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- PDB-7elx: The crystal structure of CTLA-4 and Fab -

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Basic information

Entry
Database: PDB / ID: 7elx
TitleThe crystal structure of CTLA-4 and Fab
Components
  • Cytotoxic T-lymphocyte protein 4
  • heavy chain of Fab
  • light chain of Fab
KeywordsAPOPTOSIS / complex
Function / homology
Function and homology information


protein complex involved in cell adhesion / negative regulation of regulatory T cell differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / clathrin-coated endocytic vesicle / CTLA4 inhibitory signaling / negative regulation of B cell proliferation / negative regulation of T cell proliferation / B cell receptor signaling pathway / T cell receptor signaling pathway / adaptive immune response ...protein complex involved in cell adhesion / negative regulation of regulatory T cell differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / clathrin-coated endocytic vesicle / CTLA4 inhibitory signaling / negative regulation of B cell proliferation / negative regulation of T cell proliferation / B cell receptor signaling pathway / T cell receptor signaling pathway / adaptive immune response / immune response / positive regulation of apoptotic process / external side of plasma membrane / DNA damage response / perinuclear region of cytoplasm / Golgi apparatus / plasma membrane
Similarity search - Function
Cytotoxic T-lymphocyte antigen 4 / Cytotoxic T-lymphocyte protein 4/CD28 / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
Cytotoxic T-lymphocyte protein 4
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.14 Å
AuthorsYu, X.J. / Wang, L. / Yu, C.F.
CitationJournal: To Be Published
Title: The crystal structure of CTLA-4 and Fab
Authors: Yu, X.J. / Yu, C.F.
History
DepositionApr 12, 2021Deposition site: PDBJ / Processing site: PDBJ
Revision 1.0Jun 30, 2021Provider: repository / Type: Initial release
Revision 1.1Nov 29, 2023Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_ncs_dom_lim
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
H: heavy chain of Fab
L: light chain of Fab
h: heavy chain of Fab
l: light chain of Fab
c: Cytotoxic T-lymphocyte protein 4
C: Cytotoxic T-lymphocyte protein 4


Theoretical massNumber of molelcules
Total (without water)181,3526
Polymers181,3526
Non-polymers00
Water11,385632
1
H: heavy chain of Fab
L: light chain of Fab
C: Cytotoxic T-lymphocyte protein 4


Theoretical massNumber of molelcules
Total (without water)90,6763
Polymers90,6763
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
h: heavy chain of Fab
l: light chain of Fab
c: Cytotoxic T-lymphocyte protein 4


Theoretical massNumber of molelcules
Total (without water)90,6763
Polymers90,6763
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)95.923, 196.921, 148.389
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number20
Space group name H-MC2221
Components on special symmetry positions
IDModelComponents
11h-1-

GLN

Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain C and (resid 2 through 15 or resid 17...
21(chain c and (resid 2 through 15 or resid 17...
12(chain H and (resid 1 through 42 or resid 44...
22(chain h and (resid 1 through 42 or resid 44...
13(chain L and (resid 1 through 126 or resid 128...
23(chain l and (resid 1 through 126 or resid 128...

