: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 792 / Source method: isolated from a natural source / Formula: H₂O
Has ligand of interest	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.21 Å³/Da / Density % sol: 44.38 %
Crystal grow	Temperature: 291.15 K / Method: vapor diffusion, hanging drop / pH: 6.5 / Details: 1.9-2.0M Ammonium sulfate, 0.1M Bis-tris(pH 6.5)

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: PAL/PLS / Beamline: 4A / Wavelength: 0.97942 Å
Detector	Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Oct 10, 2020
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.97942 Å / Relative weight: 1
Reflection	Resolution: 1.6→47.72 Å / Num. obs: 107048 / % possible obs: 99.63 % / Redundancy: 10.2 % / B_iso Wilson estimate: 15.42 Å² / CC_1/2: 0.999 / R_merge(I) obs: 0.09368 / Net I/σ(I): 11.92
Reflection shell	Resolution: 1.6→1.657 Å / R_merge(I) obs: 0.3682 / Num. unique obs: 10523 / CC_1/2: 0.927

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Processing

Software

Name	Version	Classification
HKL-2000	1.16_3549	data collection
HKL-2000	1.16_3549	data scaling
PHENIX		model building
PHENIX	1.19.2	refinement
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 1HE5

1he5

Resolution: 1.6→47.72 Å / SU ML: 0.1718 / Cross valid method: FREE R-VALUE / σ(F): 1.42 / Phase error: 20.1875
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.198	1999	1.87 %
R_work	0.1709	104890	-
obs	0.1714	106889	99.64 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 23.39 Å²

Refinement step

Cycle: LAST / Resolution: 1.6→47.72 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	6232	0	343	792	7367

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0088	6839
X-RAY DIFFRACTION	f_angle_d	1.042	9401
X-RAY DIFFRACTION	f_chiral_restr	0.0601	1079
X-RAY DIFFRACTION	f_plane_restr	0.0065	1182
X-RAY DIFFRACTION	f_dihedral_angle_d	10.0881	5360

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
1.6-1.64	0.2782	144	0.2491	7386	X-RAY DIFFRACTION	98.94
1.64-1.68	0.2621	138	0.227	7393	X-RAY DIFFRACTION	99.68
1.68-1.73	0.2525	136	0.2155	7402	X-RAY DIFFRACTION	99.64
1.73-1.79	0.2314	145	0.1958	7439	X-RAY DIFFRACTION	99.71
1.79-1.85	0.1986	143	0.182	7409	X-RAY DIFFRACTION	99.67
1.85-1.93	0.2184	140	0.1708	7451	X-RAY DIFFRACTION	99.88
1.93-2.02	0.1871	139	0.1659	7451	X-RAY DIFFRACTION	99.75
2.02-2.12	0.2102	145	0.162	7485	X-RAY DIFFRACTION	99.9
2.12-2.26	0.1822	140	0.1571	7462	X-RAY DIFFRACTION	99.82
2.26-2.43	0.1822	147	0.1556	7508	X-RAY DIFFRACTION	99.84
2.43-2.67	0.1976	140	0.1599	7540	X-RAY DIFFRACTION	99.93
2.67-3.06	0.195	147	0.1676	7554	X-RAY DIFFRACTION	99.91
3.06-3.86	0.171	147	0.1539	7631	X-RAY DIFFRACTION	99.92

