登録情報 | データベース: PDB / ID: 7aqg |
---|
タイトル | Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) |
---|
要素 | - Plasminogen activator inhibitor 1
- VHH-2g-42 (Nb42)
- VHH-2w-64 (Nb64)
|
---|
キーワード | HYDROLASE / plasminogen activator inhibitor-1 / PAI-1 / PAI-1-W175F / serpin / protease inhibitor / serine protease inhibitor / small molecule / antibody fragments / nanobodies / protein complex |
---|
機能・相同性 | 機能・相同性情報
positive regulation of leukotriene production involved in inflammatory response / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of smooth muscle cell migration / peptidase inhibitor complex / negative regulation of vascular wound healing / negative regulation of wound healing / positive regulation of odontoblast differentiation / negative regulation of cell adhesion mediated by integrin / negative regulation of endopeptidase activity ...positive regulation of leukotriene production involved in inflammatory response / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of smooth muscle cell migration / peptidase inhibitor complex / negative regulation of vascular wound healing / negative regulation of wound healing / positive regulation of odontoblast differentiation / negative regulation of cell adhesion mediated by integrin / negative regulation of endopeptidase activity / regulation of signaling receptor activity / negative regulation of plasminogen activation / negative regulation of blood coagulation / positive regulation of monocyte chemotaxis / Dissolution of Fibrin Clot / replicative senescence / ECM proteoglycans / positive regulation of blood coagulation / negative regulation of fibrinolysis / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / serine protease inhibitor complex / fibrinolysis / BMAL1:CLOCK,NPAS2 activates circadian gene expression / platelet alpha granule lumen / negative regulation of cell migration / positive regulation of interleukin-8 production / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / serine-type endopeptidase inhibitor activity / positive regulation of receptor-mediated endocytosis / positive regulation of inflammatory response / positive regulation of angiogenesis / Platelet degranulation / cellular response to lipopolysaccharide / protease binding / angiogenesis / collagen-containing extracellular matrix / defense response to Gram-negative bacterium / signaling receptor binding / extracellular space / extracellular exosome / extracellular region / plasma membrane類似検索 - 分子機能 Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / Serpin family / Serpin domain / Serpin superfamily / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) / SERine Proteinase INhibitors類似検索 - ドメイン・相同性 Chem-RV2 / Plasminogen activator inhibitor 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) Vicugna pacos (アルパカ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.27 Å |
---|
データ登録者 | Sillen, M. / Strelkov, S.V. / Declerck, P.J. |
---|
資金援助 | ベルギー, 2件 組織 | 認可番号 | 国 |
---|
Research Foundation - Flanders (FWO) | 11ZQ918N | ベルギー | Research Foundation - Flanders (FWO) | G072915N | ベルギー |
|
---|
引用 | ジャーナル: Int J Mol Sci / 年: 2021 タイトル: Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. 著者: Sillen, M. / Miyata, T. / Vaughan, D.E. / Strelkov, S.V. / Declerck, P.J. |
---|
履歴 | 登録 | 2020年10月21日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2021年2月24日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|