タイプ: Polypeptide / クラス: 抗生剤 / 分子量: 1291.446 Da / 分子数: 1 / 由来タイプ: 天然 詳細: ACTINOMYCIN D CONSISTS OF TWO PENTAMER RINGS LINKED BY THE CHROMOPHORE (PXZ) 由来: (天然) Streptomyces sp. (バクテリア) / 参照: NOR: NOR00228, Actinomycin D
#4: タンパク質・ペプチド
Echinomycin
タイプ: Cyclic depsipeptide / クラス: 抗生剤 / 分子量: 809.008 Da / 分子数: 1 / 由来タイプ: 天然 詳細: ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE. BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI, AND A THIOACETAL BOND BETWEEN RESIDUES 3 AND 7. THE TWO QUINOXALINE CHROMOPHORES ...詳細: ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE. BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI, AND A THIOACETAL BOND BETWEEN RESIDUES 3 AND 7. THE TWO QUINOXALINE CHROMOPHORES ARE LINKED TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. 由来: (天然) Streptomyces sp. (バクテリア) / 参照: NOR: NOR01126, Echinomycin
タイプ: Cyclic depsipeptide / クラス: 抗生剤 / 分子量: 174.156 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C9H6N2O2 詳細: ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE. BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI, AND A THIOACETAL BOND BETWEEN RESIDUES 3 AND 7. THE TWO QUINOXALINE CHROMOPHORES ...詳細: ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE. BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI, AND A THIOACETAL BOND BETWEEN RESIDUES 3 AND 7. THE TWO QUINOXALINE CHROMOPHORES ARE LINKED TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. 参照: Echinomycin
ACTINOMYCIN D IS A BICYCLIC PEPTIDE, A MEMBER OF THE ACTINOMYCIN FAMILY. HERE, ACTINOMYCIN D IS ...ACTINOMYCIN D IS A BICYCLIC PEPTIDE, A MEMBER OF THE ACTINOMYCIN FAMILY. HERE, ACTINOMYCIN D IS REPRESENTED BY THE SEQUENCE (SEQRES) THE ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE, A MEMBER OF THE QUINOXALINE CLASS OF ANTIBIOTICS. HERE, ECHINOMYCIN IS REPRESENTED BY GROUPING TOGETHER THE SEQUENCE (SEQRES) AND TWO LIGANDS (HET) QUI.
研究の焦点であるリガンドがあるか
N
-
実験情報
-
実験
実験
手法: X線回折 / 使用した結晶の数: 1
-
試料調製
結晶
マシュー密度: 2.43 Å3/Da / 溶媒含有率: 49.38 % 解説: The entry contains friedel pairs in F_plus/minus columns and I_plus/minus columns
結晶化
温度: 293 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 7 詳細: 2.5 mM Sodium Cacodylate, 1 mM Magnesium chloride, 1 mM Spermine tetrahydrochloride, 1.5 mM Zinc Chloride, 1% PEG 200
解像度: 2→25.22 Å / SU ML: 0.2 / 交差検証法: THROUGHOUT / σ(F): 1.35 / 位相誤差: 24.66 / 立体化学のターゲット値: ML 詳細: The entry contains friedel pairs in F_plus/minus columns and I_plus/minus columns
Rfactor
反射数
%反射
Rfree
0.2494
716
9.87 %
Rwork
0.2316
6541
-
obs
0.2333
7257
88.01 %
溶媒の処理
減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL