+Open data
-Basic information
Entry | Database: PDB / ID: 7ddk | ||||||||||||
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Title | Crystal structures of Na+,K+-ATPase in complex with rostafuroxin | ||||||||||||
Components |
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Keywords | MEMBRANE PROTEIN / Na+ / K+-ATPase / ion transport / Cardiotonic steroids | ||||||||||||
Function / homology | Function and homology information Basigin interactions / Ion homeostasis / positive regulation of P-type sodium:potassium-exchanging transporter activity / Na+/K+-exchanging ATPase / positive regulation of sodium ion export across plasma membrane / Ion transport by P-type ATPases / positive regulation of potassium ion import across plasma membrane / membrane repolarization / P-type sodium:potassium-exchanging transporter activity / sodium ion binding ...Basigin interactions / Ion homeostasis / positive regulation of P-type sodium:potassium-exchanging transporter activity / Na+/K+-exchanging ATPase / positive regulation of sodium ion export across plasma membrane / Ion transport by P-type ATPases / positive regulation of potassium ion import across plasma membrane / membrane repolarization / P-type sodium:potassium-exchanging transporter activity / sodium ion binding / sodium:potassium-exchanging ATPase complex / establishment or maintenance of transmembrane electrochemical gradient / sodium ion export across plasma membrane / intracellular potassium ion homeostasis / intracellular sodium ion homeostasis / potassium ion import across plasma membrane / potassium ion binding / ATPase activator activity / sodium channel regulator activity / regulation of sodium ion transport / proton transmembrane transport / sarcolemma / transmembrane transport / melanosome / protein-macromolecule adaptor activity / ATPase binding / basolateral plasma membrane / cell adhesion / apical plasma membrane / axon / innate immune response / ATP hydrolysis activity / ATP binding / membrane / plasma membrane Similarity search - Function | ||||||||||||
Biological species | Sus scrofa (pig) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å | ||||||||||||
Authors | Ogawa, H. / Cornelius, F. / Kanai, R. / Motoyama, K. / Vilsen, B. / Toyoshima, C. | ||||||||||||
Funding support | Japan, 3items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2021 Title: Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Authors: Kanai, R. / Cornelius, F. / Ogawa, H. / Motoyama, K. / Vilsen, B. / Toyoshima, C. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7ddk.cif.gz | 668.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7ddk.ent.gz | 443.5 KB | Display | PDB format |
PDBx/mmJSON format | 7ddk.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7ddk_validation.pdf.gz | 5.2 MB | Display | wwPDB validaton report |
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Full document | 7ddk_full_validation.pdf.gz | 5.3 MB | Display | |
Data in XML | 7ddk_validation.xml.gz | 99.5 KB | Display | |
Data in CIF | 7ddk_validation.cif.gz | 130.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/dd/7ddk ftp://data.pdbj.org/pub/pdb/validation_reports/dd/7ddk | HTTPS FTP |
-Related structure data
Related structure data | 7d91C 7d92C 7d93C 7d94C 7ddfC 7ddhC 7ddiC 7ddlC 6kpu 6kpy 6kpz C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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