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Structure paper

TitleSynergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects.
Journal, issue, pagesNucleic Acids Res., Year 2023
Publish dateDec 22, 2020 (structure data deposition date)
AuthorsSatange, R. / Chang, C.C. / Li, L.Y. / Lin, S.H. / Neidle, S. / Hou, M.H.
External linksNucleic Acids Res. / PubMed:36919604
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-7dq0:
Crystal structure of actinomycin D-echinomycin-d(ACGTGCT/AGCTCGT) complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7dq8:
Crystal structure of actinomycin D-echinomycin-d(ACGCGCT/AGCTCGT) complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-QUI:
2-CARBOXYQUINOXALINE

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • streptomyces sp. (bacteria)
  • synthetic construct (others)
KeywordsANTIBIOTIC/DNA / Drug-DNA complex / DNA mismatch / DNA unwinding / DNA deformation / DNA / ANTIBIOTIC-DNA complex

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