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- PDB-7bri: Atrial Natriuretic Peptide Receptor complexed with Dendroaspis Na... -
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Open data
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Basic information
Entry | Database: PDB / ID: 7bri | |||||||||
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Title | Atrial Natriuretic Peptide Receptor complexed with Dendroaspis Natriuretic Peptide | |||||||||
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![]() | MEMBRANE PROTEIN / RECEPTOR-HORMONE COMPLEX / NATRIURETIC PEPTIDE / NATRIURETIC PEPTIDE RECEPTOR / GUANYLYL-CYCLASE-COUPLED RECEPTOR / SIGNAL TRANSMISSION / ROTATION MECHANISM / SIGNALING PROTEIN | |||||||||
Function / homology | ![]() ANPR-A receptor complex / Physiological factors / natriuretic peptide receptor activity / positive regulation of cGMP-mediated signaling / receptor guanylyl cyclase signaling pathway / peptide receptor activity / guanylate cyclase / cGMP biosynthetic process / guanylate cyclase activity / hormone binding ...ANPR-A receptor complex / Physiological factors / natriuretic peptide receptor activity / positive regulation of cGMP-mediated signaling / receptor guanylyl cyclase signaling pathway / peptide receptor activity / guanylate cyclase / cGMP biosynthetic process / guanylate cyclase activity / hormone binding / adenylate cyclase activity / dopamine metabolic process / cGMP-mediated signaling / peptide hormone binding / blood vessel diameter maintenance / negative regulation of smooth muscle cell proliferation / hormone activity / regulation of blood pressure / vasodilation / toxin activity / cell surface receptor signaling pathway / receptor complex / protein kinase activity / intracellular signal transduction / GTP binding / extracellular region / ATP binding / plasma membrane Similarity search - Function | |||||||||
Biological species | ![]() ![]() ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Ogawa, H. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Structural insight into hormone-recognition and transmembrane signaling by the atrial natriuretic peptide receptor Authors: Ogawa, H. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 383.2 KB | Display | ![]() |
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PDB format | ![]() | 316 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 2.5 MB | Display | ![]() |
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Full document | ![]() | 2.5 MB | Display | |
Data in XML | ![]() | 35.9 KB | Display | |
Data in CIF | ![]() | 50.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7brgC ![]() 7brhC ![]() 7brjC ![]() 7brkC ![]() 7brlC ![]() 1dp4S S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
-Protein / Protein/peptide , 2 types, 3 molecules ABL
#1: Protein | Mass: 48434.828 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() #2: Protein/peptide | | Mass: 4199.708 Da / Num. of mol.: 1 / Source method: obtained synthetically Source: (synth.) ![]() References: UniProt: P28374 |
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-Sugars , 2 types, 4 molecules
#3: Polysaccharide | Source method: isolated from a genetically manipulated source #4: Polysaccharide | Source method: isolated from a genetically manipulated source |
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-Non-polymers , 2 types, 142 molecules ![](data/chem/img/CL.gif)
![](data/chem/img/HOH.gif)
![](data/chem/img/HOH.gif)
#5: Chemical | #6: Water | ChemComp-HOH / | |
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-Details
Has ligand of interest | Y |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.72 Å3/Da / Density % sol: 66.92 % |
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Crystal grow | Temperature: 300 K / Method: vapor diffusion, hanging drop / Details: Sodium malonate, MES / PH range: 6.3 - 6.6 |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: RAYONIX MX225HE / Detector: CCD / Date: Dec 19, 2010 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9 Å / Relative weight: 1 |
Reflection | Resolution: 2.45→50 Å / Num. obs: 51990 / % possible obs: 96.3 % / Redundancy: 22.1 % / CC1/2: 0.99 / Rmerge(I) obs: 0.053 / Net I/σ(I): 30 |
Reflection shell | Resolution: 2.45→2.52 Å / Rmerge(I) obs: 0.255 / Mean I/σ(I) obs: 4.6 / Num. unique obs: 4457 / CC1/2: 0.66 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: 1DP4 Resolution: 2.45→30.711 Å / SU ML: 0.35 / Cross valid method: FREE R-VALUE / σ(F): 2.1 / Phase error: 24.39
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.45→30.711 Å
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Refine LS restraints |
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LS refinement shell |
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Refinement TLS params. | Method: refined / Refine-ID: X-RAY DIFFRACTION
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Refinement TLS group |
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