登録情報 | データベース: PDB / ID: 7ah5 |
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タイトル | Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0706 |
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要素 | Indoleamine 2,3-dioxygenase 1 |
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キーワード | OXIDOREDUCTASE / Dioxygenase / Heme-containing enzyme / Structure-based drug design / IDO1 inhibitor / Triazole / Small-molecule inhibitor |
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機能・相同性 | 機能・相同性情報
indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response ... indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / negative regulation of T cell apoptotic process / positive regulation of T cell apoptotic process / swimming behavior / negative regulation of interleukin-10 production / multicellular organismal response to stress / T cell proliferation / negative regulation of T cell proliferation / positive regulation of interleukin-12 production / female pregnancy / response to lipopolysaccharide / electron transfer activity / inflammatory response / heme binding / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase signature 1. / Indoleamine 2,3-dioxygenase signature 2. / Tryptophan/Indoleamine 2,3-dioxygenase-like類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / 4-chloranyl-2-(1~{H}-1,2,4-triazol-5-yl)aniline / Indoleamine 2,3-dioxygenase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Roehrig, U.F. / Reynaud, A. / Pojer, F. / Michielin, O. / Zoete, V. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2021 タイトル: Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. 著者: Rohrig, U.F. / Majjigapu, S.R. / Reynaud, A. / Pojer, F. / Dilek, N. / Reichenbach, P. / Ascencao, K. / Irving, M. / Coukos, G. / Vogel, P. / Michielin, O. / Zoete, V. |
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履歴 | 登録 | 2020年9月24日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年2月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年2月24日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2021年3月10日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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