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TitleCharacterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Journal, issue, pagesPlos Negl Trop Dis, Vol. 14, Page e0008364-e0008364, Year 2020
Publish dateMay 10, 2020 (structure data deposition date)
AuthorsAlvarez-Rodriguez, B. / Tiede, C. / Hoste, A.C.R. / Surtees, R.A. / Trinh, C.H. / Slack, G.S. / Chamberlain, J. / Hewson, R. / Fresco, A. / Sastre, P. ...Alvarez-Rodriguez, B. / Tiede, C. / Hoste, A.C.R. / Surtees, R.A. / Trinh, C.H. / Slack, G.S. / Chamberlain, J. / Hewson, R. / Fresco, A. / Sastre, P. / Tomlinson, D.C. / Millner, P.A. / Edwards, T.A. / Barr, J.N.
External linksPlos Negl Trop Dis / PubMed:32492018
MethodsX-ray diffraction
Resolution2.5974 Å
Structure data

PDB-6z0o:
Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein
Method: X-RAY DIFFRACTION / Resolution: 2.5974 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • crimean-congo hemorrhagic fever orthonairovirus
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein / Affimer-NP / complex / high-affinity / anti-viral / RNA-binding

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