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
111ALAALASERSER(chain C and (resid 2 through 15 or resid 17...CF2 - 152 - 15
121GLYGLYVALVAL(chain C and (resid 2 through 15 or resid 17...CF17 - 7717 - 77
131LEULEUGLYGLY(chain C and (resid 2 through 15 or resid 17...CF79 - 8379 - 83
141ASPASPILEILE(chain C and (resid 2 through 15 or resid 17...CF88 - 11788 - 117
211ALAALASERSER(chain c and (resid 2 through 15 or resid 17...cE2 - 152 - 15
221GLYGLYVALVAL(chain c and (resid 2 through 15 or resid 17...cE17 - 7717 - 77
231LEULEUGLYGLY(chain c and (resid 2 through 15 or resid 17...cE79 - 8379 - 83
241ASPASPILEILE(chain c and (resid 2 through 15 or resid 17...cE88 - 11788 - 117
112GLNGLNGLYGLY(chain H and (resid 1 through 42 or resid 44...HA1 - 4220 - 61
122GLYGLYVALVAL(chain H and (resid 1 through 42 or resid 44...HA44 - 6463 - 83
132GLNGLNPROPRO(chain H and (resid 1 through 42 or resid 44...HA1 - 21820 - 237
142GLNGLNPROPRO(chain H and (resid 1 through 42 or resid 44...HA1 - 21820 - 237
152GLYGLYLYSLYS(chain H and (resid 1 through 42 or resid 44...HA123 - 214142 - 233
162VALVALPROPRO(chain H and (resid 1 through 42 or resid 44...HA216 - 218235 - 237
212GLNGLNGLYGLY(chain h and (resid 1 through 42 or resid 44...hC1 - 4220 - 61
222GLYGLYVALVAL(chain h and (resid 1 through 42 or resid 44...hC44 - 6463 - 83
232GLNGLNPROPRO(chain h and (resid 1 through 42 or resid 44...hC1 - 21820 - 237
242VALVALVALVAL(chain h and (resid 1 through 42 or resid 44...hC221
252VALVALPROPRO(chain h and (resid 1 through 42 or resid 44...hC216 - 218235 - 237
113GLUGLULEULEU(chain L and (resid 1 through 126 or resid 128...LB1 - 12621 - 146
123SERSERARGARG(chain L and (resid 1 through 126 or resid 128...LB128 - 143148 - 163
133ALAALAVALVAL(chain L and (resid 1 through 126 or resid 128...LB145 - 147165 - 167
143TRPTRPSERSER(chain L and (resid 1 through 126 or resid 128...LB149 - 169169 - 189
153ASPASPARGARG(chain L and (resid 1 through 126 or resid 128...LB171 - 212191 - 232
213GLUGLULEULEU(chain l and (resid 1 through 126 or resid 128...lD1 - 12621 - 146
223SERSERARGARG(chain l and (resid 1 through 126 or resid 128...lD128 - 143148 - 163
233ALAALAALAALA(chain l and (resid 1 through 126 or resid 128...lD145165
243TRPTRPSERSER(chain l and (resid 1 through 126 or resid 128...lD149 - 169169 - 189
253ASPASPARGARG(chain l and (resid 1 through 126 or resid 128...lD171 - 212191 - 232

NCS ensembles :
ID
1
2
3

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Components

#1: Antibody heavy chain of Fab


Mass: 51448.055 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Cricetulus griseus (Chinese hamster)
#2: Antibody light chain of Fab


Mass: 25717.693 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Cricetulus griseus (Chinese hamster)
#3: Protein Cytotoxic T-lymphocyte protein 4 / Cytotoxic T-lymphocyte-associated antigen 4 / CTLA-4


Mass: 13510.340 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CTLA4, CD152 / Production host: Escherichia phage EcSzw-2 (virus) / References: UniProt: P16410
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 632 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 1.93 Å3/Da / Density % sol: 36.33 %
Crystal growTemperature: 285 K / Method: vapor diffusion, sitting drop / Details: PEG8000 10%, 0.1M Na Citrate 0.1M (NH4)2SO4

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SSRF / Beamline: BL17U / Wavelength: 0.9791 Å
DetectorType: DECTRIS EIGER2 X 16M / Detector: PIXEL / Date: Sep 16, 2020
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9791 Å / Relative weight: 1
ReflectionResolution: 2.14→45.64 Å / Num. obs: 76857 / % possible obs: 100 % / Redundancy: 7.8 % / Rmerge(I) obs: 0.101 / Net I/σ(I): 27.12
Reflection shellResolution: 2.14→2.18 Å / Rmerge(I) obs: 0.101

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Phasing

PhasingMethod: molecular replacement

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Processing

Software
NameVersionClassificationNB
HKL-2000data reduction
HKL-2000data scaling
PHASERphasing
PHENIX1.18.2_3874refinement
PDB_EXTRACT3.27data extraction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 6rp8

6rp8


Resolution: 2.14→44.2 Å / SU ML: 0.23 / Cross valid method: THROUGHOUT / σ(F): 1.36 / Phase error: 22.57 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2172 1996 2.6 %
Rwork0.1768 74861 -
obs0.1778 76857 99.72 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso max: 141.98 Å2 / Biso mean: 48.4125 Å2 / Biso min: 20.63 Å2
Refinement stepCycle: final / Resolution: 2.14→44.2 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms8204 0 0 632 8836
Biso mean---47.99 -
Num. residues----1077
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11C622X-RAY DIFFRACTION3.551TORSIONAL
12c622X-RAY DIFFRACTION3.551TORSIONAL
21H1220X-RAY DIFFRACTION3.551TORSIONAL
22h1220X-RAY DIFFRACTION3.551TORSIONAL
31L1236X-RAY DIFFRACTION3.551TORSIONAL
32l1236X-RAY DIFFRACTION3.551TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 14