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	2.00270774212	-0.935710729993	-0.277015675444	2.19042918693	-0.623109778256	0.878592880229	-0.408012280735	-0.116548676015	0.254032692338	0.253678095592	0.150810207039	-0.326438884417	-0.23295882717	0.284937035459	0.0951418138111	0.123563642232	0.0136027986428	-0.0160977220629	0.178594956449	-0.015718468465	0.137073508773	15.8344286387	-23.2749909059	20.8055957159
2	0.82197465418	-0.138874975696	-0.219476014059	0.759192573929	-0.0561493819401	1.57822570589	-0.076831788348	-0.0743469025789	0.0862682164651	0.0178264061266	0.0213613032756	-0.104568423089	-0.488021680705	0.226175654843	0.0271862412452	0.163897847303	-0.040530165423	-0.0283650792212	0.115104397884	-0.00184291467676	0.110805562219	11.8599415093	-17.8918384145	21.6421013351
3	1.66471145541	0.195053262821	0.114993452829	0.901024334598	0.326512387252	1.75592078142	-0.105937932712	0.189370755435	0.22192910238	-0.155367555303	0.00609925025749	0.0497994819339	-0.437398717539	0.0548909821216	0.0656505062626	0.129197039128	0.00619761403384	-0.0234668251095	0.110912471074	0.0220237233621	0.118471997893	7.25670110774	-21.4290778119	11.519138671
4	4.40772227478	-1.40248860591	-0.227570541056	1.36927635416	0.111525554108	0.939731797213	0.0580710015471	0.21177057501	-0.0339643775685	-0.0876559382934	-0.0437770333708	-0.0406008007266	-0.0296142044368	0.0838545843537	-0.0415530442719	0.0787699243048	0.00515707531467	0.00555254343001	0.128377229228	-0.00343250398118	0.0999374901771	8.57538627419	-33.9037849238	10.2420172268
5	1.32834134792	-0.302461815049	0.174559568342	0.805865345083	0.186575270016	1.39676623069	-0.0322609672925	-0.0470850358005	-0.0933324534617	0.0520535150487	0.0193690891199	0.059478809605	0.0727080187879	-0.164933258629	0.0241596648993	0.0618547599903	0.0180609038443	0.00391865093561	0.107716044037	0.00343099515022	0.110630896265	-2.02206574475	-34.3997572351	20.784273033
6	1.07093224469	0.461417337252	-0.0727052970903	3.26783678794	-0.2151918617	0.911302226704	0.111117958393	-0.138335366671	0.0552628802692	-0.0941688495249	-0.166881548687	0.0100526415941	-0.206907543351	-0.403498402825	0.0320438561344	0.137705891509	0.0619346511324	0.00818311848672	0.134553837742	-0.015269075017	0.0637609236467	-0.940509479836	-26.7606375482	34.8304382913
7	0.832418081244	0.219175798954	0.132042980785	1.27830370798	-0.0243570888626	1.08680172336	-0.0149498033326	-0.126173732037	-0.033639394971	0.172905027686	-0.0044472078118	-0.0355392147486	-0.0784608712015	0.0236472077836	0.022032452019	0.121734828942	0.0316241949288	-0.00148799156711	0.139019308742	0.0020525077973	0.0970843571396	5.13060700592	-27.4435973902	31.6884883326
8	0.744106283716	-0.434872154965	-0.304056306423	2.55886027811	-0.795828548836	1.52931690052	-0.056436537739	-0.109994272447	0.13743151687	-0.341713663628	-0.0405248082746	-0.412295983495	0.222434126613	0.306966202866	0.0574593460709	0.403575164975	-0.0644742835226	0.0582539762981	0.089788939944	0.0244759190241	0.213930820349	0.518762093225	-61.1137143926	2.79794019455
9	0.586061731269	-0.123087606563	0.722132540405	2.55579811885	-0.767382792654	1.00959873855	0.0471861979131	0.00708869168923	-0.0132569106345	-0.296394364347	-0.0465338676035	0.0755369994181	0.488670761462	-0.212922953034	0.0262638298841	0.316216367817	-0.0863682516793	0.011920361482	0.155801361229	-0.0174297676365	0.130157276531	-9.09089928427	-51.2923460024	-3.49411133771
10	1.21235896235	-0.353294010283	0.180272602306	2.14491063922	-0.587089250467	1.40465200412	-0.0349111376091	-0.197147964074	-0.00281626206776	0.129531557908	0.139437209804	0.261484829825	0.235167406918	-0.425524110586	-0.0657328095237	0.208996106137	-0.0762023164571	0.0201344530812	0.26170678278	-0.0114607632932	0.182544983549	-13.9178136756	-50.3360305653	8.05863264085
11	0.512153704654	0.458109919956	0.444965071466	2.22502730055	-0.575041322854	0.890875193222	-0.397998813344	0.224544388409	-0.196791410492	-0.264960411833	0.19073127798	-0.282124787261	0.266555151791	0.383699952709	0.0991975484658	0.0751384233437	-0.0177139413856	0.0276352222423	0.216363410649	-0.0211207385865	0.110203335734	15.6064098069	-35.6353709696	-20.8654935926
12	0.775021703791	0.141419824548	-0.0498455081236	0.831878729341	0.184228312406	1.75089049473	-0.0533068595399	-0.0402514399344	-0.0779074252398	-0.0374425704695	0.0662950821717	-0.0864821351279	0.230788489674	0.250034604456	-0.0241122850286	0.086216676337	0.0213523122497	0.011669252367	0.0882708151578	-0.00335221043472	0.111092398276	11.3091911513	-40.9162015994	-21.8057730117
13	2.60471655849	-0.121886586244	-1.15202320393	0.256586005441	0.805173771891	3.79763420383	-0.156089390608	0.0973708462006	-0.774818305601	0.383179133204	0.0823989878072	0.198159113916	1.53892430685	-0.331601177758	0.102683517655	0.411776147131	0.0385428391078	0.042462522797	0.208361372148	0.083072130643	0.336307410831	8.0380507656	-46.9792077555	-12.7887752457
