Entry | Database: PDB / ID: 7dfp |
---|
Title | Human dopamine D2 receptor in complex with spiperone |
---|
Components | - D(2) dopamine receptor,Soluble cytochrome b562
- FabH
- FabL
|
---|
Keywords | MEMBRANE PROTEIN / G-protein coupled receptor / Dopamine receptor / Spiperone / antipsychotic / Schizophrenia |
---|
Function / homology | Function and homology information
regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity ...regulation of locomotion involved in locomotory behavior / negative regulation of dopamine receptor signaling pathway / positive regulation of dopamine uptake involved in synaptic transmission / negative regulation of circadian sleep/wake cycle, sleep / acid secretion / positive regulation of glial cell-derived neurotrophic factor production / dopamine neurotransmitter receptor activity, coupled via Gi/Go / auditory behavior / nervous system process involved in regulation of systemic arterial blood pressure / regulation of synapse structural plasticity / response to histamine / positive regulation of renal sodium excretion / adenohypophysis development / neuron-neuron synaptic transmission / hyaloid vascular plexus regression / cerebral cortex GABAergic interneuron migration / regulation of potassium ion transport / negative regulation of neuron migration / Dopamine receptors / adenylate cyclase-inhibiting dopamine receptor signaling pathway / negative regulation of cellular response to hypoxia / orbitofrontal cortex development / response to inactivity / dopamine binding / regulation of dopamine uptake involved in synaptic transmission / branching morphogenesis of a nerve / negative regulation of voltage-gated calcium channel activity / negative regulation of dopamine secretion / positive regulation of growth hormone secretion / heterotrimeric G-protein binding / behavioral response to ethanol / dopaminergic synapse / drinking behavior / peristalsis / G protein-coupled receptor complex / phospholipase C-activating dopamine receptor signaling pathway / grooming behavior / positive regulation of G protein-coupled receptor signaling pathway / positive regulation of urine volume / striatum development / negative regulation of adenylate cyclase activity / positive regulation of multicellular organism growth / negative regulation of synaptic transmission, glutamatergic / G protein-coupled receptor internalization / non-motile cilium / response to morphine / adult walking behavior / response to iron ion / ciliary membrane / dopamine uptake involved in synaptic transmission / regulation of synaptic transmission, GABAergic / arachidonic acid secretion / temperature homeostasis / pigmentation / postsynaptic modulation of chemical synaptic transmission / heterocyclic compound binding / dopamine metabolic process / positive regulation of neuroblast proliferation / negative regulation of cytosolic calcium ion concentration / regulation of dopamine secretion / positive regulation of cytokinesis / associative learning / positive regulation of receptor internalization / behavioral response to cocaine / lateral plasma membrane / endocytic vesicle / G-protein alpha-subunit binding / neuroblast proliferation / response to axon injury / response to light stimulus / GABA-ergic synapse / potassium channel regulator activity / sperm flagellum / negative regulation of protein secretion / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of insulin secretion / prepulse inhibition / long-term memory / axon terminus / adenylate cyclase-activating adrenergic receptor signaling pathway / regulation of sodium ion transport / release of sequestered calcium ion into cytosol / synapse assembly / response to amphetamine / presynaptic modulation of chemical synaptic transmission / negative regulation of blood pressure / negative regulation of innate immune response / excitatory postsynaptic potential / regulation of heart rate / negative regulation of cell migration / axonogenesis / phosphatidylinositol 3-kinase/protein kinase B signal transduction / acrosomal vesicle / negative regulation of protein phosphorylation / response to cocaine / epithelial cell proliferation / positive regulation of long-term synaptic potentiation / locomotory behavior / G protein-coupled receptor activity / electron transport chainSimilarity search - Function Dopamine D2 receptor / Dopamine receptor family / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)Similarity search - Domain/homology |
---|
Biological species | Homo sapiens (human)
![](img/tx_bacteria.gif) Escherichia coli (E. coli)
![](img/tx_mammal.gif) Mus musculus (house mouse) |
---|
Method | X-RAY DIFFRACTION / FREE ELECTRON LASER / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.1 Å |
---|
Authors | Im, D. / Shimamura, T. / Iwata, S. |
---|
Citation | Journal: Nat Commun / Year: 2020 Title: Structure of the dopamine D 2 receptor in complex with the antipsychotic drug spiperone. Authors: Im, D. / Inoue, A. / Fujiwara, T. / Nakane, T. / Yamanaka, Y. / Uemura, T. / Mori, C. / Shiimura, Y. / Kimura, K.T. / Asada, H. / Nomura, N. / Tanaka, T. / Yamashita, A. / Nango, E. / Tono, ...Authors: Im, D. / Inoue, A. / Fujiwara, T. / Nakane, T. / Yamanaka, Y. / Uemura, T. / Mori, C. / Shiimura, Y. / Kimura, K.T. / Asada, H. / Nomura, N. / Tanaka, T. / Yamashita, A. / Nango, E. / Tono, K. / Kadji, F.M.N. / Aoki, J. / Iwata, S. / Shimamura, T. |
---|
History | Deposition | Nov 9, 2020 | Deposition site: PDBJ / Processing site: PDBJ |
---|
Revision 1.0 | Dec 30, 2020 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jan 13, 2021 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
---|
Revision 1.2 | Sep 6, 2023 | Group: Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_related_exp_data_set Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
Revision 1.3 | Nov 29, 2023 | Group: Refinement description / Category: pdbx_initial_refinement_model |
---|
|
---|