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
2.14-2.20.27291380.22265190532898
2.2-2.260.22121410.214752755416100
2.26-2.320.2981420.203953355477100
2.32-2.40.25491420.195553115453100
2.4-2.480.27451410.195753095450100
2.48-2.580.2341420.195652935435100
2.58-2.70.25651420.193653515493100
2.7-2.840.23681420.183253375479100
2.84-3.020.24661420.188353415483100
3.02-3.260.26251430.18953495492100
3.26-3.580.21651440.171353805524100
3.58-4.10.20641440.162554095553100
4.1-5.170.15931450.138254185563100
5.17-44.20.19451480.18655563571199
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
13.84271.6594-3.34282.3174-0.24963.5867-0.03870.3152-0.3828-0.48260.2350.34470.454-0.6925-0.20480.43820.0658-0.10870.2294-0.07410.42222.1701-44.6054-19.8164
21.80990.1514-0.24682.3999-0.71152.06520.16470.1392-0.1731-0.1651-0.0867-0.09120.22920.2312-0.0460.4080.1273-0.08450.2975-0.05460.309210.6883-35.6313-20.86
31.78830.7593-0.90152.4759-1.33161.44710.07690.0091-0.1887-0.099-0.061-0.04780.31310.2023-0.02770.41510.1014-0.1280.2895-0.06970.29198.7458-37.6002-18.9429
48.06932.0835-1.39670.98080.03770.6694-0.5556-0.2357-0.8701-0.01760.0063-0.16660.49540.02390.5420.49770.0849-0.02420.2594-0.00660.4404-7.6543-48.6402-10.6372
56.0682-1.43941.31625.6212-2.63763.2032-0.232-0.2972-0.11550.03730.36780.76630.0096-0.4656-0.12590.3123-0.0451-0.02940.2976-0.01380.3603-28.5072-42.9468-9.2239
62.9706-0.224-0.79284.25380.29892.8122-0.0730.296-0.0884-0.4148-0.06950.44550.2615-0.41760.09240.2982-0.0696-0.00630.3309-0.00730.304-25.4337-40.1221-14.6478
72.7342-3.59660.65816.44890.53944.1065-0.09171.2417-0.5166-0.6652-0.26470.42880.3084-0.34740.24380.3823-0.0976-0.01180.4308-0.09120.3511-26.0968-48.6147-17.1964
84.3335-0.01590.48912.13050.03762.25250.1264-0.26910.19270.25460.08410.04880.0760.0672-0.14340.33580.0127-0.01330.2221-0.04730.2575-1.2236-14.0542-13.5712
95.62291.1393-1.94445.5812-0.84181.9448-0.25410.12290.105-0.45390.12440.58110.2347-0.07290.11680.38180.0722-0.09980.2507-0.04050.25390.8332-22.2722-22.4461
102.2482-1.61841.03446.94640.47196.87190.24920.69010.0573-0.57840.052-0.5-0.19150.3541-0.30160.22380.0213-0.02020.2263-0.02910.23672.1862-15.2357-29.6221
118.27820.96963.55592.0896-0.33023.8360.24920.17090.31150.32360.0073-0.04510.24560.1896-0.27210.29910.046-0.0240.2154-0.01320.31972.4059-10.5577-19.4975
128.2209-0.9129-0.20614.64450.13112.62910.12890.1663-0.4046-0.04320.14850.54050.2149-0.0838-0.24370.2953-0.0182-0.01750.2016-0.03890.2222-6.222-18.0731-22.1709
133.67690.5681-1.22910.4004-0.13360.81180.1103-0.08070.08630.13970.08610.0860.1174-0.024-0.17650.31520.0293-0.04380.2451-0.00150.3033-6.0927-20.5024-14.1335
141.94-0.1171-1.66285.1-2.88484.1751-0.09960.0169-0.1203-0.08660.00960.40950.4064-0.13150.08760.2737-0.0483-0.020.32370.00860.3559-27.6313-34.6388-2.4792