14	1.25033901923	-0.0407978840375	0.167003923579	1.29705390949	0.0770497097764	0.506397361927	-0.222177311409	-0.446842441211	0.15632486082	0.208482862712	0.198252582067	-0.0201390659997	0.211515337956	0.152642715604	0.0756889132866	0.0979507559973	0.0416048850433	-0.000655443539643	0.152999104669	0.0208034794478	0.0800788514235	9.65931860391	-36.5844242503	-6.9022204283
15	1.60916313427	-0.895097151281	-1.06486574816	2.74212668331	0.876496615575	1.50185964093	-0.230998540881	-0.0816956204432	-0.146820751284	1.05815336881	0.229455439172	0.0293377575239	0.201748956291	0.490570998061	-0.0848904901842	-0.200079838504	-0.0419307232234	-0.0512953387801	0.151854332896	-0.017087101416	0.0929435244594	14.5330252886	-31.4364954537	-11.9563915241
16	1.48596905186	-1.04715483782	-0.827710011307	0.745641082583	0.518231234746	0.624610829006	-0.1254667541	0.036117035086	-0.213981976993	0.0207375211964	-0.037929963977	0.293102044507	0.00288406582018	-0.107693910048	0.0984556195276	0.0819404847171	-0.0180359247566	0.00939282611878	0.119452755575	-0.000656736538984	0.138964342076	-5.85177584256	-33.6990841914	-12.9927749773
17	4.61661502978	1.22305401012	0.199875034746	1.58695026929	0.168498680279	1.17023684973	-0.0866907281979	-0.149783737991	0.139103716925	0.0236485303023	0.111154370843	0.000244229669321	-0.0705089865419	0.142226785087	-0.0774240459722	0.0885247649301	-0.000399693825002	-0.00531659380097	0.127859721597	-0.016658813374	0.11504336076	8.66859770356	-24.9032868602	-10.215239189
18	1.47593838987	0.444130112498	-0.226308196699	0.894685254828	0.299772286548	1.63825346695	0.0359703608732	0.359708628802	0.160460075566	-0.0695597650985	0.00827393822635	0.0882123202726	-0.163349564868	-0.132010873764	-0.0127280790752	0.083959987707	-0.0114890826076	-0.003420670536	0.119792880802	0.0244022478771	0.111657309493	-1.98587919681	-23.5923620887	-22.9021488563
19	2.70704393984	0.3056069847	0.0279850992728	0.735542868153	0.29771936876	0.811871549859	-0.0821123514203	-0.0614713394989	-0.0437713620484	-0.0504265631778	0.0497093098391	-0.0788771981269	-0.146999712552	-0.103214400922	0.00507406071935	0.0886614474607	0.0102904966983	-0.00152256494266	0.106471934984	-0.00818163871444	0.107684772012	-4.38400866862	-22.6873098036	-16.5537956793
20	0.344633582233	-0.373716967229	0.298506348483	0.626369142743	0.151984378642	1.53597445393	0.0194433377927	0.0995058533002	0.0637707870469	-0.217064473963	0.0147089031168	0.0282775218236	-0.121152911166	-0.0231473171566	-0.0607053528034	0.0698282526787	-0.0240348572841	0.0116301155553	0.0742705160321	-0.00667652155353	0.0776497860001	2.67993275998	-26.7328526085	-24.7546470891
21	0.94639548688	-0.356991834893	0.0179134542582	3.58983996228	-0.325278571465	1.15448986113	0.00156699177761	0.0334506371762	-0.0225099080827	-0.0159992057889	0.00157036976315	0.189513234109	-0.0160620615817	-0.218846107028	-0.00805218700608	0.114710471841	-0.0269264533977	-0.0141729369542	0.128079008053	-0.00679428395017	0.0896160457172	-1.27643018788	-31.7791772997	-34.5928125026
22	1.90234879224	0.700359457365	0.391078577644	1.20030020707	0.315692659436	0.728379079769	-0.22416733965	0.0644241259078	0.157435595031	-0.304665444016	0.132065744596	-0.0286227004806	0.0304416112243	0.0584787261837	0.0264824138225	0.10284840157	-0.0413804717994	-0.00224533919235	0.103433056353	-0.0048552779339	0.107925640881	5.94563277551	-34.567503638	-29.8098843724
23	1.17091579627	-0.158042116995	-0.0259980528596	1.67251499878	-0.343447039615	0.555252392281	-0.0691485336375	0.184361490098	0.0546243986386	-0.328021431387	0.0427167329826	0.0780654816429	-0.159449294844	0.0633579442843	-0.036514772391	0.136128320852	-0.049915114105	0.0186498051815	0.150540211994	0.0139919760373	0.0831365566807	4.04315492446	-27.7550640111	-33.4619557651
24	1.16359822923	0.669909806694	0.384787322561	1.95318584847	-0.236183954983	1.39244009313	-0.0143797020372	-0.0154112605568	-0.0459884234204	0.147327506353	-0.018393089719	-0.227333056419	-0.142798229099	0.164289044013	0.0421657614066	0.248496095395	0.0468936096811	-0.0080473197913	0.0977884122304	0.0162132021677	0.158191776848	1.40278513024	2.78717114631	-2.83229672583
25	0.676416222018	0.622261709922	-0.394388114547	2.96900322818	-0.540502761756	0.957196483709	0.0472358104354	-0.020342359337	0.0209540894049	0.264002649085	0.0116724883775	0.234549661928	-0.295053120696	-0.234057002895	-0.0365246626581	0.205859503278	0.0842174542236	0.0202944374993	0.154302748854	-0.0012509792554	0.131301372347	-9.24809700932	-9.21340666378	3.41923312687
26	2.2520390275	0.338364198824	-0.36610316158	2.44881071531	-0.144928096359	1.33824351664	-0.111952367727	0.342594224268	-0.0489917626018	-0.273005989883	0.122644057896	0.424501661787	-0.156865719287	-0.353517402989	0.0168118292554	0.244319364927	0.0678064004097	-0.0371656082843	0.224420068748	0.00717816307327	0.216515985824	-13.7807021702	-5.06956731115	-11.9684190841

