登録情報 | データベース: PDB / ID: 6zqs |
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タイトル | Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) |
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要素 | - Cyclic AMP-dependent transcription factor ATF-2
- Mitogen-activated protein kinase 14
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キーワード | TRANSCRIPTION / MAPK SIGNALING PATHWAYS |
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機能・相同性 | 機能・相同性情報
abducens nucleus development / hypoglossal nucleus development / detection of cell density / H4 histone acetyltransferase complex / growth plate cartilage chondrocyte proliferation / facial nucleus development / growth plate cartilage chondrocyte differentiation / positive regulation of cardiac muscle myoblast proliferation / cellular response to anisomycin / positive regulation of transforming growth factor beta2 production ...abducens nucleus development / hypoglossal nucleus development / detection of cell density / H4 histone acetyltransferase complex / growth plate cartilage chondrocyte proliferation / facial nucleus development / growth plate cartilage chondrocyte differentiation / positive regulation of cardiac muscle myoblast proliferation / cellular response to anisomycin / positive regulation of transforming growth factor beta2 production / cAMP response element binding / leucine zipper domain binding / cellular lipid metabolic process / cAMP response element binding protein binding / histone H2B acetyltransferase activity / positive regulation of mitochondrial membrane permeability involved in apoptotic process / cellular response to leucine starvation / brainstem development / NK T cell differentiation / vacuole organization / neurofilament cytoskeleton organization / histone H4 acetyltransferase activity / apoptotic process involved in development / NGF-stimulated transcription / positive regulation of cyclase activity / stress-activated protein kinase signaling cascade / intrinsic apoptotic signaling pathway in response to hypoxia / mitotic intra-S DNA damage checkpoint signaling / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / motor neuron apoptotic process / CD163 mediating an anti-inflammatory response / response to osmotic stress / regulation of synaptic membrane adhesion / stress-induced premature senescence / cell surface receptor protein serine/threonine kinase signaling pathway / 3'-UTR-mediated mRNA stabilization / KSRP (KHSRP) binds and destabilizes mRNA / cartilage condensation / DSCAM interactions / cellular response to UV-B / Platelet sensitization by LDL / mitogen-activated protein kinase p38 binding / positive regulation of myoblast fusion / positive regulation of muscle cell differentiation / negative regulation of hippo signaling / positive regulation of myotube differentiation / NFAT protein binding / Myogenesis / hepatocyte apoptotic process / outflow tract morphogenesis / glucose import / Activation of the AP-1 family of transcription factors / regulation of cytokine production involved in inflammatory response / ERK/MAPK targets / p38MAPK cascade / fatty acid oxidation / cellular response to lipoteichoic acid / MAP kinase kinase activity / response to dietary excess / response to muramyl dipeptide / Response of EIF2AK4 (GCN2) to amino acid deficiency / white fat cell differentiation / RHO GTPases Activate NADPH Oxidases / MAP kinase activity / regulation of ossification / cellular response to vascular endothelial growth factor stimulus / mitogen-activated protein kinase / signal transduction in response to DNA damage / positive regulation of myoblast differentiation / cis-regulatory region sequence-specific DNA binding / chondrocyte differentiation / adipose tissue development / BMP signaling pathway / hematopoietic progenitor cell differentiation / vascular endothelial growth factor receptor signaling pathway / stress-activated MAPK cascade / histone acetyltransferase activity / skeletal muscle tissue development / JNK cascade / positive regulation of cardiac muscle cell proliferation / lipopolysaccharide-mediated signaling pathway / negative regulation of inflammatory response to antigenic stimulus / p38MAPK events / transcription initiation-coupled chromatin remodeling / striated muscle cell differentiation / response to muscle stretch / positive regulation of interleukin-12 production / positive regulation of brown fat cell differentiation / negative regulation of angiogenesis / osteoclast differentiation / positive regulation of erythrocyte differentiation / liver development / DNA damage checkpoint signaling / Regulation of PTEN gene transcription / activated TAK1 mediates p38 MAPK activation / cellular response to ionizing radiation / stem cell differentiation / positive regulation of glucose import / promoter-specific chromatin binding / TP53 Regulates Transcription of DNA Repair Genes類似検索 - 分子機能 Transcription factor cyclic AMP-dependent, CRE-BP1-type / bZIP transcription factor / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain superfamily / Basic-leucine zipper domain / Mitogen-activated protein kinase 14 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site ...Transcription factor cyclic AMP-dependent, CRE-BP1-type / bZIP transcription factor / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain superfamily / Basic-leucine zipper domain / Mitogen-activated protein kinase 14 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Chem-3FF / Cyclic AMP-dependent transcription factor ATF-2 / Mitogen-activated protein kinase 14類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | Kirsch, K. / Sok, P. / Poti, A.L. / Remenyi, A. |
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資金援助 | ハンガリー, 2件 組織 | 認可番号 | 国 |
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National Research Development and Innovation Office (NKFIH) | NN 114309 | ハンガリー | National Research Development and Innovation Office (NKFIH) | KKP 126963 | ハンガリー |
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引用 | ジャーナル: Nat Commun / 年: 2020 タイトル: Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. 著者: Kirsch, K. / Zeke, A. / Toke, O. / Sok, P. / Sethi, A. / Sebo, A. / Kumar, G.S. / Egri, P. / Poti, A.L. / Gooley, P. / Peti, W. / Bento, I. / Alexa, A. / Remenyi, A. |
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履歴 | 登録 | 2020年7月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年11月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年11月25日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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