登録情報 | データベース: PDB / ID: 7env |
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タイトル | crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1). |
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要素 | Bromodomain-containing protein 2 |
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キーワード | TRANSCRIPTION/INHIBITOR / BET family / BET inhibitor / Bromodomain Inhibitor / BRD2-BD1 inhibitor / TRANSCRIPTION-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein phosphorylation / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. ...NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.45 Å |
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データ登録者 | Padmanabhan, B. / Arole, A. / Deshmukh, P. / Ashok, S. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.F / 年: 2022 タイトル: Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. 著者: Arole, A.H. / Deshmukh, P. / Sridhar, A. / Padmanabhan, B. |
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履歴 | 登録 | 2021年4月19日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年3月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年3月16日 | Group: Database references / カテゴリ: citation Item: _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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