156.45732.1627-5.03842.6371-1.48863.94890.1134-0.78070.02150.3005-0.2040.0652-0.27240.32130.12070.3845-0.0216-0.01250.3767-0.01470.3393-22.3374-33.64035.1079
161.73731.1596-2.20955.0012-2.70773.9029-0.022-0.07850.11630.30230.07450.36140.0904-0.1994-0.08480.2605-0.071-0.01030.35320.00480.369-28.053-31.7553-0.8889
174.3316-1.2524-2.92121.7070.84734.6978-0.3268-0.1381-0.44650.5230.10480.0750.7020.17510.23240.4962-0.0514-0.01280.2844-0.00170.3823-2.3253-30.117217.5758
183.8894-0.31341.78782.6470.25512.68750.0330.3238-0.22760.07550.08550.08870.2283-0.1277-0.10590.4648-0.01850.02620.2335-0.04790.2834-4.8841-21.50311.0413
194.94070.0316-2.78761.26840.23064.8443-0.10280.3106-0.4489-0.4471-0.04390.30250.8696-0.61090.1620.6193-0.0589-0.04240.2573-0.08050.3099-7.4689-27.98628.7956
202.6352-1.0706-0.58454.11552.32181.26510.05580.0365-0.24890.00340.0221-0.04640.227-0.1364-0.06670.4149-0.018-0.0010.22380.01520.2765-1.5187-24.186814.5223
213.48560.06012.69281.0943-0.6032.55270.46020.1495-0.20040.05940.1547-0.44090.81560.314-0.52690.52250.0557-0.08540.2626-0.10610.357515.0336-34.64977.6354
223.3019-0.69980.88824.1767-0.03213.11840.16830.16060.03530.19640.1651-0.76680.29610.4829-0.29470.39330.0952-0.06570.4756-0.15240.492329.6532-29.00116.3762
234.4872-0.1571-0.75332.0834-0.77790.47470.5201-0.2306-0.21221.0527-0.0561-1.21331.04560.9958-0.38530.67350.2096-0.29870.659-0.18640.894437.455-26.929522.6489
248.71473.79444.16773.72751.58345.04540.1285-0.5829-0.4130.37740.1995-1.1980.0710.2532-0.36690.38630.125-0.1180.5049-0.15950.644529.9511-36.947220.2791
256.48680.15932.66232.1457-0.20014.29070.0950.5169-0.0747-0.23570.067-0.2237-0.04460.2826-0.12710.3039-0.00990.03840.213-0.03820.2556.7764-1.409714.0548
267.3996-2.4685-1.27986.68150.08373.3947-0.5217-0.2131-0.11860.46980.4410.09090.23080.00810.04410.3955-0.0247-0.02610.2278-0.01130.25392.5869-10.695320.8652
273.57411.83263.91827.77111.5594.27940.0316-0.67240.13880.8916-0.2740.6462-0.0156-0.56280.25060.3813-0.05180.00750.31570.02680.3183-0.8577-4.468828.085
285.6353-1.04184.09952.26630.20527.9093-0.0967-0.04230.4004-0.04120.0344-0.1619-0.14630.12780.08320.29950.0001-0.02570.2566-0.02030.27691.6371.367918.978
296.097-0.08451.29352.1717-1.48661.79610.0059-0.1744-0.23550.1880.1089-0.22240.13580.2101-0.10060.39480.05590.01510.2273-0.00860.31489.3832-6.516423.1941
300.31310.58040.38151.22450.31341.0533-0.18050.2831-0.2059-0.24230.2932-0.66450.12910.4858-0.09660.36480.01870.13770.434-0.18270.56523.0176-16.485113.3678
311.0282-2.3505-1.19415.81122.64312.3449-0.07130.4882-0.0114-0.65320.3392-0.9416-0.21020.5818-0.19180.4169-0.04570.14350.7768-0.19020.798734.1712-15.36810.1848
326.69480.4713-4.09450.54230.17994.2201-0.39461.7172-0.4633-0.38310.197-1.3973-0.03130.13780.04890.678-0.04360.23360.9705-0.15040.872334.3967-18.20041.2079
335.0999-3.7606-3.14616.08592.92164.8152-0.19130.6046-0.3421-0.35710.1729-0.79670.29640.36940.12280.4334-0.03090.11130.585-0.17530.675332.6633-20.719811.0754
