Entry | Database: PDB / ID: 7ah8 |
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Title | NF-Y bound to suramin inhibitor |
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Components | - Isoform 6 of Nuclear transcription factor Y subunit gamma
- Nuclear transcription factor Y subunit beta
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Keywords | TRANSCRIPTION / Transcription factor / NF-Y / HFD / Inhibitor / Suramin |
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Function / homology | Function and homology information
CCAAT-binding factor complex / ATF6 (ATF6-alpha) activates chaperone genes / ATF4 activates genes in response to endoplasmic reticulum stress / FOXO-mediated transcription of cell death genes / Activation of gene expression by SREBF (SREBP) / cellular response to leukemia inhibitory factor / protein-DNA complex / PPARA activates gene expression / RNA polymerase II transcription regulator complex / protein folding ...CCAAT-binding factor complex / ATF6 (ATF6-alpha) activates chaperone genes / ATF4 activates genes in response to endoplasmic reticulum stress / FOXO-mediated transcription of cell death genes / Activation of gene expression by SREBF (SREBP) / cellular response to leukemia inhibitory factor / protein-DNA complex / PPARA activates gene expression / RNA polymerase II transcription regulator complex / protein folding / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / DNA-binding transcription factor activity, RNA polymerase II-specific / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleusSimilarity search - Function Transcription factor, NFYB/HAP3, conserved site / Transcription factor NFYB/HAP3 / NF-YB/HAP3 subunit signature. / Transcription factor CBF/NF-Y/archaeal histone domain / Histone-like transcription factor (CBF/NF-Y) and archaeal histone / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-foldSimilarity search - Domain/homology CITRATE ANION / Chem-SVR / Nuclear transcription factor Y subunit beta / Nuclear transcription factor Y subunit gammaSimilarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.70001356517 Å |
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Authors | Nardone, V. / Chaves-Sanjuan, A. / Lapi, M. / Nardini, M. |
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Funding support | Italy, 2items Organization | Grant number | Country |
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Italian Association for Cancer Research | IG-15267 | Italy | Italian Ministry of Education | 2017SBFHLH | Italy |
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Citation | Journal: Cells / Year: 2020 Title: Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin. Authors: Nardone, V. / Chaves-Sanjuan, A. / Lapi, M. / Airoldi, C. / Saponaro, A. / Pasqualato, S. / Dolfini, D. / Camilloni, C. / Bernardini, A. / Gnesutta, N. / Mantovani, R. / Nardini, M. |
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History | Deposition | Sep 24, 2020 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Aug 4, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 31, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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