Entry | Database: PDB / ID: 6z0o |
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Title | Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein |
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Components | |
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Keywords | VIRAL PROTEIN / Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein / Affimer-NP / complex / high-affinity / anti-viral / RNA-binding |
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Function / homology | Nucleocapsid N protein / Nucleocapsid N protein / helical viral capsid / viral nucleocapsid / ribonucleoprotein complex / Nucleoprotein Function and homology information |
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Biological species | Crimean-Congo hemorrhagic fever orthonairovirus synthetic construct (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.5974 Å |
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Authors | Alvarez-Rodriguez, B. / Tiede, C. / Trinh, C. / Tomlinson, D. / Edwards, T.A. / Barr, J.N. |
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Funding support | United Kingdom, 1items Organization | Grant number | Country |
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European Union (EU) | 721367 | United Kingdom |
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Citation | Journal: Plos Negl Trop Dis / Year: 2020 Title: Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests. Authors: Alvarez-Rodriguez, B. / Tiede, C. / Hoste, A.C.R. / Surtees, R.A. / Trinh, C.H. / Slack, G.S. / Chamberlain, J. / Hewson, R. / Fresco, A. / Sastre, P. / Tomlinson, D.C. / Millner, P.A. / ...Authors: Alvarez-Rodriguez, B. / Tiede, C. / Hoste, A.C.R. / Surtees, R.A. / Trinh, C.H. / Slack, G.S. / Chamberlain, J. / Hewson, R. / Fresco, A. / Sastre, P. / Tomlinson, D.C. / Millner, P.A. / Edwards, T.A. / Barr, J.N. |
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History | Deposition | May 10, 2020 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 27, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 9, 2020 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_ncs_dom_lim.selection_details |
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