341.4793-1.2134-1.67111.3910.50974.0430.19541.3325-0.2532-0.5408-0.0828-1.0833-0.2730.5169-0.34480.5085-0.07920.35961.0985-0.31361.187642.7775-14.40537.2005
356.4893-0.1668-4.30642.10461.80834.24140.2560.65520.4055-0.40890.0773-0.1151-0.1956-0.3596-0.26740.59350.0623-0.10040.5190.00870.4359-19.7083-2.151413.6431
362.7907-1.53780.0313.51281.19484.34260.0040.0709-0.2088-0.3212-0.10570.3322-0.2593-0.95490.07920.3666-0.0007-0.11350.4221-0.04650.4447-28.9743-5.35621.8814
373.6733-1.2933-0.92745.91132.51869.049-0.1087-0.2455-0.021-0.13840.2596-0.2804-0.3226-0.0228-0.20150.3493-0.07890.07180.43940.00910.4406-20.5596-13.667623.8895
386.13391.19821.34035.72182.11262.7235-0.00151.1541-0.213-0.33030.4010.91.2704-0.9922-0.42140.7421-0.24030.00550.9706-0.02070.7309-31.5262-17.672918.5379
392.624-0.1881.95662.5068-1.06142.0454-0.0898-0.2327-0.36490.07150.22370.52770.1632-1.855-0.02510.4409-0.0333-0.0730.7875-0.08060.5828-30.543-9.744327.1423
400.9931-0.6607-1.47782.51672.92438.15090.0982-0.12740.3686-0.31170.00540.0721-0.5169-0.1522-0.05540.3032-0.0657-0.03530.3708-0.03570.3755-18.3941-10.264916.0347
412.2223.04070.25365.6519-1.30692.17550.6737-1.0452-0.13370.8823-0.15630.4668-1.08020.3083-0.37970.76970.1033-0.05150.6345-0.0430.4916-26.7717-2.046635.0326
425.34690.2401-3.973.4587-0.86645.11290.4394-0.89910.20030.4519-0.41190.1951-0.68980.2305-0.00420.5575-0.0952-0.08910.6286-0.05790.57323.799-13.9448-19.0894
433.5510.1027-0.02294.9645-3.17725.9077-0.13310.08120.27570.003-0.0667-0.3354-0.18210.19050.30490.3350.0662-0.02290.3872-0.05160.505827.6813-17.2892-30.3642
446.8432-2.63163.29062.648-2.61882.9408-0.1829-0.6877-0.85680.11160.4862-0.2056-0.54580.1624-0.10890.49860.15340.02910.65010.00440.538724.8575-25.5736-31.364
455.8668-1.92490.94096.587-3.85373.28540.1021-0.2583-0.6845-0.1038-0.4462-1.41920.84881.52880.53510.81960.22690.10911.32570.21921.000135.1319-27.4285-29.8721
464.5731-0.6852.81142.5191-0.85888.07850.01580.37110.4218-0.1008-0.528-0.10990.11730.90970.50290.32340.0694-0.0250.71070.09160.608531.5557-18.6059-35.7252
471.29631.0528-2.59772.8807-1.3995.34850.2278-0.12620.07010.2568-0.2087-0.2194-0.07860.40860.07680.28630.0891-0.10380.4342-0.00720.368122.4571-21.6456-22.7866
487.3728-2.23543.66175.18710.75582.59270.0890.63720.3551-0.7584-0.498-1.3539-1.0216-0.20490.48730.55770.05870.1290.51090.13440.702526.1178-9.6445-41.1144
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'H' and (resid 1 through 17 )H1 - 17
2X-RAY DIFFRACTION2chain 'H' and (resid 18 through 60 )H18 - 60
3X-RAY DIFFRACTION3chain 'H' and (resid 61 through 111 )H61 - 111
4X-RAY DIFFRACTION4chain 'H' and (resid 112 through 124 )H112 - 124
5X-RAY DIFFRACTION5chain 'H' and (resid 125 through 150 )H125 - 150
6X-RAY DIFFRACTION6chain 'H' and (resid 151 through 198 )H151 - 198