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 0 through 13 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 14 through 34 )
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 35 through 85 )
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 86 through 101 )
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 102 through 155 )
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 156 through 174 )
7	X-RAY DIFFRACTION	7	chain 'A' and (resid 175 through 206 )
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 1 through 57 )
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 58 through 122 )
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 123 through 206 )
11	X-RAY DIFFRACTION	11	chain 'C' and (resid 0 through 13 )
12	X-RAY DIFFRACTION	12	chain 'C' and (resid 14 through 34 )
13	X-RAY DIFFRACTION	13	chain 'C' and (resid 35 through 48 )
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 49 through 57 )
15	X-RAY DIFFRACTION	15	chain 'C' and (resid 58 through 73 )
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 74 through 85 )
17	X-RAY DIFFRACTION	17	chain 'C' and (resid 86 through 101 )
18	X-RAY DIFFRACTION	18	chain 'C' and (resid 102 through 122 )
19	X-RAY DIFFRACTION	19	chain 'C' and (resid 123 through 142 )
20	X-RAY DIFFRACTION	20	chain 'C' and (resid 143 through 155 )
21	X-RAY DIFFRACTION	21	chain 'C' and (resid 156 through 174 )
22	X-RAY DIFFRACTION	22	chain 'C' and (resid 175 through 190 )
23	X-RAY DIFFRACTION	23	chain 'C' and (resid 191 through 206 )
24	X-RAY DIFFRACTION	24	chain 'D' and (resid 1 through 57 )
25	X-RAY DIFFRACTION	25	chain 'D' and (resid 58 through 142 )
26	X-RAY DIFFRACTION	26	chain 'D' and (resid 143 through 206 )

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