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-Structure paper
Title | Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. |
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Journal, issue, pages | Int J Mol Sci, Vol. 22, Year 2021 |
Publish date | Oct 21, 2020 (structure data deposition date) |
Authors | Sillen, M. / Miyata, T. / Vaughan, D.E. / Strelkov, S.V. / Declerck, P.J. |
External links | Int J Mol Sci / PubMed:33540702 |
Methods | X-ray diffraction |
Resolution | 1.77 - 2.27 Å |
Structure data | PDB-7aqf: PDB-7aqg: |
Chemicals | ChemComp-RV2: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / plasminogen activator inhibitor-1 / PAI-1 / PAI-1-stab / serpin / protease inhibitor / serine protease inhibitor / small molecule inhibitor / PAI-1-W175F / small molecule / antibody fragments / nanobodies / protein complex |