登録情報 データベース : PDB / ID : 7cli 構造の表示 ダウンロードとリンクタイトル Structure of NF-kB p52 homodimer bound to P-Selectin kB DNA fragment 要素DNA (5'-D(*CP*AP*AP*GP*GP*GP*GP*TP*CP*AP*CP*CP*CP*CP*CP*TP*TP*C)-3')DNA (5'-D(*GP*AP*AP*GP*GP*GP*GP*GP*TP*GP*AP*CP*CP*CP*CP*TP*TP*G)-3')Nuclear factor NF-kappa-B p52 subunit 詳細キーワード DNA BINDING PROTEIN (DNA結合タンパク質) / DNA-protein complex / transcription factor (転写因子) / TRANSCRIPTION (転写 (生物学))機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
follicular dendritic cell differentiation / Bcl3/NF-kappaB2 complex / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / IkBA variant leads to EDA-ID / germinal center formation / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / Interleukin-1 processing / non-canonical NF-kappaB signal transduction / TRAF6 mediated NF-kB activation ... follicular dendritic cell differentiation / Bcl3/NF-kappaB2 complex / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / IkBA variant leads to EDA-ID / germinal center formation / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / Interleukin-1 processing / non-canonical NF-kappaB signal transduction / TRAF6 mediated NF-kB activation / The NLRP3 inflammasome / canonical NF-kappaB signal transduction / Purinergic signaling in leishmaniasis infection / spleen development / extracellular matrix organization / NIK-->noncanonical NF-kB signaling / response to cytokine / Dectin-1 mediated noncanonical NF-kB signaling / TAK1-dependent IKK and NF-kappa-B activation / PKMTs methylate histone lysines / sequence-specific double-stranded DNA binding / rhythmic process / DNA-binding transcription activator activity, RNA polymerase II-specific / response to lipopolysaccharide / DNA-binding transcription factor activity, RNA polymerase II-specific / 炎症 / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / 自然免疫系 / クロマチン / regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / 核質 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Nuclear factor NF-kappa-B, p100 subunit / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. ... Nuclear factor NF-kappa-B, p100 subunit / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. / Rel homology domain (RHD), DNA-binding domain superfamily / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / ig-like, plexins, transcription factors / IPT domain / p53-like transcription factor, DNA-binding / Death-like domain superfamily / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Immunoglobulin E-set / Immunoglobulin-like fold 類似検索 - ドメイン・相同性 デオキシリボ核酸 / DNA (> 10) / Nuclear factor NF-kappa-B p100 subunit 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3 Å 詳細データ登録者 Meshcheryakov, V.A. / Wang, V.Y.-F. 資金援助 Macao, 2件 詳細 詳細を隠す組織 認可番号 国 The Science and Technology Development Fund, Macao S.A.R. project 0104/2019/A2 Macao The Multi-Year Research Grant from University of Macau MYRG2018-00093-FHS Macao
引用ジャーナル : Elife / 年 : 2023タイトル : Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation.著者 : Pan, W. / Meshcheryakov, V.A. / Li, T. / Wang, Y. / Ghosh, G. / Wang, V.Y. 履歴 登録 2020年7月21日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年7月21日 Provider : repository / タイプ : Initial release改定 1.1 2021年9月29日 Group : Author supporting evidence / Database references / カテゴリ : database_2 / pdbx_audit_supportItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.2 2023年3月15日 Group : Database references / Derived calculations / カテゴリ : atom_type / citation / citation_authorItem : _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z ... _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z / _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.3 2023年11月29日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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