7X-RAY DIFFRACTION7chain 'H' and (resid 199 through 218 )H199 - 218
8X-RAY DIFFRACTION8chain 'L' and (resid 1 through 30 )L1 - 30
9X-RAY DIFFRACTION9chain 'L' and (resid 31 through 49 )L31 - 49
10X-RAY DIFFRACTION10chain 'L' and (resid 50 through 62 )L50 - 62
11X-RAY DIFFRACTION11chain 'L' and (resid 63 through 76 )L63 - 76
12X-RAY DIFFRACTION12chain 'L' and (resid 77 through 91 )L77 - 91
13X-RAY DIFFRACTION13chain 'L' and (resid 92 through 114 )L92 - 114
14X-RAY DIFFRACTION14chain 'L' and (resid 115 through 151 )L115 - 151
15X-RAY DIFFRACTION15chain 'L' and (resid 152 through 164 )L152 - 164
16X-RAY DIFFRACTION16chain 'L' and (resid 165 through 212 )L165 - 212
17X-RAY DIFFRACTION17chain 'h' and (resid 1 through 33 )h1 - 33
18X-RAY DIFFRACTION18chain 'h' and (resid 34 through 60 )h34 - 60
19X-RAY DIFFRACTION19chain 'h' and (resid 61 through 76 )h61 - 76
20X-RAY DIFFRACTION20chain 'h' and (resid 77 through 111 )h77 - 111
21X-RAY DIFFRACTION21chain 'h' and (resid 112 through 124 )h112 - 124
22X-RAY DIFFRACTION22chain 'h' and (resid 125 through 180 )h125 - 180
23X-RAY DIFFRACTION23chain 'h' and (resid 181 through 198 )h181 - 198
24X-RAY DIFFRACTION24chain 'h' and (resid 199 through 218 )h199 - 218
25X-RAY DIFFRACTION25chain 'l' and (resid 1 through 30 )l1 - 30
26X-RAY DIFFRACTION26chain 'l' and (resid 31 through 49 )l31 - 49
27X-RAY DIFFRACTION27chain 'l' and (resid 50 through 62 )l50 - 62
28X-RAY DIFFRACTION28chain 'l' and (resid 63 through 76 )l63 - 76
29X-RAY DIFFRACTION29chain 'l' and (resid 77 through 91 )l77 - 91
30X-RAY DIFFRACTION30chain 'l' and (resid 92 through 129 )l92 - 129
31X-RAY DIFFRACTION31chain 'l' and (resid 130 through 151 )l130 - 151
32X-RAY DIFFRACTION32chain 'l' and (resid 152 through 164 )l152 - 164
33X-RAY DIFFRACTION33chain 'l' and (resid 165 through 189 )l165 - 189
34X-RAY DIFFRACTION34chain 'l' and (resid 190 through 212 )l190 - 212
35X-RAY DIFFRACTION35chain 'c' and (resid 1 through 7 )c1 - 7
36X-RAY DIFFRACTION36chain 'c' and (resid 8 through 32 )c8 - 32
37X-RAY DIFFRACTION37chain 'c' and (resid 33 through 55 )c33 - 55
38X-RAY DIFFRACTION38chain 'c' and (resid 56 through 67 )c56 - 67
39X-RAY DIFFRACTION39chain 'c' and (resid 68 through 89 )c68 - 89
40X-RAY DIFFRACTION40chain 'c' and (resid 90 through 111 )c90 - 111
41X-RAY DIFFRACTION41chain 'c' and (resid 112 through 117 )c112 - 117
42X-RAY DIFFRACTION42chain 'C' and (resid 1 through 7 )C1 - 7
43X-RAY DIFFRACTION43chain 'C' and (resid 8 through 44 )C8 - 44
44X-RAY DIFFRACTION44chain 'C' and (resid 45 through 55 )C45 - 55
45X-RAY DIFFRACTION45chain 'C' and (resid 56 through 67 )C56 - 67
46X-RAY DIFFRACTION46chain 'C' and (resid 68 through 89 )C68 - 89
47X-RAY DIFFRACTION47chain 'C' and (resid 90 through 111 )C90 - 111
48X-RAY DIFFRACTION48chain 'C' and (resid 112 through 117 )C112 - 117

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